个人简介
欧和生,男,药理学教授,博士生导师;1965年出生于湖南省永州市。1987年毕业于南华大学医学系医疗专业(本科),1992年取得医学硕士学位,1999年取得北京大学医学博士学位。1999年至2005年间留学美国,分别在芝加哥大学,罗彻斯特大学,贝勒医学院等著名学府从事心血管疾病和糖尿病分子病理学研究。2005年回国。在国内外杂志上发表专业论文60余篇,其中SCI论文23篇,包括国际一流杂志NatureMedicine,PNAS,RircRes,Circulation,Endocriology等,总影响因子113.76,最高27.13;第一或通讯作者总影响因子71.78,最高9.77。主要研究领域是心血管和糖尿病分子药理学,近年来从事microRNA的生物学功能及其在人类重大疾病(如高血压,糖尿病,癌症)中的临床应用价值研究。
重大成果奖励
获得中国高校科学技术奖(自然科学奖)二等奖(证书号:2001-028)
中华人民共和国教育部科技成果奖(成果登记号:360-01-10010053-03)
基金资助(负责人)
国家自然基金面上项目:高血压相关性内皮型miRNAs的鉴定与功能分析及其对高血压的治疗价值研究,拍批准号:81373403,期限:2014.1-2017.12
国家自然基金面上项目:脂肪型微核糖核酸在Ⅱ型糖尿病发生发展的作用及其治疗价值研究,批准号:30871186,期限:2009.1-2011.12
国家自然基金面上项目:微核糖核酸对内皮型一氧化氮合酶表达的调节作用及分子机制,批准号:30670834期限:2007.6-2009.12
近期论文
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1.LiY,YanL,ZhangW,HuN,ChenW,WangH,KangM,OuH.Suppressionofendothelialnitricoxidesynthaseexpressionandendothelialcellproliferationbyanintronic27-ntmiRNAandit'sanovellinktoAP-1.AmJTranslRes.20157(2):285-97.(IF:3.146)
2.ZhangW,YanL,LiY,ChenW,HuN,WangH,OuH.RolesofmiRNA-24inregulatingendothelialnitricoxidesynthaseexpressionandvascularendothelialcellproliferation.MolCellBiochem.2015405(1-2):281-9.(IF:2.613)
3.MinKang,HeshengOu,RenshengWang,WenqiLiu,YanMao,AnzhouTang.Effectoftrichosanthinonapoptosisandtelomeraseactivityofnasopharyngealcarcinomasinnudemice.JOURNALOFBUON,2014,19(1):130-6.(IF:0.706)
4.YumeiLi1,LimeiYan2,WenyuZhang1,HuiWang1,WeiChen1,NanHu1,HeshengOu.miR-21inhibitorsuppressesproliferationandmigrationofnasopharyngealcarcinomacellsthroughdown-regulationofBCL2expression.IntJClinExpPathol,2014,7(6):3478-87.(IF:1.891)
5.LiY,YanL,ZhangW,HuN,ChenW,WangH,KangM,OuH.MicroRNA-21inhibitsplatelet-derivedgrowthfactor-inducedhumanaorticvascularsmoothmusclecellproliferationandmigrationthroughtargetingactivatorprotein-1.AmJTranslRes,2014,6(5):507-16.(IF:3.402)
6.OuH,LiY,KangM.ActivationofmiR-21bySTAT3inducesproliferationandsuppressesapoptosisinnasopharyngealcarcinomabytargetingPTENgene.PLoSOne,2014,9(11):e109929.(IF:3.234)
7.MKang,LMYan,YMLi,WYZhang,HWang,AZTang,HSOu.InhibitoryeffectofmicroRNA-24onfattyacid-bindingproteinexpressionon3T3-L1adipocytedifferentiation.GeneticsandMolecularResearch,2013,12(4):5267-5277.(IF:0.850)
8.MinKang,Li-MeiYan,Wen-YuZhang,Yu-MeiLi,An-ZhouTang,He-ShengOu.RoleofmicroRNA-21inregulating3T3-L1adipocytedifferentiationandadiponectinexpression.MolBiolRep,2013,40:5027–5034.(IF:1.958)
9.MINKANG,YUMEILI,WENQILIU,RENSHENGWANG,ANZHOUTANG,HONGHAO,ZHENGUOLIUandHESHENGOU.miR-129-2suppressesproliferationandmigrationofesophagealcarcinomacellsthroughdownregulationofSOX4expression.INTERNATIONALJOURNALOFMOLECULARMEDICINE,2013,32:51-58.(IF:1.880)
10.LimeiYan,MinKang,ZhengqiQin,WenyuZhang,YumeiLi,HeshengOu.AnIntronicmiRNARegulatesExpressionoftheHumanEndothelialNitricOxideSynthaseGeneandProliferationofEndothelialCellsbyaMechanismRelatedtotheTranscriptionFactorSP-1.PLOSONE,2013,8(8):e70658.(IF:3.534)
11.MinKang,HeshengOu,RenshengWang,WenqiLiu,YanMao,AnzhouTang.Effectoftrichosanthinonapoptosisandtelomeraseactivityofnasopharyngealcarcinomasinnudemice.JOURNALOFBUON,2013,18(3):675-682.(IF:0.706)
12.LimeiYan,HongHao,TerryS.Elton,ZhenguoLiu,HeshengOU.IntronicmicroRNAsuppressesendothelialnitricoxidesynthaseexpressionandendothelialcellproliferationviainhibitionofSTAT3signaling.MolCellBiochem,2011,357:9–19.(IF:2.057)
13.LingHY,HuB,WangBX,ZuXY,FengSD,OuHS,ZhouSH,LiaoDF.Effectsofrosiglitazoneontheproliferationofvascularsmoothmusclecellinducedbyhighglucose.CardiovascDrugsTher.2008Dec;22(6):453-60.(IF:2.52)
14.WangX1,LeMaireSA,ChenL,ShenYH,GanY,BartschH,CarterSA,UtamaB,OuH,CoselliJS,WangXL.Increasedcollagendepositionandelevatedexpressionofconnectivetissuegrowthfactorinhumanthoracicaorticdissection.Circulation.2006Jul4;114(1Suppl):I200-5.(IF:14.92)
15.OuH,ZhangMX,ShenYH,WangJ,WangJ,CoselliJandWangXL.RegulationofeNOSexpressionbysmallRNA.ProcNatlAcadSciUSA,2005,102(47):16967-72.(IF:9.77)
16.ZhouS,ShibusawaN,NaikK,PorrasD,TempleK,OuH,BradyM,WondisfordFE.InsulinRegulationofHepaticGluconeogenesisthroughPhosphorylationof
CREBBindingProtein(CBP).NatureMedicine,2004Jun,10(6):633-7.(IF:27.13)
17.OuH,YanL,OsmanovicS,GreenbergC,BradyMJ.SpatialOrganizationofGlycogenSynthesisin3T3-L1Adipocytes.Endocrinology,2005Jan;146(1):494-502.(IF:4.75)
18.OUH,YanL,MakinenM,MustafiD,andBradyMJ.Insulin-MimesisofVanadylChelatesInvolvesTyrosinePhosphorylationoftheInsulinReceptor.JournalofInorganicBiolChem,2005Oct,19:1-13.(IF:3.25)19.OuH,ShenYH,UtamaB,WangJ,WangX,CoselliJ,WangXL.Effectofnuclearactinonendothelialnitricoxidesynthaseexpression.ArterioclerThrombVasBiol,2005,25(12):2509-14.(IF:7.23)
20.20.ZhouXY1,ShibusawaN,NaikK,PorrasD,TempleK,OuH,KaiharaK,RoeMW,BradyMJ,WondisfordFE.InsulinregulationofhepaticgluconeogenesisthroughphosphorylationofCREB-bindingprotein.NatMed.2004Jun;10(6):633-7.(IF:27.13)
21.OuH,HaendelerJ,AeblyMR,KellyLA,CholewaBC,KoikeG,KwitekBlackA,JacobHJ,BerkBC,MianoJM.Retinoicacid-inducedtissuetransglutaminaseandap-optosisinvascularsmoothmusclecells.CircRes2000Nov10;87(10):881-7.(IF:9.50)