Watson, Donald A. - University of Delaware - Department of Chemistry & Biochemistry

个人简介

Donald A. Watson was born in California in 1976. He received his BS in Chemistry from UC San Diego in 1998. During his undergraduate years, he worked in the laboratories of Professors K.C. Nicolaou and Emmanuel Theodorakis, working on natural products synthesis. He completed his PhD in Organic Chemistry at UC Irvine in 2004, working under the direction of Professor Larry E. Overman. His dissertation work focused on stereochemical problems in palladium-catalyzed transformations. From 2004 to 2006 he was a NIH Postdoctoral Fellow in the laboratories of Professor Robert G. Bergman at UC Berkeley. During this time he developed zirconium-based catalysts for asymmetric intramolecular hydroaminations. He then moved to the Massachusetts Institute of Technology to take a position as a Postdoctoral Associate in Professor Stephen L. Buchwald’s laboratory, where he studied metal catalyzed processes for C-F bond formation. He joined the Chemistry and Biochemistry faculty at the University of Delaware as an Assistant Professor in July 2009. His research focuses on the development of new chemical methods for preparing organic molecules and structures, with a particular interest in the development transition-metal based catalytic reactions and in the construction of carbon-heteroatom bonds. In 2013, he received a CAREER Award from the National Science Foundation and a Cottrell Scholar Award from the Research Cooperation. In 2015, he was promoted to Associate Professor with tenure, and served as Associate Chair for Graduate Studies and Research in the Department of Chemistry and Biochemistry from 2015 – 2018. In 2018, he was promoted to Professor. Professor Watson’s research program is currently supported by grants from the National Science Foundation (NSF) and the National Institutes of Health (NIH).

研究领域

The D. A. Watson Group is focused on the invention of new chemical reactions and their applications in organic synthesis. We choose to work in this area as organic chemistry is central to modern scientific endeavor, including in such critical areas as the treatment of human disease (providing the tools to synthesize new medicines), understanding of biological processes (providing probes and methods to interrogate biochemical pathways), and the development of advanced materials (providing the building blocks from which they are derived). Advancements in these areas, as well as many others, require new, complex organic molecules and the ability to prepare them. Our group works to invent new, more efficient methods to prepare compounds, which help drive advancements across the spectrum of modern science. Transition-metal catalysis plays a central role in our work, and lies at the heart of many of the methods that we have invented. Our approach combines expertise in catalyst development and organometallic chemistry with insight deep insight into the needs of organic synthesis and complex molecule construction. In this context, we have been particularly focused on the invention of new methods to introduce heteroatoms into non-aromatic organic molecules. The products of these reactions are important intermediates in chemical synthesis, as well as critical structural elements in biologically active molecules. Heteroatomic-Heck Reactions New Reactions of Nitroalkanes Catalytic Construction of C-N Bonds at Alkyl Centers

近期论文

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Xu. F.; Duke. O.; Rojas. D.; Eichelberger, H. M.; Kim, R. S.; Clark, T. B.*; Watson, D. A.* “Aryl Phosphonate-Directed Ortho C–H Borylation: Rapid Entry into Highly-Substituted Phosphoarenes” J. Am. Chem. Soc. 2020. [link] Wisthoff, M. F.; Pawley, S. B.; Cinderella, A. P.; Watson, D. A.* “Stereoselective Synthesis of Cis- and Trans-Tetrasubstituted Vinyl Silanes Using a Silyl-Heck Strategy and Hiyama Conditions for Their Cross-Coupling ” J. Am. Chem. Soc. 2020. [link] Reid, W. B.; McAtee, J. R.; Watson, D. A.* “Synthesis of Unsaturated Silyl Heterocycles via an Intramolecular Silyl-Heck Reaction” Organometallics, 2019, 38, 19, 3796-3803 [link] Xu, F.; Korch, K. M.; Watson, D. A.* “Synthesis of Indolines and Derivatives via Aza‐Heck Cyclization” Angew. Chem. Int. Ed. 2019, 58, 13448-13451 [link] Korch, K. M.; Watson, D. A.* “Cross-Coupling of Heteroatomic Electrophiles” Chem. Rev. 2019, 119, 8192–8228. [link] Devannah, V.; Sharma, R.; Watson, D. A.* “Nickel-Catalyzed Asymmetric C-Alkylation of Nitroalkanes: Synthesis of Enantioenriched β-Nitroamides” J. Am. Chem. Soc. 2019, 141, 8436–8440. [link] Reid, W. B.; Watson, D. A.* “Synthesis of Trisubstituted Alkenyl Boronic Esters from Alkenes Using the Boryl-Heck Reaction” Org. Lett. 2018, 20, 6832–6835. [link] Krause, S. B.; Watson, D. A.* Silyl-Heck, Silyl-Negishi, and Related Reactions. In Organosilicon Chemistry – Novel Approaches and Reactions; Hiyama, T.; Oestreich, M., Eds; Wiley-VCH: Weinheim, 2018; In Press Xu, F.; Shuler, S. A.; Watson, D. A.* “Synthesis of N-H Bearing Imidazolidinones and Dihydroimidazolones Using Aza-Heck Cyclizations” Angew. Chem. Int. Ed. 2018, 57, 12081–12085. [link] Vulovic, B.; Cinderella, A. P.; Watson, D. A.* “Palladium-Catalyzed Cross-Coupling of Monochlorosilanes And Grignard Reagents” ACS Catal. 2017, 7, 8113–8117. [link] Krause, S. B.; McAtee, J. R.; Yap, G. P. A.; Watson, D. A.* “A Bench Stable, Single Component Precatalyst for Silyl-Heck Reactions” Org. Lett. 2017, 19, 5641–5644. [link] Vulovic, B.; Watson, D. A.* “Heck-like Reactions Involving Heteroatomic Electrophiles” Eur. J. Org. Chem. 2017, 4996–5009. [link] Rezazadeh, S.; Devannah, V.; Watson, D. A.* “Nickel-Catalyzed C-Alkylation of Nitroalkanes with Unactivated Alkyl Iodides” J. Am. Chem. Soc. 2017, 139, 8110–8113. [link] Cinderella, A. P.; Vulovic, B.; Watson, D. A.* “Palladium-Catalyzed Cross-Coupling of Silyl Electrophiles with Alkylzinc Halides: A Silyl-Negishi Reaction” J. Am. Chem. Soc. 2017, 139, 7741–7744. [link] Gietter-Burch, A. A. S.; Devannah, V.; Watson, D. A.* “Trifluoromethylation of Secondary Nitroalkanes” Org. Lett. 2017, 19, 2957–2960. [link] Shuler, S. A.; Yin, G.; Krause, S. B.; Vesper, C. M.; Watson, D. A.* “Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction” J. Am. Chem. Soc. 2016, 138, 13830–13833. [link] Mori-Quiroz, L.; Shimkin, K. W.; Rezazadeh, S.; Kozlowski, R. A.; Watson, D. A.*; “Copper-Catalyzed Amidation of Primary and Secondary Alkyl Boronic Esters” Chem. Eur. J. 2016, 22, 15654–15658. [link] Watson, D. A. “Legacy of Richard Heck” Organometallics 2016, 35, 1177–1178. [link] Reid, W. B.; Spillane, J. J.; Krause, S. B.; Watson, D. A.* “Direct Synthesis of Alkenyl Boronic Esters from Unfunctionalized Alkenes: A Boryl-Heck Reaction” J. Am. Chem. Soc. 2016, 138, 5539–5542. [link] Shimkin, K. W.; Gildner, P. G.; Watson, D. A.* “Copper-Catalyzed Alkylation of Nitroalkanes with α-Bromonitriles: Synthesis of β-Cyanonitroalkanes” Org. Lett. 2016, 18, 988–991. [link] Shimkin, K. W.; Watson, D. A.* “Recent Developments in Copper-Catalyzed Radical Alkylations of Electron-Rich π-Systems” Beilstein J. Org. Chem. 2015, 11, 2278–2288. [link]