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Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang*, and Qiong Xie*. Discovery of Biaryl Amide Derivatives as Potent, Selective, and Orally Bioavailable RORγt Agonists for Cancer Immunotherapy. J. Med. Chem., 2023, 66, 16091-16108.
Chenyu Zhu, Shuyin Ze, Ronghui Zhou, Xinyu Yang, Haojie Wang, Xiaolei Chai, Meimiao Fang, Mingyao Liu, Yonghui Wang,* Weiqiang Lu,* Qiong Xie.* Discovery of Pyridinone Derivatives as Potent, Selective and Orally Bioavailable Adenosine A2A Receptor Antagonists for Cancer Immunotherapy. J. Med. Chem., 2023, 66, 4734-4754.
Fazhi Yu, Chenyu Zhu, Shuyin Ze, Haojie Wang, Xinyu Yang, Mingyao Liu, Qiong Xie*, Weiqiang Lu*, and Yonghui Wang.* Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8H)-one Derivatives as Novel Potent Adenosine A2A Receptor Antagonists for Cancer Immunotherapy. J. Med. Chem., 2022, 65, 4367–4386.
Ji-An Chen, Hui Ma, Zehui Liu, Jinlong Tian, Sisi Lu, Wenqing Fang, Weiqiang Lu, Qiong Xie,* Jin Huang,* Yonghui Wang.*Discovery of Orally Available RORgt/DHODH Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J. Med. Chem.,2022, 65, 592-615
Nannan Sun, Qiong Xie, Yongjun Dang,* Yonghui Wang.* Agonist Lock Touched and Untouched Retinoic Acid ReceptorRelated Orphan Receptor-γt (RORγt) Inverse Agonists: Classification Based on the Molecular Mechanisms of Action. J. Med. Chem.,2021, 64, 10519-10536.
Fazhi Yu, Chenyu Zhu, Qiong Xie, Yonghui Wang.*Adenosine A2a Receptor Antagonists for Cancer Immunotherapy. J. Med. Chem., 2020, 61, 12196-12212
Ruomeng Qiu, Yonghui Wang.*Retinoic acid receptor-related orphan receptor-gamma-t (RORgt) agonists as potential small molecular therapeutics for cancer immunotherapy. J. Med. Chem., 2018, 61, 5794-5804
Yafei Huang, Mingcheng Yu, Nannan Sun, Ting Tang, Fazhi Yu, Xiaoxia Song, Qiong Xie*, Wei Fu, Liming Shao, Yonghui Wang.* Discovery of Carbazole Carboxamides as Novel ROR?t Inverse Agonists. Eur. J. Med. Chem., 2018, 148, 465-476
Yonghui Wang,* Wei Cai, Ting Tang, Qian Liu, Ting Yang, Liuqing Yang, Yingli Ma, Guifeng, Zhang, Yafei Huang, Xiaoxia Song, Lisa A. Orband-Miller, Qianqian Wu, Ling Zhou, Zhijun Xiang, Jia-Ning Xiang, Stewart Leung, Liming Shao, Xichen Lin, Mercedes Lobera, and Feng Ren.* From ROR?t Agonist to Two Types of ROR?t Inverse Agonists. ACS Med. Chem. Lett. 2018, 9, 120-124
Yan Zhu, Juwen Gong, Yonghui Wang.* Free-radical-promoted copper-catalyzed decarboxylative alkylation of α,β-unsaturated carboxylic acids with ICH2CF3 and its analogs. J. Org. Chem., 2017, 82, 7428-7436
Ruomeng Qiu, Wenli Shi, Ting Cai, Siyu Pei, Ting Tang, Yafei Huang, Huan Wang, Liming Shao, Ju Qiu? and Yonghui Wang.? Design, synthesis and phenotypic evaluation of N-biaryl amides for IL-17A suppression. Med. Chem. Commun., 2016, 7, 2344 - 2348
Yonghui Wang,* Ting Yang, Qian Liu, Yingli Ma, Liuqing Yang, Ling Zhou, Zhijun Xiang, Ziqiang Cheng, Sijie Lu, Lisa A. Orband-Miller, Wei Zhang, Qianqian Wu, Kathleen Zhang, Yi Li, Jia-Ning Xiang, John D. Elliott, Stewart Leung, Feng Ren, Xichen Lin.* Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR?t inverse agonists. Bioorg. Med. Chem 2015, 23, 5293-5302
Yonghui Wang,* Wei Cai, Yaobang Cheng, Ting Yang, Qian Liu, Guifeng Zhang, Qinghua Meng, Fangbin Han, Yafei Huang, Ling Zhou, Zhijun Xiang, Yong-Gang Zhao, Yan Xu, Ziqiang Cheng, Sijie Lu, Qianqian Wu, Jia-Ning Xiang, John D. Elliott, Stewart Leung, Feng Ren, Xichen Lin.* Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant ROR?t Inhibitors. ACS Med. Chem. Lett. 2015, 6, 787-792
Sheng Xiao, Nir Yosef, Jianfei Yang, Yonghui Wang, Ling Zhou, Chen Zhu, Chuan Wu, Erkan Baloglu, Darby Schmidt, Radha Ramesh, Mercedes Lobera, Mark S. Sundrud, Pei-Yun Tsai, Zhijun Xiang, Jinsong Wang, Yan Xu, Xichen Lin, Karsten Kretschmer, Peter B. Rahl, Richard A. Young, Zhong Zhong, David A. Hafler, Aviv Regev, Shomir Ghosh, Alexander Marson,* Vijay K. Kuchroo.* “Small molecule ROR?t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms”. Immunity 2014, 40, 477-489
Yonghui Wang,* Wei Cai, Guifeng Zhang, Ting Yang, Qian Liu, Yaobang Cheng, Ling Zhou, Yingli Ma, Ziqiang Cheng, Sijie Lu, Yong-Gang Zhao, Wei Zhang, Zhijun Xiang, Shuai Wang, Liuqing Yang, Qianqian Wu, Lisa A. Orband-Miller, Yan Xu, Jing Zhang, Ruina Gao, Melanie Huxdorf, Jia-Ning Xiang, Zhong Zhong, John D. Elliott, Stewart Leung, Xichen Lin. “Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent ROR?t inhibitors”. Bioorg. Med. Chem. 2014, 22, 692-702
Ting Yang, Qian Liu, Yaobang Cheng, Wei Cai, Yingli Ma, Liuqing Yang, Qianqian Wu, Lisa A. Orband-Miller, Ling Zhou, Zhijun Xiang, Melanie Huxdorf, Wei Zhang, Jing Zhang, Jia-Ning Xiang, Stewart Leung, Yang Qiu, Zhong Zhong, John D. Elliott, Xichen Lin and Yonghui Wang.* “Discovery of tertiary amine and indole derivatives as potent ROR?t inverse agonists”. ACS Med. Chem. Lett. 2014, 5, 65-68
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