赵劲 - 北京大学 - 化学生物学与生物技术学院

个人简介

Education 2005 Ph.D. in Chemistry. Yale University, New Haven, CT 1998 B.S. in Chemistry. Nanjing University, China Research Experience 2012-present Director Shenzhen Engineering Laboratory of Functional Microscale Materials, Shenzhen, China 2010-present Professor, Associate Dean School of Chemical Biology and Biotechnology, Peking University, Shenzhen, China 2008-present Professor School of Life Sciences, Nanjing University, Nanjing, China 2007-2008 Senior Scientist Rohm and Haas Company, Spring House, PA 2007-2008 Visiting Assistant Professor with Professor Yen Wei Department of Chemistry, Drexel University, Philadelphia, PA 2006-2007 Research Scientist with Professor Chuan He Department of Chemistry, The University of Chicago, Chicago, IL 2005-2006 Postdoctoral Researcher with Professor F. Dean Toste Department of Chemistry, The University of California, Berkeley, CA 1999-2004 Graduate Research with Professor John F. Hartwig Department of Chemistry, Yale University, New Haven, CT 1997-1998 Undergraduate Research with Professor Wen-Xia Tang Department of Chemistry, Nanjing University, Nanjing, China

研究领域

(1) Bioinorganic chemistry in environmental science. (a) Surface display of metalloproteins for metal ion adsorption and environmental remediation; (b) Cell-based sensors and fluorescent probes for metals, gasotransmitters, and small RNA. (2) Biomimetic catalysis in energy science. (a) Design and synthesis of new catalysts for inert bond activation and biomass conversion to value-added chemicals; (b) Microsphere catalytic materials in hydrogen energy conversion and storage; (3) Metal therapeutics inspired by Traditional Chinese Medicine (TCM). (a) Development of detoxification agents by designing metal-binding small molecules and proteins with high affinity and specificity; (b) Design and synthesis of metal-based compounds as anticancer agents.

近期论文

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Xiong, F.; Lu, L.; Sun, T.-Y.; Wu, Q.; Yan, D.; Chen, Y.; Zhang, X.; Wei, W.; Lu, Y.; Sun, W.-Y.; Li, J. J.; Zhao, J.*, A bioinspired and biocompatible ortho-sulfiliminyl phenol synthesis. Nat. Commun. 2017, 8, 15912. Wu, Q.; Yan, D.; Chen, Y.; Wang, T.; Xiong, F.; Wei, W.; Lu, Y.; Sun, W. Y.; Li, J. J.; Zhao, J.*, A redox-neutral catechol synthesis. Nat. Commun. 2017, 8, 14227. Wu, Q.; Chen, Y.; Yan, D.; Zhang, M.; Lu, Y.; Sun, W.-Y.; Zhao, J.*, "Unified synthesis of mono/bis-arylated phenols via RhIII-catalyzed dehydrogenative coupling". Chem. Sci. 2017，8，169-173. Zhang, L.; Zheng, X. E.; Zou, F.; Shang, Y.; Meng, W.; Lai, E.; Xu, Z.; Liu, Y.; Zhao, J.*, "A highly selective and sensitive near-infrared fluorescent probe for imaging of hydrogen sulphide in living cells and mice". Sci. Rep. 2016, 6, 18868. 严义勇，吴谦，陈柱文，杨超，张健，余孟颖，洪梅，赵劲*， “潜在医用气体分子的光学小分子探针” , 中国科学：化学. 2015. 45 (11) : 1145-1158. Wei, W.; Sun, Y.; Liu, X.; Sun, P.; Wang, F.; Gui, Q.; Meng, W.; Cao, Y.*; Zhao, J.*, "Structural insights and the surprisingly low mechanical stability of the Au-S bond in the gold-specific protein GolB". J. Am. Chem. Soc. 2015. accepted. 严义勇, 张玲, 吴谦, 余孟颖, 杨超, 陈柱文, 张健, 赵镜一, 唐红梅, 王双卫, 冯耿超, 魏炜, 洪梅, 赵劲*，“气体信号分子的荧光小分子探针”, 中国科学: 化学. 2015，45（8）: 812-828. Yu, B.; Chen, Y.; Hong, M.; Duan, P.;Gan, S.; Chao, H.* ; Zhao, Z.*; Zhao, J.*, "Rhodium-Catalyzed C-H Activation of Hydrazines Leads to Isoquinolones with Tunable Aggregation-Induced Emission Property". Chem. Commun. 2015. online. Yu, B.; Ouyang, C.; Qiu, K.; Zhao, J.; Ji, L.; Chao, H.*, "Lipophilic Tetranuclear Ruthenium(II) Complexes as Two-Photon Luminescent Tracking Non-Viral Gene Vectors". Chem. Eur. J.2015, 21 (9), 3691-3700. Yang, N.; Ding, S.; Chen, F.; Zhang, X.; Xia, Y.; Di, H.; Cao, Q.; Deng, X.; Wu, M.; Wong, C. C. L.; Tian, X.-X.; Yang, C.-G.; Zhao, J.; Lan, L.*, "The Crc protein participates in down-regulation of the Lon gene to promote rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa." Mol. Microbiol. 2015, online. Yan, L.; Yan, Y.; Pei, L.; Wei, W.*; Zhao, J.*, “A G-quadruplex DNA-based, Label-Free and Ultrasensitive Strategy for microRNA Detection.” Sci. Rep. 2014, 4, 7400，online. Rong, J.; Han, J.; Dong, L.; Tan, Y.; Yang, H.; Feng, L.; Wang, Q. W.; Meng, R.; Zhao, J.*; Wang, S. Q.*; Chen, X.*, “Glycan Imaging in Intact Rat Hearts and Glycoproteomic Analysis Reveal the Upregulation of Sialylation during Cardiac Hypertrophy.” J. Am. Chem. Soc .2014, 136 (50), 17468–17476. Yang, M.; Jalloh, A. S.; Wei, W.; Zhao, J.*; Wu, P.*; Chen, P. R.*, “Biocompatible click chemistry enabled compartment-specific pH measurement inside E. coli.” Nature Commun. 2014, 5, 4981-4990. Zhou, L.; Li, X.; Wang, Y.; Hong, M.*; Liang, Y.*; Zhao, J.*, "Monodisperse, Nanoporous Ceria Microspheres Embedded with Pt Nanoparticles: General Facile Synthesis and Catalytic Application." RSC Advances 2014, 4, 42965-42970. Cao, Q.; Wang, Y.; Chen, F.; Xia, Y.; Lou, J.; Zhang, X.; Yang, N.; Sun, X.; Zhang, Q.; Zhuo, C.; Huang, X.; Deng, X.; Yang, C. G.; Ye, Y.; Zhao, J.*; Wu, M.*; Lan, L.*, “A Novel Signal Transduction Pathway that Modulates rhl Quorum Sensing and Bacterial Virulence in Pseudomonas aeruginosa. PLoS pathogens.” 2014, 10 (8), e1004340. Duan, P.; Lan, X.; Chen, Y.; Qian, S.-S.; Li, J. J.; Lu, L.; Lu, Y.; Chen, B.*; Hong, M.*; Zhao, J.*, "Rhodium(iii)-catalyzed C–H activation/[4+3] annulation of N-phenoxyacetamides and α,β-unsaturated aldehydes: an efficient route to 1,2-oxazepines at room temperature."Chem. Commun. 2014, 12135--12138. Chen, Y.; Wang, D.; Duan, P.; Ben, R.; Dai, L.; Shao, X.; Hong, M.; Zhao, J.*; Huang, Y.*, "A multitasking functional group leads to structural diversity using designer C–H activation reaction cascades." Nature Commun. 2014, 4610-4618. Zhang, L.; Meng, W.-q.; Lu, L.; Xue, Y.-S.; Li, C.; Zou, F.; Liu, Y.*; Zhao, J.*, "Selective detection of endogenous H2S in living cells and the mouse hippocampus using a ratiometric fluorescent probe." Sci. Rep. 2014, 4, 5870-5878. Yang, H.; Cui, H.; Wang, L.; Yan, L.; Qian, Y.; Zheng, X. E.; Wei, W.*; Zhao, J.*, "A label-free G-quadruplex DNA-based fluorescence method for highly sensitive, direct detection of cisplatin." Sensor. Actuat. B-Chem. 2014, 202 (0), 714-720. Zhang, L.; Li, S.; Hong, M.; Xu, Y.; Wang, S.; Liu, Y.*; Qian, Y.*; Zhao, J.*, "A colorimetric and ratiometric fluorescent probe for the imaging of endogenous hydrogen sulphide in living cells and sulphide determination in mouse hippocampus.", Org. Biomol. Chem. 2014, 12, 5115-5125. Wei, W.; Liu, X.; Sun, P.; Wang, X.; Hong, Z.; Hong, M.; Mao, Z.-W.*; Zhao, J.*, "Simple Whole-Cell Bio-detection and Bioremediation of Heavy Metals Based on an Engineered Lead-Specific Operon.", Environ. Sci. Technol. 2014, 48 (6), 3363–3371. He, J.; Chen, J.; Ren, L.; Wang, Y.*; Teng, C.; Hong, M.; Zhao, J.*; Jiang, B.*, "Fabrication of Monodisperse Porous Zirconia Microspheres and Their Phosphorylation for Friedel-Crafts Alkylation of Indoles.", ACS Appl. Mater. Interfaces 2014, 6, 2718-2725. Duan, P.; Yang, Y.-F.; Zhang, X.; Ben, R.; Yan, Y.; Dai, L.; Hong, M.; Wang, D.*; Wu, Y.-D.*; Zhao, J.*, “Palladium-Catalyzed Benzo[d]isoxazole Synthesis by C-H Activation/[4+1] Annulation”, Chem. Sci. 2014, 5, 1574-1578.