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个人简介

Edward W. Morley Award of the Cleveland Section of the ACS (2013) ACS Pittsburgh Award (2012) Fellow of the American Chemical Society (2010) Ernest Guenther Award in the Chemistry of Natural Products (2009)

研究领域

Total Synthesis of Natural Products/Organometallic and Heterocyclic Chemistry/Medicinal Chemistry

近期论文

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"[2,3]-Sigmatropic Rearrangements of 2-Phosphineborane 2-Propen-1-ols: Rapid Access to Enantioenriched Diphosphine Monoxide Derivatives," Busacca, C. A.; Qu, B.; Farber, E.; Haddad, N.; Gret, N.; Saha, A. K.; Eriksson, M. C.; Wu, J.-P.; Fandrick, K. R.; Han, S.; Grinberg, N.; Ma, S.; Lee, H.; Li, Z.; Spinelli, M.; Gold, A.; Wang, Z.; Wang, G.; Wipf, P.; Senanayake, C.H., Org. Lett., Vol. 15, 2013, Pages (5),1136-1139, http://www.ncbi.nlm.nih.gov/pubmed/23427861 "Hydrophosphination of Propargylic Alcohols and Amines with Phosphine Boranes," Busacca, C. A.; Qu, B.; Farber, E.; Haddad, N.;Gret, N.; Saha, A. K.; Eriksson, M. C.; Wu, J.-P.; Fandrick, K. R.; Has, S.; Grinber, N.; Ma, S.; Lee, H.; Li, Z.; Spinelli, M.; Gold, A.; Wang, G.; Wipf, P.; Senanayake, C.H., Org. Lett, Vol. 15, 2013, Pages (5), 1132-1135, http://pubs.acs.org/doi/pdfplus/10.1021/ol400309y "Influence of Base and Structure in the Reversible Covalent Conjugate Addition of Thiol to Polycyclic Enone Scaffolds," Rosenker, C. J.; Krenske, E. H.; Houk, K. N.; Wipf, P., Org. Lett., Vol. 15, 2013, Pages (5), 1076-1079, http://pubs.acs.org/doi/pdfplus/10.1021/ol400094k "TargetHunter: An In Silico Target Identification Tool for Predicting Therapeutic Potential of Small Organic Molecules Based on Chemogenomic Database," Wang, L.; Ma, C. Wipf, P.; Liu, H.; Su, W.; Xie, X.-Q., AAPSJ, 2013, http://www.ncbi.nlm.nih.gov/pubmed/23292636 "Mitochondrial-derived Reactive Oxygen Species (ROS) Play a Causal Role in Aging-related Intervertebral Disc Degeneration," Nasto, L. A.; Robinson, A.; Ngo, K.; Clausen, C. L.; Dong, Q.; St. Croix, C.; Sowa, G.; Pola, E.; Robbins, P. D.; Kang, J.; Niedernhofer, L. J.; Wipf, P.; Vo, M. V. , J. Orthopaed. Res. , 2013, http://www.ncbi.nlm.nih.gov/pubmed/23389888 "Cycloadditions in Heterocycle and Alkaloid Synthesis," Wipf, P.; Fang, Z.; Ferrié, L.; Ueda, M.; Walczak, M. A. A.; Yan, Y.; Yang, M., Pure Appl. Chem, Vol. 85, 2013, http://pac.iupac.org/publications/pac/pdf/asap/pdf/PAC-CON-12-09-03.pdf "Nanoassembly of Surfactants with Interfacial Drug-Interactive Motifs as Tailor-Designed Drug Carriers," Gao, X.; Huang, Y.; Makhov, A. M.; Epperly, M.; Lu, J.; Grab, S.; Zhang, P.; Rohan, L.; Xie, X.-Q.; Wipf, P.; Greenberger, J.; Li, S., S. Mol. Pharm., Vol. 10, 2013, Pages 187-198, http://www.ncbi.nlm.nih.gov/pubmed/23244299 "5-Hydroxyindoles by Intramolecular Alkynol-Furan Diels-Alder Cycloaddition," LaPorte, M.; Hong, K. B.; Xu, J.; Wipf, P., J. Org. Chem. (Prof. Robert E. Ireland Memorial Issue), Vol. 78, 2013, Pages (1), 167-174, http://pubs.acs.org/doi/pdfplus/10.1021/jo3022605 "Memory of Chirality in Rebound Cyclizations of α-Amide Radicals," Sasmal, A.; Taniguchi, T.; Wipf, P.; Curran, D. P., Can. J. Chem. (Prof. Derrick Clive Special Issue), Vol. 91, 2013, Pages (1), 1-5, http://www.nrcresearchpress.com/doi/pdf/10.1139/v2012-085 "In Vitro Cytotoxicity, Pharmacokinetics, Tissue Distribution, and Metabolism of Small-Molecule Protein Kinase D Inhibitors, kb-nb142-70 and kb-nb165-09, in Mice Bearing Human Cancer Xenografts," Guo, J.; Clausen D. M.; Beumer J. H.; Parise R. A.; Egorin M. J.; Bravo-Altamirano, K.; Wipf, P.; Sharlow E. R.; Wang Q. J.; Eiseman J. L. , Cancer Chemother. Pharmacol, Vol. 71, 2013, Pages (2), 331-344, http://link.springer.com/article/10.1007%2Fs00280-012-2010-z?LI=true#page-1 "New Calcium Channel Agonists as Potential Therapeutics in Lambert-Eaton Myasthenic Syndrome and other Neuromuscular Diseases," Tarr, T. B.; Valdomir, G.; Liang, M.; Wipf, P.; Meriney, S. D., Ann. N. Y. Acad. Sci. , Vol. 1275, 2012, Pages (1), 85-91, http://www.ncbi.nlm.nih.gov/pubmed/23278582 "Synthesis and Biological Evaluation of a Selective N- and P/Q-Type Calcium Channel Agonist," Liang, M.; Tarr, T. B.; Bravo-Altamirano, K.; Valdomir, G.; Rensch, G.; Swanson, L.; DeStefino, N. R.; Mazzarisi, C. M.; Olszewski, R. A.; Wilson, G. M.; Meriney, S. D.; Wipf, P., ACS Me. Chem. Lett., Vol. 3, 2012, Pages (12), 985-990, http://pubs.acs.org/doi/pdfplus/10.1021/ml3002083 "A Targeted Library Screen Reveals a New Inhibitor Scaffold for Protein Kinase D," Tandon, M.; Wang, L.; Xu, Q.; Xie, X.; Wipf, P.; Wang, Q. J., PLoS One , Vol. 7, 2012, Pages (9), e44653, http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0044653 "Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington’s Disease," Xun, Z.; Rivera-Sanchez, S.; Ayala-Penã, S.; Lim, J.; Budworth, H.; Skoda, E. M.; Robbins, P. D.; Niedernhofer, L. J.; Wipf, P.; McMurray, C. T. , Cell Rep. , Vol. 2, 2012, Pages (5), 1137-1142, http://www.ncbi.nlm.nih.gov/pubmed/23122961 "Global Lipidomics Identifies Cardiolipin Oxidation as a Mitochondrial Target for Redox Therapy of Acute Brain Injury," Ji, J.; Kline, A. E.; Amoscato, A.; Arias, A. S.; Sparvero, L. J.; Tyurin, V. A.; Tyrina, Y. Y.; Fink, B.; Cheng, J. P.; Alexander, H.; Clark, R. S. B.; Kochanek, P. M.; Wipf, P.; Kagan, V. E.; Bayir, H., Nat. Neurosci. , Vol. 15, 2012, Pages (10), 1407-1413, http://www.nature.com/neuro/journal/v15/n10/full/nn.3195.html?WT.ec_id=NEURO-201... "Structural Basis of Functional Group Activation by Sulfotransferases in Complex Metabolic Pathways," Mccarthy, J. G.; Eisman, E. B.; Kulkarni, S.; Gerwick, L.; Gerwick, W. H.; Wipf, P.; Sherman, D. H.; Smith, J. L. , ACS Chem. Biol., Vol. 7, 2012, Pages (12), 1994-2003, http://www.ncbi.nlm.nih.gov/pubmed/22991895 "Lipophilicity Screening of Novel Drug-Like Compounds and Comparison to cLog P," Lu, D.; Chambers, P.; Wipf, P.; Xie, X.-Q.; Englert, D.; Weber, S. , J. Chromatogr. A, Vol. 1258, 2012, Pages 161-167, http://www.ncbi.nlm.nih.gov/pubmed/22939208 "Synthesis of a Library of Tricyclic Azepinoisoindolinones," Miller, B.; Mao, S.; Rosenker, K. M. G.; Pierce, J. G.; Wipf, P. , Beilstein J. Org. Chem. (Special Issue on Recent Developments in Chemical Diversity) , Vol. 8, 2012, Pages 1091-1097, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458725/ "Diversity-Oriented Synthesis of Peptidomimetics: How and Why," Wipf, P. , DOS, Vol. 1, 2012, Pages 6-10, http://www.degruyter.com/view/j/dos.2012.1.issue/dos-2012-0002/dos-2012-0002.xml "A Screen for Modulators of Large T Antigen’s ATPase Activity Uncovers Novel Inhibitors of Simian Virus 40 and BK Virus Replication," Seguin, S. P.; Ireland, A. W.; Miyata, Y.; Wipf, P.; Pipas, J. M.; Gestwicki, J. E.; Brodsky, J. L., Antivir. Res. , Vol. 96, 2012, Pages 70-81, http://www.ncbi.nlm.nih.gov/pubmed/22898086 "Geographic Variability and Anti-Staphylococcal Activity of the Chrysophaentins and Their Synthetic Fragments," Keffer, J. L.; Hammill, J. T.; Lloyd, J. R.; Plaza, A.; Wipf, P.; Bewley, C. A., Mar. Drugs , Vol. 10, 2012, Pages (5), 1103-1125, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397459/ "A Bifunctional Dimethylsulfoxide Substitute Enhances the Aqueous Solubility of Small Organic Molecules," Sprachman, M. M.; Wipf, P., ASSAY Drug Dev. Technol., Vol. 10, 2012, Pages (3), 269-277, http://www.ncbi.nlm.nih.gov/pubmed/22192308 "Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators," Greenberger, J. S.; Clump, D.; Kagan, V.; Bayir, H.; Lazo, J. S.; Wipf, P.; Li, S.; Gao, X.; Epperly, M. W. , Front. Oncol. , Vol. 1, 2012, Pages Article 59, 1-12, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356036/ "Synthesis of 1,2,4-Triazines and the Triazinoisoquinolinedione DEF Ring System of Noelaquinone," Cao, L.; Maciejewski, J. P.; Elzner, S.; Amantini, D.; Wipf, P., Org. Biomol. Chem. (Special 10 Year Anniversary Issue), Vol. 10, 2012, Pages 5811-5814, http://www.ncbi.nlm.nih.gov/pubmed/22473572 "Selenosemicarbazones as Potent Cruzipain Inhibitors and Their Antiparasitic Properties against Trypanosoma cruzi," Pizzo, C.; Faral-Tello, P.; Salinas, G.; Flo, M.; Robello, C.; Wipf, P.; Mahler, S. G. , MedChemComm, Vol. 3, 2012, Pages 362-368, http://pubs.rsc.org/en/content/articlepdf/2012/md/c2md00283c "Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres," Skoda, E. M.; Davis, G. C.; Wipf, P. , Org. Proc. Res. Dev. , Vol. 16, 2012, Pages (1), 26-34, http://pubs.acs.org/doi/pdf/10.1021/op2002613 "Linear and Nonlinear Support Vector Machine for the Classification of Human 5-HT1a Ligand Functionality," Wang, L.; Ma, C.; Wipf, P.; Xie, X.-Q. , Mol. Informatics , Vol. 31, 2012, Pages 85-95, http://onlinelibrary.wiley.com/doi/10.1002/minf.201100126/pdf "Genetically Encoded Redox Sensor Identifies the Role of ROS in Degenerative and Mitochondrial Disease Pathogenesis," Liu, Z.; Celotto, A. M.; Romero, G.; Wipf, P.; Palladino, M. J., Neurobiol. Dis. , Vol. 45, 2012, Pages (1), 362-368, http://www.ncbi.nlm.nih.gov/pubmed/21889980 "Structure-Activity Relationships amongst 4-Position Quinoline Methanol Antimalarials that Inhibit the Growth of Drug Sensitive and Resistant Strains of Plasmodium Falciparum.," Milner, E.; McCalmont, W.; Bhonsle, J.; Caridha, D.; Carroll, D. W.; Gardner, S.; Gerena, L.; Gettayacamin, M.; Lanteri, C.; Luong, T.; Melendez, V.; Moon, J. K.; Roncal, N. E.; Sousa, J. C.; Tangteung, A.; Wipf, P.; Dow, G. S., Bioorg. Med. Chem. Lett., Vol. 20, 2010, Pages (4), 1347-1351, http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TF9-4Y3TX68-2-S&_cdi=5... "Regioselective Palladium-Catalyzed Cross-Coupling Reactions of 2,4,7-Trichloroquinazoline.," Wipf, P.; George, K. M., Synlett (Special Issue Honoring G. Pattenden), 2010, Pages 644-648, "Screening of Antimicrobial Agents for In Vitro Radiation Protection and Mitigation Capacity, Including those Used in Supportive Care Regimens for Bone Marrow Transplant Recipients.," Epperly, M. W.; Franicola, D.; Shields, D.; Rwigema, J.-C.; Zhang, X.; McBride, W.; Georges, G.; Wipf, P.; Greenberger, J. S. , In Vivo, Vol. 24, 2010, Pages (1), 9-19, "Transmetalation Reactions Producing Organocopper Compounds.," Rosenker, C. J.; Wipf, P. In "Patai Series: The Chemistry of Functional Groups. The Chemistry of Organocopper Compounds", Rappoport, Z.; Marek, I., Eds., Wiley Interscience, 2010, Pages Part 1, Chapter 10, pp 443-525, "Peptide-Like Molecules (PLMs): A Journey from Peptide Bond Isosteres to Gramicidin S Mimetics and Mitochondrial Targeting Agents," Wipf, P.; Xiao, J.; Stephenson, C. R. J. , Chimia , Vol. 63, 2009, Pages 764-775, "Phosphatases as Targets for Cancer Treatment," Lazo, J. S.; Wipf, P., Curr. Op. Invest. Drugs, Vol. 10, 2009, Pages 1297-1304, "Mitochondrial Targeting of Electron Scavenging Antioxidants: Regulation of Selective Oxidation vs Random Chain Reactions," Kagan, V. E.; Wipf, P.; Stoyanovsky, D.; Greenberger, J. S.; Borisenko, G.; Belikova, N. A.; Yanamala, N.; Samhan Arias, A. K.; Tungekar, M. A.; Jiang, J.; Tyurina, Y. Y.; Ji, J.; Klein-Seetharaman, J.; Pitt, B. R.; Shvedova, A. A.; Bayir, H. , Adv. Drug Deliv. Rev, Vol. 61, 2009, Pages 1375-1385, "The Mitochondria-Targeted Nitroxide JP4-039 Augments Potentially Lethal Irradiation Damage Repair," Rajagopalan, M. S.; Gupta, K.; Epperly, M. W.; Franicola, D.; Zhang, X.; Wang, H.; Zhao, H.; Tyurin, V. A.; Pierce, J. G.; Kagan, V. E.; Wipf, P.; Kanai, A. J.; Greenberger, J. S., In Vivo , Vol. 23, 2009, Pages 717-726, "Synthesis of Pyrrolo[1,3]diazepines by a Dipolar Cycloaddition – retro-Mannich Domino Reaction," Liang, M.; Saiz, C.; Pizzo, C.; Wipf, P. , Tetrahedron Lett. , Vol. 50, 2009, Pages 6810-6813, "Reversible Thiazolidine Exchange: A New Reaction Suitable for Dynamic Combinatorial Chemistry," Saiz, C.; Wipf, P.; Manta, E.; Mahler, G. , Org. Lett., Vol. 11, 2009, Pages 3170-3173, "Synthesis and Biological Evaluation of the First Pentafluorosulfanyl Analogs of Mefloquine," Wipf, P.; Mo, T.; Geib, S. J.; Caridha, D.; Dow, G. S.; Gerena, L.; Roncal, N.; Milner, E. E. , Org. Biomol. Chem. , Vol. 7, 2009, Pages 4163-4165, "Evaluating b-Turn Mimics as b-Sheet Folding Nucleators," Fuller, A. A.; Du, D.; Liu, F.; Davoren, J. E.; Bhabha, G.; Kroon, G.; Case, D. A.; Dyson, H. J.; Powers, E. T.; Wipf, P.; Gruebele, M.; Kelly, J. W. , Proc. Natl. Acad. Sci. USA , Vol. 106, 2009, Pages 11067-11072, "Optical Signatures of Molecular Dissymmetry: Combining Theory with Experiments to Address Stereochemical Puzzles," Mukhopadhyay, P.; Wipf, P.; Beratan, D. N., Acc. Chem. Res. , Vol. 42, 2009, Pages 809-819, "Metamorphic Enzyme Assembly in Polyketide Diversification," Gu, L.; Wang, B.; Kulkarni, A.; Geders, T. W.; Grindberg, R. V.; Gerwick, L.; Hakansson, K.; Wipf, P.; Smith, J. L.; Gerwick, W. H.; Sherman, D. H. , Nature , Vol. 459, 2009, Pages 731-735, "Nanoparticles in Cellular Drug Delivery," Faraji, A. H.; Wipf, P., Bioorg. Med. Chem. , Vol. 17, 2009, Pages 2950-2962, "Cytochrome C/Cardiolipin Relations in Mitochondria: a Kiss of Death," Kagan, V. E.; Bayir, H.; Belikova, N. A.; Kapralov, A.; Tyurina, Y. Y.; Tyurin, V. A.; Jiang, J.; Stoyanovsky, D.; Wipf, P.; Kochanek, P. M.; Borisenko, G. G.; Greenberger, J. S.; Shvedova, A. A.; Borisenko, G., G. Mol. Free Rad. Biol. Med. , Vol. 46, 2009, Pages 1439-1453, "Isolation, Biology and Chemistry of the Disorazoles: New Anti-Cancer Macrodiolides," Hopkins, C. D.; Wipf, P. , Nat. Prod. Rep. , Vol. 26, 2009, Pages 585-601, "Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum," Chiang, A.N., Valderramos, J.-C., Balachandran, R., Chovatiya, R.J., Mead, B.P., Schneider, C., Bell, S.L., Klein, M.G., Huryn, D.M., Chen, X.S., Day, B.W., Fidock, D.A., Wipf, P., Brodsky, J.L., Bioorg. Med. Chem., Vol. 17, 2009, Pages 1527-1533, "Synthesis and Biological Evaluation of Inhibitors of Botulinum Neurotoxin Metalloprotease," Wang, C.; Widom, J.; Petronijevic, F.; Burnett, J. C.; Nuss, J. E.; Bavari, S.; Gussio, R.; Wipf, P., Heterocycles (Special Issue Honoring J. Daly), Vol. 79, 2009, Pages 487-520, "A Microwave Assisted Intramolecular-Furan-Diels-Alder Approach to 4-Substituted Indoles," Petronijevic, F.; Timmons, C.; Cuzzupe, A.; Wipf, P., Chem. Commun. , Vol. 1, 2009, Pages 104-106, "Triple Hybrids of Steroids, Spiroketals, and Oligopeptides as New Biomolecular Chimeras," Banerjee, A.; Sergienko, E.; Vasile, S.; Gupta, V.; Vuori, K.; Wipf, P., Org. Lett. , Vol. 11, 2009, Pages 65-68, "Formal Alder-Ene Reaction of a Bicyclo[1.1.0]butane in the Synthesis of the Tricyclic Quaternary Ammonium Core of Daphniglaucin," Ueda, M.; Walczak, M. A. A.; Wipf, P. , Tetrahedron Lett., Vol. 49, 2008, Pages 5986-5989, "Rhodium(I)-Catalyzed Cycloisomerizations of Bicyclobutanes," Walczak, M. A. A.; Wipf, P., J. Am. Chem. Soc. , Vol. 130, 2008, Pages 6924-6925, "Targeting Mitochondria," Hoye, A. T.; Davoren, J.; Wipf, P.; Fink, M. P.; Kagan, V. E. , Acc. Chem. Res., Vol. 41, 2008, Pages 87-97,

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