李子刚 - 北京大学 - 化学生物学与生物技术学院

个人简介

EDUCATION 2009-2010 National Cancer Center Postdoctoral Fellow, Harvard University 2004-2008 Ph.D. Chemistry, The University of Chicago 2001-2004 M.S. Chemistry, Tulane University 1996-2001 B.S. Biophysics, The University of Science and Technology of China RESEARCH EXPERIENCE 2010-June Principal Investigator, Ph.D. Advisor The School of Chemical Biology and Biotechnology Peking University, Shenzhen Graduate School 2009-2010 National Cancer Center Postdoctoral Fellow Advisor: Professor Gregory L. Verdine Department of Chemistry, Harvard University, Cambridge, MA New targets from human cancer cells for stapled peptides 2004-2008 Research Assistant, Advisor: Professor Chuan He Department of Chemistry, The University of Chicago, Chicago, IL Investigation of global regulator functions on the pathogenesis of Staphylococcus aureus. Development and discovery of transition metal catalyzed nitrene transfer reactivity 2001-2004 Research Assistant, Advisor: Professor Chao-Jun Li Department of Chemistry, Tulane University, New Orleans, LA Investigation of imine reactivity in aqueous media AWARDS 2009-2010 National Cancer Center Postdoctrol Fellowship, Harvard University 2008-2009 Harper Dissertation Fellowship, University of Chicago 2008 The 12th GLCACS Annual Conference Student Poster Prize 2003 Trebellas Outstanding Teaching Assistant Award, Tulane University 1996 First prize, National Olympic Chemistry Competition, China

研究领域

1.Chemical Stabilization of Peptide Secondary Structure and Its Biological Fuctionality Protein-protein interactions (PPIs) play a crucial role in most cellular signaling events, therefore are considered as potential therapeutic targets. However, most PPIs usually have larger contact surface area than that of G-protein-coupled receptors or protein kinases described as “druggable” targets. Therefore, developing molecular mimicry of chemically stabilized protein secondary structures remains an active area in this research field to achieve clinically-relevant therapeutic agents. Artificially mimic α-helical short peptides by chemically introduction of “stapling” amino acids at the primary sequence level with covalent macrocycles become increasingly intriguing. 2.Modulation of Microbial Virulence and Research on Anti-Infection Treatment SarA (staphylococcal accessory protein A), MgrA (MarR family of global transcriptional regulator A), and SarZ (a paralogue of SarA) play critical roles in modulating the virulence, drug resistance and autolysis of Staphylococcus aureus. Recently, eukaryotic-like Ser/Thr kinase/phosphatase (Stk1/Stp1) were found to modulate phosphorylation of SarA/MgrA family regulators as well as staphylococcal virulence. Importantly, stp1-deficient strain shows significant virulence reduction in mice, implying Stp1 as an alternative drug target. Our lab found that MDSA, an inhibitor of MgrA, enhances phosphorylation of SarA/MgrA by inhibiting Stp1 in vivo. MDSA inhibits Stp1 more potently over commonly used phosphatase inhibitors. We anticipate that MDSA could be a lead compound to a new approach for combating staphylococcal infection by targeting Stp1.

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Qinhong Luo,‡ Yaqi Wang,‡ Zhanfeng Hou,‡ Huiting Liang, Licheng Tu, Yun Xing, Chuan Wan, Jianbo Liu, Rui Wang, Lizhi Zhu, Wei Han, Jianlong Wu,* Fei Lu,* Feng Yin,* and Zigang Li*, “Covalent PROTAC Design Method Based on a Sulfonyl Pyridone Probe”, Chem. Commun. 2024, https://doi.org/10.1039/D3CC05127G Zhan, M.; Xing, Y.; Li, Z.; Yin, F. “A GSH-Resistant FK228 Analogue Containing a Stable Disulfide Bond”, Bioorganic Chemistry 2024, https://doi.org/10.1016/j.bioorg.2024.107119 Wanjin Zhong, Chuan Wan, Ziyuan Zhou, Chuan Dai, Yichi Zhang, Fei Lu*, Feng Yin*, and Zigang Li*, “4-Iodine N-Methylpyridinium-Mediated Peptide Synthesis”, Org. Lett., 2023, https://pubs.acs.org/doi/10.1021/acs.orglett.3c03539 Hailing Chen, Meimiao Zhan, Yaping Zhang, Jianbo Liu, Rui Wang, Yuhao An, Zhanxia Gao, Leying Jiang, Yun Xing, Yibin Kang*, Zigang Li*, and Feng Yin*, “Intracellular Delivery of Stabilized Peptide Blocking MTDH-SND1 Interaction for Breast Cancer Suppression”, JACS Au, 2023, https://pubs.acs.org/doi/10.1021/jacsau.3c00573 Qinhong Luo#, Yue Ma#, Huiting Liang#, Yuan Feng, Na Liu, Chenshan Lian, Lizhi Zhu, Yuxin Ye, Zhihong Liu, Zhanfeng Hou, Sijin Chen, Yaqi Wang, Chuan Dai, Chunli Song, Min Zhang, Zhipeng He, Yun Xing, Wanjin Zhong, Shuiming Li, Jianlong Wu,* Fei Lu,* Feng Yin,* and Zigang Li*, “Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region”, J. Med. Chem., 2023, https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01549 Chuan Dai#, Xiaochun Guo#, Zhuoheng Pan#, Chuan Wan, Dongyan Yang, Yongli Li, Chenshan Lian, Yuhao An, Tuanjie Zhang, Fadeng Yang, Lizhi Zhu*, Feng Yin*, Rui Wang*, Zigang Li*. “Pyridinium-Based Strategy for a Bioorthogonal Conjugation-Assisted Purification Method for Profiling Cell Surface Proteome”, Anal. Chem., 2023, https://pubs.acs.org/doi/full/10.1021/acs.analchem.3c04279 Chunli Song#, Zijun Jiao#, Zhanfeng Hou#, Rui Wang, Chenshan Lian, Yun Xing, Qinhong Luo, Yuhao An, Fenfang Yang, Yuechen Wang, Xinrui Sha, Zhijun Ruan, Yuxin Ye, Zhihong Liu, Zigang Li*, and Feng Yin*, “Selective Protein of Interest Degradation through the Split-and-Mix Liposome Proteolysis Targeting Chimera Approach”, Journal of the American Chemical Society, 2023, https://doi.org/10.1021/jacs.3c05948 Xiaochun Guo, Yuena Wang, Yuhao An, Zhihong Liu, Jianbo Liu, Jiaxin Chen, Mei-miao Zhan, Mingcha Liang, Zhanfeng Hou, Chuan Wan, Feng Yin*, Rui Wang*, Zigang Li*, “Development of Lysine Crotonyl-mimic Probe to Covalently Identify H3K27Cr Interacting Proteins”, Chemistry – A European Journal, 2023, https://doi.org/10.1002/chem.202301624 Zhanfeng Hou, Chuan Wan, Yun Xing, Xiaochun Guo, Yaping Zhang, Rui Wang*, Feng Yin*, and Zigang Li*, “Bioorthogonal Fluoride-Responsive Azide and Alkynyl Pyridinium Click Cycloaddition in Vitro and in Live Cells”, Organic Letters, 2023, https://doi.org/10.1021/acs.orglett.3c01403 Fenfang Yang#, Qinhong Luo#, Yuechen Wang, Huiting Liang, Yaqi Wang, Zhanfeng Hou, Chuan Wan, Yuena Wang, Zhihong Liu, Yuxin Ye, Lizhi Zhu, Jianlong Wu, Feng Yin*, and Zigang Li*, “Targeted Biomolecule Regulation Platform: A Split-and-Mix PROTAC Approach”, Journal of the American Chemical Society, 2023, https://doi.org/10.1021/jacs.2c12824 Chuan Wan‡, Zhanfeng Hou‡, Dongyan Yang‡, Ziyuan Zhou, Hongkun Xu, Yuena Wang, Chuan Dai, Mingchan Liang, Jun Meng, Jiean Chen, Feng Yin*, Rui Wang*, Zigang Li*, “The thiol-sulfoxonium ylide photo-click reaction for bioconjugation”, Chemical Science, 2023, https://doi.org/10.1039/D2SC05650J Yaping Zhang, Hongkun Xu, Leying Jiang, Zhaodi Liu, Chenshan Lian, Xiaofeng Ding, Chuan Wan, Na Liu, Yuena Wang, Zhiqiang Yu, Lizhi Zhu*, Feng Yin*, Zigang Li*, “Sulfonium-Driven Neoantigen-Released DNA Nanodevice as a Precise Vaccine for Tumor Immunotherapy and Prevention”, ACS Nano, 2022, https://doi.org/10.1021/acsnano.2c09708 Yuena Wang, Rongtong Zhao, Chuan Wan, Xiaochun Guo, Fenfang Yang, Zhanfeng Hou, Rui Wang, Shuiming Li, Tiejian Feng*, Feng Yin*, and Zigang Li*, “A Peptide-Based Ligand-Directed Chemistry Enables Protein Functionalization”, Organic Letters, 2022, https://doi.org/10.1021/acs.orglett.2c02974 Hailing Chen#, Meimiao Zhan#, Jianbo Liu#, Zhihong Liu, Minhong Shen, Fenfang Yang, Yibin Kang*, Feng Yin*, and Zigang Li*, “Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction”, Journal of Medicinal Chemistry, 2022, https://doi.org/10.1021/acs.jmedchem.2c00862 Jinpeng Wang#, Min Zhang#, Susheng Liu, Zhipeng He, Rui Wang, Minchan Liang, Yuhao An, Chenran Jiang, Chunli Song, Zigong Ning, Feng Yin, Hao Huang*, Zigang Li*, Yuxin Ye*, “Targeting UBE2C for degradation by bioPROTACs based on bacterial E3 ligase”, Chinese Chemical Letters, 2022, https://doi.org/10.1016/j.cclet.2022.08.012 Chuan Wan†, Yuena Wang†, Chenshan Lian†, Qi Chang, Yuhao An, Jiean Chen, Jinming Sun, Zhanfeng Hou, Dongyan Yang, Xiaochun Guo, Feng Yin*, Rui Wang* and Zigang Li*, “Histidine-Specific bioconjugation via visible-light-promoted thioacetal activation”, Chemical Science, 2022, https://doi.org/10.1039/D2SC02353A Yuena Wang†, Rongtong Zhao†, Chuan Wan†, Wei Kang, Rui Wang, Chengyao Chiang, Xiaochun Guo, Qi Chang, Zhanfeng Hou, Yuxin Ye, Qinghong Luo, Ziyuan Zhou, Jianbo Liu, Shuiming Li, Dongyuan Wang*, Feng Yin* and Zigang Li*, “A proximity-triggered strategy towards transferable PROTACs”, CCS Chemistry, 2022, https://doi.org/10.31635/ccschem.022.202201985 Yao Tian†, Jianbo Liu†, Fadeng Yang, Chenshan Lian, Huawei Zhang, John H. Viles*, Zigang Li*, “Therapeutic potential for amyloid surface inhibitor: only amyloid-β oligomers formed by secondary nucleation disrupt lipid membrane integrity”, The FEBS Journal, 2022, https://doi.org/10.1111/febs.16550 Chuan Wan‡, Dongyan Yang‡, Xuan Qin, Ziyi Xue, Xiaochun Guo, Zhanfeng Hou, Chenran Jiang, Feng Yin*, Rui Wang*, Zigang Li*, “Flavin catalyzed desulfurization of peptides and proteins in aqueous media”, Organic & Biomolecular Chemistry, 2022, https://doi.org/10.1039/D2OB00641C Chuan Dai#, Chenshan Lian#, Huilong Fang, Qinhong Luo, Junrong Huang, Min Yang, Heng Yang, Lizhi Zhu*, Jinqiang Zhang*, Feng Yin*, and Zigang Li*, “Diversity-Oriented Synthesis of ERα Modulators via Mitsunobu Macrocyclization”, Organic Letters, 2022, https://doi.org/10.1021/acs.orglett.2c01239 Qinqi Ren#, Yaping Zhang#, Shenhui Ma, Xiaofang Wang, Kuan-Chang Chang, Yiming Zhang, FengYin*, Zigang Li*, MinZhang*, “Low-temperature supercritical activation enables high-performance detection of cell-free DNA by all-carbon-nanotube transistor”, Carbon, 2022, https://doi.org/10.1016/j.carbon.2022.04.068 Rui Wang, Dongyan Yang, Tian Tian, Yuhao An, Chuan Wan, Qi Chang, Mingchan Liang, Zhanfeng Hou, Ying Wang, Liang Zhang*, and Zigang Li*, “Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells”, Analytical Chemistry, 2022, https://doi.org/10.1021/acs.analchem.1c05129 Mei-miao Zhan, Rui Wang, Zhihong Liu, Na Liu, Yuxin Ye, Mingchan Liang, Yichi Zhang, Chenran Jiang, Feng Yin*, and Zigang Li*, “Chemo-Selective Cys–Pen Disulfide for Proximity-Induced Cysteine Cross-Linking”, ACS Chemical Biology, 2022, https://doi.org/10.1021/acschembio.2c00083 Zhanfeng Hou,# Yuena Wang,# Chuan Wan,# Lijuan Song,# Rui Wang, Xiaochun Guo, Dongyan Yang, Yaping Zhang, Xuan Qin, Ziyuan Zhou, Xinhao Zhang,* Feng Yin,* and Zigang Li*, “Sulfonium Triggered Alkyne−Azide Click Cycloaddition”, Organic Letters, 2022, https://doi.org/10.1021/acs.orglett.2c00021 Xuan Qin, Rui Wang, Hongkun Xu, Licheng Tu, Hailing Chen, Heng Li, Na Liu,Jinpeng Wang, Shuiming Li, Feng Yin*, Naihan Xu*& Zigang Li*, “Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30”, Autophagy, 2022, https://doi.org/10.1080/15548627.2021.2022360 Na Liu,# Yichi Zhang,# Yingshou Lei,# Rui Wang, Meimiao Zhan, Jianbo Liu, Yuhao An, Yaoqi Zhou, Jian Zhan*, Feng Yin*, and Zigang Li* “Design and Evaluation of a Novel Peptide−Drug Conjugate Covalently Targeting SARS-CoV‑2 Papain-like Protease”, Journal of Medicinal Chemistry, 2022, https://doi.org/10.1021/acs.jmedchem.1c02022 Chuan Wan,# Yuan Feng,# Zhanfeng Hou,# Chenshan Lian, Liang Zhang, Yuhao An, Jinming Sun, Dongyan Yang, Chenran Jiang, Feng Yin,* Rui Wang,* and Zigang Li*”Electrophilic Sulfonium-Promoted Peptide and Protein Amidation in Aqueous Media”, Organic Letters, 2021, https://doi.org/10.1021/acs.orglett.1c04017 Li Duan*, Xiao Xu, Limei Xu, Caining Wen, Kan Ouyang, Zigang Li and Yujie Liang*. “ERα-Targeting PROTAC as a Chemical Knockdown Tool to Investigate the Estrogen Receptor Function in Rat Menopausal Arthritis”, Frontiers in Pharmacology, 2021, DOI: 10.3389/fphar.2021.764154 Shenhui Ma, Yaping Zhang, Qinqi Ren, Xiaofang Wang, Jiahao Zhu, Feng Yin*, Zigang Li*, Min Zhang*. “Tetrahedral DNA nanostructure based biosensor for high-performance detection of circulating tumor DNA using all-carbon nanotube transistor”, Biosensors and Bioelectronics, 2022, 197, 113785. https://doi.org/10.1016/j.bios.2021.113785 Junrong Huang, Min Yang, Chuan Dai, Yajun Zhou, Huilong Fang, Lizhi Zhu*, Feng Yin* and Zigang Li*. “Novel Strategies in C-H Oxidations for Natural Product Diversification-A Remote Functionalization Application Summary”, Frontiers in Chemistry, 2021, https://doi.org/10.3389/fchem.2021.737530 Fenfang Yang, Feng Yin and Zigang Li, “Helical Stabilization of Peptide Macrocycles by Stapled Architectures”, Peptide Macrocycles. Methods in Molecular Biology, vol 2371. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1689-5_21 Rongtong Zhao,‡ Xiaodong Shi,‡ Linlin Shi, Hui Zhao, Feng Yin* and Zigang Li*, “Solid phase diversity-oriented lysine modification of cyclic peptides”, Journal of Peptide Science, 2021, https://doi.org/10.1002/psc.3373 Hongkun Xu,‡ Xuan Qin,‡ Yaping Zhang,‡ Chuan Wan, Rui Wang, Zhanfeng Hou, Xiaofeng Ding, Hailing Chen, Ziyuan Zhou, Yang Li, Chenshan Lian, Feng Yin,* and Zigang Li* “A bifunctional vinyl-sulfonium tethered peptide constructed/induced by thio-Michael-type addition reaction“, Chinese Chemical Letters, 2021, https://doi.org/10.1016/j.cclet.2021.09.071 Kuan Hu,‡ Wenyu Wu,‡ Lin Xie, Hao Geng, Yiding Zhang, Masayuki Hanyu, Lulu Zhang, Yinghuan Liu, Kotaro Nagatsu , Hisashi Suzuki, Jialin Guo, Yundong Wu,* ZigangLi,* Feng Wang* and Mingrong Zhang* “Whole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors”, Acta Pharmaceutica Sinica B, 2021, https://doi.org/10.1016/j.apsb.2021.09.016 Xuan Qin,‡ Hailing Chen,‡ Licheng Tu, Yue Ma, Na Liu, Haowei Zhang, Di Li, Bernd Riedl, Donald Bierer*, Feng Yin*, and Zigang Li* “Potent Inhibition of HIF1α and p300 Interaction by a Constrained Peptide Derived from CITED2” Journal of Medicinal Chemistry, 2021, https://doi.org/10.1021/acs.jmedchem.1c01043 Yinghuan Liu, Kuan Hu, Feng Yin* and Zigang Li* “Facile Chemoselective Modification of Thioethers Generates Chiral Center-Induced Helical Peptides” Peptide Conjugation. Methods in Molecular Biology, 2021, vol 2355. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1617-8_23 Zigang Li, Hui Zhao, Chuan Wan “Cyclized Helical Peptides: Synthesis, Properties, and Therapeutic Applications” Online ISBN:9783527343430 |DOI:10.1002/9783527343430 Chenshan Lian,‡ Yang Li,‡ Zhanfeng Hou, Wanjin Zhong, Ye Tian, Feng Yin, Zigang Li,* Dongxian Zhou,* Rui Wang* “Proximity-induced amino-yne reaction for selective MDM4 conjugation via propargylated sulfonium” Chinese Chemical Letters, 2021, https://doi.org/10.1016/j.cclet.2021.04.015. Yixiang Jiang,‡ Wan Zhang,‡ Fadeng Yang,‡ Chuan Wan, Xiang Cai, Jianbo Liu, Qianling Zhang, Zigang Li* and Wei Han* “Molecular design of stapled pentapeptides as building blocks of self-assembled coiled coil–like fibers” Science Advances, 2021, 7 (4): eabd0492. DOI: 10.1126/sciadv.abd0492 Ziyuan Zhou, Qing Pan, Xinchen Lv, Jing Yuan, Yang Zhang, Ming-Xia Zhang, Ming Ke, Xiao-Mei Mo, Yong-Li Xie, Yingxia Liu, Ting Chen, Mingchan Liang, Feng Yin, Lei Liu, Yiqing Zhou, Kun Qiao, Rui Liu, ZigangLi* and Nai-Kei Wong* “Structural insights into the inhibition of bacterial RecA by naphthalene polysulfonated compounds” iScience, 2021, 24, 101952, doi://doi.org/10.1016/j.isci.2020.101952 Wenjun Li,‡ Yaping Zhang,‡ Yanchao Wang,‡ Yue Ma, Dongyuan Wang, Heng Li, Xiyang Ye, Feng Yin and Zigang Li* “Nucleic acids induced peptide-based AIE nanoparticles for fast cell imaging” Chinese Chemical Letters, 2020, https://doi.org/10.1016/j.cclet.2020.09.054 Di Li, Tianqi Su, Lili Ma, Feng Yin, Weiguo Xu*, Jianxun Ding and ZigangLi* “Dual-acidity-labile polysaccharide-di-drugs conjugate for targeted cancer chemotherapy” Eur J Med Chem. 2020, 199:112367. Doi: 10.1016/j.ejmech.2020.112367. Na Liu,‡ Dongyuan Wang,‡ Chenshan Lian,‡ Rongtong Zhao, Licheng Tu, Yichi Zhang, Jianbo Liu, Huilin Zhu, Mengying Yu, Chuan Wan, Di Li, Shuiming Li, Feng Yin* and Zigang Li* “Selective Covalent Targeting of Anti‐Apoptotic BFL‐1 by a Sulfonium Tethered Peptide” Chembiochem, 2020, DOI:10.1002/cbic.202000473, Yang Li, Chenshan Lian, Zhanfeng Hou, Dongyuan Wang, Rui Wang, Chuan Wan, Wanjin Zhong, Rongtong Zhao, Yuena Wang, Shuiming Li, Feng Yin* and Zigang Li* “Intramolecular methionine alkylation constructs sulfonium tethered peptides for protein conjugation” Chemical Communications, 2020, DOI: 10.1039/D0CC00377H, Kuan Hu, Wei Xiong, Chengjie Sun, Chan Wang, Jingxu Li, Feng Yin, Yixiang Jiang, Ming-Rong Zhang, Zhou Li, Xinwei Wang, and Zigang Li* “Self-Assembly of Constrained Cyclic Peptides Controlled by Ring Size” CCS Chemistry, 2020, DOI: https://doi.org/10.31635/ccschem.020.201900047, Yi Wang,‡ Weirong Qin,‡ Hongdong Shi, Haijie Chen, Xiaoyan Chai, Jingang Liu*, Pingyu Zhang*, Zigang Li* and Qianling Zhang* “A HCBP1 peptide conjugated ruthenium complex for targeted therapy of hepatoma” Dalton Transactions, 2020, DOI: https://pubs.rsc.org/en/content/articlelanding/2020/DT/C9DT03856F, Zhanfeng Hou‡, Dong-Yuan Wang‡, Yang Li, Rongtong Zhao, Chuan Wan, Yue Ma, Chenshan Lian, Feng Yin* and Zigang Li*”A Sulfonium Triggered Thiol-yne Reaction for Cysteine Modification” J. Org. Chem., 2020, DOI: https://doi.org/10.1021/acs.joc.9b02505, Wenjun Li‡, Yubo Gao‡, Jiaona Zhang, Xiaofang Wang, Feng Yin*, Zigang Li*, Min Zhang* “Universal DNA detection realized by peptide based carbon nanotube biosensors ” Nanoscale Adv., 2019, DOI: 10.1039/C9NA00625G, Fadeng Yang‡, Wan Zhang‡, Yixiang Jiang, Feng Yin*, Wei Han* and Zigang Li* “Targeting the amyloid-β fibril surface by constrained helical peptide inhibitor” Biochemistry 2019, DOI: https://doi.org/10.1021/acs.biochem.9b00800, Wei Xiong‡, Kuan Hu‡, Zhe Li‡, Yixiang Jiang, Zigang Li*, Zhou Li*, Xinwei Wang* “A wearable system based on core-shell structured peptide-Co9S8 supercapacitor and triboelectric nanogenerator” Nano Energy, 2019, DOI: https://doi.org/10.1016/j.nanoen.2019.104149, Licheng Tu, Dongyuan Wang, Zigang Li* “Design and Synthetic Strategies for Helical Peptides”, Cyclic Peptide Design, 2019, pp: 107-131 Kuan Hu‡, Feng Yin‡, Ziyuan Zhou‡, Chenshan Lian, Yinghuan Liu, Chengjie Sun, Wenjun Li, Jianing Zhang and Zigang Li* “Directional assembly of a stapled α-helical peptide ” Chemical Communications, 2019, DOI: 10.1039/C9CC04591K Yixiang Jiang‡, Xuehan Jiang‡, Xiaodong Shi, Fadeng Yang, Yang Cao, Xuan Qin, Zhanfeng Hou, Mingsheng Xie, Na Liu, Qi Fang, Feng Yin*, Wei Han*, Zigang Li* “α-helical motif as inhibitors of toxic amyloid-β oligomer generation via highly specific recognition of amyloid surface” iScience, 2019, DOI: https://doi.org/10.1016/j.isci.2019.06.022 Jianing Zhang‡, Yue Ma‡, Kuan Hu, Yuan Feng, Si Chen, Xiaoyang Yang, Jacky Fong-Chuen Loo, Han Zhang, Feng Yin* and Zigang Li* “Surface Coordination of Black Phosphorus with Modified Cisplatin” Bioconjugate Chemistry, 2019, DOI: 10.1021/acs.bioconjchem.9b00128 Dongyuan Wang‡, Mengying Yu‡, Na Liu, Chenshan Lian, Zhanfeng Hou, Rui Wang, Rongtong Zhao, Wenjun Li, Yixiang Jiang, Xiaodong Shi, Shuiming Li*, Feng Yin*, Zigang Li* “A sulfonium tethered peptide ligand rapidly and selectively modifies protein cysteine in vicinity” Chemical Science, 2019, DOI: 10.1039/C9SC00034H Qinsi Xiong†, Yixiang Jiang†, Xiang Cai, Fadeng Yang, Zigang Li*, and Wei Han* “Conformation Dependence of Diphenylalanine Self-Assembly Structures and Dynamics：Insights from Hybrid-Resolution Simulations” ACS Nano, 2019, DOI: 10.1021/acsnano.8b09741 Dongyuan Wang, Wenjun Li, Rongtong Zhao, Longjian Chen, Na Liu, Yuan Tian, Hui Zhao, Mingsheng Xie, Fei Lu, Qi Fang, Wei Liang, Feng Yin and Zigang Li* “Stabilized peptide HDAC inhibitors derived from HDAC1 substrate H3K56 for the treatment of cancer stem-like cells in vivo” Cancer Research, 2019, DOI: 10.1158/0008-5472.CAN-18-1421. uewen He†, Feng Yin†, Dongyuan Wang, Ling-Hong Xiong, Ryan T. K. Kwok, Peng Fei Gao, Zheng Zhao, Jacky W. Y. Lam, Ken-Tye Yong, Zigang Li*, and Ben Zhong Tang* “AIE Featured Inorganic–Organic Core @ Shell Nanoparticles for High-Efficiency siRNA Delivery and Real-Time Monitoring” Nano Letters, 2019, DOI: 10.1021/acs.nanolett.8b04677, Xuan Qin,‡ Xiaodong Shi,‡ Licheng Tu, Yue Ma, Ziyuan Zhou, Rongtong Zhao, Meimiao Zhan, Feng Yin* and Zigang Li* “Autophagy inducing cyclic peptides constructed by methionine alkylation” Chemical Communications, 2019, DOI: 10.1039/C9CC01027K, Yue Ma,‡ Wenjun Li,‡ Ziyuan Zhou, Xuan Qin, Dongyuan Wang, Yubo Gao, Zhiqiang Yu, Feng Yin*, and Zigang Li* “Peptide-Aptamer Coassembly Nanocarrier for Cancer Therapy” Bioconjugate Chemistry, 2019, Article ASAP, doi: 10.1021/acs.bioconjchem.8b00903, Na Liu,‡ Rongtong Zhao,‡ Yue Ma, Dongyuan Wang, Chen Yan, Dongxian Zhou*, Feng Yin*, Zigang Li* “The Development of Epigenetics and Related Inhibitors for Targeted Drug Design in Cancer Therapy” Current Topics in Medicinal Chemistry, 2018, 18(28): 2380 – 2394, doi:10.2174/1568026618666181115092623, Xiaodong Shi, Kuan Hu, Hao Geng, Zhihong Liu, Feng Yin* and Zigang Li* “Effects of chiral center on an all‐hydrocarbon tethered peptide” Peptide Science, 2018, https://doi.org/10.1002/pep2.24110, Xiaodan Cai,‡ Weihao Zheng,‡ Xiaodong Shi,‡ Longjian Chen, Zhihong Liu, and Zigang Li *”HBx-derived constrained peptides inhibit the secretion of hepatitis B virus antigens”Mol. Pharmaceutics, 2018,Article ASAP, DOI: 10.1021/acs.molpharmaceut.8b00807, Zhanfeng Hou, Chengjie Sun, Hao Geng, Kuan Hu, Mingsheng Xie, Yue Ma, Fan Jiang,* Feng Yin,* and Zigang Li* “Facile Chemoselective Modiﬁcation of Thio-Ethers Generates Chiral Center-Induced Helical Peptides ” Bioconjugate Chemistry, 2018, Article ASAP DOI: 10.1021/acs.bioconjchem.8b00624, Dan Yang,‡ Weirong Qin,‡ Xiaodong Shi, Bili Zhu, Mingsheng Xie, Hui Zhao, Bin Teng, Yujie Wu, Rongtong Zhao, Feng Yin, Pei-Gen Ren, Lizhong Liu, and Zigang Li* “Stabilized β-hairpin peptide inhibits insulin degrading enzyme” Journal of Medicinal Chemistry, 2018, doi:10.1021/acs.jmedchem.8b00418, Xiaodong Shi,‡ Yinghuan Liu,‡ Rongtong Zhao, Zigang Li* “Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation” Journal of Visualized Experiments, 2018, doi:10.3791/57356, Fang Yuan,‡ Yuan Tian,‡ Weirong Qin,‡ Jingxu Li, Dan Yang, Bingchuan Zhao, Feng Yin* and Zigang Li * “Evaluation of topologically distinct constrained antimicrobial peptides with broad-spectrum antimicrobial activity” Organic & Biomolecular Chemistry, 2018, doi: 10.1039/C8OB00483H Weirong Qin,‡ Mingsheng Xie,‡ Xuan Qin, Qi Fang, Feng Yin,* Zigang Li* “Recent Advances in Peptidomimetics Antagonists Targeting Estrogen Receptor α-Coactivator Interaction in Cancer Therapy” Bioorganic & Medicinal Chemistry Letters, 2018, doi: https://doi.org/10.1016/j.bmcl.2018.05.062 Wenjun Li, Dongyuan Wang, Xiaodong Shi, Jingxu Li, Yue Ma, Yanding Wang, Tingting Li, Jianing Zhang, Rongtong Zhao, Zhiqiang Yu, Feng Yin* and Zigang Li* “A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy ” Materials Horizons, 2018, doi: 10.1039/C8MH00392K Jianing Zhang, Si Chen, Yue Ma, Dongyuan Wang, Jian Zhang, Yanding Wang, Wenjun Li, Zhiqiang Yu, Han Zhang, Feng Yin and Zigang Li* “Organosilicon modification enhanced the stability of black phosphorus nanosheets at ambient conditions ” J. Mater. Chem. B, 2018, doi: 10.1039/C8TB01349G Kuan Hu,‡ Yixiang Jiang,‡ Wei Xiong, Hu Li, Pei-Yu Zhang, Feng Yin, Qianling Zhang, Hao Geng, Fan Jiang,* Zhou Li,* Xinwei Wang,* and Zigang Li* “Tuning peptide self-assembly by an in-tether chiral center” Science Advances, 2018, doi: 10.1126/sciadv.aar5907 Weihao Zheng, Xiaodan Cai, Shuiming Li and Zigang Li* “Autophosphorylation Mechanism of the Ser/Thr Kinase Stk1 From Staphylococcus aureus” Front. Microbiol., 2018, https://doi.org/10.3389/fmicb.2018.00758 Xuan Qin,‡ Hui Zhao,‡ Yanhong Jiang, Feng Yin, Yuan Tian, Mingsheng, Xie, Xiyang Ye, Naihan Xu, Zigang Li* “Development of a potent peptide inhibitor of estrogen receptor α” Chinese Chemical Letters, 2018, https://doi.org/10.1016/j.cclet.2018.04.004 Xiaodong Shi, Rongtong Zhao, Yixiang Jiang, Hui Zhao, Yuan Tian, Yanhong Jiang, Jingxu Li, Weirong Qin, Feng Yin*, Zigang Li* “Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation ” Chem. Sci., 2018, DOI: 10.1039/C7SC05109C. Wenjun Li,‡ Kuan Hu,‡ Qingzhou Zhang, Dongyuan Wang, Yue Ma, Zhanfeng Hou, Feng Yin*, Zigang Li* “N terminal N-methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties ” Chem. Commun. 2018; doi: DOI: 10.1039/C7CC09201F.