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个人简介

博士,研究员。中科院昆明动物研究所“动物模型与人类疾病机理重点实验室”PI,肿瘤干细胞生物学学科组负责人,中科院昆明灵长类研究中心主任。2013年入选云南省高端科技人才引进计划,从事肿瘤干细胞、动物模型等相关研究,已在NatureCellBiology、DevelopmentalCell、JCI、CancerResearc、Oncogene等刊物发表论文30余篇。 2011.03至今中科院昆明动物研究所,肿瘤干细胞生物学学科组,研究员 2005.11—2011.03美国哥伦比亚大学癌症遗传学研究所,博士后,AssociateResearchScientist 2003.07—2005.10上海南方模式生物中心,助理研究员、副研究员 2000.09—2003.07上海第二医科大学(现上海交通大学医学院),获博士学位 1997.09—2000.08重庆医科大学第一附属医院消化疾病实验室,研究实习员、助理研究员 1994.09—1997.08中国科学院昆明动物研究所,获硕士学位 1990.09—1994.07西南师范大学(现西南大学)生物系,获学士学位 承担科研项目 1.国家基金委-云南省联合基金“胰腺癌灵长类模型建立及其在循环肿瘤细胞研究中的应用”(204万) 2.国家自然科学基金面上项目“基于胶质母细胞瘤干细胞的高通量抗肿瘤药物筛选技术的建立和应用”(80万元) 3.国家自然科学基金面上项目“HUWE1在卵巢癌发生发展中的作用”(60万元) 4.中科院“干细胞与再生医学研究”先导科技专项子课题(600万元) 5.云南省高端科技人才引进计划“癌症干细胞特异性分子标记发掘和药物筛选”(200万元) 6.中国科学院战略生物资源科技服务网络计划模式与特色动物实验平台野生动物实验动物化项目“树鼩实验动物化研究”(90万元) 获奖及荣誉 (一)获奖 2005年云南省科学技术奖二等奖(自然科学类);获奖名称:两性生殖道内抗原特异性抗体和抗体分泌细胞的功能、来源和性激素的调控。获奖人员:贲昆龙、曹筱梅、王玉奇、王晓蕾、陈云亮、俞明灿、王云美、赵旭东。 (二)专利 1.赵旭东、杨东、代智、王路.一种抗肿瘤药物筛选细胞模型及其应用(专利号:201410381401.6) 2.赵旭东、涂秋.一种建立胰腺癌模型的方法.(申请号:201510531787.9) 3.严兰珍、赵旭东、涂秋、孙彬.一种曲细精管支持细胞转基因非人灵长类动物模型及其用途(申请号:201611187895.X) 4.赵旭东、涂秋.一种用慢病毒在野生型成体小鼠中建立胰腺癌模型的方法.(申请号:201710718479.6)

研究领域

实验室主要在肿瘤干细胞和动物模型平台上研究癌症发病机理和药物研发,以及抗衰老药物及生物技术研发等。主要研究方向: 1.抗肿瘤干细胞药物发现; 2.抗衰老药物发现及生物技术; 3.创新动物模型的建立,特别是灵长类肿瘤模型建立及其应用; 4.肿瘤免疫和免疫治疗。

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1.ZhouX,LiG,AnS,…,IavaroneA#,ZhaoX#.Anewmethodofidentifyingglioblastomasubtypesandcreationofcorrespondinganimalmodels.Oncogene.(Accepted) 2.YangD*,ChengD*,TuQ*,…,YuX#,JiangH#,ZhaoX#.TheHUWE1-p53axisControlstheDevelopmentofNon-SmallCellLungCancer.Theranostics.(Accepted) 3.LiC,YanL,BanW,TuQ,WuY,WangL,BiR,JiS,MaY,NieW,LvL,YaoY#,ZhaoX#,ZhengP#.Long-termpropagationoftreeshrewspermatogonialstemcellsincultureandsuccessfulgenerationoftransgenicoffspring.CellRes.2017;27(2):241-252. 4.YangD,SunB,ZhangX,ChengD,YuX,YanL,liL,AnS,JiangH,LasorellaA,IavaroneA,ZhangS,ZouF#,ZhaoX#.Huwe1sustainsnormalovarianepithelialcelltransformationandtumorgrowththroughthehistoneH1.3-H19cascade.CancerRes2017;77(18):4773-4784. 5.TuQ*,HaoJ*,ZhouX*,YanL,DaiH,SunB,YangD,AnS,LvL,JiaoB,ChenC,LaiR,ShiP#,ZhaoX#.CDNK2Bdeletionisessentialforpancreaticcancerdevelopmentinsteadofunmeaningfulco-deletinduetojuxtpositiontoCDKN2A.Oncogene2018;37(1):128-138. 6.TongY*,HaoJ*,TuQ*,YuH,YanL,LiY,LvL,WangF,IavaroneA,ZhaoX.Atreeshrewglioblastomamodelrecapitulatesfeaturesofhumanglioblastoma.Oncotarget.2017;8:17897-19072. 7.LiY,ZhaoY,ZhouX,NiW,DaiZ,YangD,HaoJ,LuoL,LiuY,LuoX#,ZhaoX#.Cytotoxicindolealkaloid3a-acetonyltabersonineglioblastomaapoptosisviainhibitionofDNAdamagerepair.Toxins.2017;9(5):150-167. 8.LiuT*,GuoY*,YanL,SunB,ZhengP,ZhaoX.Depletionofendogenousgermcellsintreeshrewsinpreparationforspermatogonialtransplantation.ExpTherMed.2017;14(3):2349-2354 9.DaiZ,LiS,ZhuP,LiuL,WangB,LiuY,LuoX#,ZhaoX#.Isocostunolideinhibitedgliomastemcellbysuppressionproliferationandinducingcaspasedependentapoptosis.BioorgMedChemLet.2017;27(13):2863-2867 10.WeiX,DaiZ,YangJ,KhancA,YuHF,ZhaoYL,WangYF,LiuYP,YangZF,HuangWY,WangXH#,ZhaoX#,LuoXD#.Unprecedentedsugarbridgedbisindolesselectiveinhibitinggliomastemcells.BioorgMedChem2018;26(8):1776-83 11.YanL,SunB,LvL,MaY,ChenJ,LinQ,ZhengP,ZhaoX.Earlyembryonicdevelopmentandtransplantationintreeshrews.DongwuxueYanjiu.2016;37(4):252-258. 12.NiolaF*,ZhaoX*,SinghD,SullivanR,CastanoA,VerricoA,ZoppoliP,Friedmann-MorvinskiD,SulmanE,BarrettL,ZhuangY,VermaI,BenezraR,AldapeK,IavaroneA,LasorellaA.Mesenchymalhigh-gradegliomaismaintainedbytheID-RAP1axis.JClinInvest,2013;123(1):405–417. 13.NiolaF*,ZhaoX*,SinghD,CastanoA,SullivanR,LauriaM,NamHS,ZhuangY,BenezraR,DiBernardoD,IavaroneA,LasorellaA.Idproteinssynchronizestemnessandanchoragetothenicheofneuralstemcells.NatCellBiol,2012;14(5):477-487.(*equalcontribution) 14.ZhaoX*,D’ArcaD*,LimWK,BrahmacharyM,CarroMS,LudwigT,CardoCC,GuillemotF,AldapeK,CalifanoA,IavaroneA,andLasorellaA.theN-Myc-DLL3cascadeissuppressedbytheubiquitinligaseHuwe1toinhibitproliferationandpromoteneurogenesisinthedevelopingbrain.DevCell,2009;17(2):210-221.(Coverarticle) 15.ZhaoX,HengJI,GuardavaccaroD,JiangR,PaganoM,GuillemotF,IavaroneA,LasorellaA.TheHECT-domainubiquitinligaseHuwe1controlsneuraldifferentiationandproliferationbydestabilizingtheN-Myconcoprotein.NatCellBiol,2008;10(6):643-653. 16.LiuX*,ZhaoX*,WangX*,YaoY,ZhangL,ShuR,RenW,HuangY,HuangL,GuM,KuangY,WangL,LuS,ChiJ,FenJ,WangY,FeiJ,DaiW,WangZ.GerminalcellaplasiainKif18amutantmalemiceduetoimpairedchromosomecongressionanddysregulatedBubR1andCENP-E.GenesCancer,2010;1(1):26–39.(Coverarticle) 17.ZhaoX,RenW,YangW,WangY,KongH,WangL,YanL,XuG,FeiJ,FuJ,ZhangC,WangZ.WntpathwayisinvolvedintumorigenesisofpleomorphicadenomasinducedbyoverexpressionofPLAG1intransgenicmice.IntJCancer,2006;118(3):643-648. 18.ZhaoX,DangS,LiangB,LeiX,ChenZ,WangL,YanL,SunH,FuJ,FeiJ,WangZ.PCR-basedapproachesforidentificationofmulti-copytransgeneintegrationsitesinmousegenome.ChinSciBull,2006;51(18):2231-2235. 19.WangX*,ZhaoX*,BenK,CaoX,WangY,ZhouH.CirculatingimmunoglobulinA-andimmunoglobulinG-secretinghybridomacellsinperipheralbloodpreferablymigratetofemalegenitaltracts.Theroleofsexhormones.Immunology.2002Jul;106(3):343-53. 20.ZhaoX,YangWJ,WangL,KongH,RenWH,ZhangM,FeiJ,ZhangCP,WangZG.Developmentofsalivaryglandtumorsinpleomorphicadenomagene1transgenicmice.ZhonghuaYiXueYiChuanXueZaZhi.2003;20(5):390-5.Chinese. 21.XuJ,YuM,PengC,CarterP,TianJ,NingX,ZhouQ,TuQ,ZhangG,DaoA,JiangX,KapurP,HsiehJT,ZhaoX,LiuP,ZhengJ.DoseDependenciesandBiocompatibilityofRenalClearableGoldNanoparticles:FromMicetoNon-humanPrimates.AngewChemIntEdEngl.2018;57(1):266-271. 22.ZhuP,DaiZ,WangB,WeiX,YuH,YanZ,ZhaoX,LiuY,LuoX.TheAnticancerActivitiesPhenolicAmidesfromtheStemofLyciumbarbarum.NatProdBioprospect.2017;7(4):323-327. 23.ZhuPF,DaiZ,WangB,WeiX,YuHF,YanZR,ZhaoXD,LiuYP,LuoXD.TheAnticancerActivitiesPhenolicAmidesfromtheStemofLyciumbarbarum.NatProdBioprospect.2017;7(6):421-431. 24.FanY,HuangZ,CaoC,ChenC,ChenY,FanD,HeJ,HouH,HuL,HuX,JiangX,LaiR,LangY,LiangB,LiaoS,MuD,MaY,NiuY,SunX,XiaJ,XiaoJ,XiongZ,XuL,YangL,ZhangY,ZhaoW,ZhaoX,ZhengY,ZhouJ,ZhuY,ZhangG,WangJ,YaoY.GenomeoftheChinesetreeshrew.NatCommun,2013;4:1426-1434. 25.Jones-MasonME,ZhaoX,KappesD,LasorellaA,IavaroneA,ZhuangYE.proteintranscriptionfactorsarerequiredforthedevelopmentofCD4(+)lineageTcells.Immunity,2012;36(3):348-361. 26.D’ArcaD,ZhaoX,XuW,Ramirez-MartinezNC,IavaroneA,LasorellaA.TheHuwe1ubiquitinligaseisessentialtosynchronizeneuronalandglialdifferentiationinthedevelopingcerebellum.ProcNatlAcadSciUSA,2010;107:5875-5880. 27.CarroMS,LimWK,AlvarezMJ,BolloRJ,ZhaoX,SnyderEY,SulmanEP,AnneSL,DoetschF,ColmanH,LasorellaA,AldapeK,CalifanoA,IavaroneA.Thetranscriptionalnetworkformesenchymaltransformationofbraintumours.Nature,2010;463(7279):318-325. 28.GanY,ZhaoX,HuJ,WangZGandZhaoXT.HCCS1overexpressioninducesapoptosisviacathepsinDandintracellularcalcium,andHCCS1disruptioninmicecausesplacentalabnormality.CellDeathandDiff,2008;15(9):1481–1490. 29.RothschildG,ZhaoX,IavaroneA,LasorellaA.EProteinsandId2convergeonp57Kip2toregulatecellcycleinneuralcells.MolCellBiol,2006;26(11):4351-4361.

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