研究领域

Electrochemistry/Bioanalytical Chemistry

Our research focuses on real time chemical analysis in the central nervous system. Analytical chemistry has an important role to play in generating new understanding not only of normal brain function but also the pathology of various brain diseases as well as brain injury. In order to fulfill this role, it will be necessary to develop reliable analytical methods and techniques capable of producing novel and significant results not presently accessible by other means.

近期论文

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"In Vivo Monitoring of Serotonin in the Striatum of Freely Moving Rats with One Minute Temporal Resolution by Online Microdialysis-Capillary High-Performance Liquid Chromatography at Elevated Temperature and Pressure," Zhang J, Jaquins-Gerstl A, Nesbitt KM, Rutan SC, Michael AC, and Weber SG , Anal. Chem, Vol. 85, 2013, Pages 9889-9897, "Pharmacological mitigation of tissue damage during brain microdialysis," Nesbitt KM, Jaquins-Gerstl A, Skoda E, Wipf P, Michael AC , Anal. Chem, Vol. 85, 2013, Pages 8173-8179, "The dopamine patchwork of the rat nucleus accumbens core," Shu Z, Taylor IM, Michael AC, Eur. J. Neurosci, Vol. 38, 2013, Pages 3221-3229, "Restricted diffusion of dopamine in the rat dorsal striatum," Taylor IM, Illitchev A, Michael AC , ACS Chem. Neurosci, Vol. 4, 2013, Pages 870-878, "Optimization for speed and sensitivity in capillary high performance liquid chromatography: The importance of column diameter in online monitoring of serotonin by microdialysis," Zhang J, Liu Y, Jaquins-Gerstl A, Shu Z, Michael AC, and Weber , J. Chromatog, Vol. 1251, 2012, Pages 54-62, "A method for the intracranial delivery of reagents to voltammetric recording sites," Moquin KF, Jaquins-Gerstl A, and Michael AC , J. Neurosci. Methods , Vol. 208, 2012, Pages 101-107, "Domain-dependent effects of DAT inhibition in the rat dorsal striatum," Taylor IM, Jaquins-Gerstl, Sesack SR, and Michael AC , J. Neurochem, Vol. 122, 2012, Pages 283-294, "Microdialysis probes alter presynaptic regulation of dopamine terminals in rat striatum," Wang Y and Michael , J. Neurosci. Methods, Vol. 208, 2012, Pages 34-39, "Effect of Dexamethasone on gliosis, ischemia, and dopamine extraction during microdialysis sampling in brain tissue," Jaquins-Gerstl A, Shu Z, Zhang J, Liu YS, Weber SG, and Michael AC, Anal. Chem., Vol. 83, 2011, Pages 7662-7667, "An inverse correlation between the apparent rate of dopamine clearance and tonic autoinhibition in the rat striatum: a possible role of transporter-mediated dopamine efflux," Moquin KF and Michael AC , J. Neurochem, Vol. 117, 2011, Pages 133-142, "Evidence for coupling between steady-state and dynamic extracellular dopamine concentrations in the rat striatum ," Wang YX, Moquin KF, Michael AC, JOURNAL OF NEUROCHEMISTRY, Vol. 114, 2010, Pages 150-159, http://www3.interscience.wiley.com/cgi-bin/fulltext/123346843/PDFSTART "Comparison of the brain penetration injury associated with microdialysis and voltammetry," Jaquins-Gerstl A, Michael AC, JOURNAL OF NEUROSCIENCE METHODS, Vol. 183, 2009, Pages 127-135, http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T04-4WM0J65-2-3&_cdi=4... "Tonic autoinhibition contributes to the heterogeneity of evoked dopamine release in the rat striatum," Moquin KF, Michael AC, JOURNAL OF NEUROCHEMISTRY, Vol. 110, 2009, Pages 1491-1501, http://ejournals.ebsco.com/Direct.asp?AccessToken=46591Y68K9SEC565B2UK6PCBP5CU8Y... "Controlled cortical impact injury influences methylphenidate-induced changes in striatal dopamine neurotransmission," Wanger AK, Sokoloski JE, Chen XB, Harun R, Clossin DP, Khan AS, Andes-Koback M, Michael AC, Dixon, CE, JOURNAL OF NEUROCHEMISTRY, Vol. 110, 2009, Pages 801-810, http://ejournals.ebsco.com/Direct.asp?AccessToken=3PDM%2DXP81%2D1OOPNDNNMQZXQ1L%... "Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury," Wagner AK, Drewencki LL, Chen X, Santos FR, Amina SK, Harun R, Torres GE, Michael AC, Dixon, CE, JOURNAL OF NEUROCHEMISTRY, Vol. 108, 2009, Pages 986-997, http://content.ebscohost.com/pdf9/pdf/2009/1F9/15Feb09/36142753.pdf?T=P&P=AN&K=3... "Impact of microdialysis probes on vasculature and dopamine in the rat striatum: A combined fluorescence and voltammetric study," Mitala CM, Wang YX, Borland LM, Jung MC, Shand S, Watkins S, Weber SG, Michael AC, JOURNAL OF NEUROSCIENCE METHODS, Vol. 174, 2008, Pages 177-185, http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T04-4T0FF2B-2-H&_cdi=4... "The 16th James L. Waters annual symposium: Electrochemistry," Michael AC, JOURNAL OF CHEMICAL EDUCATION, Vol. 84, 2007, Pages 643-643, http://pubs.acs.org/doi/pdf/10.1021/ed084p643 "Simultaneous determination of biogenic monoamines in rat brain dialysates using capillary high-performance liquid chromatography with photoluminescence following electron transfer," Jung MC, Shi GY, Borland L, Michael AC, Weber, SG, ANALYTICAL CHEMISTRY, Vol. 78, 2006, Pages 1755-1760, http://pubs.acs.org/doi/pdf/10.1021/ac051183g "Use of tris(2,2 '-bipyridine)osmium as a photoluminescence-following electron-transfer reagent for postcolumn detection in capillary high-performance liquid chromatography," Jung MC, Munro N, Shi GY, Michael AC, Weber SG, ANALYTICAL CHEMISTRY, Vol. 78, 2006, Pages 1761-1768, http://pubs.acs.org/doi/pdf/10.1021/ac051182o "Improving the performance of electrochemical microsensors based on enzymes entrapped in a redox hydrogel," Mitala JJ, Michael AC, ANALYTICA CHIMICA ACTA, Vol. 556, 2006, Pages 326-332, http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TF4-4HF5KMM-1-S&_cdi=5... "Voltammetric study of extracellular dopamine near nicrodialysis probes acutely implanted in the striatum of the anesthetized rat," L. M. Borland, G. Shi, H. Yang, A. C. Michael, , J. Neurosci. Methods, Pages 2005, in press,