个人简介

马润林实验室研究方向为免疫功能基因组学与免疫遗传学。主要研究人类免疫与自身免疫性疾病的动物模型与组胺过敏相关基因的功能；反刍类动物免疫基因组MHC结构与功能的关系以及MHC比较进化；肺器官早期发育与免疫；侵染性及自身免疫性疾病的致病致癌分子机理。 创新研究课题组长马润林博士,研究员。1982年获石河子大学学士学位，1987年获美国明尼苏达大学硕士学位，1991年获堪萨斯州立大学博士学位，1992-1996在伊利诺依大学做分子遗传学博士后研究，1997起任伊利诺依大学（UIUC）研究助理教授，1999起任辛辛拉提大学医学院研究助理教授，入选中国科学院"百人计划"，2001年获得国家杰出青年基金，2004入选新世纪首批“百千万”人才国家级人选，2009成为国务院颁发的政府特殊津贴专家。先后在国际英文专业学术刊物上发表50余篇SCI研究论文。 马润林博士还是新西兰梅西大学荣誉教授。

研究领域

研究方向：人类及动物功能基因组学

当前研究课题方向： 1.绵羊免疫基因组MHC的精细结构与反刍类动物比较进化研究。 2.肺器官发育及Rcn3敲除导致小鼠肺功能失败的分子机理。 3.病毒基因对细胞有丝分裂的调控机理与癌症干细胞。

近期论文

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NieFY,TianJH,LinXD,YuB,XingJG,CaoJH,HolmesEC,MaRZ,ZhangYZ.(2019).DiscoveryofahighlydivergenthepadnavirusinshrewsfromChina.Virology,531,162-170.doi:10.1016/j.virol.2019.03.007 Abdel-FatahTMA,BroomRJ,LuJ,MoseleyPM,HuangB,LiL,LiuS,ChenL,MaRZ,CaoW,WangX,LiY,PerryJK,AleskandaranyM,NolanCC,RakhaEA,LobiePE,ChanSYT,EllisIO,HwangLA,LaneDP,GreenAR,LiuDX.(2019)SHONexpressionpredictsresponseandrelapseriskofbreastcancerpatientsafteranthracycline-basedcombinationchemotherapyortamoxifentreatment.BrJCancer.doi:10.1038/s41416-019-0405-x NieFY,LinXD,HaoZY,ChenXN,WangZX,WangMR,WuJ,WangHW,ZhaoG,MaRZ,HolmesEC,ZhangYZ.(2018)ExtensivediversityandevolutionofhepadnavirusesinbatsinChina.Virology,514,88-97.doi:10.1016/j.virol.2017.11.005 JinJ,ShiX,LiY,ZhangQ,GuoY,LiC,TanP,FangQ,MaY,MaRZ.(2018)Reticulocalbin3DeficiencyinAlveolarEpitheliumExacerbatedBleomycin-inducedPulmonaryFibrosis.AmJRespirCellMolBiol,59(3),320-333.doi:10.1165/rcmb.2017-0347OC GongF,GuoY,NiuY,JinJ,ZhangX,ShiX,ZhangL,LiR,ChenL,MaRZ.(2017)EpigeneticsilencingofTET2andTET3inducesanEMT-likeprocessinmelanoma.Oncotarget,8(1),315-328.doi:10.18632/oncotarget.13324 ZhangX,LingY,GuoY,BaiY,ShiX,GongF,TanP,ZhangY,WeiC,HeX,RamirezA,LiuX,CaoC,ZhongH,XuQ,MaRZ.(2016)Mps1kinaseregulatestumorcellviabilityviaitsnovelroleinmitochondria.CellDeathDis.2016Jul7;7(7):e2292.doi:10.1038/cddis.2016.193. HouY,LiY,GongF,JinJ,HuangA,FangQ,MaRZ.(2016)APreliminaryStudyonRCN3ProteinExpressioninNon-smallCellLungCancer.ClinLab.62(3):293-300. JinJ,LiY,RenJ,ManLamS,ZhangY,HouY,ZhangX,XuR,ShuiG,MaRZ.(2016)NeonatalRespiratoryFailurewithRetardedPerinatalLungMaturationinMiceCausedbyReticulocalbin3Disruption.AmJRespirCellMolBiol.54(3):410-423.doi:10.1165/rcmb.2015-0036OC. ZhangX,PeiL,LiR,ZhangW,YangH,LiY,GuoY,TanP,HanJJ,ZhengX,MaRZ.(2016)SpinabifidainfetusisassociatedwithanalteredpatternofDNAmethylationinplacenta.JHumGenet.60(10):605-611 JiaH,ZhangX,WangW,BaiY,LingY,CaoC,MaRZ,ZhongH,WangX,XuQ.(2015)AputativeN-terminalnuclearexportsequenceissufficientforMps1nuclearexclusionduringinterphase.BMCCellBiol.2015Feb27;16:6.doi:10.1186/s12860-015-0048-6. JungY,Abdel-FatahTM,ChanSY,NolanCC,GreenAR,EllisIO,LiL,HuangB,LuJ,XuB,ChenL,MaRZ,ZhangM,WangJ,WuZ,ZhuT,PerryJK,LobiePE,LiuDX.（2014）SHONisanovelestrogen-regulatedoncogeneinmammarycarcinomathatpredictspatientresponsetoendocrinetherapy.CancerRes.73(23):6951-6962. LingY,ZhangX,BaiY,LiP,WeiC,SongT,ZhengZ,GuanK,ZhangY,ZhangB,LiuX,MaRZ,CaoC,ZhongH,XuQ.(2014)OverexpressionofMps1incoloncancercellsattenuatesthespindleassemblycheckpointandincreasesaneuploidy.BiochemBiophysResCommun.450(4):1690-1695. ZhangP,LiuP,DouH,ChenL,ChenL,LinL,TanP,VajtaG,GaoJ,DuY,MaRZ.(2013)Handmadeclonedtransgenicsheeprichinomega-3Fattyacids.PLoSOne.8(2):e55941.doi:10.1371. ShiH,QiX,ZhongH,PengY,ZhangX,MaRZ,SuB.(2013)GeneticEvidenceofanEastAsianOriginandPaleolithicNorthwardMigrationofY-chromosomeHaplogroupN.PLoSOne.8(6):e66102.doi:10.1371/journal.pone.0066102 WangJ,ZhuZ,WangH,LiF,DuX,MaRZ.(2013)Trop2regulatestheproliferationanddifferentiationofmurinecompact-bonederivedMSCs.IntJOncol.Jun19.doi:10.3892/ijo.2013.1987. ZhangX,LingY,WangW,ZhangY,MaQ,TanP,SongT,WeiC,LiP,LiuX,MaRZ,ZhongH,CaoC,XuQ.(2013)UV-CirradiationdelaysmitoticprogressionbyrecruitingMps1tokinetochores.CellCycle.Apr15;12(8):1292-302.doi:10.4161/cc.24403. LiG,LiuK,JiaoS,LiuH,BlairHT,ZhangP,CuiX,TanP,GaoJ,MaRZ.(2012)AphysicalmapofaBACclonecontigcoveringtheentireautosomeinsertionbetweenovineMHCClassIIaandIIb.BMCGenomics.16;13(1):398-404. ZhangP,ZhangY,DouH,YinJ,ChenY,PangX,VajtaG,BolundL,DuY,MaRZ.(2012)Handmadeclonedtransgenicpigletsexpressingthenematodefat-1gene.CellReprogram.14(3):258-266. WuX,ZhangY,ChenS,XuY,PeiZ,LinD,ChenY,MaRZ.(2012)Methylseleninicacidrestrictstumorgrowthinnudemicemodelofmetastaticbreastcancerprobablyviainhibitingangiopoietin-2.BMCCancer.28;12(1):192-198. ChenL,LiuK,ZhaoZ,BlairHT,ZhangP,LiD,MaRZ.(2012)Identificationofsheepovarygenespotentiallyassociatedwithoff-seasonreproduction.JGenetGenomics.39(4):181-190. ZhongH,LiXL,LiM,HaoLX,ChenRW,XiangK,QiXB,MaRZ,SuB.(2011)ReplicatedassociationsofTNFAIP3,TNIP1andETS1withsystemiclupuserythematosusinasouthwesternChinesepopulation.ArthritisResTher.13(6):R186.[Epubaheadofprint] ZhangX,YinQ,LingY,ZhangY,MaRZ,MaQ,CaoC,ZhongH,LiuX,XuQ.(2011)TwoLXXLLmotifsintheNterminusofMps1arerequiredforMps1nuclearimportduringG(2)/Mtransitionandsustainedspindlecheckpointresponses.CellCycle.10(16):2742-50. ZhongH,ShiH,QiXB,DuanZ,TanP,JinL,SuB,MaRZ.(2011)ExtendedY-chromosomeinvestigationsuggestspost-GlacialmigrationsofmodernhumansintoEastAsiaviathenorthernroute.MolBiolEvol28(1):717-727. LiuK,ZhangP,GaoJ,LiuH,LiG,QiuZ,ZhangY,RenJ,TanP,MaRZ.(2011)Closingagapinthephysicalmapoftheovinemajorhistocompatibilitycomplex.AnimalGenetics42(2):204-207. PengY,ShiH,QiXB,XiaoCJ,ZhongH,MaRZ,SuB.(2010)TheADH1BArg47HispolymorphismineastAsianpopulationsandexpansionofricedomesticationinhistory.BMCEvolBiol10:15-22. GaoJ,LiuK,LiuH,BlairHT,LiG,ChenC,TanP,MaRZ.(2010)AcompleteDNAsequencemapoftheovineMajorHistocompatibilityComplex.BMCGenomics.11(1):466-474. ZhongH,ShiH,QiXB,XiaoCJ,JinL,MaRZ,SuB.(2010)GlobaldistributionofY-chromosomehaplogroupCrevealstheprehistoricmigrationroutesofAfricanexodusandearlysettlementinEastAsia.JHumGenet.55(7):428-435. LiuL,YinJ,LiW,LiuK,PengY,TanP,MaRZ.(2010)ConstructionofabacterialartificialchromosomelibraryfortheRongchangpigbreedanditsusefortheidentificationofgenesinvolvedinintramuscularfatdeposition.BiochemBiophysResCommun.391:1280-1284. SongJ,ZhangX,QiZ,SunG,ChiS,ZhuZ,RenJ,QiuZ,LiuK,MyattL,MaRZ.(2009)CloningandCharacterizationofaCalcium-ActivatedChlorideChannelinRatUterus.BiolReprod.80:788-794. ShiH,TanSJ,ZhongH,HuW,LevineA,XiaoCJ,PengY,QiXB,ShouWH,MaRL,LiY,SuB,LuX.(2009)WintertemperatureandUVaretightlylinkedtogeneticchangesinthep53tumorsuppressorpathwayinEasternAsia.AmJHumGenet.84:534-541 ShiH,ZhongH,PengY,DongYL,QiXB,ZhangF,LiuLF,TanSJ,MaRZ,XiaoCJ,WellsRS,JinL,SuB.(2008)YchromosomeevidenceofearliestmodernhumansettlementinEastAsiaandmultipleoriginsofTibetanandJapanesepopulations.BMCBiol.29,6:45. WeiH,DingX,RenJ,LiuK,TanP,LiD,MaRZ.(2008)Amurinemodelforhumanimmunethrombocytopenicpurpuraandcomparativeanalysisofmultiplegeneexpressioninbonemarrowandspleen.JGenetGenomics.35(11):665-671. ZhangY.,DasguptaJ.,MaRZ,BanksL.,ThomasM.,ChenX.S.(2007)StructuresofaHPV-E6polypeptideboundtoMAGUKproteins:Mechanismsoftargetingtumorsuppressorsbyahigh-riskHPVoncoprotein.J.Virology81:3618-3626. ZhangX.,ZhuZ.,HuangC.,TanP.,MaRZ(2007)MicrosatellitegenotypingforfourexpectedinbredmousestrainsfromKMmice.JGenetGenomics.34:214-222. LiuHB，LiuK，WangJF，MaRZ.(2006)ABAC-basedphysicalmapofOvineMajorHistocompatibilityComplex(MHC).Genomics,88:88-95. SzakonyiG,KleinMG,HannanJP,YoungKA,MaRZ,AsokanR,HolersVM,ChenXS.(2006)StructureoftheEpstein-Barrvirusmajorenvelopeglycoprotein.NatStructMolBiol.13,996-1001. LiuYF,MaRL,WangSL,DuanZY,ZhangJH,WuLJ,WuCF.(2003)Expressionofanantitumor-analgesicpeptidefromthevenomofChinesescorpionButhusmartensiikarschinEscherichiacoli.ProteinExpresandPurif.27(2):253-258. SunK,MaRZ,CuiX,CamposB,WebsterR,BrockmanD,MyattL.(2003)GlucocorticoidsInduceCytosolicPhospholipaseA(2)andProstaglandinHSynthaseType2ButNotMicrosomalProstaglandinESynthase(PGES)andCytosolicPGESExpressioninCulturedPrimaryHumanAmnionCells.JClinEndocrinolMetab88:5564-5571. ButterfieldR.J.,RoperR.J.,RheinD.M.,MelvoldR.W.,HaynesL,MaRZ,DoergeR.W.,TeuscherC.(2003)Sex-SpecificQuantitativeTraitLociGovernSusceptibilitytoTheiler’sMurineEncephalomyelitisVirus-InducedDemyelination.Genetics163:1041-1046. MaRZ,GaoJ.,MeekerN.D.,FillmoreP.D.,TungK.S.K.,WatanabeT.,BlankenhornE.B.andTeuscherC.(2002)IdentificationofBphs,anautoimmunediseaseslocus,ashistaminereceptorH1.Science297:620-623. RoperR.J.,Ma,RZ,Biggins,J.E.,McAllister,R.D.,Min,S.,Call,S.B.,Butterfield,R.J.,MichaelS.M.,Tung,K.S.K.,Doerge,R.W.,andTeuscher,C.(2002)GeneticControlofImmunoregulation,LossofPeripheralTolerance,andAutoimmuneOvarianDysgenesisafterDayThreeThymectomyinMice.JImmunol169:1640-1646. AmbadyS,KappesSM,ParkC,MaRZ,BeeverJE,LewinHA,SmithTP,BeattieCW,BasrurPK,PoncedeLeonFA.(2001)DevelopmentandmappingofmicrosatellitesfromamicrodissectedBTA11-specificDNAlibrary.AnimalGenetics32:152-155. KimK.I,YangY.H,LeeS.S,ParkC,MaRZ,BouzatJ.L,LewinH.A.(1999)PhylogeneticrelationshipsofChejuhorsestootherhorsebreedsasdeterminedbymtDNAD-loopsequencepolymorphism.AnimalGenetics30:102-108. MeekerN.D.,A.N.Stafford,J.K.Lunceford,P.Avner,RZMaandC.Teuscher.(1999)Physicalmappingoftheautoimmunediseasesusceptibilitylocus,Bphs:Co-localizationwithaclusterofgenesfromtheTNFreceptorsuperfamilyonmousechromosome6.MammGemone10:858-863. TeuscherC,ButterfieldR.J,MaRZ,ZacharyJ.F,DoergeR.W,BlankenhornE.P.(1999)Sequencepolymorphismsinthechemokinesscya1(TCA-3),scya2(Monocytechemoattractantprotein(MCP)-1),andscya12(MCP-5)arecandidatesforeae7,alocuscontrollingsusceptibilitytomonophasicRemitting/Nonrelapsingexperimentalallergicencephalomyelitis.JImmunol163:2262-2266. DaY,P.M.VanRaden,M.Ron,J.E.Beever,A.A.Paszek,J.Song,G.R.Wiggans,MaR,J.I.Weller,H.A.Lewin.(1999)Standardizationandconversionofmarkerpolymorphismmeasures.AnimBiotecol10:25-35. MaRZ,J.C.ReeseandW.C.BlackIV.(1999)Chlorophylllosesinthesorghumsusceptibletogreengubs(Schizaphisgraminum).JKansasEntSoc71:51-60. TaylorJ.F.,A.Eggen,A.Aleyasin,S.M.Armitage,W.Barendse,J.E.Beever,M.D.Bishop,R.A.Brenneman,B.M.Burns,S.K.Davis,K.Elo,B.Harlizius,S.M.Kappes,J.W.Keele,J.S.Kemp,B.W.Kirkpatrick,H.A.Lewin,RZMa,R.A.McGraw,D.Pomp,R.T.Stone,Y.Sugimoto,A.J.Teale,D.Vaiman,M.C.Zanotti,etal.(1998)Reportofthefirstworkshoponthegeneticmapofbovinechromosome1.AnimalGenetics29:228-235. Ma,RZ,M.J.T.vanEijk,J.E.Beever,G.Guèrin,C.L.Mummery,H.A.Lewin.(1998)Comparativeanalysisof82expressedsequencetagsfromabovineovarycDNAlibrary.MammGenome9:545-549. Zhang,A.W.,G.L.Hartman,L.Riccioni,W.D.Chen,RZMaandPedersen.(1997)UsingPCRtodistinguishDiaporthephaseolorunandPhomopsislongicollafromothersoybeanfungalpathogensandtodetecttheminsoybeantissues.PlantDisease81:1143-1149. Ma,RZ,J.E.Beever,Y.DA,C.A.Green,I.Russ,C.Park,D.W.Heyen,R.E.Everts,A.J.Teale,S.J.Kemp,H.C.Hines,G.GuérinandH.A.Lewin.(1996)Amalelinkagemapofthecattle(Bostaurus)genome.JHeredity87:261-271. Beever,J.E.,H.A.Lewin,W.Barendse,L.Andersson,S.M.Armitage,C.W.Beattie,B.M.Burns,S.M.Kappes,B.W.Kirkpatrick,RZMa,R.A.McGraw,R.T.StoneandJ.F.Taylor.(1996)Reportonthefirstworkshoponthegeneticmapofbovinechromosome23.AnimalGenetics27:69-75. Ma,RZ,I.Russ,C.Park,D.W.Heyen,J.E.Beever,C.A.GreenandH.A.Lewin.(1996)Isolationandcharacterizationof45polymorphicmicrosatellitesfromthebovinegenome.AnimalGenetics27:43-47. Kemp,S.J.,O.Hishida,J.Wambugu,A.Rink,RZMa,Y.Da,H.A.Lewin,W.BarendseandA.J.Teale.(1995)Apanelofbovine,ovineandcaprinemicrosatellites.AnimalGenetics26:299-306. Shalhevet,D.,D.Yang,J.E.Beever,M.J.T.vanEijk,R.Ma,H.A.LewinandH.R.Gaskins.(1995)GeneticmappingoftheLMP2proteasomesubunitgenetotheBoLAclassIIbregion.Immunogenetics41:44-46. Ma,R.,M.B.Cohen,M.R.BerenbaumandM.A.Schuler.(1994)BlackSwallowtail(Papilliopolyxenes)allelesencodeCytochromeP-450sthatselectivelymetabolizelinearfuranocumarins.ArchBiochemBiophysics310:332-340. Ma,RZ,D.SwedenborgandR.L.Jones.(1992)HostseekingbehaviorofEriborusterebrans(Hymenoptera:Ichneumonidae)towardtheEuropeancornborer(Ostrinianubilalis),andtheroleofchemicalstimuli.AnnEntSocAmer85:72-79. Ma,RZ,W.C.BlackIVandJ.C.Reese.(1992)Genomesizeandorganizationinanaphid(Schizaphisgraminum).JInsectPhysiol38:161-165. Ma,R,J.C.Reese,W.C.BlackIVandP.J.Bramel-Cox.(1990)Detectionofpectinesteraseandpolygalacturonasefromsalivarysecretionsoflivinggreenbugs(Schizaphisgraminum)(Homoptera:Aphididae).JInsectPhysiol.37:507-512. BookandChapters ChenLX,LiRT,andMaRZ.(2014)PotentialsofRNAAptamersforviraldetectionandtreatment.InRNANanotechnologyandTherapeutics(Eds.GuoPX&HaqueF.)CRCPressTaylor&FrancisGroup.pp.449-463.