霍玉庆 - 北京大学 - 化学生物学与生物技术学院

研究领域

本课题组主要探讨血液细胞，包括白细胞、红细胞、血小板在炎症相关疾病，如动脉粥样硬化、血栓形成、糖尿病、肥胖等疾病的功能作用。在生理及以上病理条件下使用在体成像技术观察血液细胞及其碎片与血管内皮细胞的相互作用的差别，分析在使用封闭抗体或基因敲除后抑制其相互作用可否发挥治疗性作用。另外，我们课题组亦致力于探讨腺苷代谢途径及腺苷受体信号通路在炎症、败血症、动脉硬化、血栓、糖尿病、肥胖及其他相关疾病中的作用。这些研究将为探索治疗以上相关疾病提供可能的潜在途径。

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Xu Y, An X, Guo X, Habtetsion TG, Wang Y, Xu X, Kandala S, Li Q, Li H, Zhang C, Caldwell RB, Fulton DJ, Su Y, Hoda MN, Zhou G, Wu C, Huo Y. Endothelial PFKFB3 plays a critical role in angiogenesis. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1231-9. doi: 10.1161/ATVBAHA.113.303041. Wei S, Wang H, Zhang G, Lu Y, An X, Ren S, Wang Y, Chen Y, White JG, Zhang C, Simon DI, Wu C, Li Z, Huo Y. Platelet IκB kinase-β deficiency increases mouse arterial neointima formation via delayed glycoprotein Ibα shedding. Arterioscler Thromb Vasc Biol. 2013, 33(2):241-8. Huo Y, Guo X, Li H, Xu H, Halim V, Zhang W, Wang H, Fan YY, Ong KT, Woo SL, Chapkin RS, Mashek DG, Chen Y, Dong H, Lu F, Wei L, Wu C. Targeted Overexpression of Inducible 6-Phosphofructo-2-kinase in Adipose Tissue Increases Fat Deposition but Protects against Diet-induced Insulin Resistance and Inflammatory Responses. J Biol Chem. 2012, 287(25): 21492-500. (Co-corresponding author) Wang H, Zhang W, Tang R, Zhu C, Bucher C, Blazar B, Geng J, Zhang C, Linden J, Wu C, Huo Y. Adenosine receptor A2A deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2010, 30(5): 915-22. Zhang W, Wang J, Wang H, Tang R, Belcher JD, Viollet B, Geng JG, Zhang C, Wu C, Slungaard A, Zhu C, Huo Y. Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway. Arterioscler Thromb Vasc Biol. 2010, 30(5): 1000-6. Wang H, Zhang W, Zhu C, Bucher C, Blazar B, Zhang C, Chen J, Linden J, Wu C, Huo Y. Inactivation of the adenosine A2A receptor protects apolipoprotein E-deficient mice from atherosclerosis. Arterioscler Thromb Vasc Biol. 2009, 29(7): 1046-52. Wang H, Zhang W, Tang R, Hebbel RP, Kowalska MA, Zhang C, Marth JD, Minoru F, Zhu C and Huo Y. Core2 1-6-N-glucosaminyltransferase-I deficiency protects injured arteries from neointima formation in apoE-deficient mice. Arterioscler Thromb Vasc Biol. 2009, 29(7): 1053-9. An G, Wang H, Tang R, Yago T, McDaniel M, McGee S, Huo Y, Xia L.. PSGL-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation 2008, 117: 3227-37. (Corresponding author) Huo Y, Zhao L, Hyman M,Shashkin P, Harry B, Burcin T, Forlow B, Stark M, Smith D, Clarke S, Srinivasan S, Hedrick CC, Pratico D, Witztum JL, Nadler JL, Funk CD, Ley K. Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation 2004, 110: 2024-31. (Corresponding author) Huo Y, Forlow B, Schober A, Smith D, Hyman M, Weber C, Ley K. Circulating activated platelets exacerbate atherosclerosis in apoE-/- mice. Nature Medicine 2003, 9: 61-67. Huo Y, Weber C, Forlow B, Sperandio M, Lung S, Littman DR, Ley K. The chemokine KC and RANTES, but not MCP-1 arrest monocyte on native early atherosclerotic endothelium. Journal of Clinical Investigation 2001, 108: 1307-1314.