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个人简介

教育背景、工作经历 2020-至今 兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授 2012-2020 兰州大学化学化工学院、功能有机分子化学国家重点实验室,副教授 2009-2012 诺华生物医学研究中心(CNIBR) (导师: 江磊),博士后 2004-2009 中国科学院上海有机化学研究所 (导师: 伍贻康),理学博士 2000-2004 四川大学,工学学士 荣誉奖励 2020 德国“Thieme Chemistry Journals Award” 2019 亚洲核心计划“ACP Lectureship Award” 2019 入选甘肃省“飞天学者特聘计划”青年学者

研究领域

天然产物全合成,有机合成方法学及药物化学

近期论文

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Enantioselective Total Synthesis of (−)-Cyathin B2: A Desymmetric Double-Allylboration Approach. Jianping Wang, Jiacheng Yin, Hayatullah Imtiaz, Hongyu Wang and Yun Li* J. Am. Chem. Soc. 2024, 146, 25078-25087 Diastereoselective Ring Expansion of Cyclic Ketones Enabled by HAT-Initiated Radical Cascade, Wenxue Wang, Shouyang Feng, Yansheng Wei, Hongyu Wang and Yun Li* Org. Lett., 2023, 25, 8022-8026. Generic Interpretable Reaction Condition Predictions with Open Reaction Condition Datasets and Unsupervised Learning of Reaction Center, Xiaorui Wang, Chang-Yu Hsieh, Xiaodan Yin, Jike Wang, Yuquan Li, Yafeng Deng, Dejun Jiang, Zhenxing Wu, Hongyan Du, Hongming Chen, Yun Li, Huanxiang Liu, Yuwei Wang,Pei Luo, Tingjun Hou*,‡, Xiaojun Yao* Research. 2023, DOI: 10.34133/research.0231 Fused-Ring-Linked Covalent Organic Frameworks, Jie Feng, Ya-Jie Zhang, Sheng-Hua Ma, Chen Yang, Zhi-Peng Wang, San-Yuan Ding, Yun Li, and Wei Wang* J. Am. Chem. Soc. 2022, 144, 6594–6603 Synthetic studies on pseudolaric acid B: Enantioselective synthesis of C4,C10-di-epi-trans-fused [5-7]-bicyclic skeleton, Rui Guo, Hongbin Zhai, and Yun Li* Chin. Chem. Lett., 2021, 32, 1400-1402 Quick Access to Pyridines through 6π-3-Azatriene Electrocyclization: Concise Total Synthesis of Suaveoline Alkaloids, Hongbo Wei, and Yun Li* Synlett, 2019, 30, 1615-1620 Enantioselective Total Synthesis of (+)-Arboridinine, Zhen Zhang, Sujun Xie, Bin Cheng, Hongbin Zhai*, and Yun Li* J. Am. Chem. Soc. 2019, 141, 7147-7154 Stereoselective Synthesis of Spiro-2-oxabicyclo[2.2.2]octane Enabled by Ag(I)/ Brønsted Acid Relay Catalysis, Qingyu Zhang, Jianping Wang, Yansheng Wei, Hongbin Zhai and Yun Li* Org. Lett., 2019, 21, 1694-1698 Facile Synthesis of Pyridines from Propargyl Amines: Concise Total Synthesis of Suaveoline Alkaloids, Zhiwen Zhao,^ Hongbo Wei, ^ Ke Xiao, Bin Cheng, Hongbin Zhai and Yun Li* Angew. Chem. Int. Ed., 2019, 58, 1148-1152 |^ contributed equally. Relay Catalysis of Rh (II) and Cobaloxime: Stereoselective Synthesis of Spiroindanones from N-sulfonyl-1,2,3-triazoles, Zhao Liu, Qiuchen Du, Hongbin Zhai, and Yun Li*, Org. Lett. 2018, 20, 7514-7517 The Expanding Utility of Rhodium‐Iminocarbenes: Recent Advances in the Synthesis of Natural Products and Related Scaffolds, Yun Li*, Hongjian Yang, and Hongbin Zhai* Chem. –Eur. J. 2018, 24, 12757-12766 Organocatalytic Synthesis of 4-Aryl-1,2,3,4-tetrahydropyridines from Morita-Baylis-Hillman Carbonates through a One-Pot Three-Component Cyclization, Jian Wei, Yuntong Li, Cheng Tao, Huifei Wang, Bin Cheng , Hongbin Zhai* , and Yun Li* J. Org. Chem. 2018, 83, 835-842 Bioinspired Total Synthesis of (±)-Chaetophenol C Enabled by a Pd-Catalyzed Cascade Cyclization, Yun Li*, Qingyu Zhang, Hongyu Wang, Bin Cheng, Hongbin zhai* Org. Lett. 2017, 19, 4387-4390 Rhodium-Catalyzed Denitrogenative [3+2] Cycloaddition: Access to Functionalized Hydroindolones and the Framework of Montanine-Type Amaryllidaceae Alkaloids, Hongjian Yang, Shengtai Hou, Cheng Tao, Zhao Liu, Chao Wang, Bin Cheng, Yun Li* and Hongbin Zhai* Chem. –Eur. J. 2017, 23, 12930-12936 Cobaloxime-catalyzed hydration of terminal alkynes without acidic promoters. Shengtai Hou, Hongjian Yang, Bin Cheng, Hongbin Zhai and Yun Li* Chem. Commun., 2017, 53, 6926-6929 Rh-Catalyzed [3 + 2] Cycloaddition of 1-Sulfonyl-1,2,3-triazoles: Access to the Framework of Aspidosperma and Kopsia Indole Alkaloids. Yun Li*, Qingyu Zhang, Qiucheng Du, and Hongbin Zhai* Org. Lett. 2016, 18, 4076-4079 An environmentally friendly approach to pyrrolo[1,2-a]quinoxalines using oxygen as the oxidant. Chao Wang, Yun Li*, Jianfei Zhao, Bin Cheng, Huifei Wang, Hongbin Zhai* Tetrahedron Lett. 2016, 57, 3908-3911 Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy. Hongbo Wei, Yun Li,* Ke Xiao, Bin Cheng, Huifei Wang, Lin Hu, and Hongbin Zhai* Org. Lett. 2015, 17, 5974−5977 [link] Stereoselective Synthesis of (2Z)‑2,4-Dienamides via NBS-Mediated Allyloxyl Addition−Claisen Rearrangement−Dehydrobromination Cascade Reaction of Ynsulfonamides. Runbo Ding, Yun Li,* Cheng Tao, Bin Cheng, and Hongbin Zhai* Org. Lett. 2015, 17, 3994−3997 [link] Total Synthesis of the Diterpenoid (+)-Harringtonolide. Zhang, H.; Hu, L.; Ma, Z.; Li, R.; Zhang, Z.; Tao, C.; Cheng, B.; Li, Y.; Wang, H.; Zhai, H.* Angew. Chem. Int. Ed. 2016, 55, 11638-11641 A One-Pot Synthesis of Dibenzofurans from 6-Diazo-2-cyclohexenones. Zhao, Hua; Yang, Ke; Zheng, H.; Ding, R.; Yin, F.; Wang, N.; Li, Y.; Cheng, B.; Wang, H.; Zhai, H.* Org. Lett. 2015, 17, 5744-5747 Iodine-Catalyzed Facile Synthesis of Pyrrolo- and Indolo[1,2-a]quinoxalines. Wang, C.; Li, Y.; Guo, R.; Tian, J.; Tao, C.; Cheng, B.; Wang, H.; Zhang, J.; Zhai, H.* Asian J. Org. Chem. 2015, 4, 866-869 Expedient construction of the [5-6-7] tricyclic core of calyciphylline a-type alkaloids. Guo, J. J.; Li, Y.; Cheng, B.; Xu, T.; Tao, C.; Yang, X.; Zhang, D.; Yan, G.; Zhai, H.* Chem.-Asian J. 2015, 10, 865-868 Silver(I)-catalyzed ring-contractive rearrangement: a new entry to 5-alkylidene-2-cyclopentenones. Zhao, L.; Wang, J.; Zheng, H.; Li, Y.; Yang, K.; Cheng, B.; Jin, X.; Yao, X.; Zhai, H.* Org. Lett. 2014, 16, 6378-6381 Stereocontrolled total syntheses of (+/-)-fawcettimine, (+/-)-lycoflexine, and (+/-)-lycoflexine N-oxide. Xu, K.; Cheng, B.; Li, Y.; Xu, T.; Yu, C.; Zhang, J.; Ma, Z.; Zhai, H.* Org. Lett. 2014, 16, 196-199 Total synthesis of indole alkaloid (+/-)-subincanadine E. Tian, J.; Du, Q.; Guo, R.; Li, Y.; Cheng, B.; Zhai, H.* Org. Lett. 2014, 16, 3173-3175 Total synthesis of (+/-)-sculponeatin N. Pan, Z.; Zheng, C.; Wang, H.; Chen, Y.; Li, Y.; Cheng, B.; Zhai, H.* Org. Lett. 2014, 16, 216-219 Direct access to tetrahydro[1,2]diazepinones from alpha,beta-epoxy-N-aziridinylimines via anionic rearrangement. Wu, F.; Dong, M.; Fang, F.; Sang, Y.; Li, Y.; Cheng, B.; Zhang, L.; Zhai, H.* Org. Lett. 2013, 15, 914-916

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