Horne, Seth - University of Pittsburgh - Department of Chemistry

研究领域

Organic synthesis/bioorganic chemistry/biophysics/protein engineering

近期论文

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"Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure," Z.E. Reinert, W.S. Horne*, Org. Biomol. Chem., 2014, Pages 8796-8802, http://dx.doi.org/10.1039/C4OB01769B "Origins of structural flexibility in protein-based supramolecular polymers revealed by DEER spectroscopy," N.A. Tavenor, K.I. Silva, S. Saxena*, W.S. Horne*, J. Phys. Chem. B, 2014, Pages 9881-9889, http://dx.doi.org/10.1021/jp505643w "Folding thermodynamics of protein-like oligomers with heterogeneous backbones," Z.E. Reinert, W.S. Horne*, Chem. Sci., 2014, Pages 3325-3330, http://dx.doi.org/10.1039/C4SC01094A "Comparison of backbone modification in protein β-sheets by α->γ residue replacement and α-residue methylation," G.A. Lengyel, Z.E. Reinert, B.D. Griffith, W.S. Horne*, Org. Biomol. Chem., 2014, Pages 5375-5381, http://dx.doi.org/10.1039/C4OB00886C "Tuning assembly size in peptide-based supramolecular polymers by modulation of subunit association affinity," K.M. Oshaben, W.S. Horne*, Biomacromolecules, 2014, Pages 1436-1442, http://dx.doi.org/10.1021/bm5000423 "Dynamic covalent side-chain cross links via intermolecular oxime or hydrazone formation from bifunctional peptides and simple organic linkers," C.M. Haney, W.S. Horne*, J. Pept. Sci., 2014, Pages 108-114, http://dx.doi.org/10.1002/psc.2596 "Protein-like tertiary folding behavior from heterogeneous backbones," Z.E. Reinert, G.A. Lengyel, W.S. Horne*, J. Am. Chem. Soc., 2013, Pages 12528-12531, http://dx.doi.org/10.1021/ja405422v "Oxime side-chain cross-links in an α-helical coiled-coil protein: Structure, thermodynamics, and folding-templated synthesis of bicyclic species," C.M. Haney, W.S. Horne*, Chem. Eur. J., 2013, Pages 11342-11351, http://dx.doi.org/10.1002/chem.201300506 "Introduction of cyclically constrained γ-residues stabilizes an α-peptide hairpin in aqueous solution," G.A. Lengyel, G.A. Eddinger, W.S. Horne*, Org. Lett., 2013, Pages 944-947, http://dx.doi.org/10.1021/ol4001125 "β-Hairpin-mediated nucleation of polyglutamine amyloid formation," K. Kar, C.L. Hoop, K.W. Drombosky, M.A. Baker, R. Kodali, I. Arduini, P.C.A. van der Wel, W.S. Horne, R. Wetzel*, J. Mol. Biol., 2013, Pages 1183-1197, http://dx.doi.org/10.1016/j.jmb.2013.01.016 "The native GCN4 leucine-zipper domain does not uniquely specify a dimeric oligomerization state," K.M. Oshaben, R. Salari, D.R. McCaslin, L.T. Chong*, W.S. Horne*, Biochemistry, 2012, Pages 9581-9591, http://dx.doi.org/10.1021/bi301132k "Design strategies for the sequence-based mimicry of side-chain display in protein β-sheets by α/β-peptides," G.A. Lengyel, W.S. Horne*, J. Am. Chem. Soc., 2012, Pages 15906-15913, http://dx.doi.org/10.1021/ja306311r "A modular synthetic platform for the construction of protein-based supramolecular polymers via coiled-coil self-assembly," J.K. Staples, K.M. Oshaben, W.S. Horne*, Chem. Sci., 2012, Pages 3387-3392, http://dx.doi.org/10.1039/C2SC20729J "High-resolution structure of a protein spin-label in a solvent-exposed β-sheet and comparison with DEER spectroscopy," T.F. Cunningham, M.S. McGoff, I. Sengupta, C.P. Jaroniec, W.S. Horne*, S.K. Saxena*, Biochemistry, 2012, Pages 6350-6359, http://dx.doi.org/10.1021/bi300328w "A PEG-based oligomer as a backbone replacement for surface-exposed loops in a protein tertiary structure," Z.E. Reinert, E.D. Musselman, A.H. Elcock, W.S. Horne*, ChemBioChem, 2012, Pages 1107-1111, http://dx.doi.org/10.1002/cbic.201200200 "Peptide and peptoid foldamers in medicinal chemistry," W.S. Horne*, Expert Opin. Drug Discovery, 2011, Pages 1247-1262, http://dx.doi.org/10.1517/17460441.2011.632002 "Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs," S. Wan, F. Wu, J.C. Rech, M.E. Green, R. Balachandran, W.S. Horne*, B.W. Day*, P.E. Floreancig*, J. Am. Chem. Soc., Vol. 133, 2011, Pages 16668-16679, http://dx.doi.org/10.1021/ja207331m "Promoting peptide α-helix formation with dynamic covalent oxime side-chain cross-links," C.M. Haney, M.T. Loch, W.S. Horne*, Chem. Commun., 2011, Pages 10915-10917, http://dx.doi.org/10.1039/C1CC12010G "Hairpin folding behavior of mixed α/β-peptides in aqueous solution," G.A. Lengyel, R.C. Frank, W.S. Horne*, J. Am. Chem. Soc., 2011, Pages 4246-4249, http://dx.doi.org/10.1021/ja2002346