研究领域

Total and Combinatorial (Bio)Synthesis of Natural Product/Novel Synthetic Method and Platform Development/Carbohydrate Chemistry/Glycobiology/Drug Discovery/Biomaterial/Synthetic Biology

We are a research group that consists of a mixture of synthetic chemists, natural product isolation specialists, biochemists and microbiologists. We are interested in the discovery and functional study of broadly defined natural products using synthetic chemical, biological and genomics-guided approaches. The natural products of our current focus belong to the famly of oligosaccharids and small molecular secondary metabolites of microbial origins that exhibit broad functional roles in mamalian am=nd microbial physiology. These molecules serve as the catalyst to drive the discovery cycle between chemistry, biology and medicine in our laboratory. Projects that we are actively pursuing in the lab include: 1) synthetis carbohydrate chemistry concerns new synthetic methods development and total synthesis of biologically relevant oligosaccharides, 2) study of functional significanceof glycosylation in bacterial infection and cancer pathogenesis, 3) genomics-guided discovery of natural products, particularly thos with antibiotic activities and thos e with functional roles in bacterial physiology, 4) novel enzymatic transformations associated with complex natural product biosynthesis.

近期论文

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"Serratamolide is a Hemolytic Factor Produced by Serratia marcescens," Robert M. Q. Shanks, Nicholas A. Stella, Roni Lahr, Shaoru Wang, Tara I. Veverka, Regis P. Kowalski and Xinyu Liu, PLoS One, Vol. 7, 2012, Pages e36398. PMID: 22615766, "Chemical Biology of Glycosylphosphatidylinositol Anchors," Yu-Hsuan Tsai, Xinyu Liu and Peter H. Seeberger, Chem. In. Ed., Vol. 51, 2012, Pages 11438-11456, "New insight on 2-naphthylmethyl (NAP) ether as a protecting group in carbohydrate synthesis: a divergent approach towards a high-mannose type oligosaccharide library ," Yao Li, Bimalendu Roy and Xinyu Liu, Chem. Commun., Vol. 47, 2011, Pages 8952-8954, http://pubs.rsc.org/en/content/articlepdf/2011/cc/c1cc13264d "Insulin-mimetic Activity of Synthetic Inositol Phosphoglycans," Marie-Lyn Hecht, Yu-Hsuan Tsai, Xinyu Liu, Christian Wolfrum and Peter H. Seeberger, ACS Chem. Biol., Vol. 5, 2010, Pages 1075-1086, http://pubs.acs.org/doi/pdfplus/10.1021/cb1002152 "Enzymatic Processing of Fumiquinazoline F: A Tandem Oxidative-Acylation Strategy for the Generation of Multicyclic Scaffolds in Fungal Indole Alkaloid Biosynthesis," Brian D. Ames, Xinyu Liu and Christopher T. Walsh , Biochemistry, Vol. 49, 2010, Pages 8564-8576, http://pubs.acs.org/doi/pdfplus/10.1021/bi1012029 "Synthetic glycosylphosphatidylinositol microarray reveals differential antibody levels and fine specificities in children with mild and severe malaria," Marco Tamborrini, Xinyu Liu, Joseph Paschal Mugasa, Yong-Uk Kwon, Faustin Kamena, Peter H. Seeberger and Gerd Pluschke , Bioorganic & Medicinal Chemistry, Vol. 18, 2010, Pages 3747-3752, http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TF8-4YXK4CP-1-F&_cdi=5... "Facile Synthesis of Size Dependent Ru(II)-Carbohydrate Dendrimers via Click Chemistry," Raghavendra Kikkeri, Xinyu Liu, Alexander Adibekian, Yu-Hsuan Tsai and Peter H. Seeberger, Chem. Comm., 2010, Pages DOI:10.1039/b925113h, "Characterization of cyclo-Acetoacetyl-L-TryptophanDimethylallyltransferase in Cyclopiazonic Acid Biosynthesis: Substrate Promiscuity and Site Directed Mutagenesis Studies," Xinyu Liu and Christopher T. Walsh , Biochemistry, Vol. 48, 2009, Pages 11032-11044, http://pubs.acs.org/doi/pdf/10.1021/bi901597j?source=chemport "Cyclopiazonic Acid Biosynthesis in Aspergillus sp.: Characterization of a reductase-like R* domain in cyclopiazonate synthetase that forms and releases cyclo-acetoacetyl-L-tryptophan," Xinyu Liu and Christopher T. Walsh, Biochemistry , Vol. 48, 2009, Pages 8746-8757, http://pubs.acs.org/doi/pdf/10.1021/bi901123r?source=chemport "Andrimid Producers Encode and Acetyl-CoA Carboxyltransferase Subunit Resistant to the Action of the Antibiotic," Xinyu Liu, Pascal D. Fortin and Christopher T. Walsh, Proc. Natl. Acad. Sci., Vol. 105, 2008, Pages 13321-13326, http://www.pnas.org/content/105/36/13321.full.pdf "Synthetic GPI-Array to Study Anti-toxic Malaria ," Faustin Kamena, Marco Tamborrini, Xinyu Liu, Yong-Uk Kwon, Gerd Pluschke, Fiona Thompson and Peter H. Seeberger , Nature Chem. Biol., Vol. 4, 2008, Pages 238-240, http://www.nature.com/nchembio/journal/v4/n4/pdf/nchembio.75.pdf "Semisynthesis of a Glycosylphosphatidylinositol-Anchored Prion ," Christian F. W. Becker, Xinyu Liu, Diana Olschewski, Riccardo Castelli, Ralf Seidel and Peter H. Seeberger, Angew. Chem. Int. Ed. , Vol. 47, 2008, Pages 8215–8219, http://www3.interscience.wiley.com/cgi-bin/fulltext/121414005/PDFSTART "Chemical Synthesis of All Phosphatidylinositol Mannoside (PIM) Glycans from Mycobacterium tuberculosis," Siwarutt Boonyaranattakalin, Xinyu Liu, Mario Michieletti, Bernd Lepenies and Peter H. Seeberger, J. Am. Chem. Soc., Vol. 130, 2008, Pages 16791-16799, http://pubs.acs.org/doi/pdf/10.1021/ja806283e?source=chemport "Automated Synthesis of Lipomannan Backbone a(1-6) Oligomannoside via ," Xinyu Liu, Reiko Wada, Siwarutt Boonyaranattakalin, Bastien Castagner and Peter H. Seeberger, Chem. Comm., 2008, Pages 3510–3512, http://www.rsc.org/ej/CC/2008/b804069a.PDF "Enhancement of the Immunogenicity of Synthetic Carbohydrates by Conjugation to Virosomes: A Leishmaniasis Vaccine Candidate," Xinyu Liu, Sibylle Siegrist, Mario Amacker, Rinaldo Zurbriggen, Gerd Pluschke and Peter H. Seeberger, ACS Chem. Biol., Vol. 1, 2006, Pages 161–164, "Total Synthesis of Phosphatidylinositol Mannosides of Mycobacterium tuberculosis," Xinyu Liu, Bridget L. Stocker and Peter H. Seeberger, J. Am. Chem. Soc., Vol. 128, 2006, Pages 3638–3648, http://pubs.acs.org/doi/pdf/10.1021/ja0565368?source=chemport "Convergent Synthesis of a Fully Lipidated Glycosylphosphatidylinositol Anchor of Plasmodium falciparum," Xinyu Liu, Yong-Uk Kwon and Peter H. Seeberger, J. Am. Chem. Soc., Vol. 127, 2005, Pages 5005–5006, http://pubs.acs.org/doi/pdf/10.1021/ja042374o?source=chemport "A Facile Stereocontrolled Approach to CF3-substituted Triarylethenes: Synthesis of Panomifene," Xinyu Liu, Masaki Shimizu and Tamejiro Hiyama , Angew. Chem. Int. Ed., Vol. 43, 2004, Pages 879–882, http://www3.interscience.wiley.com/cgi-bin/fulltext/107597937/PDFSTART "A Suzuki-Miyaura Coupling Mediated Deprotection as Key to the Synthesis of A Fully Lipidated Malarial GPI Disaccharide," Xinyu Liu and Peter H. Seeberger , Chem. Comm., 2004, Pages 1708–1709, http://www.rsc.org/ej/CC/2004/b407324j.PDF