Burke, Martin D. - University of Illinois at Urbana-Champaign

个人简介

Professor Burke completed his undergraduate studies at Johns Hopkins University in 1998 and his Ph.D. at Harvard University in 2003. After completing an M.D. at Harvard Medical School, he joined the faculty in the Department of Chemistry at the University of Illinois in June of 2005.

研究领域

the area of organic chemistry with a specific focus on the synthesis and study of small molecules with protein-like functions.

近期论文

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Li, J.; Ballmer, S. G.; Gillis, E. P.; Fujii, S.; Schmidt, M. J.; Palazzolo, A. M. E.; Lehmann, J. W.; Morehouse, G. F.; Burke, M. D. "Synthesis of Many Different Types of Organic Small Molecules Using One Automated Process" Science 2015, 347, 1221-1226. Woerly, E. M.; Roy, J.; Burke, M. D. "Synthesis of Most Polyene Natural Product Motifs Using Just Twelve Building Blocks and One Coupling Reaction" Nature Chemistry 2014, 6, 484-491. Anderson, T. M.; Clay, M. C.; Cioffi, A. G.; Diaz, K. A.; Hisao, G. S.; Tuttle, M. D.; Nieuwkoop, A. J.; Comellas, G.; Wang, S.; Uno, B. E.; Wildeman, E. L.; Maryum, N.; Gonen, T.; Rienstra, C. M.; Burke, M. D. "Amphotericin Forms an Extramembranous and Fungicidal Sterol Sponge" Nature Chemical Biology 2014, 10, 400-406. Wilcock, B. C.; Endo, M. M.; Uno, B. E.; Burke, M. D. "C2'-OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human Cells but Not Yeast Cells" J. Am. Chem. Soc. 2013, 135, 8488-8491. Woerly, E. M.; Miller, J. E.; Burke, M. D. "(1-Bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis" Tetrahedron Special Issue in Honor of Professor Paul Wender for receipt of the Tetrahedron Award 2013, 69, 7732-7740. Wilcock, B. C.; Uno, B. E.; Bromann, G. L.; Clark, M. J.; Anderson, T. M.; Burke, M. D. "Electronic tuning of site-selectivity" Nature Chemistry 2012, 4, 996-1003. K.C. Gray, D.S. Palacios, I. Dailey, M.M. Endo, B.E. Uno, B.C. Wilcock, M.D. Burke. "Amphotericin primarily kills yeast by simply binding ergosterol" Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 2234-2239. G.R. Dick, E.M. Woerly, M.D. Burke. "A General Solution for the 2-Pyridyl Problem" Angew. Chem. Int. Ed. 2012, 51, 2667-2672 . J. Li, M.D. Burke. "Pinene-Derived Iminodiacetic Acid (PIDA): A Powerful Ligand for Stereoselective Synthesis and Iterative Cross-Coupling of C(sp3) Boronate Building Blocks" J. Am. Chem. Soc. 2011, 133, 13774-13777. S. Fujii, S.Y. Chang, M.D. Burke. "Total Synthesis of Synechoxanthin through Iterative Cross-Coupling" Angew. Chem. Int. Ed. 2011, 50, 7862-7864. D.S. Palacios, I. Dailey, D.M. Siebert, B.C. Wilcock, M.D. Burke. "Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities" Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 6733-6738. E.M. Woerly, J.R. Struble, N. Palyam, S.P. O'Hara, M.D. Burke. "(Z)-(2-Bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis" Tetrahedron: Special Issue in honor of Professor Dean Toste for receipt of the Tetrahedron Young Investigator Award 2011, 67, 4333-4343. S.J. Lee, T.M. Anderson, M.D. Burke. "A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross-Coupling" Angew. Chem. Int. Ed. 2010, 49, 8860-8863. E.M. Woerly, A.H. Cherney, E.K. Davis, M.D. Burke. "Stereoretentive Suzuki-Miyaura Coupling of Haloallenes Enables Fully Stereocontrolled Access to (-)-Peridinin" J. Am. Chem. Soc. 2010, 132, 6941-6943. G.R. Dick, D.M. Knapp, E.P. Gillis, M.D. Burke. "General Method for Synthesis of 2-Heterocyclic N-Methyliminodiacetic Acid Boronates" Org. Lett. 2010, 12, 2314-2317. J.R. Struble, S.J. Lee, M.D. Burke. "Ethynyl MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis." Tetrahedron: Special Issue in honor of Professor Brian Stoltz for receipt of the Tetrahedron Young Investigator Award, 2010, 66, 4710-4718. I.A. Dailey, M.D. Burke. "N-(Carboxymethyl)-N-methyl-glycine." Encyclopedia of Reagents for Organic Synthesis, 2010. S.G. Ballmer, E.P. Gillis, M.D. Burke. "B-Protected Haloboronic Acids for Iterative Cross-Coupling" Org. Syn. 2009, 86, 344-359. E.P. Gillis, M.D. Burke. "Iterative Cross-Coupling with MIDA Boronates: Towards a General Strategy for Small Molecule Synthesis," Aldrichimica Acta, 2009, 42, 17-27. D.M. Knapp, E.P. Gillis, M.D. Burke. "A General Solution for Unstable Boronic Acids: Slow-Release Cross-Coupling from Air-Stable MIDA Boronates." J. Am. Chem. Soc. 2009, 131, 6961-6963.