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个人简介

邱星辉,男,理学博士,研究员,昆虫毒理学与生物技术研究组组长。 分别于1991年、1998年在中国科学院获生态学硕士和动物学(昆虫毒理学方向)博士学位。现为农业虫害鼠害综合治理研究国家重点实验室研究员,昆虫毒理学与生物技术研究组组长,兼任卫生部病媒生物控制专业委员会委员、北京市爱卫会专家委员会委员、中国昆虫学会常务理事。2001年2月-2002年5月澳大利亚联邦科学与工业研究组织(CSIRO)生物技术项目访问学者,2007年1月-2008年1月美国PurdueUniversity基因组学实验室访问学者。至今在国内外发表论文篇近百篇(其中SCI论文35篇),专著1部,授权国家发明专利4项。曾于1997年获中国科学院自然科学奖一等奖,1999年获国家自然科学奖三等奖。承担科研项目情况: 研究工作得到国家重点基础研究计划(973)、国家自然科学基金面上项目和中国科学院创新方向项目的资助。

研究领域

研究领域: 该实验室的目标是运用基因组学、生物化学、毒理学和分子生物学技术,解决重要农业、环境与食品安全领域的基础科学问题和实际问题。近年来的研究工作主要集中在以下几个方面:(1)细胞色素P450酶系的功能与调控;(2)有毒物质的生物转化,重点在外源有害物质的生物降解途径分析和降解酶基因的分离、表达与调控研究;(3)昆虫毒理基因组学,在基因组尺度上研究杀虫剂毒性和昆虫抗药性的分子机制。

近期论文

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FengX,YangC,YangY,JunLi,LinK,LiM,QiuX*,2015.DistributionandfrequencyofG119Smutationinace-1genewithinAnophelessinensispopulationsfromGuangxi,China.MalariaJournal,14:470 LiuD,YuanY,LiM,QiuX*,2015EffectsofdietaryquercetinonperformanceandcytochromeP450expressionofthecottonbollworm,Helicoverpaarmigera.BulletinofEntomologicalResearch,105(06):771-777 SunW,ValeroMC,SeongKM,SteeleLD,HuangIT,LeeCH,ClarkJM,QiuXandPittendrighBR,2015.Aglycineinsertionintheestrogen-relatedreceptor(ERR)isassociatedwithenhancedexpressionofthreecytochromeP450genesintransgenicDrosophilamelanogaster.PLoSONE,10(3):e0118779 LiuD,ZhouX,LiM,ZhuS,QiuX*,2014.CharacterizationofNADPH-cytochromeP450reductasegenefromthecottonbollworm,Helicoverpaarmigera.Gene,545:262-270. WanH,LiuY,LiM,ZhuS,LiX,PittendrighBR,QiuX*,2014.Nrf2/Mafbindingsite-containingfunctionalCyp6a2alleleisassociatedwithDDTresistanceinDrosophilamelanogaster.PestManagementScience,70:1048-1058. ZhouX,QianK,TongY,ZhuJJ,QiuX*,ZengX*,2014,DenovotranscriptomeofthehemimetabolousGermancockroach(Blattellagermanica).PLoSONE,9(9):e106932 YanY,ZhouX,YangJ.LiM.QiuX*,2013.T-2toxinishydroxylatedbychickenCYP3A37.FoodandChemicalToxicology,62:622-627. YangJ,AnJ,LiM,HouX,QiuX*,2013.CharacterizationofchickencytochromeP4501A4and1A5:Inter-paralogcomparisonsofsubstratepreferenceandinhibitorselectivity.ComparativeBiochemistryandPhysiology,PartC157:337–343. YangJ,LiuZ,LiM,QiuX*,2013.HydroxylationofquinocetoneandcarbadoxismediatedbyCYP1Asinthechicken(Gallusgallus).ComparativeBiochemistryandPhysiology,PartC158:84-90. QiuX,SunW,McDonnellC,LiH,SteeleLD,WuJ,XieJ,MuirW,Pittendrigh.BR.2013.Genome-wideanalysisofgenesassociatedwithmoderateandhighDDTresistanceinDrosophilamelanogaster.PestManagementScience,69:930-937. RinkevichFD,HedtkeSH,LeichterCA,HarrisSA,SuC,BradySG,TaskinV,QiuX,ScottJG,2012.MultipleOriginsofkdr-typeResistanceintheHouseFly,Muscadomestica.PlosOne,7(12):e52761. GaoQ,LiM,ShengC,ScottJG,QiuX*,2012.MultiplecytochromeP450soverexpressedinpyrethroidresistanthouseflies(Muscadomestica).PesticideBiochemistryandPhysiology,104:252-260. QiuX*,PanJ,LiM,LiY,2012.PCR-RFLPmethodsfordetectionofinsecticideresistance-associatedmutationsinthehousefly(Muscadomestica).PesticideBiochemistryandPhysiology,104:201–205. WangQ,LiM,PanJ,DiM,LiuQ,MengF,ScottJG,QiuX*,2012.Diversityandfrequenciesofgeneticmutationsinvolvedininsecticideresistanceinfieldpopulationsofthehousefly(MuscadomesticaL.)fromChina.PesticideBiochemistryandPhysiology,102:153-159. ZhouX,LiM,ShengC,QiuX*,2011.NADPH-cytochromeP450oxidoreductasefromthechicken(Gallusgallus):sequencecharacterization,functionalexpressionandkineticstudy.ComparativeBiochemistryandPhysiology,PartC,153:53-59. WangD,QiuX,WangH,QiaoK,WangK,2010.ReducedfitnessassociatedwithspinosadresistanceinHelicoverpaarmigera.Phytoparasitica,38:103–110. ZhouX,ShengC,LiM,WanH,LiuD,QiuX*,2010.ExpressionresponsesofninecytochromeP450genestoxenobioticsinthecottonbollwormHelicoverpaarmigera,PesticideBiochemistryandPhysiology,97:209-213. ZhouX,MaC,ShengC,LiuH,GongP,QiuX*,2010.CYP9A12andCYP9A17inthecottonbollworm,Helicoverpaarmigera:sequencesimilarity,expressionprofileandxenobioticresponse.PestManagementScience,66:65-73. QiuX*,WuP,ZhangH,LiM,YanZ,2009.IsolationandcharacterizationofArthrobactersp.HY2capableofdegradingahighconcentrationofp-nitrophenol.BioresourceTechnology,100:5243-5248. WangD,QiuX*,RenX,ZhangW,WangK*,2009.EffectsofspinosadonHelicoverpaarmigera(Lepidoptera:Noctuidae)fromChina:tolerancestatus,synergismandenzymaticresponses.PestManagementScience,65:1040-1046. WangD.QiuX.RenX,NiuF,WangK*,2009.ResistanceselectionandbiochemicalcharacterizationofspinosadresistanceinHelicoverpaarmigera(Hubner)(Lepidoptera:Noctuidae).PesticideBiochemistryandPhysiology,95:90-94. WangD,GongP,LiM,QiuX*,WangK*,2009,Sublethaleffectsofspinosadonsurvival,growthandreproductionofHelicoverpaarmigera(Lepidoptera:Noctuidae).PestManagementScience,65(2):223-227. XuJ,YangM,DaiJ,CaoH,PanC,QiuX*,XuM,2008.Degradationofacetochlorbyfourmicrobialcommunities.BioresourceTechnology,99:7797–7802. QiuX*,LiM,LuoH,FuT.,2007.Molecularanalysisofresistanceinadeltamethrin-resistantstrainofMuscadomesticafromChina.PesticideBiochemistryandPhysiology,89(2):146-150. ZhongQ,ZhangH,BaiW,LiM,LiB,QiuX*,2007.Degradationofaromaticcompoundsanddegradationpathwayof4-nitrocatecholbyOchrobactrumsp.B2.JournalofEnvironmentalScienceandHealth,PartA42:2111-2116. QiuX*,ZhongQ,LiM,BaiW,LiB,2007.Biodegradationofp-nitrophenolbymethylparathion-degradingOchrobactrumsp.B2.InternationalBiodeterioration&Biodegradation,59(4):297-301. QiuX*,BaiW,ZhongQ,LiM,HeF,LiB,2006.IsolationandcharacterizationofabacterialstrainofthegenusOchrobactrumwithmethylparathionmineralizingactivity.JournalofAppliedMicrobiology,101:986-994. HorneI,QiuX,OllisDL,RussellRJ,OakeshottJG,2006.FunctionaleffectsofaminoacidsubstitutionswithinthelargebindingpocketofthephosphotriesteraseOpdAfromAgrobacteriumsp.P230.FEMSMicrobiologyLetters,259:187-194. XuJ,QiuX,DaiJ,CaoH,YangM,ZhangJ,XuM.,2006,IsolationandcharacterizationofaPseudomonasoleovoransdegradingthecholoracetamideherbicideacetochlor.Biodegradation,17:219-225. QiuX,LiW,TianY,LengX,2003.CytochromeP450monooxygenaseinthecottonbollworn(Lepidoptera:Noctuidae):tissuedifferenceandinduction.JournalofEcononicEntomology,96(4):1283-128. 邱星辉2014细胞色素P450介导的昆虫抗药性的分子机制昆虫学报57:477-482 邱星辉,2005.杀虫剂抗性:遗传学、基因组学及应用启示昆虫学报48(6):960-967 冷欣夫邱星辉2001细胞色素P450的结构、功能与应用前景科学出版社

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