李英霞 - 复旦大学

个人简介

教育经历 1982.09-1989.07 山东海洋学院化学系，学士/硕士 1993.09-1999.06 青岛海洋大学药学系，博士 1995.10-1998.04 日本大阪大学，交换博士生工作经历 1989.08-1998.12 青岛海洋大学，助教/讲师/副教授 2001.12-2009.05 中国海洋大学,教授 2009.6 – 现在复旦大学药学院，教授

研究领域

基于靶标结构的药物设计与优化，主要包括抗肿瘤和代谢调节性小分子药物基于活性天然产物的成药性优化

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Chang, Qi; Li, Jiayi; Deng, Yue; Zhou, Ruilin; Wang, Bingwei; Wang, Yujie; Zhang, Mingming; Huang, Xun*; Li, Yingxia*. Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma. Journal of Medicinal Chemistry 2024, 67, 4, 2466-2486. He, Yulong; Li, Shunyi; Zhu, Yueyue; Wang, Yujie; Chen, Yuqi; Zhang, Deqiang; Wang, Heyao; Li, Yingxia, Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation. European Journal of Medicinal Chemistry 2023, 253, 115319. Wang, Xianyang; Wang, Yujie; Zhu, Yueyue; Lei, Xinsheng; Zhang, Mingming; Li, Yingxia, Identification and immunological evaluation of novel TLR2 agonists through structural optimization of Diprovocim. European Journal of Medicinal Chemistry 2022, 243, 114771. Liu, Ruiqi; Yang, Hong; Chen, Zonglong; Zhou, Kaixin; Shi, Qiongyu; Li, Jiayi; Huang, Yuting; Huang, Xun; Li, Yingxia, Design, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines. Bioorganic Chemistry 2022, 124, 105803. Chen, Zonglong; Li, Jiayi; Yang, Hong; He, Yulong; Shi, Qiongyu; Chang, Qi; Liu, Ruiqi; Huang, Xun; Li, Yingxia, Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells. Bioorganic & Medicinal Chemistry 2022, 66, 116784. Gao, Dingding; Jin, Nan; Fu, Yixian; Zhu, Yueyue; Wang, Yujie; Wang, Ting; Chen, Yuehong; Zhang, Mingming; Xiao, Qiang; Huang, Min; Li, Yingxia, Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. European Journal of Medicinal Chemistry 2021, 216, 113333. Ren, Sumei; Zhang, Minmin; Wang, Yujie; Guo, Jia; Wang, Junfei; Li, Yingxia; Ding, Ning, Synthesis and biological evaluation of novel cabazitaxel analogues. Bioorganic & Medicinal Chemistry 2021, 41, 116224. Liu, Yichu; Wang, Yibing; Dai, Wenhao; Huang, Wei; Li, Yingxia; Liu, Hong, Palladium-Catalysed C(sp3)-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids. Angewandte Chemie International Edition 2020, 59 (9), 3491-3494.

学术兼职

2019.08 – 现在中国药学会药物化学业委员会委员 2019.01 – 现在上海市海洋药物专业委员会委员 2019.10 – 现在上海市药物化学专业委员会副主任委员《中国药物化学杂志》、《海洋药物》、《国际药学杂志》和Frontiers杂志的编委