王建新 - 复旦大学

个人简介

1971年8月出生，1999年毕业于华西医科大学药学院药剂学专业，获博士学位。同年7月进入上海市中药研究所工作，2001年12月任高级工程师。 2001年7月至2005年4月曾任上海市中药研究所常务副所长，2005年5月作为复旦大学引进人才进校工作。 2009年7月至2010年8月于美国密西根大学药学院做访问学者。 2007年6月至2013年1月担任复旦大学药学院药剂学教研室主任。 2012年12月至2021年8月任复旦大学药学院副院长。 2021年9月至今任复旦大学药学院党委书记。获奖及荣誉 2002年荣获中国药学会第六届全国青年药学科技工作者最新科研成果学术交流会优秀论文一等奖 2002年荣获上海市 “讲理想、比贡献”十佳先进个人 2003年被共青团上海市委员会授予“上海市新长征突击手”称号 2004年被上海市人民政府授予2001-2003年度“上海市劳动模范”荣誉称号 2004年6月被上海市国有资产管理委员会授予“优秀共产党员”荣誉称号 2011年10月获中国药学会-石药集团青年药剂学奖 2014年5月获上海市优秀技术带头人荣誉称号 2017年12月荣获上海产学研合作优秀项目奖二等奖（排名第一） 2018年10月荣获首届人卫慕课在线开放课程建设比赛本科组一等奖 2018年11月荣获四川省科技进步三等奖（排名第三） 2018年12月荣获“上海市教育系统优秀劳模工作室”称号 2021年9月荣获“上海市劳模创新工作室”称号

研究领域

1. 靶向给药系统研究 —基于疾病病理特征靶向给药系统研究 —克服药物穿透屏障的肿瘤靶向给药系统研究 2. 口服给药系统设计及吸收机制研究 —采用纳米技术（纳米粒、胶束、纳米共晶等）改善难溶性药物与大分子药物的口服吸收研究 —改善药物口服生物利用度的制剂技术（固体分散体自乳化、磷脂复合物等）与机制研究 3. 中药新型给药系统研究 —中药缓控释、靶向给药系统研究 —基于ADME的中药新剂型评价与组分中药研究 4. 药物新制剂新剂型研究开发 —口服缓控释制剂（微丸、微丸压片、骨架片）研究开发 —中药复方、有效部位、新剂型研究开发 —外用制剂（巴布剂、软膏、贴剂）研究开发

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Jiaxuan Xia, Shaojie Ma, Xi Zhu, Chen Chen, Ru Zhang, Zhonglian Cao, Xing Chen, Longlong Zhang, Ying Zhu, Shuya Zhang, Shiyi Li, Guolong Gu, Xunbin Wei, Kunqian Yu, Jianxin Wang*. Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches. Science Advances. 2022，http://doi.org/10.1126/sciadv.abj1262. Longlong Zhang, Yuefei Zhu, Xunbin Wei, Xing Chen, Yang Li, Ying Zhu, Jiaxuan Xia, Yiheng Huang, Yongzhuo Huang, Jianxin Wang* and Zhiqing Pang*. Nanoplateletsomes Restrain Metastatic Tumor Formation through Decoy and Active Targeting in a Preclinical Mouse Model. Acta Pharmaceutica Sinica B. 2022，https://doi.org/10.1016/j.apsb.2022.01.005. Xing Chen, Xiang Ling, Jiaxuan Xia, Ying Zhu, Longlong Zhang, Yuwei He, Anni Wang, Guolong Gu, Bo Yin,*, and Jianxin Wang*. Mature Dendritic Cell-derived Dendrosomes Swallow Oxaliplatin-loaded Nanoparticles to Boost Immunogenic Chemotherapy and Tumor Antigen-specific Immunotherapy. Bioactive Materials, 2021，https://doi.org/10.1016/j.bioactmat.2021.12.020. Chen Chen1, Jiaxuan Xia1, Hongwei Ren1, Anni Wang1, Ying Zhu1,2, Ru Zhang1,, Zicheng Gan1, and Jianxin Wang*. Effect of the structure of ginsenosides on the in vivo fate of their liposomes. Asian Journal of Pharmaceutical Sciences, 2021，https://doi.org/10.1016/j.ajps.2021.12.002. Guolong Gu, Chen Chen, Shichao Zhang, Bo Yin*, Jianxin Wang*. Self-Assembly Dual-Responsive NO Donor Nanoparticles for Effective Cancer Therapy. ACS Applied Materials & Interfaces, 2021, 13, 43, 50682–50694 Ying Zhu#, Jianming Liang#, Caifang Gao, Anni Wang, Jiaxuan Xia, Chao Hong, Zhirong Zhong, Zhong Zuo, Jisu Kim, Hongwei Ren, Shiyi Li, Qi Wang, Fengxue Zhang*, Jianxin Wang*. Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy. Journal of Controlled Release, 2021,330：640-657 Chao Hong, Jianming Liang, Jiaxuan Xia, Ying Zhu, Yizhen Guo, Anni Wang, Chunyi Lu, Hongwei Ren, Chen Chen, Shiyi Li, Dan Wang, Huaxing Zhan, Jianxin Wang*. One Stone Four Birds: A Novel Liposomal Delivery System Multifunctionalized with Ginsenoside Rh2 for Tumor Targeting Therapy. Nano-Micro Letters, 2020, 12:129 Jianming Liang, Ying Zhu, Caifang Gao, Chengli Ling, Jing Qin, Qi Wang, Yongzhuo Huang, Weigen Lu* and Jianxin Wang*. Menthol-modified BSA nanoparticles for glioma targeting therapy using an energy restriction strategy. NPG Asia Materials, 2019, 11:38 https://doi.org/10.1038/s41427-019-0138-6 Jia Hou#, Xu Yang#, Shiyi Li, Zhekang Cheng, Yuhua Wang, Jing Zhao, Chun Zhang,Yongji Li, Man Luo, Hongwei Ren, Jianming Liang, Jue Wang, Jianxin Wang*, Jing Qin*. Accessing neuroinflammation sites: Monocyte/neutrophil-mediated drug delivery for cerebral ischemia. Science Advances, 2019;5: eaau8301 Wenxue Mao, Fan Wu, Robert J Lee, Weigen Lu*, Jianxin Wang*. Development of a stable single-vial liposomal formulation for vincristine. International Journal of Nanomedicine, 2019:14 4461–4474 Hongwei Ren, Yuwei He, Jianming Liang, Zhekang Cheng, Meng Zhang, Ying Zhu, Chao Hong, Jing Qin, Xinchun Xu*,Jianxin Wang*. Role?of?Liposome Size, Surface Charge, and PEGylation on Rheumatoid Arthritis Targeting Therapy. ACS Applied Materials &Interfaces, 2019, 11, 22, 20304-20315 Chao Hong#, Dan Wang#, Jianming Liang, Yizhen Guo, Ying Zhu, Jiaxuan Xia, Jing Qin, Huaxing Zhan, Jianxin Wang*. Novel ginsenoside-based multifunctional liposomal delivery system for combination therapy of gastric cancer. Theranostics, 2019, 9(15): 4437-4449 Yuwei He#,Ruixiang Li#, Haichun Li, Shuya Zhang,Wentao Dai, Qian Wu, Lixian Jiang, Zicong Zheng, Shun Shen, Xing Chen, Yuefei Zhu, Jianxin Wang*and Zhiqing Pang*. Erythroliposomes: Integrated Hybrid Nanovesicles Composed of Erythrocyte Membranes and Artificial Lipid Membranes for Pore-Forming Toxin Clearance. ACS Nano, 2019, 13, 4148?4159 Ruixiang Li#, Yuwei He#, Ying Zhu, Lixian Jiang, Shuya Zhang, Jing Qin, Qian Wu, Wentao Dai, Shun Shen, Zhiqing Pang* and Jianxin Wang*. Route to Rheumatoid Arthritis by Macrophage derived Microvesicle-Coated Nanoparticles. Nano Letters, 2019, 19 (1), pp 124–134 Caifang Gao, Jianming Liang, Ying Zhu, Chengli Ling, Zhekang Cheng, Ruixiang Li, Jing Qin, Weigen Lu*, Jianxin Wang*. Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy. Acta Pharmaceutica Sinica B, 2019, https://doi.org/10.1016/j.apsb.2019.01.006 Jianming Liang, Caifang Gao, Ying Zhu, Chengli Ling, Qi Wang, Yongzhuo Huang, Jing Qin, Jue Wang, Weigen Lu*, and Jianxin Wang*. Natural Brain Penetration Enhancers Modified Albumin Nanoparticles for Glioma Targeting Delivery. ACS Applied Materials &Interfaces, 2018, 10 (36):30201–30213 Yuwei He, Ruixiang Li, Jianming Liang, Ying Zhu, Shuya Zhang, Zicong Zheng, Jing Qin, Zhiqing Pang* and Jianxin Wang*. Platelet membrane-coated nanoparticles for rheumatoid arthritis targeting. Nano Research, 2018, 11(11): 6086–6101 Jianming Liang, Ruixiang Li, Yuwei He, Chengli Ling, Qi Wang, Yongzhuo Huang, Weigen Lu*, Jianxin Wang*. A Novel Tumor Targeting Treatment Strategy through Energy Restriction by Co-delivery of Albendazole and Nano-silver. Nano Research, 2018, 11: 4507-4523 Ruixiang Li#, Yuwei He#, ShuyaZhang, JingQin, Jianxin Wang*. Cell membrane based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment. Acta Pharmaceutica Sinica B 2018;8(1):14–22 Ruixiang Li, Jianming Liang, Yuwei He, Jing Qin, Huining He, Seungjin Lee, Zhiqing Pang* and Jianxin Wang*. Sustained Release of Immunosuppressant by Nanoparticle-anchoring Hydrogel Scaffold Improved the Survival of Transplanted Stem Cells and Tissue Regeneration. Theranostics, 2018; 8(4): 878-893 Yisi Tang, Jianming Liang, Aihua Wu, Yingzhi Chen, Pengfei Zhao, Tingting Lin, Meng Zhang, Qin Xu, Jianxin Wang*and Yongzhuo Huang*. Co-Delivery of Trichosanthin and Albendazole by Nano-Self- Assembly for Overcoming Tumor Multidrug-Resistance and Metastasis. ACS Appl Mater Interfaces 2017, 9(32):26648-26664 Chun Zhang, Chengli Ling, Liang Pang, Qi Wang, Jingxin Liu, Bingshan Wang, Jianming Liang, Jing Qin*, Jianxin Wang*. Direct macromolecular drug to cerebral ischemia area using Neutrophil mediated nanoparticles. Theranostics, 2017,7(13):3260-3275 Ruixiang Li, Zhiqing Pang, Huining He, Seungjin Lee, Jing Qin, Jian Wu, Liang Pang, Jianxin Wang*and Victor C. Yang*. Drug depot-anchoring hydrogel: A self-assembling scaffold for localized drug release and enhanced stem cell differentiation. Journal of Controlled Release, 2017, 261:234-245 Cuitian Chen, Ziqing Duan, Ruixiang Li, Liang Pang, Yan Yuan, Jianming Liang, Xinchun Xu* and Jianxin Wang*. Peptide-22 and cyclic RGD functionalized liposomes for glioma targeting drug delivery overcoming BBB and BBTB. ACS Appl Mater Interfaces. 2017, 9:5864-5873 Jianyong Sheng , Huining He, Limei Han, Jing Qi, Sunhui Chen, Ge Ru, Ruixiang Li, Pei Yang, Jianxin Wang*and Victor C. Yang*. Enhancing Insulin Oral Absorption by Using Mucoadhesive Nanoparticles Loaded with LMWP-linked Insulin Conjugates. Journal of Controlled Release，2016,233:181-190 Jianyong Sheng, Limei Han, Jing Qin, Ge Ru, Ruixiang Li, Lihong Wu, Dongqi Cui, Pei Yang, Yuwei He, Jianxin Wang*. N-Trimethyl Chitosan Chloride-Coated PLGA Nanoparticles Overcoming Multiple Barriers to Oral Insulin Absorption. ACS Appl Mater Interfaces. 2015, (28) 7:15430-41 Jing Qin，Xu Yang，Ruoxi Zhang，Yixiao Luo，Jiali Li，Jia Hou，Chun Zhang，Yongji Li，Jie Shi，Lin Lu，Jianxin Wang*，Wei-Li Zhu*. Monocyte mediated brain targeting delivery of macromolecular drug for the therapy of depression.Nanomedicine: Nanotechnology, Biology and Medicine，2015,11(2):391-400 Huining He, Jianyong Sheng, Allan E David, Youngmin Kwon, Jian Zhang, Yongzhuo Huang, Jianxin Wang*,Victor C Yang*. The use of low molecular weight protamine chemical chimera to enhance monomeric insulin intestinal absorption. Biomaterials, 2013, 34(31):7733-7743 Lin Zhang, Limei Han, Jing Qin, Weiyue Lu andJianxin Wang*. Borneol as an Enhancer for Targeting Aprotinin-Conjugated PEG-PLGA Nanoparticles to the Brain. Pharmaceutical research, 2013, 30(10) : 2560-72 Ming Shen, Yongzhuo Huang, Limei Han, Jing Qin, Xiaoling Fang, Jianxin Wang *, Victor C Yang*. Multifunctional drug delivery system for targeting tumor and its acidic microenvironment. Journal of Controlled Release, 2012, 161:884-892

学术兼职

国家药品注册审评专家咨询委员会委员国家中药品种保护审评专家中国药学会药剂专委会委员中国药学会工业药剂学专业委员会委员、世界中医药学会联合会新型给药系统专业委员会秘书长/常务理事中国生物医学工程学会纳米医学与工程分会委员中华中医药学会中药制剂分会常务理事上海市药学会理事上海市药学会药剂专业委员会副主任委员上海市药学会中药专业委员会《国际药学研究》、《中国医药工业杂志》、《中成药》、《药学研究》杂志编委