李文凤 - 南京林业大学 - 生物与环境学院

个人简介

个人简介：李文凤，女，博士，教授，博士生导师。2001年在中国农业科学院获博士学位，先后在中国科学院遗传发育所、德国、澳大利亚和台湾做博士后研究工作。 2013年10月入选江苏特聘教授，至南京林业大学工作。 1. 江苏省自然科学基金面上项目， 2014-2017年 2. 土壤与农业可持续发展国家重点实验室开放课题， 2014-2017年 3. 国家自然科学基金面上项目， 2015-2018年

研究领域

研究领域是植物营养分子生物学。磷和铁是植物必需的矿质元素,供应不足会对植物的生长发育、产量形成及品质优劣具有重大影响。固着生长的植物发展出从转录、转录后到翻译后修饰等多个层面复杂精细的调控网络，以适应生长地缺磷和缺铁的外界环境。作为调控基因表达的重要机制，可变剪切（Alternative Splicing, AS）广泛存在于高等真核生物中，影响植物的生长发育和响应外界环境变化。我们对缺铁和缺磷条件下拟南芥根部全基因组范围的可变剪切进行了分析，发现了很多受缺铁和缺磷调控的可变剪切，提出了mRNA的可变剪切可能参与了植物缺铁反应的精细调控（Li et al,2013)。在此基础上，我们将进一步挖掘功能性可变剪切异构体，明确其生物学功能和可能的作用机制，并探讨缺铁调控可变剪切变化的机制。

近期论文

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1.Li Wenfeng, Perry P, Prafulla N, Schmidt W. 2009. Ubiquitin-specific protease 14 (UBP14) is involved in root responses to phosphate deficiency in Arabidopsis. Molecular Plant, 3: 212 - 223. 2.Wenfeng Li and Wolfgang Schmidt. 2010. A Lysine 63-Linked Ubiquitin Chain Forming Conjugase, UBC13, Promotes the Developmental Responses to Iron Deficiency in Arabidopsis Roots. Plant Journal, 62: 330-343 3.Wenfeng Li and Wolfgang Schmidt. 2010. Non-proteolytic Protein Ubiquitination is Crucial for Iron Deficiency Signaling. Plant Signaling & Behavior, 5(5) 4.Wenfeng Li, Wen-Dar Lin, Prasun Ray, Ping Lan, and Wolfgang Schmidt. Genome-Wide Detection of Condition-Sensitive Alternative Splicing in Arabidopsis Roots. Plant Physiol., 2013 Jul;162(3):1750-63 5.Li Wenfeng, Csukai M, Corran A, Crowley P, Solomon PS & Oliver RP (2008) Malayamycin, a new streptomycete antifungal compound, specifically inhibits sporulation of Stagonospora nodorum, cause of wheat glume blotch disease Pest Management Science, 64(12):1294-302. 6.Ping Lan#,Wenfeng Li#, Wen-Dar Lin,Simonetta Santi,and Wolfgang Schmidt. Mapping gene activity of Arabidopsis root hairs. Genome Biol. 2013 Jun 25;14(6):R67 7.Ping Lan#, Wenfeng Li#, Huizhong Wang, Wujun Ma. Characterization, sub-cellular localization and expression profiling of the isoprenylcysteine methylesterase gene family in Arabidopsis thaliana. BMC Plant Biol. 2010 Sep 27;10: 212 8.Ping Lan, Wenfeng Li, Tuan-Nan Wen, Jeng-Yuan Shiau, Yu-Ching Wu, Wendar Lin, and Wolfgang Schmidt. iTRAQ Protein Profile Analysis of Arabidopsis Roots Reveals New Aspects Critical for Iron Homeostasis. Plant Physiol. 2011 Feb;155(2):821-34 9.Ping Lan, Wenfeng Li, Tuan-Nan Wen, Wolfgang Schmidt. Quantitative phosphoproteome profiling of iron-deficient Arabidopsis roots. Plant Physiol. 2012 May; 159(1):403-17 10.Ping Lan, Wenfeng Li and Wolfgang Schmidt. Complementary Proteome and Transcriptome Profiling in Phosphate-Deficient Arabidopsis Roots Reveals Multiple Levels of Gene Regulation. Molecular and Cellular Proteomics. 2012, 11(11):1156-66 11.Ping Lan, Wenfeng Li and Wolfgang Schmidt. Genome-wide co-expression analysis predicts protein kineses as important regulators of phosphate deficiency-induced root hair remodeling in Arabidopsis. BMC Genomics, 2013, 14:210 12.Rodr�guez-Celma J, Pan IC, Li W, Lan P, Buckhout TJ, Schmidt W. The transcriptional response of Arabidopsis leaves to Fe deficiency. Front Plant Sci. 2013 Jul 23;4:276. doi: 10.3389/fpls.2013.00276 13.Wang J, Lan P*, Gao H, Zheng L, Li W*, Schmidt W. Expression changes of ribosomal proteins in phosphate- and iron-deficient Arabidopsis roots predict stress-specific alterations in ribosome composition. BMC Genomics. 2013 Nov 13;14(1):783. 14.Lan P, Li WF and Schmidt W. A digital compendium of genes mediating the reversible phosphorylation of proteins in Fe-deficient Arabidopsis roots. Front Plant Sci. 2013 Jun 3;4:173.