个人简介

教育经历 1986.09 – 1990.06 南开大学化学系 学士 1990.09 – 1993.06 南开大学化学系 硕士 1996.09 – 1999.08 中国协和医科大学&中国医学科学院药物研究所 博士 工作经历 1999.09 – 2001.07 中国科学院上海有机化学研究所,博士后 2001.11 – 2003.12 法国国立应用科学研究院（INSA de Rouen），博士后 2004.01 – 2007.06 上海恒瑞医药科技有限公司，研发中心研究员 2007.07 – 2020.11 复旦大学药学院药化教研室，副研究员，硕士生导师 2012.06 – 2012.07 法国国立应用科学研究院（INSA de Rouen），访问教授 2020.12 – 至今 复旦大学药学院药化系，教授，博士生导师

研究领域

合成方法学及药物合成工艺研究 基于海洋天然产物的新药研究

主要从事手性药物合成、有机合成方法学及天然产物化学方面的教学与科研工作

近期论文

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Bingbing Zhang, Zhu-Wei Ruan, Dongdong Luo, Yueyue Zhu, Tingbo Ding, Qiang Sui and Xinsheng Lei* Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole Marine Drugs 2020, 18, 344. Yinying Zheng, Jiami Liu and Xinsheng Lei* Ru-Catalyzed cascade reaction of α,ω-alkynoic acids and arylethylamines towards the synthesis of aryl-fused heterocycles Organic Chemistry Frontiers2020, 7, 660–665. Bingbing Zhang; Jiami Liu; Dingding Gao; Xiaolin Yu; Jinlei Wang; Xinsheng Lei* A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: synthesis, biological evaluation, and molecular modeling European Journal of Medicinal Chemistry 2019 , 182, 111672. Bingbing Zhang, Guangsheng Shan, Yinying Zheng, Xiaolin Yu, Zhu-Wei Ruan, Yang Li, Xinsheng Lei* Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A Marine Drugs2019, 17, 333-346. Chao Huang, Juan Xiong, Hui-Da Guan, Chang-Hong Wang, Xinsheng Lei,* Jin-Feng Hu* Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors Bioorganic & Medicinal Chemistry2019, 27, 2027–2040. Qiaoning Ma, Xiaodi Yang, Xinsheng Lei*, Guo-Qiang Lin* A highly enantioselective synthetic method towards the α2c-adrenoceptor antagonist ORM-10921 Organic Chemistry Frontier2019, 6, 773–779. Yuheng Wang, Bingbing Zhang, Yinying Zheng, Qiaoning Ma, Qiang Sui, Xinsheng Lei* Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines Tetrahedron2019, 75, 1064-1071. Yue Wu, Bingbing Zhang, Yinying Zheng, Yuheng Wang, Xinsheng Lei* Cs2CO3-promoted defluorination and functionalization of a-CF3 carbonyl compounds in the presence of N-, O-, and/or S-nucleophiles RSC Advances2018, 8, 16019–16023. Xiaoling Yu, Bingbing Zhang, Guangsheng Shan, Yue Wu, Feng-Ling Yang, Xinsheng Lei* Synthesis of the molecular hybrid inspired by Largazole and Psammaplin A Tetrahedron2018, 74, 549-555.