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Bao W#, You Y#, Ni J#, Hou H, Lyu J, Feng G, Wang Y, You K, Zhang S, Zhang L, Cao X, Wang X, Li H, Li H, Xu J, Liu C, Luo X, Du P*, Chen D*, Shen X*. Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells. Sci Adv. 2023;9(35): eadh5016.
Liao L#, Dang W#, Lin T#, Yu J, Liu T, Li W, Xiao S, Feng L, Huang J, Fu R, Li J, Liu L, Wang M, Tao H, Jiang H, Chen K, Diao X, Zhou B*, Shen X*, Luo C*. A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6. Acta Pharmaceutica Sinica B 2022 Nov;12(11):4180-4192.
Wang Y#, You K#, You Y, Li Q, Feng G, Ni J, Cao X, Zhang X, Wang Y, Bao W, Wang X, Chen T, Li H, Huang Y, Lyu J, Yu S, Li H, Xu S*, Zeng K*, Shen X*. Paeoniflorin prevents aberrant proliferation and differentiation of intestinal stem cells by controlling C1q release from macrophages in chronic colitis. Pharmacol Res. 2022 Aug;182:106309.
Tang ML#, Li H#, Ning JF, Shen X*, Sun X*. Discovery of First-in-Class TAK1-MKK3 Protein-Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production. J Med Chem. 2022 May 12;65(9):6690-6709.
Ma H#, Guo X, Cui S, Wu Y, Zhang Y, Shen X*, Xie C*, Li J*. Dephosphorylation of AMP-activated kinase exacerbates ischemia/reperfusion-induced acute kidney injury via mitochondrial dysfunction. Kidney Int. 2022; 101(2):315-330.
Wang X#, Ni J#, You Y#, Feng G, Zhang S, Bao W, Hou H, Li H, Liu L, Zheng M, Wang Y, Zhou H*, Shen W*, Shen X*. SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade. EMBO J. 2021 Nov 8;e108080. doi: 10.15252/embj.2021108080.
Bao W, Liu X, You Y, Hou H, Wang X, Zhang S, Li H, Feng G, Cao X, Jiang H, Zheng M*, Shen X*. Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation. Pharmacol Res. 2021 Jul;169:105679.
You Y#, Bao WL#, Zhang S, Li HD, Li H, Dang WZ, Zou SI, Cao XY, Wang X, Liu LX, Jiang H, Qu L*, Zheng M*, Shen X*. Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-dependent TFEB Signaling Pathway. Circ Res. 2020; 127(4):534-549.
Liu L#, Zhang S#, Wang Y, Bao W, Zhou Y, Dang W, Wang X, Li H, Cao X, You Y, Fang H, Shen X*. BIG1 controls macrophage pro-inflammatory responses through ARF3-mediated PI(4,5)P2 synthesis. Cell Death Dis. 2020;11(5):374.
Zhang S#, Yang Z#, Bao W, Liu L, You Y, Wang X, Shao L, Fu W, Kou X, Shen W, Yuan C, Hu B, Dang W, Nandakumar KS, Jiang H, Zheng M*, Shen X*. SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC. Autophagy 2020; 16(4):735-749.
You Y, Li WZ, Zhang S, Hu B, Li YX, Li HD, Tang HH, Li QW, Guan YY, Liu LX, Bao WL, Shen X*. SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy. J Hepatol. 2018;69(1):129-141.
Zhou C, You Y, Shen W, Zhu YZ, Peng J, Feng HT, Wang Y, Li D, Shao WW, Li CX, Li WZ, Xu J, Shen X*. Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation. Ann Rheum Dis. 2016 Jun;75(6):1211-8
Lin S, Zhou C, Neufeld E, Wang YH, Xu SW, Lu L, Wang Y, Liu ZP, Li D, Li C, Chen S, Le K, Huang H, Liu P, Moss J, Vaughan M, Shen X* . BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein modulates ABCA1 trafficking and function. Arterioscler Thromb Vasc Biol. 2013;33(2):e31-8.
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