郑萍 - 中国科学院大学 - 生命科学学院

个人简介

招生专业 071009-细胞生物学招生方向生殖生物学发育生物学教育背景 1995-09--2001-08 中科院昆明动物研究所博士研究生工作简历 2009-05~现在, 中科院昆明动物研究所, 研究员，学科组长 2005-06~2009-03,美国NIH, 博士后 2003-03~2005-06,美国Temple University, 博士后 2001-08~2003-03,中科院昆明动物研究所, 助理研究员 1995-09~2001-08,中科院昆明动物研究所, 博士研究生专利成果（ 1 ）一种建立可持续传代的树鼩精原干细胞细胞系的方法, 2019, 第 1 作者, 专利号: 201610460383X 发表著作（ 1 ）猕猴繁殖生物学, reproduction and breeding of rhesus monkey, 科学出版社, 2013-01, 第 5 作者科研项目（ 1 ）小鼠卵巢生殖干细胞分子标记的筛选及干细胞功能研究, 主持, 国家级, 2016-01--2019-12 （ 2 ）利用树鼩精原干细胞建立树鼩基因修饰技术, 主持, 省级, 2015-01--2019-12 （ 3 ）代谢、自噬和DNA损伤修复协同维持多能干细胞干性和染色体稳定性的机理研究, 主持, 国家级, 2016-01--2020-12 （ 4 ）基于精原干细胞系的灵长类动物遗传操作平台构建, 主持, 部委级, 2017-05--2019-06 （ 5 ）阿尔茨海默症（AD）转基因树鼩模型的创建及有效性评价, 主持, 国家级, 2018-01--2021-12 （ 6 ）卵巢早衰病因学及临床防治研究, 主持, 国家级, 2017-10--2020-09 （ 7 ）多能干细胞高效调控DNA复制压力反应的关键lncRNA鉴定与功能分析, 主持, 国家级, 2020-01--2024-12

近期论文

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（1） Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia, Science Advances, 2020, 通讯作者（2） Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia, Science Advances, 2020, 通讯作者（3） Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys, Nature Communications, 2019, 通讯作者（4） KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells, PLoS Biology, 2019, 通讯作者（5） In vitro culture of cynomolgus monkey embryos beyond early gastrulation, Science, 2019, 通讯作者（6） Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex, Cell Research, 2018, 通讯作者（7） Single-cell RNA-sequencing reveals the existence of naive and primed pluripotency in pre-implantation rhesus monkey embryos, Genome Research, 2018, 通讯作者（8） Transcriptome analyses of rhesus monkey pre-implantation embryos reveal a reduced capacity for DNA double strand break repair in primate oocytes and early embryos, Genome Research, 2017, 通讯作者（9） Long-term propagation of tree shrew spermatogonial stem cells (SSCs) in culture and the successful generation of transgenic offspring, Cell Research, 2017, 通讯作者（10） Germ stem cells are active in postnatal mouse ovary under physiological conditions, Mol Hum Reprod, 2016, 通讯作者（11） Decrease in expression of maternal effect gene Mater is associated with maternal ageing in mice, Mol Hum Reprod, 2016, 通讯作者（12） Filia is an ESC-specific regulator of DNA damage response and safeguards genomic stability, Cell Stem Cell, 2015, 通讯作者（13） mRNA-Seq and microRNA-Seq whole-transcriptome analysis of rhesus monkey ESC neural differentiation revealed the potential regulators of rosette neural stem cells, DNA Research, 2014, 通讯作者（14） PtdIns(3,4,5)P3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes, J Cell Sci, 2013, 通讯作者（15） Maternal control of early mouse development, Development, 2010, 第 2 作者（16） Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embyrogenesis, PNAS, 2009, 第 1 作者（17） Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos, Development, 2008, 第 2 作者（18） Effects of in vitro oocyte maturation and embryo culture on the expression of glucose transporters, glucose metabolism and insulin signaling genes in rhesus monkey oocytes and preimplantation embryos, Mol Hum Reprod, 2007, 第 1 作者（19） Effects of in vitro maturation of monkey oocytes on their developmental capacity, Semin Reprod Med, 2007, 通讯作者（20） Effects of in vitro maturation of monkey oocytes on their developmental capacity, Anim Reprod Sci, 2007, 通讯作者（21） Expression and downregulation of WNT signaling pathway genes in rhesus monkey oocytes and embryos, Mol Reprod Dev, 2006, 第 1 作者（22） Effects of follicle size and oocyte maturation conditions on maternal message RNA regulation and gene expression in rhesus monkey oocytes and embryos, Biol Reprod, 2005, 第 1 作者（23） Developmental regulation and in vitro culture effects on expression of DNA repair and cell cycle checkpoint control genes in rhesus monkey oocytes and embryos, Biol Reprod, 2005, 第 1 作者（24） The primate embryo gene expression resource: A novel resource to facilitate rapid analysis of gene expression patterns in non-human primate oocytes and preimplantation stage embryos. , Biol Reprod, 2004, 第 1 作者（25） Expression of genes encoding chromatin regulatory factors in developing rhesus monkey oocytes and preimplantation stage embryos: Possible roles in genome, Biol Reprod, 2004, 第 1 作者（26） Effect of Glycerol and Dimethyl Sulfoxide on cyropreservation of rhesus monkey (Macaca mulatta) sperm, Am J Primatol, 2004, 第 2 作者（27） Estradiol and progesterone improve in-vitro？Yang JF, Ding CH, Ji WZ. 2003. 17 cytoplasmic maturation of oocytes from unstimulated prepubertal and adult rhesus monkeys, Hum Reprod, 2003, 第 1 作者（28） Amino acid requirements for maturation of rhesus monkey oocytes in culture, Reproduction, 2002, 第 1 作者（29）纤溶酶原激活因子与猕猴精子运动力的关系及其在附睾和附性腺中的表达调节, 动物学研究, 2002, 第 1 作者（30） Maturation of rhesus monkey oocytes in chemically defined culture media and their functional assessmental by IVF and embryo development, Hum Reprod, 2001, 第 1 作者（31） Energy substrate requirement for in vitro maturation of oocytes from unstimulated adult rhesus monkeys, Mol Reprod Dev, 2001, 第 1 作者（32） Effect of age and breeding season on the developmental capacity of oocytes from unstimulated and FSH-stimulated rhesus monkeys, Biol Reprod, 2001, 第 1 作者（33）猕猴精浆纤溶酶原激活因子的来源及在精子获能中的作用, 生理学报, 2001, 第 1 作者（34） Cryopreservation of rhesus monkey (Macaca mulatta) spermatozoa and their functional assessment by in vitro fertilization., Cryobiology, 2000, 第 2 作者