个人简介
EDUCATION
1985 B.S. Applied Chemistry, Peking University, Beijing
1988 M.S. Analytical Chemistry, Peking Union Medical College, Beijing
1995 Ph.D. Organic Chemistry , The Ohio State University, Columbus, Ohio
EXPERIENCE
1996-1997, Postdoctoral Research Associate, with Professor Albert Soloway, College of Pharmacy, The Ohio State University, Columbus, Ohio
1998-2000, Postdoctoral Research Associate, with Professor Henry Rapoport, Department of Chemistry, University of California, Berkeley, California
2000-2010, Professor, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
2010-2015.07, Professor and Director, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China
2015.08-Present, Professor, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, China
HONORS AND AWARDS
1. Lectureship Awards of Asian Core Program, “Cutting-Edge Organic Chemistry in Asia” (2013, 2012, 2011, 2008, 2006)
2. New century talents national candidates (2009)
3. “Distinguished Young Investigator” Program, National Natural Science Foundation of China (2006)
4. “Post-Venus” Program, Science and Technology Commission of Shanghai Municipal (2005)
5. “Venus” Program, Science and Technology Commission of Shanghai Municipal (2002)
6.“Hundreds of Talent” Program, Chinese Academy of Sciences (1999)
近期论文
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Xu, B; Xun, W; Su, S; Zhai, H.* Total Syntheses of (–)-Conidiogenone B, (–)-Conidiogenone and (–)-Conidiogenol, Angew. Chem. Int. Ed. 2020, 59, 1−6. DOI: 10.1002/anie.202007247
Zhao, H.; Wang, T.; Qing, Z.; Zhai, H.* Cobalt-catalyzed 2-(1-methylhydrazinyl)pyridine-assisted cyclization of thiophene-2-carbohydrazides with maleimides: efficient synthesis of thiophene-fused pyridones, Chem. Commun., 2020, 56, 5524−5527. DOI: 10.1039/d0cc01582b
Qiu, S.; Zhai, S.; Wang, H.; Chen, X.; Zhai, H.* One-pot synthesis of benzo b fluorenones via a cobalt-catalyzed MHP-directed 3+2 annulation/ring-opening/dehydration sequence. Chem. Commun. 2019, 55, 4206−4209. DOI: 10.1039/c9cc00948e
Zhao, H.; Shao, X.; Qing, Z.; Wang, T.; Chen, X.; Yang, H.; Zhai, H.* Cobalt‐Catalyzed 2‐(1‐Methylhydrazinyl)pyridine‐Assisted Direct C−H/N−H Functionalization of Benzoyl Hydrazide with Isocyanide: Efficient Synthesis of Iminoisoindolinone Derivatives. Adv. Synth. Catal. 2019, 361, 1678−1682. DOI: 10.1002/adsc.20181801459
Zhang, Z.; Xie, S.; Cheng, B.; Zhai, H.*; Li, Y.* Enantioselective Total Synthesis of (+)-Arboridinine, J. Am. Chem. Soc. 2019, 141, 7147−7154. DOI: 10.1021/jacscaal.9b02362
Wang, H.； Qiu, S.； Wang, S.； Zhai, H.* Pd-Catalyzed Umpolung of p-Allylpalladium Intermediates: Assembly of All-Carbon alpha-Vinyl Quaternary Aldehydes through Csp3-Csp3 Coupling, ACS Catal. 2018, 8, 11960−11965. DOI: 10.1021/acscatal.8b03814
Qiu, S.; Zhai, S.; Wang, H. Tao, C.; Zhao,H.; Zhai, H.* Efficient Synthesis of Phthalimides via Cobalt-Catalyzed C(sp(2))-H Carbonylation of Benzoyl Hydrazides with Carbon Monoxide,Adv. Synth. Catal. 2018, 360, 3271−3276. DOI. 10.1002/adsc.201800388
Sa, S.; Liu, M.; Chen, X.; Wang, H.; Zhai, H.* Copper-catalyzed decarboxylative propargylation/hydroamination reactions: access to C3 beta-ketoester-functionalized indoles,Chem. Commun. 2018, 54, 8375−8378. DOI: 10.1039/C8CC04499F
Zhai, S.; Qiu,S.; Chen,X.; Tao, C.; Li, Y.; Cheng, B.; Wang, H.; Zhai, H.* Trifunctionalization of Allenes via Cobalt-Catalyzed MHP-Assisted C−H Bond Functionalization and Molecular Oxygen Activation, ACS Catal. 2018, 8, 6645−6649. DOI: 10.1021/acscatal.8b01720
Hua Zhao, Xiaoru Shao, Taimin Wang, Shengxian Zhai, Shuxian Qiu, Cheng Tao, Huifei Wang.; Zhai,H.* A 2-(1-methylhydrazinyl)pyridine-directed C–H functionalization/spirocyclization cascade: facile access to spirosuccinimide derivatives,Chem. Commun. 2018, 54, 4927−4930. DOI: 10.1039/C8CC01774C
Shengxian Zhai, Shuxian Qiu, Xiaoming Chen, Jiang Wu, Hua Zhao,Cheng Tao, Yun Li, Bin Cheng, Huifei Wang and Zhai,H.* 2-(1-Methylhydrazinyl)pyridine as a reductively removable directing group in a cobalt-catalyzed C(sp2)–H bond alkenylation/annulation cascade,Chem. Commun. 2018, 54, 98−101. DOI: 10.1039/C7CC08533H
Xiaoming Chen, Hai-Jun Zhang, Xinkan Yang, Houqiang Lv, Xiaoru Shao, Cheng Tao, Huifei Wang, Bin Cheng, Yun Li, Jingjing Guo, Jing Zhang, Zhai, H.*Divergent Total Syntheses of (-)-Daphnilongeranin B and (-)-Daphenylline, Angew. Chem. Int. Ed. 2018, 57, 947−951. DOI: 10.1002/anie.201709762
Duan, S.; Cheng, B.; Duan, X.; Bao, B.; Li, Y.; Zhai, H.* Synthesis of cis-5,5a,6,10b-Tetrahydroindeno 2,1-b indoles through Palladium-Catalyzed Decarboxylative Coupling of Vinyl Benzoxazinanones with Arynes. Organic Letters. 2018, 20, 1417-1420.. DOI: 10.1021/acs.orglett.8b00192
Li, Y.; Yang, H.; Zhai, H.* The Expanding Utility of Rhodium-Iminocarbenes: Recent Advances in the Synthesis of Natural Products and Related Scaffolds. Chemistry-a European Journal. 2018, 24, 12757-12766. DOI: 10.1002/chem.201800689
Wei, J.; Li, Y.; Tao, C.; Wang, H.; Cheng, B.; Zhai, H.*; Li, Y. Organocatalytic Synthesis of 4-Aryl-1,2,3,4-tetrahydropyridines from Morita-Baylis-Hillman Carbonates through a One-Pot Three-Component Cyclization. J. Org. Chem. 2018, 83, 835-842. DOI: 10.1021/acs.joc.7b02818
Xu, W.; Zhao, J.; Tao, C.; Wang, H.; Li, Y.; Cheng, B.; Zhai, H.* Collective Total Synthesis of (-)-Lundurines A-C. Organic Letters. 2018, 20, 1509-1512. DOI: 10.1021/acs.orglett.8b00210
Tao, Cheng; Zhang, J; Chen, X.-M; Wang, H.-F.; Li, Y; Cheng, B; Zhai, H.* Formal Synthesis of (±)-Aplykurodinone-1 through a Hetero-Pauson–Khand Cycloaddition Approach, Org. Lett. 2017, 19, 1056−1059. DOI: 10.1021/acs.orglett.7b00068
Chen, X.-Z.; Qiu S.-X.; Wang, S.-S; Wang, H.-F.; Zhai, H.* Blue-Light-Promoted Carbon-Carbon Double Bond Isomerization and Its Application in Syntheses of Quinolines, Org. Biomol. Chem. 2017, Accepted Manuscript. DOI: 10.1039/C7OB00558J
Chen, H.-Y.; Shao X.-R.; Wang, H.-F.; Zhai, H.* New reactivity of ethynyl benziodoxolone: modulating iron-catalyzed dehydration of propargyl alcohols, Org. Chem. Front. 2017, Advance Article DOI: 10.1039/C6QO00631K
Zhang, H.-J.;+ Hu, L.;+ Ma, Z.; Li, R.; Zhang, Z.; Tao, C.; Cheng, B.; Li, Y.; Wang, H.; Zhai, H.* Total Synthesis of Diterpenoid (+)-Harringtonolide, Angew. Chem. Int. Ed. 2016, 55, 11638−11641. DOI: 10.1002/anie.201605879
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