个人简介

B.S., Louisiana State University, 1964 Ph.D., University of California, Berkeley, 1967 NIH Postdoctoral Fellow, University of California, Los Angeles, 1967

研究领域

BIOORGANIC CHEMISTRY

My research group is interested in problems at the interface between organic chemistry and biochemistry. We study reactions catalyzed by enzymes in the isoprene biosynthetic pathway with special emphasis on establishing the mechanisms of the enzyme-catalyzed transformations and how the enzymes promote the reactions.

近期论文

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Walker, J.R.; Rothman, S.C.; Poulter, C.D. Synthesis and Evaluation of Substrate Analogues as Mechanism Based Inhibitors of Type II Isopentenyl Diphosphate Isomerase. J. Org. Chem.2008, 73, 726-729. Thulasiram, H.V.; Erickson, H.K.; Poulter, C.D. A Common Mechanism for Branching, Cyclopropanation, and Cyclobutanation Reactions in the Isoprenoid Biosynthetic Pathway. J. Am. Chem. Soc. 2008, 130, 1966-1971. McDougal, O. M.; Turner, M.W.; Ormond, A.J.; Poulter, C.D. Three-Dimensional Structure of Conotoxin tx3a: An m-1 Branch Peptide of the M-Superfamily. Biochemistry2008, 47, 2826-2832. Rothman, S.C.; Johnston, J.B.; Lee, S.; Walker, J.R.; Poulter, C.D. Type II Isopentenyl Diphosphate Isomerase: Irreversible Inactivation by Covalent Modification of Flavin. J. Am. Chem. Soc.2008, 130, 4906-4913. Lee, S.; Poulter, C.D. Cloning, Solubilization, and Characterization of Squalene Synthase from Thermosynechococcus elongates BP-1. J. Bacteriol.2008, 190, 3808-3816. de Ruyck, J.; Pouyez, J.; Rothman, S.C.; Poulter, C.D.; Wouters, J. Crystal Structure of Type 2 Isopentenyl Diphosphate Isomerase from Thermus thermophilus in Complex with Inorganic Pyrophosphate. Biochemistry2008, 47, 9051-9053. Poulter, C.D.; Bioorganic Chemistry. A Natural Reunion of the Physical and Life Sciences. J. Org. Chem.2009, 74, 2631-2645. Pan, J.-J.; Bugni, T.S.; Poulter, C.D. Recombinant Squalene Synthase. Synthesis of Cyclopentyl Non-Head-to-Tail Triterpenes. J. Org. Chem.2009, 74, 7562-7565. Chen, M.; Poulter, C.D. Characterization of Thermophilic Archaeal Isopentenyl Phosphate Kinases., Biochemistry2010, 49, 207-217. Mabanglo, M.F.; Schubert, H.L.; Chen, M.; Hill, C.P.; Poulter, C.D. X-ray Structures of Isopentenyl Phosphate Kinase. ACS Chem. Biol.2010, 5, 317-327. Koohang, A.; Bailey, J.L.; Coates, R.M.; Erickson, H.L.; Owen, D.; Poulter, C.D. Enantioselective Inhibition of Squalene Synthase by Azridine Analogues of Presqualane Diphosphate. J. Org. Chem.2010, 75, 4769-4777. Sharma, N.K.; Pan, J.J; Poulter, C. D. Type II Isopentenyl Diphosphate Isomerase: Probing the Mechanism with Alkyne/Allene Diphosphate Substrate Analogues. Biochemistry2010, 49, 6228-6233. Poulter, C.D.; Hahn, F.; Cornish, R.; Testa, C. Antibacterial and Herbicidal Compounds and System for Screening the Same. U.S. Patent 7,736,881, June 15, 2010. Heaps, N. A.; Poulter, C. D. Synthesis and Evaluation of Chlorinated Substrate Analogues for Franesyl Diphosphate Synthase. J. Org. Chem2011, 76, 1838-1843.