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个人简介

主要从事肝纤维化的基础研究工作,先后主持了与肝纤维化研究相关的国家自然科学基金课题3项、省级课题3项;以通讯或第一作者发表SCI论文29篇(总的影响因子为90.93,被引用435次,IF5.0以上有3篇)、中文核心期刊论文26篇;获得国家授权发明专利3项;获得广西自然科学奖二等奖1项(排名第2)、广西科技进步奖三等奖1项(排名第3)、中国药学会科学技术奖三等奖1项(排名第3)。 科研项目: 近5年主持的纵向省级以上科研课题6项,经费200万元。 1.Raf激酶抑制蛋白在肝纤维化发生机制中的调控作用,国家自然科学基金,批准号:81260505,55万元,主持。 2.从TGF-β1/Smads、ERK信号途径探讨山芝麻酸甲酯抗肝纤维化的作用机制,国家自然科学基金,批准号:81473431,73万元,主持。 3.基于PI3K/Akt信号通路探讨鹅不食草心菊内酯抑制肝纤维化的作用机制,国家自然科学基金,批准号:81660693,直接经费36万元,主持。 4.鹅不食草心菊内酯抗肝纤维化的作用及其机制研究,广西自然科学基金重点项目,批准号:2016GXNSFDA380025,经费30万无,主持。 5.山芝麻酸甲酯介导ERK信号传导通路对肝纤维化的抑制作用机制,广西自然科学基金面上项目,批准号:2014GXNSFAA118154,经费5万无,主持。 6.基于Raf-1/MEK/ERK1,2信号通路研究RKIP在肝纤维化中的调控作用,广西自然科学基金面上项目,批准号:2013GXNSFAA019150,经费5万无,主持。 获得专利 (1)山芝麻提取物在制备抗肝纤维化药物中的应用,专利号:ZL201010154207.6,授权公告:2013.05(专利权人:林兴)。 (2)山芝麻提取物在制备抗乙型肝炎药物中的应用,专利号:ZL201110102153.3,授权公告:2013.07(专利权人:林兴)。 (3)满天星异荭草苷在制备治疗酒精性肝损伤药物中的应用,授权专利号:ZL201310190276.6,授权公告:2015.01(专利权人:黄权芳,林兴)。

研究领域

研究方向: 1.民族药抗肝纤维化研究 2.中药活性成分抗脂肪肝的研究

近期论文

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1.BaiF,HuangQF,WeiJB,LvSJ,ChenYX,LiangCH,WeiL,LuZP,LinX*.Gypsophilaelegansisoorientin-2″-O-α-L-arabinopyranosylamelioratesporcineserum-inducedimmuneliverfibrosisbyinhibitingNF-κBsignalingpathwayandsuppressingHSCactivation.InternationalImmunopharmacology.2018,54:60-67(IF2.956)(通讯作者) 2.HuangQF,BaiF,NieJ,LuS,LuC,ZhuX,ZhuoL,LuZ,LinX*.DidyminameliorateshepaticinjurythroughinhibitionofMAPKandNF-κBpathwaysbyup-regulatingRKIPexpression.InternationalImmunopharmacology.2017,42:130-138(IF2.956)(通讯作者) 3.WeiJ1,HuangQF1,BaiF,LinJ,NieJ,LuS,LuC,HuangR,LuZ,LinX*.Didymininducesapoptosisthroughmitochondrialdysfunctionandup-regulationofRKIPinhumanhepatomacells.Chemico-BiologicalInteractions.2017,261(5):118-126(IF3.143)(通讯作者) 4.BaiF,HuangQF,NieJL,LuSJ,LuCY,ZhuXS,WangYX,ZhuoL,LuZP,LinX*.TrollineAmelioratesLiverFibrosisbyInhibitingtheNF-κBPathway,PromotingHSCApoptosisandSuppressingAutophagy.CellularPhysiologyandBiochemistry.2017,44:436-446(IF5.104)(通讯作者) 5.LinX,WeiJB,ChenYX,HeP,LinJ,TanSM,NieJL,LuSJ,HeM,LuZP,HuangQF*,IsoorientinfromGypsophilaelegansinducesapoptosisinlivercancercellsviamitochondrial-mediatedpathway.JournalofEthnopharmacology.2016,187:187–194(IF2.981)(第一作者) 6.HuangQF,WeiL,LiangC,NieJ,LuS,LuC,TanS,LvS,ZhuoL,LuZ,LinX*.LossofRafkinaseinhibitorproteinisassociatedwithmalignantprogressioninhepaticfibrosis.Biomedicine&Pharmacotherapy.2016,82:669-676(IF2.759)(通讯作者) 7.HuangQF,LiangC,WeiL,NieJ,LuS,LuC,TanS,LvS,ZhuoL,LuZ,LinX*.Rafkinaseinhibitoryproteindown-expressionexacerbateshepaticfibrosisInVivoandInVitro.CellularPhysiologyandBiochemistry.2016,40:49-61(IF5.104)(通讯作者) 8.LinX,BaiF,NieJ,LuS,LuC,ZhuX,WeiJ,LuZ,HuangQF*.DidyminalleviateshepaticfibrosisthroughinhibitingERKandPI3K/AktpathwaysviaregulationofRafkinaseinhibitorprotein.CellularPhysiologyandBiochemistry.2016,40:1422-1432(IF5.104)(第一作者) 9.WeiL,LvSJ,HuangQF,WeiJB,ZhangSJ,HuangRB,LuZP,LinX*.PratenseinattenuatesAβ-inducedcognitivedeficitsinrats:Enhancementofsynapticplasticityandcholinergicfunction.Fitoterapia.2015,101:208-217(IF2.698)(通讯作者) 10.LiangCH,TanSM,HuangQF,LinJ,LuZP,LinX*.Pratenseinamelioratesβ-amyloid-inducedcognitiveimpairmentinratsviareducingoxidativedamageandrestoringsynapseandBDNFlevels.NeuroscienceLetters.2015,592:48–53(IF2.18)(通讯作者) 11.LinX,ChenY,LvS,TanS,ZhangS,HuangR,ZhuoL,LiangS,LuZ,HuangQF*.GypsophilaelegansisoorientinattenuatesCCl4-inducedhepaticfibrosisinratsviamodulationofNF-κBandTGF-β1/Smadsignalingpathways.Internationalimmunopharmacology.2015Jun25,28(1):305-312.(IF2.956)(第一作者) 12.LinX1,HuangZS1,ChenXY,RongYP,ZhangSJ,JiaoY,HuangQF,HuangRB*.ProtectiveeffectofMillettiapulchrapolysaccharideoncognitiveimpairmentinducedbyd-galactoseinmice.Carbohydratepolymers.2014,101:533-543(IF4.811)(并列第一作者) 13.LinX,ZhangSJ,HuangRB,TanS,LiangS,WuX,ZhuoL,HuangQF*.ProtectiveeffectoftormenticacidfromPotentillachinensisagainstlipopolysaccharide/D-galactosamineinducedfulminanthepaticfailureinmice.InternationalImmunopharmacology,2014,19:365-372(IF2.956)(第一作者) 14.LinX,ZhangSJ,HuangRB,WeiL,LiangC,ChenY,LvS,LiangS,WuX,HuangQF*.ProtectiveEffectofGenisteinonLipopolysaccharide/D-galactosamine-inducedHepaticFailureinMice.Biologicalandpharmaceuticalbulletin.2014,37(4):1-8(IF1.574)(第一作者) 15.LinX,ZhangSJ,HuangRB,WeiL,TanS,LiangS,TianYC,WuXY,LuZP,HuangQF*.Helenalinattenuatesalcohol-inducedhepaticfibrosisbyenhancingethanolmetabolism,inhibitingoxidativestressandsuppressingHSCactivation.Fitoterapia.2014,95:203-213(IF2.698)(第一作者) 16.LinX,ZhangSJ,HuangRB,WeiL,TanS,LiangC,LvS,ChenY,LiangS,TianY,LuZ,HuangQF*.ProtectiveeffectofmadecassosideagainstcognitiveimpairmentinducedbyD-galactoseinmice.Pharmacology,BiochemistryandBehavior.2014,124:343-442(IF2.537)(第一作者) 17.HuangQF,HuangRB,WeiL,ChenY,LvS,LiangC,ZhangX,YinF,LiHT,ZhuoL,LinX*.AntiviralactivityofmethylhelicterateisolatedfromHelicteresangustifolia(Sterculiaceae)againsthepatitisBvirus.Antiviralresearch.100(2):373-381,2013(IF4.909)(通讯作者) 18.HuangQF,HuangRB,ZhangZJ,LinJ,WeiL,HeM,ZhuoL,LinX*.ProtectiveeffectofgenisteinisolatedfromHydrocotylesibthorpioidesonhepaticinjuryandfibrosisinducedbychronicalcoholinrats.ToxicologyLetters.217(2):102-110,2013(IF3.522)(通讯作者) 19.HuangQF,ZhangSJ,HuangRB,WeiL,ChenY,LvS,LiangC,TanS,ZhuoL,LinX*.Isolationandidentificationofananti-hepatitisBviruscompoundfromHydrocotylesibthorpioidesLam.Journalofethnopharmacology.150(2):568-575,2013(IF2.981)(通讯作者) 20.LinX,HuangRB,ZhangSJ,WeiL,ZhuoL,WuX,TangA,HuangQF*.Beneficialeffectsofasiaticosideoncognitivedeficitsinsenescence-acceleratedmice.Fitoterapia.87:69-77,2013(IF2.698)(第一作者) 21.WeiJ,HuangQF,HuangRB,ChenY,LvS,WeiL,LiangC,LiangS,ZhuoL,LinX*.AsiaticacidfromPotentillachinensisattenuateethanol-inducedhepaticinjuryviasuppressionofoxidativestressandKupffercellactivation.Biological&pharmaceuticalbulletin.36(12):1980-1989,2013(IF1.574)(通讯作者) 22.HuangQF,ZhangSJ,ZhengL,LiaoM,HeM,HuangRB,ZhuoL,LinX*.Protectiveeffectofisoorientin-2″-O-α-L-arabinopyranosylisolatedfromGypsophilaelegansonalcoholinducedhepaticfibrosisinrats.Foodandchemicaltoxicology.50(6):1992-2001,2012(IF3.778)(通讯作者) 23.HuangQF,ZhangSJ,ZhengL,HeM,HuangR.B,LinX*.HepatoprotectiveeffectsofTotalSaponinsIsolatedfromTaraphochlamysaffinisagainstcarbontetrachlorideinducedliverinjuryinrats.Foodandchemicaltoxicology.50,713-718,2012(IF3.778)(通讯作者) 24.LinX,HuangRB,ZhangSJ,ZhengL,WeiL,HeM,ZhouY,ZhuoL,HuangQF*.MethylhelicterateprotectsagainstCCl4-inducedliverinjuryinratsbyinhibitingoxidativestress,NF-κBactivation,Fas/FasLpathwayandcytochromeP4502E1level.Foodandchemicaltoxicology.50(10):3413-3420,2012(IF3.778)(第一作者) 25.HuangQF,LiYW,ZhangSJ,HuangRB,ZhengL,WeiL,HeM,LiaoM,LiL,ZhuoL,LinX*.EffectandmechanismofmethylhelicterateisolatedfromHelicteresangustifolia(Sterculiaceae)onhepaticfibrosisinducedbycarbontetrachlorideinrats.JournalofEthnopharmacology.143(3):889-895,2012(IF2.981)(通讯作者) 26.LinX,ZhangSJ,HuangQF,WeiL,ZhengL,ChenZ.N,JiaoY,HuangJC,FuSJ,HuangRB*.ProtectiveeffectofFufang-Liu-Yue-Qing,atraditionalChineseherbalformula,onCCl4inducedliverfibrosisinrats.JournalofEthnopharmacology.142(2):548-56,2012(IF2.981)(第一作者) 27.ZhuoL,MingM,ZhengL,HeM,HuangQF,WeiL,HuangRB,ZhangZJ,LinX*.Combinationtherapywithtaurine,epigallocatechingallateandgenisteinforprotectionagainsthepaticfibrosisinducedbyalcoholinrats.BiologicalandPharmaceuticalBulletin.35(10),1802-1810,2012(IF1.574)(通讯作者) 28.LinX1,LiuX1,HuangQF,ZhangSJ,ZhengL,WeiL,HeM,JiaoY,HuangJC,FuSJ,ChenZN,LiYW,ZhuoL,HuangRB*.HepatoprotectiveeffectsofthepolysaccharideisolatedfromTarphochlamysaffinis(Acanthaceae)againstCCl4-inducedhepaticinjury.BiologicalandPharmaceuticalBulletin.35(9),1574-1580,2012(IF1.574)(并列第一作者) 29.Chen1ZN,Lin1X,ZhangZ.W,HuangJC,FuSJ,HuangRB*.EXO70proteininfluencesdenguevirussecretion.MicrobesandInfection,13(2):143-150,2011(IF2.291,并列第一作者)

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