李勤凯 - 北京大学 - 化学生物学与生物技术学院

研究领域

体内过度的脂肪蓄积是许多代谢相关疾病，如糖尿病、心脑血管相关疾病等的重要病因之一。我们的主要研究方向是探讨体内脂肪的积蓄方式对代谢相关疾病发生发展的影响及其机理，从而为开发相关的治疗性药物提供潜在的策略及分子靶点。

近期论文

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Xu Y, An X, Guo X, Habtetsion TG, Wang Y, Xu X, Kandala S, Li Q, Li H, Zhang C, Caldwell RB, Fulton DJ, Su Y, Hoda MN, Zhou G, Wu C, Huo Y*.Endothelial PFKFB3 plays a critical role in angiogenesis. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1231-9. doi: 10.1161/ATVBAHA.113.303041. Dai Y, Jia Y, Chen N, Bian W, Li Q, Ma Y, Chen Y, Pei D*. Zebrafish as a model system to study toxicology. Environ Toxicol Chem. 2014 Jan; 33(1):11-7. doi: 10.1002/etc.2406. Li Q*, Hosaka T, Harada N, Nakaya Y. Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes. Mol Cell Endocrinol. 2013 Jan 5; 365(1):25-35. doi: 10.1016/j.mce.2012.08.022. Li Q, Hosaka T, Shikama Y, Bando Y, Kosugi C, Kataoka N, Nakaya Y, Funaki M*. Heparin-Binding EGF-Like Growth Factor (HB-EGF) Mediates 5-HT-Induced Insulin Resistance Through Activation of EGF Receptor-ERK1/2-mTOR Pathway. Endocrinology. 2012 Jan; 153(1):56-68. Liu Y*, Wang Z, Yin W, Li Q, Cai M, Yu J, Li H, Zhang C, Zu X. Preventive effect of Ibrolipim on suppressing lipid accumulation and increasing lipoprotein lipase in the kidneys of diet-induced diabetic minipigs. Lipids Health Dis. 2011 Jul 16; 10:117. Li Q*, Hata A, Kosugi C, Kataoka N, Funaki M. The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes. FEBS Lett. 2010 Oct 8; 584(19):4145-50. Epub 2010 Sep 15. Li Q, Yin W*, Cai M, Liu Y, Hou H, Shen Q, Zhang C, Xiao J, Hu X, Wu Q, Funaki M, Nakaya Y. NO-1886 suppresses diet-induced insulin resistance and cholesterol accumulation through STAT5-dependent upregulation of IGF1 and CYP7A1. J Endocrinol. 2010 Jan; 204(1):47-56. Li Q, Hosaka T, Jambaldorj B, Nakaya Y, Funaki M*. Extracellular matrix with the rigidity of adipose tissue helps 3T3-L1 adipocytes maintain insulin responsiveness. J Med Invest. 2009 Aug; 56(3-4):142-9. Liu Y*, Wang Z, Yin W, Li Q, Cai M, Zhang C, Xiao J, Hou H, Li H, Zu X. Severe insulin resistance and moderate glomerulosclerosis in a minipig model induced by high-fat/ high-sucrose/ high-cholesterol diet. Exp Anim. 2007 Jan; 56(1):11-20. Hu X, She M, Hou H, Li Q, Shen Q, Luo Y, Yin W*. Adiponectin decreases plasma glucose and improves insulin sensitivity in diabetic Swine. Acta Biochim Biophys Sin (Shanghai). 2007 Feb;39(2):131-6. Zhang C, Yin W*, Liao D, Huang L, Tang C, Tsutsumi K, Wang Z, Liu Y, Li Q, Hou H, Cai M, Xiao J. NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs. J Lipid Res. 2006 Sep; 47(9):2055-63. Cai M, Yin W*, Li Q, Liao D, Tsutsumi K, Hou H, Liu Y, Zhang C, Li J, Wang Z, Xiao J. Effects of NO-1886 on inflammation-associated cytokines in high-fat/high-sucrose/high-cholesterol diet-fed miniature pigs. Eur J Pharmacol. 2006 Jul 1; 540(1-3):139-46.