董肖椿 - 复旦大学

个人简介

教育经历 2004.9.-2007.6：复旦大学药学院药物化学专业，博士 2000.9.-2003.6：复旦大学药学院药物化学专业，硕士 1993.9.-1997.6：华东师范大学化学系化学专业，学士工作经历 2013.12- 至今：复旦大学药学院药物化学教研室，副教授 2008.9 -2009.9：美国明尼苏达大学药学院药物化学系，博士后 1997.7- 2013.11：复旦大学药学院药物化学教研室，助教/讲师

研究领域

基于分子靶向、肿瘤信号通路及免疫相关小分子抗肿瘤药物先导化合物研究有机药物合成方法研究

近期论文

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Chang Liu, Xin Ji, Zhiliang Yu, Shaohui Zhang, Rong Zhang, Weili Zhao, Xiaochun Dong*. Discovery of Subcellular-Targeted Aza-BODIPY Photosensitizers for Efficient Photodynamic Antitumor Therapy. J. Med. Chem., 2023, 66 (11): 7205-7220 Li Ruan, Junping Bai, Xin Ji, Weili Zhao, Xiaochun Dong*. A series of meso amide BODIPY based lysosome-targeting fluorescent probe with high photostability and sensitivity. Analytica Chimica Acta, 2022, 1205: 339771 Chang Liu, Yue Jin, Xin Ji, Weili Zhao*, Xiaochun Dong*. Access to Pyridinyl or Pyridinium Aza-BODIPYs with Tunable Near-Infrared Fluorescence through ICT from 4-Pyridinyl Pyrroles. Chem. Eur. J., 2022, e202201503 Shaohui Zhang, Xin Ji, Rong Zhang, Weili Zhao*, Xiaochun Dong*. Water-soluble near-infrared fluorescent heptamethine dye for lymphatic mapping applications. Bioorg. Med. Chem. Lett., 2022, 73: 128910 Guangyu Lin, Mei Hu, Rong Zhang, Yuanxing Zhu, Kedan Gu, Junping Bai, Jiyang Li*, Xiaochun Dong*, Weili Zhao*. Discovery of Meso-(meta-Pyridinium) BODIPY Photosensitizers: In Vitro and In Vivo Evaluations for Antimicrobial Photodynamic Therapy. J. Med. Chem., 2021, 64 (24): 18143-18157 Zhiliang Yu, Junliang Zhou,Xin Ji, Guangyu Lin, Shuang Xu, Xiaochun Dong*, Weili Zhao*. Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy. J. Med. Chem., 2020, 63 (17): 9950-9964 Kedan Gu, Guangyu Lin, Yuanxing Zhu, Xin Ji, Jiyang Li*, Xiaochun Dong*, Weili Zhao*. Anchoring BODIPY photosensitizers enable pan-microbial photo-inactivation. Eur. J Med. Chem.,2020, 199: 112361 Zhifeng Xia, Yanyang Nan, Chang Liu, Guangyu Lin, Kedan Gu, Cheng Chen, Weili Zhao, Dianwen Ju, XiaochunDong*. Design, Synthesis and Biological Evaluation of Novel1,2,5-Oxadiazol-3-Carboximidamide Derivatives as Indoleamine 2, 3-Dioxygenase 1(IDO1) Inhibitors. Anti-Cancer Agents in Medicinal Chemistry, 2020, 20: 1592-1603 Mingfei Zhu, Hong Wang, Chenglin Wang, Yanfen Fang, Tong Zhu, Weili Zhao, Xiaochun Dong*, Xiongwen Zhang*. L-4, a well-tolerated and orally active inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against medulloblastoma in vitro and in vivo. Front. Pharmacol., 2019, 10, e89. Xiaochun Dong, Chenglin Wang, Zhongjian Chen*, Weili Zhao*. Overcoming the Resistance mechanisms of Smoothened inhibitors, Drug Discovery Today,2018, 23: 704-710 Chenglin Wang, Mingfei Zhu,Xiuhong Lu, Hong Wang, Weili Zhao, Xiongwen Zhang*, Xiaochun Dong*. Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors. Bioorg. Med. Chem., 2018, 26, 3308-3320 Xiuhong Lu, ZhongjianChen*, Xiaochun Dong*, Weili Zhao*. Water -Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos. ACS Sensors, 2018,3: 59-64 Xiuhong Lu, Yuanqiu Peng,Chenglin Wang, Jun Yang, Xiaolong Bao, Qian Dong, Weili Zhao*, WenfuTan*, Xiaochun Dong*. Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors. Eur. J Med. Chem., 2017, 138, 384-395.