个人简介
Education
SUNY Stony Brook Ph.D. 1998 Neurobiology
University of Pittsburgh M.Sc 1993 Physiology
Tsinghua University, Beijing, China B.Sc 1990 Biochemistry
Positions
1998-2000 Post-doctoral fellow UC San Francisco, CA
2001-2003 Post-doctoral fellow UC Berkeley, CA
2003-2004 Associate specialist UC Berkeley, CA
2004-2009 Assistant professor Mount Sinai School of Medicine, New York, NY
2009-2013 Scientist Genentech, Inc.,South San Francisco, CA
2014-present Professor Peking University Shenzhen Graduate school Shenzhen, China
研究领域
Current projects/collaboration
Our primary focus is to understand the biological basis of neurodegenerative diseases (such as Alzheimer’s disease) and psychiatric disorders (such as depression, schizophrenia and autism), and in doing so identify new drug targets. We are especially interested how synaptic connection/plasticity and neural network functions are altered in these diseases. We believe by focusing on these areas we can have a much deeper understanding of the basic function of the brain, the genesis of brain pathology and a breakthrough in how we treat brain diseases. We are also quite interested in how Chinese herbal medicine may contribute to treating brain diseases and by identifying effective components we will push forward the modernization of Chinese medicine. We are using a variety of experimental approaches, including electrophysiology, fluorescence imaging, molecular and biochemistry approaches.
Inspiration/vision
To us, human brain is the final frontier. Although knowing how a normal brain works is extremely satisfying, being able to treat a diseased brain is the ultimate prize. To crack a brain disease, we need to think and work like a brain, highly creative, interactive, supportive of each other, and all for the benefits of fellow human beings. I am excited about working with highly motivated and talented colleagues in the race for a cure.
近期论文
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Zhou Q, Godwin DW, O’Malley DM and Adams PR. Visualization of calcium influx through channels that shape the burst and tonic modes of thalamic relay cells. J. Neurophysiol. 77: 2816-2825, 1997.
Cox CL, Zhou Q and Sherman SM. Glutamate locally activates dendritic outputs of thalamic interneurons. Nature 394: 478-482, 1998.
Zhou Q, Xiao MY and Nicoll RA. Contribution of cytoskeleton to the internalization of AMPA receptors. Proc. Natl. Acad. USA. 98: 1261-1266, 2001.
Zhou Q, Tao HW and Poo M-m. Reversal and stabilization of synaptic modifications in a developing visual system. Science 300, 1953-1957, 2003.
Zhou Q, Homma, K and Poo, M-m. Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron 44:749-757, 2004.
Wang X, Yang Y and Zhou Q. Independent expression of synaptic and morphological plasticity associated with long-term depression. J. Neurosci. 27:12419-29, 2007.
Yang Y, Wang X, Frerking M and Zhou Q. Delivery of AMPA receptors to perisynaptic sites precedes the full expression of long-term potentiation. Proc. Natl. Acad. USA. 105: 11388-11393, 2008.
Yang Y, Wang XB, Zhou Q. Perisynaptic GluR2-lacking AMPA receptors control the reversibility of synaptic and spines modifications. Proc. Natl. Acad. USA. 107: 11999-2004, 2010.
Hanson J, Weber M, Meilandt W, Wu T, Luu T, Deng L, Shamloo M, Sheng M, Scearce-Levie K and Qiang Zhou. GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior. Neuropsychopharmacology. 38(7):1221-33, 2013.
Hanson J, Deng L, Hackos D, Lo JS, Lauffer B, Steiner P and Zhou Q. HDAC2 cell-autonomously suppresses excitatory and enhances inhibitory synaptic functions in hippocampal neurons. J. Neurosci. 33:5924-9, 2013.
Hanson J, Meilandt W, Gogineni A, Reynen P, Herrington J, Weimer R, Scearce-Levie K and Zhou Q. Chronic GluN2B Antagonism Disrupts Behavior in Wild-Type Mice Without Protecting Against Synapse Loss or Memory Impairment in Alzheimer's Disease Mouse Models. J. Neurosci. 34(24):8277-88, 2014.
Yan R and Zhou Q. Coding of "Home Cage" by PFC Neurons. Neuroscience. 393:33-41, 2018.
Yao L, Grand T, Hanson J, Paoletti P and Zhou Q. Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity. Nat Commun. 9(1):4000, 2018.
Yan R, Wang T and Zhou Q. Elevated dopamine signaling from ventral tegmental area to prefrontal cortical parvalbumin neurons drives conditioned inhibition. Pro. Natl. Acad. USA. 116(26): 13077-13086, 2019.
Yan R, Wang T, Ma X, Zhang X, Zheng R and Zhou Q. Prefrontal inhibition drives formation and dynamic expression of probabilistic Pavlovian fear conditioning. Cell Rep. 36(6):109503, 2021.
Yao L, Rong Y, Ma X, Li H, Deng D, Chen Y, Yang S, Peng T, Ye T, Liang F, Xu N and Zhou Q. Extrasynaptic NMDA Receptors Bidirectionally Modulate Intrinsic Excitability of Inhibitory Neurons. J. Neurosci. 42(15):3066-3079, 2022.
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