楼滨 - 复旦大学

个人简介

教育经历 1979.09-1983.07 上海医科大学药学院药化专业，学士 1986.09-1989.07 上海医科大学药学院放射化学专业，硕士 2000.09-2005.03 复旦大学药学院生物化学和分子生物学专业，博士工作经历 1983.08-1986.07 江苏省原子医学所工作 1989.08-2007.02 复旦大学药学院生物化学教研室任讲师、副教授 2007.03-2010.05 美国艾默里（Emory University）大学药理系进修 2010.06-至今复旦大学药学院工作，现任药学院药理生化教研室副教授

研究领域

主要从事鞘磷脂与脂蛋白代谢、动脉粥样硬化及其炎症等研究。曾研发抗血栓药物-低分子肝素,并转让给企业, 获四类新药证书。参与“载脂蛋白A-I的抗内毒素、抗炎症新功能研究及人载脂蛋白A-I的基因工程制备”获2004年上海市药学会颁发的上海药学成果奖二等奖。 2007年到2010年在美国Emory大学药理系进修，用高通量筛选技术筛选ASK1炎症信号通路抑制剂，并研究这些化合物抗ASK1炎症通路的作用机理。用高内涵筛选技术研究curcumin及其衍生物抗肿瘤作用。参与人民卫生出版社出版的全国高等学校教材“药学分子生物学”第二，第三，第四版,第五版编写。

近期论文

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Yali Li, Taomin Huang, Bin Lou*, Deyong Ye, Xiangyu Qi, Xiaoxia Li, Shuang Hu, Tingbo Ding, Yan Chen, Yang Cao, Mingguang Mo, Jibin Dong, Min Wei, Yong Chu, Huiti Li, Xian-Cheng Jiang, Nengneng Cheng a, Lu Zhou. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 1; 163: 864-882, 2019 Bin Lou*, Qi Liu Jiahui Hou, Inamul Kabir, Peipei Liu, Tingbo Ding, Jibin Dong, Mingguang Mo, Deyong Ye, Yang Chen, Hai H. Bui, Kenneth Roth, Yu Cao, Xian-Cheng Jiang. 2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity. J Biol Chem. 293(47):18328-18336, 2018 Chunyan Feng, Bin Lou*, Jibin Dong, Zhiqiang Lib, Yunqin Chen, Yue Li, Xuemei Zhang, Xian-Cheng Jiang, Tingbo Ding. Lysophosphatidylcholine acyltransferase 3 de?ciency impairs 3T3L1 cell adipogenesis through activating Wnt/β-catenin pathway. BBA - Molecular and Cell Biology of Lipids 1863: 834–843,2018 Hui Jiang, Amirfarbod Yazdanyar, Bin Lou*, Yunqin Chen, Xiaomin Zhao, Ruohan Li, Hai Hoang Bui, Ming-Shang Kuo, Mohamad Navab, Shucun Qin, Zhiqiang Li, Weijun Jin, Xian-Cheng Jiang. Adipocyte Phospholipid Transfer Protein and Lipoprotein Metabolism. Arteriosclerosis, Thrombosis, and Vascular Biology.; 35:316–322,2015 Bin Lou*, Jibin Dong., Yali Li, Tingbo Ding, Tingting Bi, Yue Li, Xiaodong Deng, Deyong Ye, Xian-Cheng Jiang.Pharmacologic Inhibition of Sphingomyelin Synthase (SMS) Activity Reduces Apolipoprotein-B Secretion from Hepatocytes and Attenuates Endotoxin-Mediated Macrophage Inflammation. PLoS ONE 9(7): e102641，2014 Xiaodong Deng, Fu Lin, Ya Zhang, Yan Li, Lu Zhou, Bin Lou*, Yue Li, Jibin Dong, Tingbo Ding, Xiancheng Jiang, Renxiao Wang, Deyong Ye. Identification of small molecule sphingomyelin synthase inhibitors. European Journal of Medicinal Chemistry, 73(12), 1–7, 2014 Tingbo Ding, Jibin Dong, Bin Lou*, XianCheng Jiang. Sphingomyelin synthase activity measurement by the fluorescent product in cell culture medium or animal plasma. J. Chin. Pharm. Sci. 2014, 23 (4), 256–261 Guo-Xun Yang, Rui-Ze Zhang, Bin Lou*, Ke-Jun Cheng, Juan Xiong & Jin-Feng Hua. Chemical constituents from Melastoma dodecandrum and their inhibitory activity on interleukin-8 production in HT-29 cells. Natural Product Research, Volume 28, Issue 17, 2014, pages 1383 1387 . Yuhong Du, Robert W. Fu, Bin Lou*, Jing Zhao,Min Qui, Fadlo R. Khuri, and Haian Fu. A Time-Resolved Fluorescence Resonance EnergyTransfer Assay for High-Throughput Screening. ASSAY and Drug Development Technologies.11 (6), 367-381, 2013. Jing Zhao, Yuhong Du, John Horton, Anup Upadhyay, Bin Lou*, Xing Zhang, Lupei Du, Minyong Li, Binghe Wang, Lixin Zhang, Joseph Barbieri, Fadlo Khuri, Xiaodong Cheng, and Haian Fu. Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. PNAS 108 (39) 16212–16216, 2011.