李孟华 - 中国科学院动物研究所 -

个人简介

李孟华，研究员，博士生导师，基因组学与动物(主要是绵羊)遗传育种研究组组长。 2003年毕业于华中农业大学畜牧兽医学院动物遗传育种与繁殖专业，获得博士学位；2003年-2008年任芬兰农业食品科学研究院博士后，其中2007年11-12月在挪威生命科学技术大学任访问学者（合作教授：TheoMeuwissen）；2008年-2010年于赫尔辛基大学生物和环境科学系从事博士后研究；2010年至2011年任芬兰农业食品科学研究院生物技术和食品研究部PrincipalResearchScientist(PI)，其中2011年3-5月在意大利圣心天主教大学（UniversitàCattolicadelSacroCuore）任访问学者。入选芬兰科学院研究员（ResearchFellowoftheAcademyofFinland，2011年）,获得欧洲科学基金（生命、地球、环境和极地科学部）青年学者奖励资助（2011年）。2010年6月被授予赫尔辛基大学Docent，2011年9月入选中国科学院“百人计划”引进海外杰出人才，2018年获得国家杰出青年基金。担任国际动物遗传学会羊专业委员会执行委员，AnimalGenetics,JournalofAnimalBreedingandGenetics,FrontierinGenetics(Livestockgenomics),ScientificReports等SCI杂志编委(EditorialBoardmember)，爱沙尼亚国家研究委员会科学基金评审人以及第一届和第二届“世界绵羊大会”主席。共发表50多篇SCI论文，其中第一作者或通讯作者40多篇（分别在MolecularBiologyandEvolution、MolecularEcology、DNAResearch、GenomeBiologyandEvolution,Heredity、FrontierinGenetics,BMCGenomics、G3：Genes,Genomics,Genetics、BMCEvolutionaryBiology、GeneticsSelectionandEvolution和AnimalGenetics等专业刊物）。承担科研项目情况：国家自然科学基金和国家重点研发计划政府间国际科技创新合作重点专项。

近期论文

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(#为共同第一作者，*为通讯作者) 2018年度： Xiao-JuHu,JiYang,Xing-LongXie,Feng-HuaLv,Yin-HongCao,Wen-RongLi,Ming-JunLiu,Yu-TaoWang,Jin-QuanLi,Yong-GangLiu,Yan-LinRen,Zhi-QiangShen,FengWang,EErHehua,Jian-LinHan,Meng-HuaLi*(2018)ThegenomelandscapeofTibetansheeprevealsadaptiveintrogressionfromargaliandthehistoryofearlyhumansettlementsontheQinghai-TibetanPlateau.MolecularBiologyandEvolution(doi.org/10.1093/molbev/msy208) JiYang(#),XinLi(#),Yin-HongCao(#),KisunPokharel(#),Xiao-JuHu(#),Ze-HuiChen(#),Song-SongXu,JaanaPeippo,MerviHonkatukia,JuhaKantanen,Meng-HuaLi*(2018)ComparativemRNAsandmiRNAsexpressioninEuropeanmouflon(Ovismusimon)andsheep(Ovisaries)providenovelinsightsintothegeneticmechanismsforfemalereproductivesuccess.Heredity(doi:10.1038/s41437-018-0090-1). LeiGao(#),Song-SongXu(#),Jing-QuanYang(#),MinShen*,Meng-HuaLi*(2018)Genome-wideassociationstudyrevealsnovelgenesfortheearsizeinsheep(Ovisaries)AnimalGenetics49:345-348. Ze-HuiChen(#),MinZhang(#),Feng-HuaLv(#),XueRen,Wen-RongLi,Ming-JunLiu,KiwoongNam,MichaelWBruford,Meng-HuaLi*(2018)ContrastingpatternsofgenomicdiversityrevealacceleratedgeneticdriftbutreduceddirectionalselectiononX-chromosomeinwildanddomesticsheepspecies.GenomeBiologyandEvolution10:1282-1297. Song-SongXu(#),LeiGao(#),Xing-LongXie,Yan-LingRen,Zhi-QiangShen,FengWang,MinShen,EmmaEyporsdottir,JonH.Hallsson,TatyanaKiseleva,JuhaKantanenandMeng-HuaLi*(2018)Genome-wideassociationanalyseshighlightthepotentialfordifferentgeneticmechanismsforlittersizeamongsheepbreeds.FrontierinGenetics(Livestockgenomics)9:118. PokharelKisun,PeippoJaana,HonkatukiaMervi,SeppalaArja,RautiainenJohanna,GhanemNasser,HamamaTuula-Marjatta,CroweMarkA,AnderssonMagnus,LiMeng-Hua*,KantanenJuha*(2018)IntegratedovarianmRNAandmiRNAtranscriptomeprofilingcharacterizesthegeneticbasisofprolificacytraitsinsheep(Ovisaries)BMCGenomics19:104. 2017年度： ZhaoYong-Xin(#),YangJi(#),LvFeng-Hua(#),HuXiao-Ju,XieXing-Long,ZhangMin,LiWen-Rong,LiuMing-Jun,WangYu-Tao,LiJin-Quan,LiuYong-Gang,RenYan-Ling,WangFeng,EerHehua,Kantanen,JuhaLenstra,JohannesArjen,HanJian-Lin,LiMeng-Hua*(2017)GenomicreconstructionofthehistoryofnativesheeprevealsthepeoplingpatternsofnomadsandtheexpansionofearlypastoralisminEastAsia.MolecularBiologyandEvolution34:2380-2395. XuSong-Song#,RenXue#,YangGuang-Li#,XieXing-Long,ZhaoYong-Xin,ZhangMin,ShenZhi-Qiang,RenYan-Ling,GaoLei,ShenMin,JuhaKantanenandMeng-HuaLi*(2017)Genome-wideassociationanalysisidentifiesthegeneticbasisoffatdepositioninthetailsofsheep(Ovisaries)AnimalGenetics48:560-569. PengW.-F.(#),XuS.-S.(#),RenX.(#),LvF.-H.,XieX.-L.,ZhaoY.-X.,ZhangM.,ShenZ.-Q.,RenY.-L.,GaoL.,ShenM.,KantanenJ.,LiM.-H.*(2017)Agenome-wideassociationstudyrevealscandidategenesforthesupernumerarynipplephenotypeinsheep(Ovisaries)AnimalGenetics48:570-579. XuSong-Song,Meng-HuaLi*(2017)Recentadvancesinunderstandinggeneticvariantsassociatedwitheconomicallyimportanttraitsinsheep(Ovisaries)revealedbyhigh-throughputscreeningtechnologies.FrontiersofAgriculturalSciencesandEngineering4:279-288. 2016年度： JiYang#,Wen-RongLi#,Feng-HuaLv#,San-GangHe#,Shi-LinTian#,Wei-FengPeng,Ya-WeiSun,Yong-XinZhao,Xiao-LongTu,MinZhang,Xing-LongXie,Yu-TaoWang,Jin-QuanLi,Yong-GangLiu,Zhi-QiangShen,FengWang,Guang-JianLiu,Hong-FengLu,JuhaKantanen,Jian-LinHan,Meng-HuaLi*andMing-JunLiu*（2016）Whole-GenomeSequencingofNativeSheepProvidesInsightsintoRapidAdaptationstoExtremeEnvironments.MolecularBiologyandEvolution33(10):2576–2592. 封面文章受到“InternationalLivestockResearchInstitute(ILRI)”点评和报道 RenX#.YangGL#,PengWF,ZhaoYX,ZhangM,ChenZH,WuFA,KantanenJ,ShenM,LiM.-H.*(2016)Agenome-wideassociationstudyidentifiesagenomicregionforthepolyceratephenotypeinsheep(Ovisaries)ScientificReports6:201111. XiaojuHu,KisunPokharel，JaanaPeippo,NasserGhanem，IsmaelZhaboyev，JuhaKantanenandMeng-HuaLi*.(2016)IdentificationandcharacterizationofmiRNAsintheovariesofahighlyprolificsheepbreed.AnimalGenetics47：234-239. 2015年度： LvF-H,PengW-F,YangJ,ZhaoY-X,LiW-R,LiuM-J,MaY-H,ZhaoQ-J,YangG-L,WangF,LiJ-Q,LiuY-G,ShenZ-Q,ZhaoS-G,HehuaE,GorkhaliNA,FarhadVahidiSM,MuladnoM,NaqviAN,TabellJ,Iso-TouruT,BrufordMW,KantanenJ,HanJ-L*,LiM-H*(2015).MitogenomicMeta-AnalysisIdentifiesTwoPhasesofMigrationintheHistoryofEasternEurasianSheep.MolecularBiologyandEvolution32:2515-2533. 封面文章受到“FinancialTimes”,“ModernFarmer”和“ILRI”等媒体报道和点评受到《中国科学》的评述中国科学院科研进展英文评述 JunLiu,CuiminWang,DongliFu,XiaojuHu,XiangmoXie,PengfeiLiu,QiongZhangandMeng-HuaLi*(2015)PhylogeographyofNanoranaparkeri(Anura:Ranidae)ontheTibetanPlateau:effectsofPlateauupliftandQuaternaryclimaticchanges.ScientificReports5：9857 中国科学院科研进展英文评述 WeiminZhao,YulianMu,LeiMa,ChenWang,ZhonglinTang,ShulinYang,RongZhou,XiaojuHu,Meng-HuaLi*andKuiLi*(2015)Systematicidentificationandcharacterizationoflongintergenicnon-codingRNAsinfetalporcineskeletalmuscledevelopment.ScientificReports5:8957. KisunPokharel,JaanaPeippo,G？ranAndersson,Meng-HuaLi*,JuhaKantanen(2015)TranscriptomeprofilingofFinnsheepovariesduringout-of-seasonbreedingperiod.AgriculturalandFoodScience24:1-9. KantanenJ,L？vendahlP,StrandbergE,EythorsdottirE,LiM.-H.,Kettunen-Pr？belA,BergP,MeuwissenT.(2015)Utilizationoffarmanimalgeneticresourcesinachangingagro-ecologicalenvironmentintheNordiccountries.FrontiersinGenetics6:52. 2014年度： Feng-HuaLv,SaifAgha,JuhaKantanen,LiciaColli,SylvieStucki,JamesW.Kijas,StéphaneJoost,Meng-HuaLi*,PaoloAjmoneMarsan(2014)AdaptationstoClimate-MediatedSelectivePressuresinSheep.MolecularBiologyandEvolution31:3324-3343. 封面文章受到Sciencedaily等媒体报道和点评 JiYang,TakahitoShikano,Meng-HuaLi*,JuhaMeril？(2014)Genome-widelinkagedisequilibriuminnine-spinedstickleback.G3–GenesGenomesGenetics4:1119-1129 YangJ,LiM.-H.*(2014)Amulti-omicsintegratedstudydeciphersbiologyoftherumenandlipidmetabolism.ScienceChinaLifeScience57:951-953 特邀评述 LiuJ.,T.Shikano,T.Leinonen,J.M.Cano,M.-H.Li*,J.Meril？(2014)IdentificationofmajorandminorQTLforecologicallyimportantmorphologicaltraitsinthree-spinedsticklebacks(Gasterosteusaculeatus).G3-Genes,Genomes,Genetics4:594-604 ShanL.,WuQ.,LiY.,ShangH.,GuoK.,WuJ.,WeiH.,ZhaoJ.,YuJ.,LiM.-H.*(2014)Transcriptomeprofilingidentifiesdifferentiallyexpressedgenesinpostnataldevelopingpituitaryglandofminiaturepig.DNAResearch21:207-216 LiM.-H.*,T.Tiirikka,J.Kantanen(2014)Agenome-widescanstudyidentifiesasinglenucleotidesubstitutioninASIPassociatedwithwhiteversusnon-whitecoat-colourvariationinsheep(Ovisaries).Heredity112:122–131. ZhangMin,Wei-FengPeng,Guang-LiYang,Feng-HuaLv,Ming-JunLiu,Wen-RongLi,Yong-GangLiu,Jin-QuanLi,FengWang,Zhi-QiangShen,Sheng-GuoZhao,EErHehua,NurbiyMarzanov,MaziekMurawski,JuhaKantanenandMeng-HuaLi(2014)Ychromosomehaplotypediversityofdomesticsheep(Ovisaries)innorthernEurasia.AnimalGenetics45:903-907. 2011-2013年度： WangC.,HuX.,XieX.,LiuP.,Meril？J.,ZhangQ.*,LiM.-H.*(2013)Isolationandcharacterizationof113polymorphicmicrosatellitelocifortheTibetanfrog(Nanoranaparkeri)usingnextgenerationsequencing.ConservationGeneticsResources5:915-924. LiM.-H.,A.Osva,J.Kantanen(2012)Integratingmultidisciplinarydatafortheconservationoflivestockbiodiversity:acasestudyoftheYakutiancattleinSiberia,thefareastofRussia.AnimalGeneticsResources50:97-104. LiM.H.*andJ.Meril？(2011)Populationdifferencesinlevelsoflinkagedisequilibriuminthewild.MolecularEcology20:2916-2928. LiM.-H.,I.Strandén,T.Tiirikka,M.-L.Sevón-Aimonen,J.Kantanen(2011)Acomparisonofapproachestoestimatetheinbreedingcoefficientandpairwiserelatednessusinggenomicandpedigreedatainasheeppopulation.PLoSONE6:e26256. CanoJ.M.,M.-H.Li,LaurilaA,VilkkiJ,Meril？J.(2011)First-generationlinkagemapforthecommonfrogRanatemporariarevealssexlinkagegroup.Heredity107:530-536. LiM.-H.*,J.Kantanen,A.Michelson,U.Saarma(2011)GeneticcomponentsofgreycattleinEstoniaasrevealedbymicrosatelliteanalysisusingtwoBayesianclusteringmethods.BMCResearchNotes4:37. ZerabrukM.#,LiM.-H.#,J.Kantanen,I.Olsaker,E.M.Ibeagha-Awemu,G.Erhardt,D.G.BradleyandOVangen(2011)GeneticdiversityandadmixtureofindigenouscattlebreedsofNorthEthiopia:implicationstohistoricalintrogressionsinthegatewayregionofcattletoAfrica.AnimalGenetics43:257-266. NairA.,S.Kumar,S.George,S.Gopalan,M.-H.Li,E.LederandJ.Meril？(2011)SixtytwonewmicrosatellitemarkersforanendemicfrogIndiranabeddomiifromtheWesternGhatsbiodiversityhotspot.ConservationGeneticsResources3:167-171. 2001-2010年度： Tapio,I.,Tapio,M.,M.-H.Li,Popov,R.,Ivanova,Z.,Kantanen,J(2010)Estimationofrelatednessamongnon-pedigreedYakutiancryo-bankbullsusingmoleculardata:implicationsforconservationandbreedmanagement.GeneticsSelectionEvolution42:9. LiM.H.*andJ.Meril？(2010)Geneticevidenceformale-biaseddispersalintheSiberianjay(Perisoreusinfaustus)basedonautosomalandZchromosomalmarkers.MolecularEcology19:5281-5295. Li,M.H.,Kantanen,J(2010)GeneticstructureofEurasiancattle(Bostaurus)basedonmicrosatellites:clarificationfortheirbreedclassification.AnimalGenetics41:150-158. Li,M.H.,Iso-Touru,T.,Lauren,H.,Kantanen,J(2010)Amicrosatellite-basedanalysisforthedetectionofselectiononBTA1andBTA20innorthernEurasiancattle(Bostaurus)populations.GeneticsSelectionEvolution42:14. LiM.H.*andJ.Meril？(2010)AvianZ-specificmicrosatellitesmaptopseudoautosomalorautosomalchromosomesintheSiberianjay(Perisoreusinfaustus):insightsintoaviangenomeevolutionfromcross-speciesamplificationtests.JournalofGenetics89:223-228. LiM.-H.*andJ.Meril？(2010)Sex-specificpopulationstructure,naturalselection,andlinkagedisequilibriuminawildbirdpopulationasrevealedbygenome-widemicrosatelliteanalyses.BMCEvolutionaryBiology10:66. 受到Science（328:19）“编辑的选择”栏目评述 LiM.-H.*,andJ.Meril？(2010)Extensivelinkagedisequilibriuminawildbirdpopulation.Heredity104:600-610. Iso-Touru,T.,J.Kantanen,M.H.Li,Z.GizejewskiandJ.Vilkki(2009)DivergentevolutionincattleandpigsinthecytoplasmicdomainsofGHRandPRLR.BMCEvolutionaryBiology9:172. LiM.-H.*K.V？lim？ki,M.Piha,T.PakkalaandJ.Meril？(2009)Extrapairpaternityandmaternityinthethree-toedwoodpecker,Picoidestridactylus:insightsfrommicrosatellite-basedparentageanalysis.PLoSONE4:1-6. LiM.-H.,I.Strandén,andJ.Kantanen(2009)GeneticdiversityandpedigreeanalysisoftheFinnsheepbreed.JournalofAnimalScience87:1598-1605. JarriS.,M.-H.Li*,andJ.Meril？(2009)Afirst-generationmicrosatellite-basedgeneticlinkagemapoftheSiberianjay(Perisoreusinfaustus):insightsintoaviangenomeevolution.BMCGenomics10:1. AghaS.H.,F.Pilla,S.Galal,I.Shaat,M.D’Andrea,S.Reale,A.Z.A.Abdelsalam,andM.-H.Li(2008)GeneticdiversityinEgyptianandItaliangoatbreedsmeasuredwithmicrosatellitepolymorphism.JournalofAnimalBreedingandGenetics125:194-200. LiM.-H.,I.Tapio,J.Vilkki,Z.Ivanova,T.Kiselyova,N.Marzanov,M.Cinkulov,S.Stojanovic,I.Ammosov,R.Popov,andJ.Kantanen(2007)Geneticstructureofcattlepopulations(Bostaurus)innorthernEurasiaandtheneighboringNearEasternregions:implicationsforbreedingstrategiesandconservation.MolecularEcology16:3839-3853. 封面文章 LiM.-H.,M.Zerabruk,O.Vangen,I.Olsaker,andJ.Kantanen(2007)ReducedgeneticstructureofnorthEthiopiancattlerevealedbyY-chromosomeanalysis.Heredity98:214-221. LiM.-H.,T.Adamowicz,M.Switonski,I.Ammosov,Z.Ivanova,T.Kiselyova,R.Popov,andJ.Kantanen(2006)AnalysisofpopulationdifferentiationinNorthEurasiancattle(Bostaurus)usingsinglenucleotidepolymorphismsinthreegenesassociatedwithproductiontraits.AnimalGenetics37:390-392. BennewitzJ.，J.Kantanen,I.Tapio,M.-H.Li,E.Kalm,J.Vilkki,I.Ammosov,Z.Ivanova,T.Kiselyova,R.Popov,andT.H.Meuwissen(2006)Estimationofbreedcontributionstopresentandfuturegeneticdiversityof44NorthEurasiancattlebreedsusingcoresetdiversitymeasures.GeneticsSelectionEvolution38:201-220. LiM.-H.,K.Li,J.Kantanen,Z.Feng,B.Fan,andS.H.Zhao(2006)Allelicvariationsinexon2ofcaprineMHCclassIIDRB3geneinChineseindigenousgoats.SmallRuminantResearch66:236-243. LiM.-H.,E.Nogovitsina,Z.Ivanova,G.Erhardt,J.Vilkki,R.Popov,I.Ammosov,T.Kiselyova,andJ.Kantanen(2005)GeneticcontributionsofindigenousYakutiancattletotwohybridpopulationsasrevealedbymicrosatellitevariation.Asian-AustralasianJournalofAnimalSciences18:613-1619. Li,M.-H.,K.Sternbauer,P.T.Haahr,andJ.Kantanen(2005)GeneticcomponentsincontemporaryFaroeIslandsCattleasrevealedasmicrosatelliteanalysis.JournalofAnimalBreedingandGenetics122:309-317. LiS.J.,S.H,Yang,S.H.Zhao,B.Fan,M.Yu,H.S.Wang,M.-H.Li,B.Liu,T.A.Xiong,andK.Li(2004)Geneticdiversityanalysesof10indigenousChinesepigpopulationsbasedon20microsatellites.JournalofAnimalScience82:368-374. LiM.-H.,S,H.Zhao,andK.Li(2004)DiversityofChineseindigenousgoatbreeds:aconservationperspective–areview.Asian-AustralasianJournalofAnimalSciences17:726-732. MoD.L.,B.Liu,Z.G.Wang,S.H.Zhao,M.Yu,B.Fan,M.-H.Li,T.A.Xiong,M.Yu,andK.Li(2003)GeneticvariationandgeneticrelationshipofseventeenChineseindigenouspigbreedsusingtenserumproteinloci.Asian-AustralasianJournalofAnimalSciences16:939-945. YangS.L,Z.GWang,B.Liu,G.X.Zhang,S.H.Zhao,M.Yu,B.Fan,M.-H.Li,andK.Li(2003)GeneticvariationandrelationshipsofeighteenChineseindigenouspigbreeds.GeneticsSelectionEvolution35:657-671. FanB.,Z.G.Wang,Y.J.Li,X.L.Zhao,B.Liu,S.H.Zhao,MYu,M.-H.Li,S.L.Chen,T.A.Xiong,andK.Li(2002)GeneticvariationanalysiswithinandamongChineseindigenousswinepopulationsusingmicrosatellitemarkers.AnimalGenetics33:422-427. LiM.-H.,S.H.Zhao,C.Bian,H.S.Wang,H.Wei,B.Liu,M.Yu,B.Fan,S.L.Chen,M.J.Zhu,T.A.Xiong,andK.Li(2002)GeneticrelationshipsamongtwelveindigenousChinesegoatpopulationsbasedonmicrosatelliteanalysis.GeneticsSelectionEvolution34:729-744. ChenS.L.,M.-H.Li,Y.J.Li,S.H.Zhao,C.Z.Yu,M.Yu,B.Fan,T.A.Xiong,andK.Li(2001)RAPDvariationandgeneticdistancesamongTibetan,InnerMongoliaandLiaoningCashmeregoats.Asian-AustralasianJournalofAnimalSciences14:1520-1522. SakhaYnaga.CattleoftheYakuts(GranbergL.,J.Kantanen&K.Soinieds).FinnishAcademyofScienceandLetters,Helsinki,Finland.218pp.(ISBN978-951-41-1032-0,LiM.-H.是该书的主要的编著者之一).(#为共同第一作者，*为通讯作者) 2018年度： Xiao-JuHu,JiYang,Xing-LongXie,Feng-HuaLv,Yin-HongCao,Wen-RongLi,Ming-JunLiu,Yu-TaoWang,Jin-QuanLi,Yong-GangLiu,Yan-LinRen,Zhi-QiangShen,FengWang,EErHehua,Jian-LinHan,Meng-HuaLi*(2018)ThegenomelandscapeofTibetansheeprevealsadaptiveintrogressionfromargaliandthehistoryofearlyhumansettlementsontheQinghai-TibetanPlateau.MolecularBiologyandEvolution(doi.org/10.1093/molbev/msy208) JiYang(#),XinLi(#),Yin-HongCao(#),KisunPokharel(#),Xiao-JuHu(#),Ze-HuiChen(#),Song-SongXu,JaanaPeippo,MerviHonkatukia,JuhaKantanen,Meng-HuaLi*(2018)ComparativemRNAsandmiRNAsexpressioninEuropeanmouflon(Ovismusimon)andsheep(Ovisaries)providenovelinsightsintothegeneticmechanismsforfemalereproductivesuccess.Heredity(doi:10.1038/s41437-018-0090-1). LeiGao(#),Song-SongXu(#),Jing-QuanYang(#),MinShen*,Meng-HuaLi*(2018)Genome-wideassociationstudyrevealsnovelgenesfortheearsizeinsheep(Ovisaries)AnimalGenetics49:345-348. Ze-HuiChen(#),MinZhang(#),Feng-HuaLv(#),XueRen,Wen-RongLi,Ming-JunLiu,KiwoongNam,MichaelWBruford,Meng-HuaLi*(2018)ContrastingpatternsofgenomicdiversityrevealacceleratedgeneticdriftbutreduceddirectionalselectiononX-chromosomeinwildanddomesticsheepspecies.GenomeBiologyandEvolution10:1282-1297. Song-SongXu(#),LeiGao(#),Xing-LongXie,Yan-LingRen,Zhi-QiangShen,FengWang,MinShen,EmmaEyporsdottir,JonH.Hallsson,TatyanaKiseleva,JuhaKantanenandMeng-HuaLi*(2018)Genome-wideassociationanalyseshighlightthepotentialfordifferentgeneticmechanismsforlittersizeamongsheepbreeds.FrontierinGenetics(Livestockgenomics)9:118. PokharelKisun,PeippoJaana,HonkatukiaMervi,SeppalaArja,RautiainenJohanna,GhanemNasser,HamamaTuula-Marjatta,CroweMarkA,AnderssonMagnus,LiMeng-Hua*,KantanenJuha*(2018)IntegratedovarianmRNAandmiRNAtranscriptomeprofilingcharacterizesthegeneticbasisofprolificacytraitsinsheep(Ovisaries)BMCGenomics19:104. 2017年度： ZhaoYong-Xin(#),YangJi(#),LvFeng-Hua(#),HuXiao-Ju,XieXing-Long,ZhangMin,LiWen-Rong,LiuMing-Jun,WangYu-Tao,LiJin-Quan,LiuYong-Gang,RenYan-Ling,WangFeng,EerHehua,Kantanen,JuhaLenstra,JohannesArjen,HanJian-Lin,LiMeng-Hua*(2017)GenomicreconstructionofthehistoryofnativesheeprevealsthepeoplingpatternsofnomadsandtheexpansionofearlypastoralisminEastAsia.MolecularBiologyandEvolution34:2380-2395. XuSong-Song#,RenXue#,YangGuang-Li#,XieXing-Long,ZhaoYong-Xin,ZhangMin,ShenZhi-Qiang,RenYan-Ling,GaoLei,ShenMin,JuhaKantanenandMeng-HuaLi*(2017)Genome-wideassociationanalysisidentifiesthegeneticbasisoffatdepositioninthetailsofsheep(Ovisaries)AnimalGenetics48:560-569. PengW.-F.(#),XuS.-S.(#),RenX.(#),LvF.-H.,XieX.-L.,ZhaoY.-X.,ZhangM.,ShenZ.-Q.,RenY.-L.,GaoL.,ShenM.,KantanenJ.,LiM.-H.*(2017)Agenome-wideassociationstudyrevealscandidategenesforthesupernumerarynipplephenotypeinsheep(Ovisaries)AnimalGenetics48:570-579. XuSong-Song,Meng-HuaLi*(2017)Recentadvancesinunderstandinggeneticvariantsassociatedwitheconomicallyimportanttraitsinsheep(Ovisaries)revealedbyhigh-throughputscreeningtechnologies.FrontiersofAgriculturalSciencesandEngineering4:279-288. 2016年度： JiYang#,Wen-RongLi#,Feng-HuaLv#,San-GangHe#,Shi-LinTian#,Wei-FengPeng,Ya-WeiSun,Yong-XinZhao,Xiao-LongTu,MinZhang,Xing-LongXie,Yu-TaoWang,Jin-QuanLi,Yong-GangLiu,Zhi-QiangShen,FengWang,Guang-JianLiu,Hong-FengLu,JuhaKantanen,Jian-LinHan,Meng-HuaLi*andMing-JunLiu*（2016）Whole-GenomeSequencingofNativeSheepProvidesInsightsintoRapidAdaptationstoExtremeEnvironments.MolecularBiologyandEvolution33(10):2576–2592. 封面文章受到“InternationalLivestockResearchInstitute(ILRI)”点评和报道 RenX#.YangGL#,PengWF,ZhaoYX,ZhangM,ChenZH,WuFA,KantanenJ,ShenM,LiM.-H.*(2016)Agenome-wideassociationstudyidentifiesagenomicregionforthepolyceratephenotypeinsheep(Ovisaries)ScientificReports6:201111. XiaojuHu,KisunPokharel，JaanaPeippo,NasserGhanem，IsmaelZhaboyev，JuhaKantanenandMeng-HuaLi*.(2016)IdentificationandcharacterizationofmiRNAsintheovariesofahighlyprolificsheepbreed.AnimalGenetics47：234-239. 2015年度： LvF-H,PengW-F,YangJ,ZhaoY-X,LiW-R,LiuM-J,MaY-H,ZhaoQ-J,YangG-L,WangF,LiJ-Q,LiuY-G,ShenZ-Q,ZhaoS-G,HehuaE,GorkhaliNA,FarhadVahidiSM,MuladnoM,NaqviAN,TabellJ,Iso-TouruT,BrufordMW,KantanenJ,HanJ-L*,LiM-H*(2015).MitogenomicMeta-AnalysisIdentifiesTwoPhasesofMigrationintheHistoryofEasternEurasianSheep.MolecularBiologyandEvolution32:2515-2533. 封面文章受到“FinancialTimes”,“ModernFarmer”和“ILRI”等媒体报道和点评受到《中国科学》的评述中国科学院科研进展英文评述 JunLiu,CuiminWang,DongliFu,XiaojuHu,XiangmoXie,PengfeiLiu,QiongZhangandMeng-HuaLi*(2015)PhylogeographyofNanoranaparkeri(Anura:Ranidae)ontheTibetanPlateau:effectsofPlateauupliftandQuaternaryclimaticchanges.ScientificReports5：9857 中国科学院科研进展英文评述 WeiminZhao,YulianMu,LeiMa,ChenWang,ZhonglinTang,ShulinYang,RongZhou,XiaojuHu,Meng-HuaLi*andKuiLi*(2015)Systematicidentificationandcharacterizationoflongintergenicnon-codingRNAsinfetalporcineskeletalmuscledevelopment.ScientificReports5:8957. KisunPokharel,JaanaPeippo,G？ranAndersson,Meng-HuaLi*,JuhaKantanen(2015)TranscriptomeprofilingofFinnsheepovariesduringout-of-seasonbreedingperiod.AgriculturalandFoodScience24:1-9. KantanenJ,L？vendahlP,StrandbergE,EythorsdottirE,LiM.-H.,Kettunen-Pr？belA,BergP,MeuwissenT.(2015)Utilizationoffarmanimalgeneticresourcesinachangingagro-ecologicalenvironmentintheNordiccountries.FrontiersinGenetics6:52. 2014年度： Feng-HuaLv,SaifAgha,JuhaKantanen,LiciaColli,SylvieStucki,JamesW.Kijas,StéphaneJoost,Meng-HuaLi*,PaoloAjmoneMarsan(2014)AdaptationstoClimate-MediatedSelectivePressuresinSheep.MolecularBiologyandEvolution31:3324-3343. 封面文章受到Sciencedaily等媒体报道和点评 JiYang,TakahitoShikano,Meng-HuaLi*,JuhaMeril？(2014)Genome-widelinkagedisequilibriuminnine-spinedstickleback.G3–GenesGenomesGenetics4:1119-1129 YangJ,LiM.-H.*(2014)Amulti-omicsintegratedstudydeciphersbiologyoftherumenandlipidmetabolism.ScienceChinaLifeScience57:951-953 特邀评述 LiuJ.,T.Shikano,T.Leinonen,J.M.Cano,M.-H.Li*,J.Meril？(2014)IdentificationofmajorandminorQTLforecologicallyimportantmorphologicaltraitsinthree-spinedsticklebacks(Gasterosteusaculeatus).G3-Genes,Genomes,Genetics4:594-604 ShanL.,WuQ.,LiY.,ShangH.,GuoK.,WuJ.,WeiH.,ZhaoJ.,YuJ.,LiM.-H.*(2014)Transcriptomeprofilingidentifiesdifferentiallyexpressedgenesinpostnataldevelopingpituitaryglandofminiaturepig.DNAResearch21:207-216 LiM.-H.*,T.Tiirikka,J.Kantanen(2014)Agenome-widescanstudyidentifiesasinglenucleotidesubstitutioninASIPassociatedwithwhiteversusnon-whitecoat-colourvariationinsheep(Ovisaries).Heredity112:122–131. ZhangMin,Wei-FengPeng,Guang-LiYang,Feng-HuaLv,Ming-JunLiu,Wen-RongLi,Yong-GangLiu,Jin-QuanLi,FengWang,Zhi-QiangShen,Sheng-GuoZhao,EErHehua,NurbiyMarzanov,MaziekMurawski,JuhaKantanenandMeng-HuaLi(2014)Ychromosomehaplotypediversityofdomesticsheep(Ovisaries)innorthernEurasia.AnimalGenetics45:903-907. 2011-2013年度： WangC.,HuX.,XieX.,LiuP.,Meril？J.,ZhangQ.*,LiM.-H.*(2013)Isolationandcharacterizationof113polymorphicmicrosatellitelocifortheTibetanfrog(Nanoranaparkeri)usingnextgenerationsequencing.ConservationGeneticsResources5:915-924. LiM.-H.,A.Osva,J.Kantanen(2012)Integratingmultidisciplinarydatafortheconservationoflivestockbiodiversity:acasestudyoftheYakutiancattleinSiberia,thefareastofRussia.AnimalGeneticsResources50:97-104. LiM.H.*andJ.Meril？(2011)Populationdifferencesinlevelsoflinkagedisequilibriuminthewild.MolecularEcology20:2916-2928. LiM.-H.,I.Strandén,T.Tiirikka,M.-L.Sevón-Aimonen,J.Kantanen(2011)Acomparisonofapproachestoestimatetheinbreedingcoefficientandpairwiserelatednessusinggenomicandpedigreedatainasheeppopulation.PLoSONE6:e26256. CanoJ.M.,M.-H.Li,LaurilaA,VilkkiJ,Meril？J.(2011)First-generationlinkagemapforthecommonfrogRanatemporariarevealssexlinkagegroup.Heredity107:530-536. LiM.-H.*,J.Kantanen,A.Michelson,U.Saarma(2011)GeneticcomponentsofgreycattleinEstoniaasrevealedbymicrosatelliteanalysisusingtwoBayesianclusteringmethods.BMCResearchNotes4:37. ZerabrukM.#,LiM.-H.#,J.Kantanen,I.Olsaker,E.M.Ibeagha-Awemu,G.Erhardt,D.G.BradleyandOVangen(2011)GeneticdiversityandadmixtureofindigenouscattlebreedsofNorthEthiopia:implicationstohistoricalintrogressionsinthegatewayregionofcattletoAfrica.AnimalGenetics43:257-266. NairA.,S.Kumar,S.George,S.Gopalan,M.-H.Li,E.LederandJ.Meril？(2011)SixtytwonewmicrosatellitemarkersforanendemicfrogIndiranabeddomiifromtheWesternGhatsbiodiversityhotspot.ConservationGeneticsResources3:167-171. 2001-2010年度： Tapio,I.,Tapio,M.,M.-H.Li,Popov,R.,Ivanova,Z.,Kantanen,J(2010)Estimationofrelatednessamongnon-pedigreedYakutiancryo-bankbullsusingmoleculardata:implicationsforconservationandbreedmanagement.GeneticsSelectionEvolution42:9. LiM.H.*andJ.Meril？(2010)Geneticevidenceformale-biaseddispersalintheSiberianjay(Perisoreusinfaustus)basedonautosomalandZchromosomalmarkers.MolecularEcology19:5281-5295. Li,M.H.,Kantanen,J(2010)GeneticstructureofEurasiancattle(Bostaurus)basedonmicrosatellites:clarificationfortheirbreedclassification.AnimalGenetics41:150-158. Li,M.H.,Iso-Touru,T.,Lauren,H.,Kantanen,J(2010)Amicrosatellite-basedanalysisforthedetectionofselectiononBTA1andBTA20innorthernEurasiancattle(Bostaurus)populations.GeneticsSelectionEvolution42:14. LiM.H.*andJ.Meril？(2010)AvianZ-specificmicrosatellitesmaptopseudoautosomalorautosomalchromosomesintheSiberianjay(Perisoreusinfaustus):insightsintoaviangenomeevolutionfromcross-speciesamplificationtests.JournalofGenetics89:223-228. LiM.-H.*andJ.Meril？(2010)Sex-specificpopulationstructure,naturalselection,andlinkagedisequilibriuminawildbirdpopulationasrevealedbygenome-widemicrosatelliteanalyses.BMCEvolutionaryBiology10:66. 受到Science（328:19）“编辑的选择”栏目评述 LiM.-H.*,andJ.Meril？(2010)Extensivelinkagedisequilibriuminawildbirdpopulation.Heredity104:600-610. Iso-Touru,T.,J.Kantanen,M.H.Li,Z.GizejewskiandJ.Vilkki(2009)DivergentevolutionincattleandpigsinthecytoplasmicdomainsofGHRandPRLR.BMCEvolutionaryBiology9:172. LiM.-H.*K.V？lim？ki,M.Piha,T.PakkalaandJ.Meril？(2009)Extrapairpaternityandmaternityinthethree-toedwoodpecker,Picoidestridactylus:insightsfrommicrosatellite-basedparentageanalysis.PLoSONE4:1-6. LiM.-H.,I.Strandén,andJ.Kantanen(2009)GeneticdiversityandpedigreeanalysisoftheFinnsheepbreed.JournalofAnimalScience87:1598-1605. JarriS.,M.-H.Li*,andJ.Meril？(2009)Afirst-generationmicrosatellite-basedgeneticlinkagemapoftheSiberianjay(Perisoreusinfaustus):insightsintoaviangenomeevolution.BMCGenomics10:1. AghaS.H.,F.Pilla,S.Galal,I.Shaat,M.D’Andrea,S.Reale,A.Z.A.Abdelsalam,andM.-H.Li(2008)GeneticdiversityinEgyptianandItaliangoatbreedsmeasuredwithmicrosatellitepolymorphism.JournalofAnimalBreedingandGenetics125:194-200. LiM.-H.,I.Tapio,J.Vilkki,Z.Ivanova,T.Kiselyova,N.Marzanov,M.Cinkulov,S.Stojanovic,I.Ammosov,R.Popov,andJ.Kantanen(2007)Geneticstructureofcattlepopulations(Bostaurus)innorthernEurasiaandtheneighboringNearEasternregions:implicationsforbreedingstrategiesandconservation.MolecularEcology16:3839-3853. 封面文章 LiM.-H.,M.Zerabruk,O.Vangen,I.Olsaker,andJ.Kantanen(2007)ReducedgeneticstructureofnorthEthiopiancattlerevealedbyY-chromosomeanalysis.Heredity98:214-221. LiM.-H.,T.Adamowicz,M.Switonski,I.Ammosov,Z.Ivanova,T.Kiselyova,R.Popov,andJ.Kantanen(2006)AnalysisofpopulationdifferentiationinNorthEurasiancattle(Bostaurus)usingsinglenucleotidepolymorphismsinthreegenesassociatedwithproductiontraits.AnimalGenetics37:390-392. BennewitzJ.，J.Kantanen,I.Tapio,M.-H.Li,E.Kalm,J.Vilkki,I.Ammosov,Z.Ivanova,T.Kiselyova,R.Popov,andT.H.Meuwissen(2006)Estimationofbreedcontributionstopresentandfuturegeneticdiversityof44NorthEurasiancattlebreedsusingcoresetdiversitymeasures.GeneticsSelectionEvolution38:201-220. LiM.-H.,K.Li,J.Kantanen,Z.Feng,B.Fan,andS.H.Zhao(2006)Allelicvariationsinexon2ofcaprineMHCclassIIDRB3geneinChineseindigenousgoats.SmallRuminantResearch66:236-243. LiM.-H.,E.Nogovitsina,Z.Ivanova,G.Erhardt,J.Vilkki,R.Popov,I.Ammosov,T.Kiselyova,andJ.Kantanen(2005)GeneticcontributionsofindigenousYakutiancattletotwohybridpopulationsasrevealedbymicrosatellitevariation.Asian-AustralasianJournalofAnimalSciences18:613-1619. Li,M.-H.,K.Sternbauer,P.T.Haahr,andJ.Kantanen(2005)GeneticcomponentsincontemporaryFaroeIslandsCattleasrevealedasmicrosatelliteanalysis.JournalofAnimalBreedingandGenetics122:309-317. LiS.J.,S.H,Yang,S.H.Zhao,B.Fan,M.Yu,H.S.Wang,M.-H.Li,B.Liu,T.A.Xiong,andK.Li(2004)Geneticdiversityanalysesof10indigenousChinesepigpopulationsbasedon20microsatellites.JournalofAnimalScience82:368-374. LiM.-H.,S,H.Zhao,andK.Li(2004)DiversityofChineseindigenousgoatbreeds:aconservationperspective–areview.Asian-AustralasianJournalofAnimalSciences17:726-732. MoD.L.,B.Liu,Z.G.Wang,S.H.Zhao,M.Yu,B.Fan,M.-H.Li,T.A.Xiong,M.Yu,andK.Li(2003)GeneticvariationandgeneticrelationshipofseventeenChineseindigenouspigbreedsusingtenserumproteinloci.Asian-AustralasianJournalofAnimalSciences16:939-945. YangS.L,Z.GWang,B.Liu,G.X.Zhang,S.H.Zhao,M.Yu,B.Fan,M.-H.Li,andK.Li(2003)GeneticvariationandrelationshipsofeighteenChineseindigenouspigbreeds.GeneticsSelectionEvolution35:657-671. FanB.,Z.G.Wang,Y.J.Li,X.L.Zhao,B.Liu,S.H.Zhao,MYu,M.-H.Li,S.L.Chen,T.A.Xiong,andK.Li(2002)GeneticvariationanalysiswithinandamongChineseindigenousswinepopulationsusingmicrosatellitemarkers.AnimalGenetics33:422-427. LiM.-H.,S.H.Zhao,C.Bian,H.S.Wang,H.Wei,B.Liu,M.Yu,B.Fan,S.L.Chen,M.J.Zhu,T.A.Xiong,andK.Li(2002)GeneticrelationshipsamongtwelveindigenousChinesegoatpopulationsbasedonmicrosatelliteanalysis.GeneticsSelectionEvolution34:729-744. ChenS.L.,M.-H.Li,Y.J.Li,S.H.Zhao,C.Z.Yu,M.Yu,B.Fan,T.A.Xiong,andK.Li(2001)RAPDvariationandgeneticdistancesamongTibetan,InnerMongoliaandLiaoningCashmeregoats.Asian-AustralasianJournalofAnimalSciences14:1520-1522. SakhaYnaga.CattleoftheYakuts(GranbergL.,J.Kantanen&K.Soinieds).FinnishAcademyofScienceandLetters,Helsinki,Finland.218pp.(ISBN978-951-41-1032-0,LiM.-H.是该书的主要的编著者之一).