沙先谊 - 复旦大学

个人简介

教育经历 1995.09 – 1999.07 新疆医科大学药学院药学专业 1999.09 – 2002.07 新疆医科大学药学院药剂学硕士 2002.09 – 2005.06 复旦大学药学院药剂学博士工作经历 2005.07 – 2009.12 复旦大学药学院，讲师 2007.2 – 2008.08 美国Karmanos癌症研究所，博士后 2009.12 – 2017.11 复旦大学药学院，副教授 2016.01 – 至今复旦大学药学院，博士生导师 2017.12 – 至今复旦大学药学院，教授获奖及荣誉 2015.12 中国药学会赛诺菲青年生物药物奖 2005.12 上海药学科技奖二等奖 2010.05 上海青年科技启明星

研究领域

新型纳米递送载体的构建与评价药物体内生物药剂学评价中药新剂型的研究

近期论文

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Gu Jijin, Chen Xinyi, Fang Xiaoling, Sha Xianyi*. Retro-inverso d-peptide-modified hyaluronic acid/bioreducible hyperbranched poly (amido amine)/pDNA core-shell ternary nanoparticles for the dual-targeted delivery of short hairpin RNA-encoding plasmids. Acta Biomater 2017, 57:156-169. Zhang Xiulei, Chen Qinyue, Chen M, Ren Xiaoqing, Wang Xiaofei, Qian Jianghui, Sun Yajuan, Sha Xianyi*. Ambroxol enhances anti-cancer effect of microtubule-stabilizing drug to lung carcinoma through blocking autophagic flux in lysosome-dependent way. Am J Cancer Res. 2017, 7(12):2406-2421. Gu Jijin, Chen Xinyi, Ren Xiaoqing, Zhang Xiulei, Fang Xiaoling, Sha Xianyi*. CD44-Targeted Hyaluronic Acid-Coated Redox-Responsive Hyperbranched Poly(amido amine)/Plasmid DNA Ternary Nanoassemblies for Efficient Gene Delivery. Bioconjugate Chemistry 2016, 27:1723?1736. Ren Xiaoqing, Zheng Rui, Fang Xiaoling, Yang Wuli*, Sha Xianyi*. Red blood cell membrane camouflaged magnetic nanoclusters for imaging-guided photothermal therapy. Biomaterials 2016,92:13-24. Liang Huihui, Ren Xiaoqing, Qian Jianghui, Zhang Xiulei, Meng Lin, Wang Xiaofei, Li Lei, Fang Xiaoling, Sha Xianyi*. Size-Shifting Micelle Nanoclusters Based on a Cross-Linked and pH-Sensitive Framework for Enhanced Tumor Targeting and Deep Penetration Features. ACS Appl Mater Interfaces 2016, 8(16):10136-46. Gu Jijin, Hao Junguo, Fang Xiaoling, Sha Xianyi*. Factors influencing the transfection efficiency and cellular uptake mechanisms of Pluronic P123-modified polypropyleneimine/pDNA polyplexes in multidrug resistant breast cancer cells. Colloids Surf B Biointerfaces 2016, 140(1):83-93. Zhang Xiaoyan, Wang Xiaofei, Zhong Weitong, Ren Xiaoqing, Sha Xianyi*, Fang Xiaoling*. Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation. Int J Nanomedicine 2016, 11:1643-61. Fan Zhuoyang, Chen Cheng, Pang Xiaoying, Yu Zhou, Qi Yan, Chen Xinyi, Liang Huihui, Sha Xianyi*. Adding Vitamin E-TPGS to the Formulation of Genexol-PM: Specially Mixed Micelles Improve Drug-Loading Ability and Cytotoxicity against Multidrug-Resistant Tumors Significantly. PLoS One 2015, 10(4):e0120129. Gu Jijin, Hao Junguo, Fang Xiaoling, Sha Xianyi*. Reversal of P-glycoprotein-mediated multidrug resistance by CD44 antibody-targeted nanocomplexes for short hairpin RNA-encoding plasmid DNA delivery. Biomaterials, 2015 45: 99-114. Gu Jijin, Chen Xinyi, Xin Hongliang, Fang Xiaoling, Sha Xianyi*. Serum-resistant complex nanoparticles functionalized with imidazole-rich polypeptide for gene delivery to pulmonary metastatic melanoma. Int J Pharm 2014, 461(1-2):559-69. Chen Xinyi, Fan Zhuoyang, Chen Yanzuo, Fang Xiaoling, Sha Xianyi*. Retro-inverso carbohydrate mimetic peptides with annexin1-binding selectivity, are stable in vivo, and target tumor vasculature. PLoS One 2013, 8(12):e80390. Chen Yanzuo, Yang Wuli, Chang Baisong, Hu Hangting, Fang Xiaoling, Sha Xianyi*. In vivo distribution and antitumor activity of doxorubicin-loaded N-isopropylacrylamide-co-methacrylic acid coated mesoporous silica nanoparticles and safety evaluation. Eur J Pharm Biopharm 2013, 85(3):406-12. Chen Yanzuo, Zhang Wei, Gu Jijin, Ren Qinyue, Fan Zhuoyang, Zhong Weitong, Fang Xiaoling, Sha Xianyi*. Enhanced antitumor efficacy by methotrexate conjugated Pluronic mixed micelles against KBv multidrug resistant cancer. Int J Pharm 2013, 452(1-2):421-33. Gu Zhengyi, He Jinhua, Yang Xi, Sha Xianyi*. Quantitative determination of rupestonic acid in rat plasma by high-performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study. Biomed Chromatogr 2013, 27(5):563-7. Fan Zhuoyang, Wu Juan,Fang Xiaoling, Sha Xianyi*. A new function of Vitamin E-TPGS in the intestinal lymphatic transport of lipophilic drugs: Enhancing the secretion of chylomicrons. Int J Pharm 2013, 445(1-2):141-7.

学术兼职

2016.01 – 至今上海市药学会中药专委会委员 2008.05 – 至今美国临床肿瘤治疗协会（ASCO）会员 2005.07 – 至今中国药学会, 会员