林硕 - 北京大学 - 化学生物学与生物技术学院

研究领域

由于斑马鱼具有体外发育，胚胎透明，可以在单细胞水平上对胚胎发育和器官形成进行直接的分析等优点，被认为是一个很好的体内化学生物学研究的模式脊椎动物。随着斑马鱼基因组序列项目的完成，其作为功能基因组学和化学生物学的工具为解决基本的生物学问题，人类疾病建模和新药研发提供了新的巨大的机会。我们正在使用化学生物学方法，利用斑马鱼鉴定在癌症，心血管，代谢和神经系统疾病上具有治疗性应用的新的小分子

近期论文

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Wei Qin, Zelin Chen,Yihan Zhang, Ruibin Yan,Guanrong Yan,Song Li,Hanbing Zhong, and Shuo Lin.,” Nom1 Mediates Pancreas Development by Regulating Ribosome Biogenesis in Zebrafish” PLoS One.2014,9(6):e100796. Da Liu, Zhanxiang Wang, An Xiao, Yutian Zhang,Wenyuan Li, Yao Zu,, Shaohua Yao, Shuo Lin,Bo Zhang.,” Efficient Gene Targeting in Zebrafish Mediated by a Zebrafish-Codon-Optimized Cas9 and Evaluation of Off-Targeting Effect” Journal of Genetics and Genomics.2014,41(1): 43-46. ChaoCheBo YangXianlong JiangTaofeng ShaoZhixiong YuChuanye TaoSong LiShuoLin.,” Syntheses of Fused Tetracyclic Quinolines via Ugi-Variant MCR and Pd-Catalyzed Bis-annulation” The Journal of organic chemistry.2014,79(1): 436-440. Guiqi Ren, Song Li, Hanbing Zhong and Shuo.,”Encodes Tryptophan Hydroxylase Zebrafish tyrosine hydroxylase 2 Gene” J. Biol. Chem. 2013, 288:22451-22459. Lu J, Xin S, Meng H, Veldman M, Schoenfeld D, Che C, Yan R, Zhong H, Li S, Lin S.,”A Novel Anti-Tumor Inhibitor Identified by Virtual Screen with PLK1 Structure and Zebrafish Assay” PLoS One. 2013,26;8(4):e53317. Che C., Li S., Yu Z. X., Li F. F., Xin S. C., Zhou L. Y., Lin S., Yang, Z., “One-Pot Syntheses of Isoquinolin-3-ones and Benzo-1,4-diazepin-2,5-diones Utilizing Ugi-4CR Post-Transformation Strategy”ACS Combinatorial Science.2013, 15 (4):202-207. Xin SC, Zhao YQ, Li S, Lin S, Zhong HB,Application of zebrafish models in drug screening”Yi Chuan. 2012, 34(9):1144-52. Peng Huang, An Xiao, Mingguo Zhou, Zuoyan Zhu, Shuo Lin，Bo Zhang.,” Heritable gene targeting in zebrafish using customized TALENs” Nature Biotechnology.2011,29(8) :699–700. ZhidanXiaXiangjunTongFangLiang Yihan ZhangChikin KuokYingla ZhangXinxingLiuZuoyanZhuShuoLinBoZhang.,” Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish” Developmental Biology.2013,381(1):83-96. Yike YuanYuwei ZhaoShengchang XinNi WuJiaolin WenSong LLijuan ChenYuquan WeHanshuo YangShuo Lin.,” A Novel PEGylated Liposome-Encapsulated SANT75Suppresses Tumor Growth through Inhibiting HedgehogSignaling Pathway” PLoS One.2013,8(4):e60266. Chao Che， Song Li， Bo Yang， Shengchang Xin， Zhixiong Yu，Taofeng Shao， Chuanye Tao， Shuo Lin， and Zhe.,” Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors” Beilstein J. Org. Chem..2012,8: 841-849. Yanqun Chen, Bin Wu, Liangliang Xu, Huapeng Li, Jianhong Xia, Wenguang Yin, Zhuo Li, Song Li, Shuo Lin, Xiaodong Shu and Duanqing Pei.,”A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo”Cell Research . 2012, 22(2)” 333-345. Liangliang Xu, Wenguang Yin, Jianhong Xia,Meixiu Peng,Song Li,Shuo Lin,Duanqing Pei,and Xiaodong Shu.,” An Antiapoptotic Role of Sorting Nexin 7 Is Required for Liver Development in Zebrafish”HEPATOLOGY 2012;55:1985-1993 Lu Chen, Xi Ren, Fang Liang, Song Li, Hanbing Zhong, Shuo Lin.,“ Characterization of two novel small molecules targeting melanocyte development in zebrafish embryogenesis” Pigment Cell & Melanoma Research.2012,25(4):446–453. Zhang Y, Morimoto K, Danilova N, Zhang B, Lin S.,” Zebrafish Models for Dyskeratosis Congenita Reveal Critical Roles of p53 Activation Contributing to Hematopoietic Defects through RNA Processing” PLoS ONE.2012,7(1) :e30188. Guiqi Ren, Shengchang Xin, Song Li, Hanbing Zhong, Shuo Lin.,” Disruption of LRRK2 Does Not Cause Specific Loss of Dopaminergic Neurons in Zebrafish” PLoS one.2011,6(6) :e20630. Hanbing Zhong, Danyang Wang, Nan Wang, Yesenia Rios, Haigen Huang, Song Li, Xinrong Wu,Shuo Lin.,” Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity” Cell Research.2011,4(1):1080-1087. Fei Qi, Jianbo Song, Hanshuo Yang, Wei Gao, Ning-ai Liu, Bo Zhang, and Shuo Lin.,” Mmp23b promotes liver development and hepatocyte proliferation through the tumor necrosis factor pathway in zebrafish” Hepatology.2010,52(6) :2158-66. Chao Che, Song Li, Xianlong Jiang, Junmin Quan, Shuo Lin, and Zhen Yang.,” One-Pot Syntheses of Chromeno[3,4-c]pyrrole-3,4-diones via Ugi-4CR and Intramolecular Michael Addition” ORGANIC LETTERS.2010,12(20)”4682-4685. Ren X, Gomez GA, Zhang B, Lin S. “Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells” Blood. 2010, 115:5338-5346. Hanbing Zhong, Shengchang Xin, Yanqiu Zhao , Jing Lu , Song Li, Jianxian Gong, Zhen Yang and Shuo.,” Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish” Molecular BioSystems,2010,6(8):1463-8. Haixia Zou, Liyan Zhou,Yuanzhen Li, Yi Cui, Hanbing Zhong,Zhengying Pan,Zhen Yang.,” Benzo[e]isoindole-1,3-diones as Potential Inhibitors of Glycogen Synthase Kinase-3 (GSK-3)” Journal of Medicinal Chemistry.2010,53(3): 994-1003. Hanbing Zhong, Haixia Zou, Mikhail V. Semenov, Deborah Moshinsky, Xi He, Haigen Huang, Song Li, Junmin Quan, Zhen Yang and Shuo Lin.,” Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling” Molecular BioSystems.2009,11(5):1356-1360 Hongbo Yang, Jing Xiang, Nengdong Wang, Yun Zhao, Joel Hyman, Song Li, Jin Jiang, James K. Chen, Zhen Yang, Shuo Lin.,” Converse conformational control of smoothened activity by structurally related small molecules” JOURNAL OF BIOLOGICAL CHEMISTRY.2009,284(31):20876-884. Jing Xiang, Hongbo Yang, Chao Che, Haixia Zou, Hanshuo Yang, Yuquan Wei, Junmin Quan, Hui Zhang, Zhen Yang, Shuo Lin.,” Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays” PLoS ONE.2009, 4(2):e4361.