叶志强 - 北京大学 - 化学生物学与生物技术学院

研究领域

（1）研究策略和开发技术用于整合各类异质的生物数据，以开展数据挖掘工作；（2）采用机器学习或者基于经验的手段，预测基因组变异包括单核苷酸变异和拷贝数变异的疾病相关性，特别是WD40结构域中的错义单核苷酸变异；（3）研究WD40结构域的结构特征以及其与功能的关系；（4）运用生物信息学工具开展药物基因组学和个体化医疗的研究。

近期论文

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Wang, Y.; Hu, X.J.; Zou, X.D.; Wu, X.H.; Ye, Z.Q.*; Wu, Y.D.*, WDSPdb: A Database for WD40-repeat Proteins. Nucleic Acids Res, 2015. 43(Database Issue) D339-344. Li, Y.Y.; Chang, X.; Yu, W.B.; Li, H.; Ye, Z.Q.; Yu, H.; Liu, B.H.; Zhang, Y.; Zhang, S.L.; Ye, B.C.; Li, Y.X.; Systems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains. BMC Genomics, 2013. 14(1) 523. Yang, J.; Li, Y. Y.; Li, Y. X.; Ye, Z. Q. Partition dataset according to amino acid type improves the prediction of deleterious non-synonymous SNPs. Biochem. Biophys. Res. Commun. 2012, 419: 99-103. Yu, H.; Liu, B. H.; Ye, Z. Q.; Li, C.; Li, Y. X.; Li, Y. Y. Link-based Quantitative Methods to Identify Differentially Coexpressed Genes and Gene Pairs. BMC bioinformatics 2011, 12: 315. Ye, Z. Q.; Niu, S.; Yu, Y.; Yu, H.; Liu, B. H.; Li, R. X.; Xiao, H. S.; Zeng, R.; Li, Y. X.; Wu, J. R.; Li, Y. Y. Analyses of Copy Number Variation of GK Rat Reveal New Putative Type 2 Diabetes Susceptibility Loci. PLoS One 2010, 5: e14077. #Huang, T.; #Wang, P.; #Ye, Z. Q.; Xu, H.; He, Z.; Feng, K. Y.; Hu, L.; Cui, W.; Wang, K.; Dong, X.; Xie, L.; Kong, X.; Cai, Y. D.; Li, Y. X. Prediction of deleterious non-synonymous SNPs based on protein interaction network and hybrid properties. PLoS One 2010, 5: e11900. Shen, L.; Gao, G.; Zhang, Y.; Zhang, H.; Ye, Z. Q.; Huang, S.; Huang, J.; Kang, J. A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA. Nucleic Acids Res 2010, 38: 6054-6064. Du, C.; Liu, C.; Kang, J.; Zhao, G.; Ye, Z. Q.; Huang, S.; Li, Z.; Wu, Z.; Pei, G. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat. Immunol. 2009, 10: 1252-1259. Ye, Z. Q.; Zhao, S. Q.; Gao, G.; Liu, X. Q.; Langlois, R. E.; Lu, H.; Wei, L. Finding new structural and sequence attributes to predict possible disease association of single amino acid polymorphism (SAP). Bioinformatics 2007, 23: 1444-1450. Li, C. Y.; #Yu, Q.; #Ye, Z. Q.; Sun, Y.; He, Q.; Li, X. M.; Zhang, W.; Luo, J.; Gu, X.; Zheng, X.; Wei, L. A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. Cell Res. 2007, 17: 357-362. (Joint firest author) Kong, L.; Zhang, Y.; Ye, Z. Q.; Liu, X. Q.; Zhao, S. Q.; Wei, L.; Gao, G. CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine. Nucleic Acids Res 2007, 35: W345-349.