李志成 - 北京大学 - 化学生物学与生物技术学院

研究领域

发展高效通用的双模式路易斯酸介导的串联反应及其在天然产物全合成中的应用

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Du, G.; Bao, W.; Huang, J.; Huang, S.; Yue, H.; Yang, W.; Zhu, L.; Liang, Z.; Lee, C.-S. “Enantioselective Synthesis of the ABC-Tricyclic Core of Phomactin A by a γ-Hydroxylation Strategy” Org. Lett. 2015, 17, 2062-2065. Liang, Z.; Chan, C.-F.; Liu, Y.; Wong, W.-T.; Lee, C.-S.; Law, G.-L.; Wong, K.-L. “The effects of the increasing number of the same chromophore on photosensitization of water-soluble cyclen-based europium complexes with potential for biological applications” RSC Adv. 2015, 5, 13347-13356. Yang, W.; Cao, J.; Zhang, M.; Lan, R.; Zhu, L.; Du, G.; He, S.; Lee, C.-S. “Systemic Study on the Biogenic Pathways of Yezo’otogirins: Total Synthesis and Antitumor Activities of (±)-Yezo’otogirin C and Its Structural Analogues” J. Org. Chem. 2015, 80, 836-846. Min, L.; Zhang, Y.; Liang, X.; Huang, J.; Bao, W.; Lee, C.-S. “A Biomimetic Synthesis of (±)-Basiliolide B” Angew. Chem. Int. Ed. 2014, 53, 11294-11297. He, S.; Yang, W.; Zhu, L.; Du, G.; Lee, C.-S. “Bioinspired Total Synthesis of (±)-Yezo’otogirin C” Org. Lett. 2014, 16, 496-499. Zhu, L.; Du, G.; Yang, W.; Min, L.; Liu, X.; Huang, S.; Han, Y.; Lee, C.-S. “Applications of Dual-Mode Lewis Acids Induced Cascade Cyclization Reactions in Natural Product Synthesis” Chin. J. Org. Chem. 2013, 33, 2031-2045. (Invited Account, Cover) Li, H.; Chadbourne, F. L.; Lan, R.; Chan, C.-F.; Chan, W.-L.; Law, G.-L.; Lee, C.-S.; Cobb, S. L.; Wong, K.-L. “Real time detection of cell cycle regulator cyclin A on living tumor cells with europium emission” Dalton Trans. 2013, 13495-13501. Zhu, L.; Zhou, C.; Yang, W.; He, S.; Cheng, G.-J.; Zhang, X.; Lee, C.-S. “Formal Syntheses of (±)-Platensimycin and (±)-Platencin via a Dual-Mode Lewis Acid Induced Cascade Cyclization Approach” J. Org. Chem. 2013, 78, 7912-7929. Zhu, L.; Han, Y.; Du, G.; Lee, C.-S. “A Bifunctional Lewis Acid Induced Cascade Cyclization to the Tricyclic Core of ent-Kaurenoids and Its Application to the Formal Synthesis of (±)-Platensimycin” Org. Lett. 2013, 15, 524-527. Xiaozu Liu and Chi-Sing Lee* “Total Synthesis of (?)-Teucvidin” Org. Lett. 2012, 14: 2886-2889. Shuzhong He, Hongguang Li, Yuk-Wang Yip, Chi-Tung Yeung, Yuen On Fung, Hoi-Kuan Kong, Ho-Lun Yeung, Ga-Lai Law, Ka-Leung Wong, Chi-Sing Lee,* Michael Hon-Wah Lam,* Margaret B. Murphy, Paul Kwan-Sing Lam and Wing-Tak Wong “Responsive Two-Photon Induced Europium Emission as Fluorescent Indicator for Paralytic Shellfish Saxitoxin” Org. Lett. 2011, 13: 5036-5039. Shanping Huang, Du, Guangyan and Chi-Sing Lee* “Construction of the Tricyclic Furanochroman Skeleton of Phomactin A via the Prins/Conia-Ene Cascade Cyclization Approach” J. Org. Chem. 2011, 76: 6534-6541. Hoi-Kwan Kong, Frances L. Chadbourne, Ga-Lai Law, Hongguang Li, Hoi-Lam Tam, Steven L Cobb,* Chi-Kong Lau,* Chi-Sing Lee* and Ka-Leung Wong* “Two-Photon Induced Responsive f-f Emissive Detection for Cyclin A with a Europium-Chelating Peptide” Chem. Commun. 2011, 47: 8052-8054. Wanqing Wu, Long Min, Lizhi Zhu and Chi-Sing Lee* “A New Class of Enantioselective Catalytic 2-Pyrone Diels-Alder Cycloadditions” Adv. Synth. Catal. 2011, 353: 1135-1145.