钱忠明 - 复旦大学

个人简介

1981年毕业于北京大学医学院，获医学硕士学位。1993年毕业于澳大利亚西澳大利亚大学（UWA），获博士学位。1993年-2012年任职香港理工大学应用生物化学系讲师，助理教授，副教授，教授等，以及香港理工大学深圳现代中药研究所副所长和香港理工大学动物资源中心主任及管理委员会主席。2012年9月至今任职复旦大学特聘教授（全职）。同时，担任中国制药工业药理学会副主任委员，中国应用药理学会理事，和国际生物医药与生物技术学会(IABB) 副理事长。曾先后担任美国耶鲁大学访问教授、北京大学、浙江大学、中国科学院北京生物物理所联合培养计划博士生导师。长期从事“脑铁代谢及相关疾病机理与神经药理学”领域的研究。至今发表论文289篇，其中SCI论文145篇，总影响因子大于650，他引大于6200次。获药物相关专利13项（另10项处于审批阶段）、保健食品注册批件6件、主编铁代谢专著2部、参编5部。获2009年度“何梁何利基金科学与技术进步奖（医学与药学组）”等奖项。目前承担国家973（课题组长/骨干）和国家自然科学基金重点和面上等项目。

研究领域

长期从事“脑铁代谢及相关疾病机理与神经药理学”领域的研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Zhou YF, Wu XM, Zhou G, Mu MD, Zhang FL, Li FM, Qian C, Du F, Yung WH, Qian ZM*, Ke Y*. Cystathionine β-synthase is required for body iron homeostasis. Hepatology 2018 Jan;67(1):21-35. doi: 10.1002/hep.29499. Li Q, Ko H, Qian ZM, Yan LYC, Chan DCW, Arbuthnott G, Ke Y, Yung WH. Refinement of learned skilled movement representation in motor cortex deep output layer. Nat Commun 2017 Jun 9;8:15834. doi: 10.1038/ncomms15834. Zhang FL, Hou HM, Yin ZN, Chang L, Li FM, Chen YJ, Ke Y*, Qian ZM*. Impairment of Hepcidin Upregulation by Lipopolysaccharide in the Interleukin-6 Knockout Mouse Brain. Front Mol Neurosci 2017 Nov 7;10:367. doi: 10.3389/fnmol.2017.00367. Zhou YF, Zhang C, Yang G, Qian ZM*, Zhang MW, Ma J, Zhang FL, Ke Y*. Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron. Front Physiol 2017 May 23; 8:332. doi: 10.3389/fphys.2017.00332. Wu XM, Qian C, Zhou YF, Yan YC, Luo QQ, Yung WH, Zhang FL, Jiang LR, Qian ZM*, Ke Y*. Bi-directionally protective communication between neurons and astrocytes under ischemia. Redox Biol 2017 May 20; 13:20-31. doi: 10.1016/j.redox.2017.05.010. Lou QQ, Zhou YF, Chen YJ, Liu L, Ma J, Zhang MW, Zhang FL, Ke Y*, Qian ZM*. Ghrelin promotes ferroportin 1 expression via a GHSR/MAPK signaling pathway. J Cell Physiol 2018 Jan; 233(1):30-37. doi: 10.1002/jcp.25931. Yu SS, Jiang LR, Ling Y, Qian ZM*, Zhou YF, Li J, Ke Y*. Nifedipine Increases Iron Content in WKPT-0293 Cl.2 Cells via Up-Regulating Iron Influx Proteins. Front Pharmacol 2017 Feb 13; 8:60. doi: 10.3389/fphar.2017.00060. eCollection 2017. Wang PP, Wu L, Ju Y, Qian ZM*, Wang R*. Age-dependent Allergic Asthma Development and Cystathionine gamma-Lyase Deficiency. Antioxid Redox Signal 2017 Nov 1; 27(13): 931-944. doi: 10.1089/ars.2016.6875 Lu LN, Qian ZM*, Wu KC, Yung WH, Ke Y*. Expression of Iron Transporters and Pathological Hallmarks of Parkinson's and Alzheimer's Diseases in the Brain of Young, Adult, and Aged Rats. Mol Neurobiol 2017 Sep; 54(7):5213-5224. doi: 10.1007/s12035-016-0067-0. Zhu ZJ, Wu KC, Yung WH, Qian ZM*, Ke Y*. Differential interaction between iron and mutant alpha-synuclein causes distinctive Parkinsonian phenotypes in Drosophila. Biochim Biophys Acta 2016 Apr; 1862(4): 518-525. doi: 10.1016/j.bbadis.2016.01.002. Gong J, Du F, Qian ZM*, Luo QQ, Sheng Y, Yung WH, Xu YX, Ke Y*. Pre-treatment of rats with ad-hepcidin prevents iron-induced oxidative stress in the brain. Free Radic Biol Med 2016 Jan; 90:126-32. doi: 10.1016/j.freeradbiomed.2015.11.016. Wu XM, Liu Y, Qian ZM*, Luo QQ, Ke Y*. CX3CL1/CX3CR1 axis plays a key role in ischemia-induced oligodendrocyte injury via p38MAPK signaling pathway. Mol Neurobiol 2016 Aug; 53(6):4010-4018. doi: 10.1007/s12035-015-9339-3 Liu Y, Wu XM, Luo QQ, Huang S, Yang QW, Wang FX, Ke Y*, Qian ZM*. CX3CL1/CX3CR1-mediated microglia activation plays a detrimental role in ischemic mice brain via p38MAPK/PKC pathway. J Cereb Blood Flow Metab 2015 Oct; 35(10):1623-31. doi: 10.1038/jcbfm.2015.97 Du F, Qian ZM*, Luo Q, Yung WH, Ke Y*. Hepcidin suppresses brain iron accumulation by downregulating iron transport proteins in iron-overloaded rats. Mol Neurobiol 2015 Aug; 52(1):101-114. doi: 10.1007/s12035-014-8847-x. Qian ZM*, He X, Lu LN, Wu KC, Yan YC, Yang G, Luo QQ, Yung WH, Ke Y*. Lipopolysaccharides upregulate hepcidin expression in the neurons via microglia and the IL-6/STAT3 signaling pathway. Mol Neurobiol 2014 Mar 23. 50(3):811-820. doi: 10.1007/s12035-014-8671-3 Qian ZM, Ke Y. Huperzine A: is it an effective disease-modifying drug for Alzheimer’s disease? Front Aging Neurosci 2014 Aug 19;6:216. doi: 10.3389/fnagi.2014.00216. Li L, Xiong ZY, Qian ZM*, Zhao TZ, Feng H, Hu S, Hu R, Ke Y, Lin J. Complement C5a is detrimental to histological and functional locomotor recovery after spinal cord injury in mice. Neurobiol Dis 2014 Jun; 66:74-82. doi: 10.1016/j.nbd.2014.02.008 Huang XT, Qian ZM*, He X, Gong Q, Zhu ZJ, Lu LN, Wu KC, Zhang HY, Xin H, Yung WH, Ke Y. Reducing iron in the brain: a novel pharmacological mechanism of Huperzine A in the treatment of Alzheimer’s Disease. Neurobiol Aging 2014 May; 35(5):1045-1054. doi: 10.1016/j.neurobiolaging.2013.11.004 Li Q, Qian ZM, Arbuthnott GW, Ke Y, Yung WH. Cortical Effects of Deep Brain Stimulation Implications for Pathogenesis and Treatment of Parkinson Disease. JAMA Neurol 2014 Jan 1; 71(1):100-103. doi: 10.1001/jamaneurol.2013.4221. Li Q, Ke Y, Chan DC, Qian ZM, Yung KK, Ko H, Arbuthnott GW, Yung WH. Therapeutic deep brain stimulation in parkinsonian rats directly influences motor cortex. Neuron 2012 Dec 6; 76(5):1030-1041. doi: 10.1016/j.neuron.2012.09.032.