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招生专业 071007-遗传学 071009-细胞生物学 招生方向 神经和免疫系统疾病 线粒体疾病 树鼩生物学 教育背景 1997-09--2003-02 中国科学院昆明动物研究所 博士 1993-09--1997-07 安徽师范大学 理学学士 学历 1993.09 - 1997.07 安徽师范大学生物系,获学士学位 1997.09 - 2003.02 中国科学院昆明动物研究所/中国科学院研究生院,获博士学位 出国学习工作 2001.05 - 2001.08 德国汉堡大学从事合作研究 2003.02 - 2004.09 约翰斯.霍普金斯大学医学院 (Johns Hopkins University School of Medicine) 从事博士后研究工作 2004.10 - 2008.01 美国国家卫生研究院心脏、肺和血液研究所(National Heart, Lung and Blood Institute, National Institutes of Health), Visiting Fellow 工作简历 2007-12~现在, 中国科学院昆明动物研究所, 学科组负责人 2004-10~2008-01,NHLBI, NIH, Visiting Fellow 2003-02~2004-09,Johns Hopkins University School of Medicine, 博士后 专利与奖励 2014年 云南省科学技术奖励二等奖(自然科学奖); 项目名称:Leber遗传性视神经病遗传易感分析 2012年 中国科学院朱李月华优秀教师奖 2010年 云南省有突出贡献优秀专业技术人才奖 二等奖 2009年 入选新世纪百千万人才工程国家级人选 2006年 国家自然科学奖二等奖; 项目名称: 线粒体基因组多样性与东亚人群历史的研究; 第二获奖人 2005年 全国百篇优秀博士论文 2002年 中国科学院院长奖特别奖

研究领域

人类神经精神疾病的遗传解析 树鼩基础生物学

近期论文

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(1) SZDB2.0: an updated comprehensive resource for schizophrenia research., Human Genetics, doi: 10.1007/s00439-020-02171-1., 2020, 通讯作者 (2) The anatomy of the skin of the Chinese tree shrew is very similar to that of human skin., Zoological Research, 41: 208 - 212, 2020, 通讯作者 (3) Is there an antagonistic pleiotropic effect of a LRRK2 mutation on leprosy and Parkinson's disease?, Proceedings of the National Academy of Sciences of the United States of America, 117: 10122 - 10123, 2020, 通讯作者 (4) Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation., Redox Biology, 34: 101560, 2020, 通讯作者 (5) An alternative splicing of Tupaia STING modulated anti-RNA virus responses by targeting MDA5-LGP2 and IRF3., The Journal of Immunology, doi: 10.4049/jimmunol.1901320, 2020, 通讯作者 (6) The lipoxygenase pathway of Tupaia belangeri representing Scandentia. Genomic multiplicity and functional characterization of the ALOX15 orthologs in the tree shrew., Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865: 158550, 2020, 第 7 作者 (7) Activation of PPARA-mediated autophagy reduces Alzheimer’s disease-like pathology and cognitive decline in a murine model., Autophagy, 16: 52 - 69, 2020, 通讯作者 (8) Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I, Journal of Genetics and Genomics, 46: 499 - 503, 2019, 通讯作者 (9) KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells., PLOS Biology, 17: e3000468., 2019, 第 7 作者 (10) Chromosomal level assembly and population sequencing of the Chinese tree shrew genome., Zoological Research, 40: 506 - 521, 2019, 通讯作者 (11) Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese., National Science Review, 6: 257-274, 2019, 通讯作者 (12) The 3′UTR of human MAVS mRNA contains multiple regulatory elements for the control of protein expression and subcellular localization., Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1862: 47 - 57, 2019, 通讯作者 (13) Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder., Neuropsychopharmacology, 44: 1552 - 1561, 2019, 其他(合作组作者) (14) Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci., EBioMedicine, 44: 530 - 541, 2019, 通讯作者 (15) Molecular identification and antiviral function of the guanylate-binding protein (GBP) genes in the Chinese tree shrew (Tupaia belangeri chinesis)., Developmental and Comparative Immunology, 96: 27-36, 2019, 通讯作者 (16) Genetic analyses of Alzheimer's disease in China: achievements and perspectives., ACS Chemical Neuroscience, 10: 890-901, 2019, 通讯作者 (17) Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis)., Applied Microbiology and Biotechnology, 103: 2171-2180, 2019, 通讯作者 (18) Molecular characterization of the 2',5'-oligoadenylate synthetase family in the Chinese tree shrew (Tupaia belangeri chinensis)., Cytokine, 114: 106-114, 2019, 通讯作者 (19) Mutation and association analyses of dementia-causal genes in Han Chinese patients with early-onset and familial Alzheimer's disease., Journal of Psychiatric Research, 113: 141-147, 2019, 通讯作者 (20) The GWAS risk genes for depression may be actively involved in Alzheimer’s Disease., Journal of Alzheimer’s Disease, 64: 1149 - 1161, 2018, 通讯作者 (21) Genetic association of the cytochrome c oxidase-related genes with Alzheimer's disease in Han Chinese., Neuropsychopharmacology, 43: 2264 - 2276., 2018, 通讯作者 (22) Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese., American Journal of Human Genetics, 102: 794 - 805, 2018, 通讯作者 (23) Does the genetic feature of the Chinese tree shrew (Tupaia belangeri chinensis) support its potential as a viable model for Alzheimer’s disease research?, Journal of Alzheimer’s Disease, 61: 1015 - 1028, 2018, 通讯作者 (24) A pleiotropic effect of the APOE gene: association of APOE polymorphisms with multibacillary leprosy in Han Chinese from Southwest China., British Journal of Dermatology, 178: 931 - 939., 2018, 通讯作者 (25) A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease., Alzheimer's & Dementia, 14: 215 - 229., 2018, 通讯作者 (26) The Arc gene confers genetic susceptibility to Alzheimer’s disease in Han Chinese., Molecular Neurobiology, 55: 1217 - 1226., 2018, 通讯作者 (27) SZDB: A database for schizophrenia genetic research., Schizophrenia Bulletin,43: 459 - 471., 2017, 通讯作者 (28) The OPA1 gene mutations are frequent in Han Chinese patients with suspected optic neuropathy., Molecular Neurobiology, 54: 1622 - 1630., 2017, 通讯作者 (29) Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia., Journal of Genetics and Genomics, 44: 295-306., 2017, 通讯作者 (30) Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine, Autophagy, 13: 1496 - 1511, 2017, 通讯作者 (31) The mtDNA replication-related genes TFAM and POLG are associated with leprosy in Han Chinese from Southwest China, Journal of Dermatological Science, 88: 349 - 356., 2017, 通讯作者 (32) Leber hereditary optic neuropathy: a mitochondrial disease unique in many ways., Handbook of Experimental Pharmacology, 309 - 336., 2017, 通讯作者 (33) mtDNA heteroplasmy in monozygotic twins discordant for schizophrenia., Molecular Neurobiology, 54: 4343 - 4352., 2017, 通讯作者 (34) Female-specific effect of the BDNF gene on Alzheimer's disease., Neurobiology of Aging, 53: 192.e11 - 192.e19., 2017, 通讯作者 (35) Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)?, Zoological Research, 38: 118 - 126., 2017, 通讯作者 (36) Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring., Cell Research, 27: 241 - 252., 2017, 通讯作者 (37) Rare genetic variants of the transthyretin gene are associated with Alzheimer’s disease in Han Chinese., Molecular Neurobiology, 54: 5192 - 5200, 2017, 通讯作者 (38) Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew., Proceedings of the National Academy of Sciences of the United States of America, 113: 10950 - 10955, 2016, 通讯作者 (39) PLD3 in Alzheimer's disease: a modest effect as revealed by updated association and expression analyses., Molecular Neurobiology, 53: 4034–4045, 2016, 通讯作者 (40) Mitochondrial DNA haplogroup A decreases the risk of drug addiction but conversely increases the risk of HIV-1 infection in Chinese addicts., Molecular Neurobiology, 53: 3873-3881, 2016, 通讯作者 (41) CFH variants affect structural and functional brain changes and genetic risk of Alzheimer's disease., Neuropsychopharmacology, 41: 1034-1045, 2016, 通讯作者 (42) Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile., Journal of Dermatological Science, 82: 18-27, 2016, 通讯作者 (43) Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia., Schizophrenia Research, 171: 200-206, 2016, 通讯作者 (44) Complement factor H and susceptibility to major depressive disorder in Han Chinese., British Journal of Psychiatry, 208(5): 446-452, 2016, 通讯作者 (45) Identification and characterization of toll-like receptors (TLRs) in the Chinese tree shrew (Tupaia belangeri chinensis)., Developmental and Comparative Immunology, 60: 127-138, 2016, 通讯作者 (46) Validating GWAS-identified risk loci for Alzheimer’s disease in Han Chinese populations., Molecular Neurobiology,53(1): 379-390, 2016, 通讯作者 (47) Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China., Scientific Reports, 6: 37086, 2016, 通讯作者 (48) Was ADH1B under selection in European populations?, The American Journal of Human Genetics, 99: 1217 - 1219, 2016, 第 3 作者 (49) Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China., Infection, Genetics and Evolution, 45: 105 - 110, 2016, 通讯作者 (50) Fine mapping of the GWAS loci identifies SLC35D1 and IL23R as potential risk genes for leprosy., Journal of Dermatological Science, 84: 322-329, 2016, 通讯作者 (51) Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication., Cell Research, 26: 556-573, 2016, 第 10 作者 (52) Neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese., Molecular Neurobiology, 53: 4883-4892, 2016, 通讯作者 (53) Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China., Genes & Immunity 16(2): 112-119, 2015, 通讯作者 (54) Do nuclear-encoded core subunits of mitochondrial complex I confer genetic susceptibility to schizophrenia in Han Chinese populations?, Scientific Reports, 5: 11076, 2015, 通讯作者 (55) Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation, Autophagy, 11: 1745-1759, 2015, 通讯作者 (56) Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China, Journal of Dermatological Science, 80: 133-141, 2015, 通讯作者 (57) Characterization of a MAVS ortholog from the Chinese tree shrew (Tupaia belangeri chinensis)., Developmental and Comparative Immunology, 52(1): 58-68, 2015, 通讯作者 (58) Common variants of IRF3 conferring risk of schizophrenia, Journal of Psychiatric Research, 64: 64-73, 2015, 通讯作者 (59) Mitochondrial DNA haplogroup B5 confers genetic susceptibility to Alzheimers disease in Han Chinese., Neurobiology of Aging, 36: 1604.e7-1604.e16, 2015, 通讯作者 (60) Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina., Gene, 571: 279-285, 2015, 通讯作者 (61) Mitochondrial DNA mutations in single human blood cells., Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 779: 68 - 77, 2015, 第 1 作者 (62) Common variants in the MKL1 gene confer risk of schizophrenia., Schizophrenia Bulletin, 41: 715-727, 2015, 第 7 作者 (63) Caveats about interpretation of ancient chicken mtDNAs from northern China., Proceedings of the National Academy of Sciences of the United States of America, 112: E1970- E1971, 2015, 第 3 作者 (64) Identification of PSEN1 mutations p.M233L and p.R352C in Han Chinese families with early-onset familial Alzheimer's disease., Neurobiology of Aging, 36: 1602.e3-1602.e6, 2015, 通讯作者 (65) Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese., Molecular Genetics and Genomics, 290: 585-592, 2015, 通讯作者 (66) Tree shrew database (TreeshrewDB): a knowledge base for Chinese tree shrew genome biology, Scientific Reports, 4: 7145, 2014, 通讯作者 (67) No association between genetic variants of the LRRK2 gene and schizophrenia in Han Chinese., Neuroscience Letters, 566: 210-215, 2014, 通讯作者 (68) No association of the LRRK2 genetic variants with Alzheimers disease in Han Chinese individuals., Neurobiology of Aging, 35: 444.e5-444.e9, 2014, 通讯作者 (69) Diverse interleukin-7 mRNA transcripts in Chinese tree shrew (Tupaia belangeri chinensis)., PLoS One, 9(6): e99859, 2014, 通讯作者 (70) Promoter variant rs2301228 on the neural cell adhesion molecule 1 gene conferring risk of schizophrenia in Han Chinese., Schizophrenia Research, 160: 88-96, 2014, 通讯作者 (71) Molecular evolution in the CREB1 signal pathway and a rare haplotype in CREB1 with genetic predisposition to schizophrenia., Journal of Psychiatric Research, 57: 84-89, 2014, 通讯作者 (72) A matrilineal genetic legacy from the last glacial maximum confers susceptibility to schizophrenia in Han Chinese., Journal of Genetics and Genomics, 41: 397-407, 2014, 通讯作者 (73) Mapping genetic variants in the CFH gene for association with leprosy in Han Chinese., Genes and Immunity, 15: 506-510, 2014, 通讯作者 (74) Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer., Gene, 546: 263-270, 2014, 通讯作者 (75) Genetic variations of mitochondrial antiviral signaling gene (MAVS) in domestic chickens., Gene, 545: 226-232, 2014, 通讯作者 (76) The positively selected genes of the locomotion system in Chinese tree shrew (Tupaia belangeri chinensis)., Zoological Research, 35: 240-248, 2014, 通讯作者 (77) Evaluating risk loci for schizophrenia distilled from genome-wide association studies in Han Chinese from central China., Molecular Psychiatry 18(6):638-9., 2013, 通讯作者 (78) No association between genetic polymorphisms of the NDUFS7 gene and schizophrenia in Han Chinese., Psychiatric Genetics, 23(1): 29-32, 2013, 通讯作者 (79) Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background., Stem Cell Research, 10: 361-370, 2013, 通讯作者 (80) Genome of the Chinese tree shrew., Nature Communications, 4: 1426, 2013, 通讯作者 (81) Genetic variants of complement genes Ficolin-2, Mannose-binding lectin and Complement factor H are associated with leprosy in Han Chinese from Southwest China., Human Genetics, 132: 629-640, 2013, 通讯作者 (82) Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-druplex ligands., FEBS Lett. 587(11):1656-62, 2013, 通讯作者 (83) An update to MitoTool: Using a new scoring system for faster mtDNA haplogroup determination., Mitochondrion, 13: 360-363, 2013, 通讯作者 (84) Apparent mtDNA sequence heterogeneity in single human blood CD34+ cells is markedly affected by storage and transport., Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 751-752: 36-41, 2013, 通讯作者 (85) Mutation p.G83R in the transthyretin gene is associated with hereditary vitreous amyloidosis in Han Chinese families., Molecular Vision, 19: 1631-1638, 2013, 通讯作者 (86) Genetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from Southwest China., PLoS One, 8(7): e67577, 2013, 通讯作者 (87) Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin., Autophagy, 9: 1395-1406, 2013, 通讯作者 (88) Evaluating the phylogenetic position of Chinese tree shrew (Tupaia belangeri chinensis) based on complete mitochondrial genome: implication for using tree shrew as an alternative experimental animal to primates in biomedical research., Journal of Genetics and Genomics, 39: 131-137, 2012, 通讯作者 (89) Mitochondrial DNA mutation m.10680G/A is associated with Leber hereditary optic neuropathy in Chinese patients., Journal of Translational Medicine, 10: 43, 2012, 通讯作者 (90) Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China., Human Genetics, 131: 1251-1260, 2012, 通讯作者 (91) Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China., PLoS ONE, 7(6): e38848, 2012, 通讯作者 (92) Presence of mutation m.14484T/C in a Chinese family with maternally inherited essential hypertension but no expression of LHON., Biochimica et Biophysica Acta-Molecular Basis of Disease, 1822: 1535-1543, 2012, 通讯作者 (93) Complete mitochondrial DNA genome sequence variation of Chinese families with mutation m.3635G/A and Leber hereditary optic neuropathy., Molecular Vision, 18: 3087-3094, 2012, 通讯作者 (94) Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny., Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 709-710:15-20, 2011, 通讯作者 (95) Mitochondrial DNA haplogroup background affects LHON, but not suspected LHON, in Chinese patients., PLoS ONE, 6(11): e27750, 2011, 通讯作者 (96) MitoTool: A web server for the analysis and retrieval of human mitochondrial DNA sequence variations. , Mitochondrion, 11: 351-356, 2011, 通讯作者 (97) Is mitochondrial tRNA-phe variant m.593T/C a synergistically pathogenic mutation in Chinese LHON families with m.11778G/A, PLoS ONE, 6: e26511, 2011, 通讯作者 (98) Identification of mutation c.632G/A (p.G211D) in the ATP2A2 gene and genotype-phenotype correlation in a large Chinese family with Darier disease., International Journal of Dermatology, 50: 1366-1370, 2011, 通讯作者 (99) Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkins lymphoma in Chinese patients., Annals of Hematology, 90: 1137-1144, 2011, 通讯作者 (100) Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese. , Behavioral and Brain Functions 6: 75 (doi:10.1186/1744-9081-6-75), 2010, 通讯作者 (101) Mitochondrial DNA sequence variation and haplogroup distribution in Chinese patients with LHON and m.14484T>C., PLoS ONE, 5(10): e13426, 2010, 通讯作者 (102) The acquisition of an inheritable 50-bp deletion in the human mtDNA control region does not affect the mtDNA copy number in peripheral blood cells., Human Mutation, 31: 538-543, 2010, 通讯作者 (103) No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G-A., Human Genetics, 128: 465-468, 2010, 通讯作者 (104) mtDNA data-mining in GenBank needs surveying., American Journal of Human Genetics, 85: 929-933, 2009, 第 1 作者 (105) The exaggerated status of "novel" and "pathogenic" mtDNA sequence variants due to inadequate database searches., Human Mutation, 30: 191-196, 2009, 通讯作者 (106) Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of Leber Hereditary Optic Neuropathy in Chinese families with the m.11778G→A mutation., American Journal of Human Genetics, 83: 760-768, 2008, 通讯作者 (107) Pseudo-mitochondrial genome haunts disease studies., Journal of Medical Genetics, 45: 769-772, 2008, 通讯作者 (108) A homogenous nature of Chinese native duck matrilineal pool., BMC Evolutionary Biology, 8: 298, 2008, 通讯作者 (109) Population phylogenomic analysis of mitochondrial DNA in wild boars and domestic pigs revealed multiple domestication events in East Asia., Genome Biology, 8:R245, 2007, 第 2 作者 (110) Mitochondrial DNA sequence heterogeneity of single CD34+ cells after nonmyeloablative allogeneic stem cell transplantation., Stem Cells, 25:2670-2676, 2007, 第 1 作者 (111) Mitochondrial DNA sequence variation in single cells from leukemia patients., Blood, 109: 756-762, 2007, 通讯作者 (112) Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background., Human Molecular Genetics, 16: 286-294, 2007, 第 1 作者 (113) Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations., Human Molecular Genetics, 15: 2076-2086, 2006, 第 4 作者 (114) A reappraisal of complete mtDNA variation in East Asian families with hearing impairment., Human Genetics, 119: 505-515, 2006, 通讯作者 (115) Upregulation of placental growth factor by vascular endothelial growth factor via a post-transcriptional mechanism., FEBS Letters, 579: 1227-1234, 2005, 第 1 作者 (116) Different matrilineal contributions to genetic structure of ethnic populations in Silk-Road region in China., Molecular Biology and Evolution, 21: 2265-2280, 2004, 第 1 作者 (117) To trust or not to trust an idiosyncratic mitochondrial data set., American Journal of Human Genetics, 72: 1341-1346, 2003, 通讯作者 (118) Reconstructing the evolutionary history of China: a caveat about inferences drawn from ancient DNA., Molecular Biology and Evolution, 20: 214-219, 2003, 第 1 作者 (119) Phylogeny of East Asian mitochondrial DNA lineages inferred from complete sequences., American Journal of Human Genetics, 73: 671-676, 2003, 第 2 作者 (120) Phylogeographic differentiation of mitochondrial DNA in Han Chinese., American Journal of Human Genetics, 70: 635-651, 2002, 第 1 作者

学术兼职

2018-09-30-今,Editorial board member of Cellular and Molecular Neurobiology, 2018-01-01-2018-12-30,Associate editor of Journal of Alzheimer’s Disease, 2016-07-31-今,Editorial board member of Scientific Reports, 2015-07-30-2017-08-31,Associate editor of Science Bulletin, 2012-10-01-今,Editor-in-chief of Zoological Research, 2012-08-01-今,Receiving editor of Infection, Genetics and Evolution, 2012-01-01-今,Academic Editor of PLoS ONE, 2010-12-31-今,Associate editor of Journal of Human Genetics, 2010-09-30-今,Editorial board member of Journal of Genetics and Genomics,

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