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Mei-Lin Tang, Haidong Li, Jin-Feng Ning, Xiaoyan Shen*, and Xun Sun*，Discovery of First-in-Class TAK1–MKK3 Protein–Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production. J. Med. Chem. 2022, 65, 6690?6709. (IF: 7.446)
Zhipeng Huo, Kunlin Liu, Xi Zhang, Yongxi Liang*, Xun Sun*. Discovery of pyrimidine-bridged CA-4 CBSIs for the treatment of cervical cancer in combination with cisplatin with significantly reduced nephrotoxicity. Eur J Med Chem. 2022, 235, 114271. (IF: 6.514)
Jianwu Lu, Xiao Li, Shun Yuan, Yinquan Wang, Han Sun, Weizhao Weng, Yinfei Shi, Xiaoxu Wang, Kongcheng Huang, Xun Sun*, and Taizhi Wu*. Identification, Synthesis, and Comprehension of an Imidazole N-3 Regioisomeric Impurity of Olmesartan Medoxomil Key Intermediate. Org. Process Res. Dev. 2022, 26, 4, 1247–1257.(IF: 3.317)
Wang Xianlian, Xu Yongmei, Zong Zaiwei, Cai Jinna, Chen Chunlin, Zhang Qingwei, Sun Xun*, Li Jianqi*. Design, synthesis and biological evaluation of novel 5-methyl-2,4,5,6-tetrahydropyrrolo [3,4-c] pyrazole derivatives as potent potassium-competitive acid blockers. Bioorganic & Medicinal Chemistry. 2022, 64, 116765.(IF: 3.641)
Zheng-Nan Ren, Jun Yang, Meng-Ya Zhang, Yi-Wen Huang, Dong-Xiao Song, Xun Sun*, Li-Long Pan, Jia Sun. A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis. Acta. Pharmacol. Sin., 2022. 43，1624. (IF: 6.15)
Baohui Yuan, He Liu, Xiaoliang Dong, Xiaohua Pan, Xun Sun*, Jia Sun*, Li-Long Pan*. A Novel Resveratrol Analog Upregulates SIRT1 Expression and Ameliorates Neointima Formation. Frontiers in Cardiovascular Medicine 2021, 8, 756098.(IF:6.050)
Jiaxin Huang, Hongyi Wang, Zenong Wu, Xun Sun, Fuli Zhang. Improved synthesis of cenobamate, Chin. J. Med. Chem., 2021, 31, 419-421, 425. (IF: 0.31)
Yi Zhao, Long An, Shupan Guo, Xiaoxing Huang, Huajie Tian, Li Liu, Tao Chen, Xun Sun*, Qibing Mei, Rutao Wang. LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ-aminobutyric acid type A receptors. Epilepsia, 2021, 62, 238-249. (IF: 5.864)
Chen-Chen Zhang, Zhi-Peng Huo, Mei-Lin Tang, Yong-Xi Liang*, Xun Sun*. TMSOTf-mediated approach to 1,3-oxazin-2-one skeleton through one-pot successive reduction-[4 + 2] cyclization process of imides with ynamides. Tetrahedron Lett., 2021, https://doi.org/10.1016/j.tetlet.2021.152946
Renwu Lia, Lingling Yan, Xun Sun?, Weiping Zheng?. A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine. Bio. Med. Chem. Lett., 2020, 28, 115356.
Ji-lai Han; Mei-Lin Tang; Xun Sun*. Study on the Total Synthesis of Resveratrol Dimers Quadrangularin A and Pallidol. Chinese J. Org. Chem., 2020, 40(6): 1571-1577.
Yongxi Liang; Mei-Lin Tang; Zhipeng Huo; Chenchen Zhang; Xun Sun*. A Concise Approach to N-substituted Rhodanines through a Base-assisted One-pot Coupling and Cyclization Process. Molecules. 2020, 5, 1138.
Zheng-Yu Liu, Mei-Lin Tang, Jin-Feng Ning, Yun-Peng Hao, Lu Zhou, Xun Sun*. Novel octapeptide-DTX prodrugs targeting MMP-7 as effective agents for the treatment of colorectal cancer with lower systemic toxicity. Eur. J. Med. Chem.2020, 193,112194. (IF:4.833)
Xi-Xi Liu, Mei-Lin Tang, Chen Zhong, Yun Tang, Jian-Ming Yu, Xun Sun*. Design, synthesis and biological evaluation of novel indone derivatives as selective ERβ modulators. Med. Chem. Res.2019, 28, 1010–1026.
Zhi Meng, Mei-Lin Tang, Liting Yu, Yongxi Liang, Jilai Han, ChenChen Zhang, Fupin Hu, Jian-Ming Yu, and Xun Sun*. Novel Mercapto Propionamide Derivatives with Potent New Delhi Metallo-β-Lactamase?1 Inhibitory Activity and Low Toxicity. ACS Infect. Dis.2019, 5, 903?916.
Liting Yu, Mei-Lin Tang, Chang-Mei Si, Zhi Meng, Yongxi Liang, Jilai Han, and Xun Sun*, Zinc-Mediated Decarboxylative Alkylation of Gem-difluoroalkenes. Org. Lett.2018, 20, 4579?4583.
Yong-Wei Jiang, Liang Xu, Wei Fu, Hua Lin, Jian-Ming Yu, Xun Sun*. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron2018, 74,3527-3533.
Mingliang Wang, Yanjia Fang, Shoulai Gu, Fangfang Chen, Zhengjiang Zhu,Xun Sun*, Jidong Zhu, Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. Eur. J. Med. Chem.2017, 132, 157–172.
Mingliang Wang, Yimin Hu*, Zhe Jiang, Hong C. Shen, Xun Sun*. Divergent copper-mediated dimerization and hydroxylation of benzamides involving C–H bond functionalization. Org. Biomol. Chem., 2016, 14, 4239?4246.
Yun-peng Hao, Zheng-yu Liu, Cheng Xie, Lu Zhou, Xun Sun*. Novel Fluorinated Docetaxel Analogue for Anti-hepatoma：Molecular Docking and Biological Evaluation. Eur. J. Pharm. Sci.2016, 88, 274?281.
Mei-Lin Tang, Chen Zhong, Zheng-Yu Liu, Peng Peng, Xin-Hua Liu*, Xun Sun*. Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents. Eur. J. Med. Chem. 2016, 113, 63–74.
Mei-Lin Tang, Lu Zhou, Jun Chang, Zhuo-Han Hu, Yan Qin*, Xun Sun*. Differential metabolism of 3FDT and docetaxel in RLMs, rats, and HLMs. Eur. J. Med. Chem.2016, 113, 81–91.
Jiao Song, Peng Peng, Jun Chang, Ming-Ming Liu, Jian-Ming Yu, Lu Zhou*, Xun Sun*. Selective non-zinc binding MMP-2 inhibitors: novel benzamide Ilomastat analogs with anti-tumor metastasis. Bioorgan. Med. Chem. Lett.2016, 26, 2174-2178.
Qiang-Sheng Sun, Hua Lin*, Xun Sun, Xing-Wen Sun*, Highly efficient synthesis of enantioenriched fully-substituted spirocyclohexane oxindoles via a Michael-Michael-aldol cascade reaction. Tetrahedron Letters 2016, 57 , 5673–5676.
Wei Tao, Wen Zhou, Zhu Zhou, Chang-Mei Si, Xun Sun, Bang-Guo Wei*, An enantioselective total synthesis of tubulysin V. Tetrahedron, 2016, 72, 5928–5933.
Ge Xu, Baihua Xu, Yanli Song, Xun Sun*, An efficient method for synthesis of bexagliflozin and its carbon-13 labeled analogue, Tetrahedron Letters, 2016, 57, 4684–4687.
Mei-Lin Tang, Peng Peng, Zheng-Yu Liu, Jian Zhang, Jian-Ming Yu and Xun Sun*，Sulfoxide-Based Enantioselective Nazarov Cyclization: Divergent Syntheses of (+)-Isopaucifloral F, (+)-Quadrangularin A, and(+)-Pallidol. Chem. Eur. J.2016, 22, 14535 – 14539.
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