个人简介
教育经历
1995.09 – 1999.07 新疆医科大学药学院药学专业
1999.09 – 2002.07 新疆医科大学药学院药剂学硕士
2002.09 – 2005.06 复旦大学药学院药剂学博士
工作经历
2005.07 – 2009.12 复旦大学药学院,讲师
2007.2 – 2008.08 美国Karmanos癌症研究所,博士后
2009.12 – 2017.11 复旦大学药学院,副教授
2016.01 – 至今 复旦大学药学院,博士生导师
2017.12 – 至今 复旦大学药学院,教授
获奖及荣誉
2015.12 中国药学会赛诺菲青年生物药物奖
2005.12 上海药学科技奖二等奖
2010.05 上海青年科技启明星
研究领域
新型纳米递送载体的构建与评价
药物体内生物药剂学评价
中药新剂型的研究
近期论文
查看导师最新文章
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Gu Jijin, Chen Xinyi, Fang Xiaoling, Sha Xianyi*. Retro-inverso d-peptide-modified hyaluronic acid/bioreducible hyperbranched poly (amido amine)/pDNA core-shell ternary nanoparticles for the dual-targeted delivery of short hairpin RNA-encoding plasmids. Acta Biomater 2017, 57:156-169.
Zhang Xiulei, Chen Qinyue, Chen M, Ren Xiaoqing, Wang Xiaofei, Qian Jianghui, Sun Yajuan, Sha Xianyi*. Ambroxol enhances anti-cancer effect of microtubule-stabilizing drug to lung carcinoma through blocking autophagic flux in lysosome-dependent way. Am J Cancer Res. 2017, 7(12):2406-2421.
Gu Jijin, Chen Xinyi, Ren Xiaoqing, Zhang Xiulei, Fang Xiaoling, Sha Xianyi*. CD44-Targeted Hyaluronic Acid-Coated Redox-Responsive Hyperbranched Poly(amido amine)/Plasmid DNA Ternary Nanoassemblies for Efficient Gene Delivery. Bioconjugate Chemistry 2016, 27:1723?1736.
Ren Xiaoqing, Zheng Rui, Fang Xiaoling, Yang Wuli*, Sha Xianyi*. Red blood cell membrane camouflaged magnetic nanoclusters for imaging-guided photothermal therapy. Biomaterials 2016,92:13-24.
Liang Huihui, Ren Xiaoqing, Qian Jianghui, Zhang Xiulei, Meng Lin, Wang Xiaofei, Li Lei, Fang Xiaoling, Sha Xianyi*. Size-Shifting Micelle Nanoclusters Based on a Cross-Linked and pH-Sensitive Framework for Enhanced Tumor Targeting and Deep Penetration Features. ACS Appl Mater Interfaces 2016, 8(16):10136-46.
Gu Jijin, Hao Junguo, Fang Xiaoling, Sha Xianyi*. Factors influencing the transfection efficiency and cellular uptake mechanisms of Pluronic P123-modified polypropyleneimine/pDNA polyplexes in multidrug resistant breast cancer cells. Colloids Surf B Biointerfaces 2016, 140(1):83-93.
Zhang Xiaoyan, Wang Xiaofei, Zhong Weitong, Ren Xiaoqing, Sha Xianyi*, Fang Xiaoling*. Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation. Int J Nanomedicine 2016, 11:1643-61.
Fan Zhuoyang, Chen Cheng, Pang Xiaoying, Yu Zhou, Qi Yan, Chen Xinyi, Liang Huihui, Sha Xianyi*. Adding Vitamin E-TPGS to the Formulation of Genexol-PM: Specially Mixed Micelles Improve Drug-Loading Ability and Cytotoxicity against Multidrug-Resistant Tumors Significantly. PLoS One 2015, 10(4):e0120129.
Gu Jijin, Hao Junguo, Fang Xiaoling, Sha Xianyi*. Reversal of P-glycoprotein-mediated multidrug resistance by CD44 antibody-targeted nanocomplexes for short hairpin RNA-encoding plasmid DNA delivery. Biomaterials, 2015 45: 99-114.
Gu Jijin, Chen Xinyi, Xin Hongliang, Fang Xiaoling, Sha Xianyi*. Serum-resistant complex nanoparticles functionalized with imidazole-rich polypeptide for gene delivery to pulmonary metastatic melanoma. Int J Pharm 2014, 461(1-2):559-69.
Chen Xinyi, Fan Zhuoyang, Chen Yanzuo, Fang Xiaoling, Sha Xianyi*. Retro-inverso carbohydrate mimetic peptides with annexin1-binding selectivity, are stable in vivo, and target tumor vasculature. PLoS One 2013, 8(12):e80390.
Chen Yanzuo, Yang Wuli, Chang Baisong, Hu Hangting, Fang Xiaoling, Sha Xianyi*. In vivo distribution and antitumor activity of doxorubicin-loaded N-isopropylacrylamide-co-methacrylic acid coated mesoporous silica nanoparticles and safety evaluation. Eur J Pharm Biopharm 2013, 85(3):406-12.
Chen Yanzuo, Zhang Wei, Gu Jijin, Ren Qinyue, Fan Zhuoyang, Zhong Weitong, Fang Xiaoling, Sha Xianyi*. Enhanced antitumor efficacy by methotrexate conjugated Pluronic mixed micelles against KBv multidrug resistant cancer. Int J Pharm 2013, 452(1-2):421-33.
Gu Zhengyi, He Jinhua, Yang Xi, Sha Xianyi*. Quantitative determination of rupestonic acid in rat plasma by high-performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study. Biomed Chromatogr 2013, 27(5):563-7.
Fan Zhuoyang, Wu Juan,Fang Xiaoling, Sha Xianyi*. A new function of Vitamin E-TPGS in the intestinal lymphatic transport of lipophilic drugs: Enhancing the secretion of chylomicrons. Int J Pharm 2013, 445(1-2):141-7.
学术兼职
2016.01 – 至今 上海市药学会中药专委会委员
2008.05 – 至今 美国临床肿瘤治疗协会(ASCO)会员
2005.07 – 至今 中国药学会, 会员