黄新祥 - 江苏大学

个人简介

教授，博士生导师，医学院副院长，中国微生物学学会分析微生物学专业委员会委员，江苏省“333高层次人才培养工程”中青年科学技术带头人。1985年毕业于苏州医学院获医学学士学位，1991年大连医学院研究生毕业获生物化学硕士学位，2004年于日本岐阜大学微生物学与生物信息学博士研究生毕业并获日本（甲类）医学博士学位。主讲课程：《医学生物化学》（本科）、《高级生物化学》（硕士研究生）、《BiochemistryandMolecularBiology》(MBBS留本科学生)、《AdvanceinBiochemistryandMolecularBiology》(留学研究生)。近期获得主要科研课题： 1.长链反义RNA调控伤寒沙门菌毒力机制研究（81371780）（2014.1-2017.12），国家自然科学基金（主持）； 2.抗H:z66抗体诱导伤寒沙门菌鞭毛相变换机制（30570088）（2009.1-2011.12），国家自然科学基金（主持）； 3.病原体变异及其生物信息学分析技术研究（2008ZX10402）（2008.10-2011.12），国家科技重大专项课题（子课题负责）； 4.重要食源性致病菌的标识基因和基因差异表达的研究（2006BAK02A15－2）（2006.1-2008.12），国家科技支撑计划“食品安全关键技术”重大项目子项目（子课题负责）； 5.伤寒沙门菌z66鞭毛抗原表达调节机制研究（30570088）（2006.1-2008.12），国家自然科学基金（主持）； 6.伤寒沙门菌z66鞭毛抗原表达调节机制研究（2005.1-2006.12），教育部回国人员科研启动基金（主持）。

研究领域

近年来主要从事有关人类肠道致病菌基因表达研究，首次发现伤寒沙门菌的z66鞭毛抗原的编码基因并揭示其具有二相鞭毛基因的分子遗传学特性；建立了伤寒沙门菌全基因组DNA芯片分析系统，并应用于伤寒沙门菌高渗应激下基因组表达变化研究，发现并验证了PhoP、OmpR、Mig14，RpoE与RpoS对伤寒沙门菌侵袭相关的毒性基因表达调节作用；利用高通量序列分析结合分子细菌学方法，发现并验证了一系列新的沙门菌非编码RNA，并揭示其在沙门菌中的功能和作用特性。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.ZhangQ,ZhangY,ZhangX,ZhanL,ZhaoX,XuS,ShengX,HuangX*.Thenovelcis-encodedantisenseRNAAsrCpositivelyregulatestheexpressionofrpoE-rseABCoperonandthusenhancesthemotilityofSalmonellaentericaserovarTyphi.FrontMicrobiol.2015,17;6:990. 2.GongM,XuS,JinY,ZhangY,DadzieI,ZhangX,WangZ,ZhuY,NiB,ShengX,HuangX*.5'-UTRofmalSincreasestheinvasivecapacityofSalmonellaentericaserovarTyphibyinfluencingtheexpressionofbax.FutureMicrobiol.2015Jun,10:941-54. 3.ZhengX,JiY,WengX,HuangX*.RpoS-DependentExpressionofOsmYinSalmonellaentericaserovarTyphi:ActivationUnderStationaryPhaseandSPI-2-InducingConditions.CurrMicrobiol.2015Jun,70(6):877-82. 4.DadzieI,NiB,GongM,YingZ,ZhangH,ShengX,XuS,HuangX*.IdentificationandcharacterizationofacisantisenseRNAoftheparCgeneencodingDNAtopoisomeraseIVofSalmonellaentericaserovarTyphi.ResMicrobiol.2014Jul-Aug,165(6):439-46. 5.ZhaoX,ZhuY,ZhangH,DuH,NiB,HuangX*.TranscriptionalexpressionofsixgeneslocatedonpBSSB1ofSalmonellaentericaserovarTyphiindifferentgrowthphasesandenvironmentalstresses.CurrMicrobiol.2014Sep;69(3):252-7. 6.ShengX,XuS,LuR,IsaacD,ZhangX,ZhangH,WangH,QiaoZ,HuangX*.Designofacomprehensivebiochemistryandmolecularbiologyexperiment:phasevariationcausedbyrecombinationalregulationofbacterialgeneexpression.BiochemMolBiolEduc.2014May-Jun;42(3):224-9. 7.ShengX,ZhangH,XiaQ,XuS,XuH,HuangX*.Mig-14playsanimportantroleininfluencinggeneexpressionofSalmonellaentericaserovarTyphi,whichcontributestocellinvasionunderhyperosmoticconditions.ResMicrobiol.2013,164:903-912. 8.DadzieI,XuS,NiB,ZhangX,ZhangH,ShengX,XuH,HuangX*.IdentificationandCharacterizationofaCis-EncodedAntisenseRNAAssociatedwiththeReplicationProcessofSalmonellaentericaSerovarTyphi.PLoSOne.2013,8:e61308. 9.ZhangH,NiB,ZhaoX,DadzieI,DuH,WangQ,XuH,HuangX*.FisisessentialforthestabilityoflinearplasmidpBSSB1andaffectsthemotilityofSalmonellaentericaSerovarTyphi.PLoSOne.2012,7:e37462. 10.ZhangH,DuH,JiX,NiB,MaoL,XuS,ShengX,XuH,HuangX*.OmpRmayregulatetheputativeYehU/YehTtwo-componentsysteminSalmonellaentericaserovarTyphiunderhypotonicgrowthcondition.CurrMicrobiol.2012,64:283-289. 11.LuoZ,WangM,DuH,YangT,WangF,NiB,XuS,HuangX*.TheputativesensorkinaseQseCofSalmonellaentericaserovarTyphicanpromoteinvasioninthepresenceofglucose.FoodResearchInternational.2012,45:1004–1010. 12.ZhangH,ZhangX,YanM,PangB,KanB,XuH,HuangX*.GenotypingofSalmonellaentericaserovarTyphistrainsisolatedfrom1959to2006inChinaandanalysisofgeneticdiversitybygenomicmicroarray.CroatMedJ.2011,52:688-693. 13.DuH,ShengX,ZhangH,ZouX,NiB,XuS,ZhuX,XuH,HuangX*.RpoEmaypromoteflagellargeneexpressioninSalmonellaentericaserovartyphiunderhyperosmoticstress.CurrMicrobiol.2011,62:492-500. 14.DuH,WangM,LuoZ,NiB,WangF,MengY,XuS,HuangX*.CoregulationofgeneexpressionbysigmafactorsRpoEandRpoSinSalmonellaentericaserovarTyphiduringhyperosmoticstress.CurrMicrobiol.2011,62:1483-1489. 15.WangM,LuoZ,DuH,XuS,NiB,ZhangH,ShengX,XuH,HuangX*.MolecularcharacterizationofafunctionaltypeVIsecretionsysteminSalmonellaentericaserovarTyphi.CurrMicrobiol.2011,63:22-31. 16.GaoH,ZhangY,YangL,LiuX,GuoZ,TanY,HanY,HuangX,ZhouD*,YangR*.RegulatoryeffectsofcAMPreceptorprotein(CRP)onporingenesanditsowngeneinYersiniapestis.BMCMicrobiol.2011,11:40. 17.GaoH,ZhangY,HanY,YangL,LiuX,GuoZ,TanY,,HuangX,ZhouD*,YangR*.PhenotypicandtranscriptionalanalysisoftheosmoticregulatorOmpRinYersiniapestis.2011,11:39. 18.XieX,LiA,DuH,ShengX,ZhangH,XuS,HuangX*.ExpressionoftviAistransientlyrepressedbyHfqinSalmonellaentericaserovarTyphiathyperosmoticstress.MicrobPathog.2010,49:54-57. 19.XuS,ZouX,ShengX,ZhangH,MaoL,DuH,XuH,HuangX*.ExpressionoffljB:z66onalinearplasmidofSalmonellaentericaserovarTyphiisdependentonFliAandFlhDCandregulatedbyOmpR.BrJMicrobiol.2010,41:729-740. 20.ZouX,HuangX*,XuS,ZhouL,ShengX,ZhangH,XuH,EzakiT.IdentificationofafljAgeneonalinearplasmidastherepressorgeneoffliCinSalmonellaentericaserovarTyphi.MicrobiolImmunol.2009,53:191-197. 21.ShengX,HuangX*,LiJ,XieX,XuS,ZhangH,XuH.RegulationofsulfurassimilationpathwaysinSalmonellaentericaserovarTyphiuponup-shifthighosmotictreatment:theroleofUhpArevealedthroughtranscriptomeprofiling.CurrMicrobiol.2009,59:628-635. 22.ZhangH,ShengX,XuS,GaoY,DuH,LiJ,XuH,HuangX*.GlobaltranscriptionalresponseofSalmonellaentericaserovarTyphitoanti-z66antiserum.FEMSMicrobiolLett.2009,298:51-55. 23.ShengX,HuangX*,MaoL,ZhuC,XuS,ZhangH,XuH,LiuX.PreparationofgenomicDNAmicroarrayofSalmonellaentericaserovarTyphiforgeneexpressionprofileanalysis.ProgBiochemBiophs.2009,36:206-212. 24.XuS,ZhangH,ShengX,XuH,HuangX*.TranscriptionalexpressionoffljB:z66,aflagellingenelocatedonanovellinearplasmidofSalmonellaentericaserovarTyphiunderenvironmentalstresses.NewMicrobiol.2008,31:241-247. 25.XuS,HuangX,XuH,ZhangC*.ImprovedpredictionofcoreceptorusageandphenotypeofHIV-1basedoncombinedfeaturesofV3loopsequenceusingrandomforest.JMicrobiol.2007,45:441-446. 26.HuangX,XuH,SunX,OhkusuK,KawamuraY,EzakiT*.Genome-WidescanofthegeneexpressionkineticsofSalmonellaentericaserovarTyphiduringhyperosmoticstress.IntJMolSci.2007,8:116-135. 27.HuangX,XuH,ShaMM,ZhaoL,OhkusuK,KawamuraY,EzakiT*.Virulence-defectivestrainsofSalmonellaentericaserovarTyphiascandidatesforeducationatlevel2facilities.MicrobiolImmunol.2006,50:273-279. 28.HuangX,PhungleV,DejsirilertS,TishyadhigamaP,LiY,LiuH,HiroseK,KawamuraY,EzakiT*.Cloningandcharacterizationofthegeneencodingthez66antigenofSalmonellaentericaserovarTyphi.FEMSMicrobiolLett.2004,234:239-246.