Lambert, Tristan - Cornell University - Department of Chemistry and Chemical Biology

个人简介

Tristan was born in Madison, WI, in 1976 and grew up in the small town of Black Earth. He graduated from the University of Wisconsin at Platteville in 1998 with a B.S. in chemistry. The same year he began graduate studies at UC-Berkeley as one of Dave MacMillan’s first students. In 2000, Tristan moved with the MacMillan group to Caltech where he earned his Ph.D. for the development and application of novel Claisen rearrangements. In 2004, he began postdoctoral studies with Sam Danishefsky at the Memorial Sloan-Kettering Cancer Center in New York. At Sloan-Kettering he completed a total synthesis of UCS1025A, a putative telomerase inhibitor. In 2006, Tristan accepted a faculty position in the Department of Chemistry at Columbia University. In 2011 he was promoted to Associate Professor and in 2016 to Full Professor. In January 2018, he moved to the Department of Chemistry and Chemical Biology at Cornell University. His research group focuses on the study of intriguing chemical building blocks such as aromatic ions and their application to problems in the areas of catalysis, reaction design, and polymers.

研究领域

Research in the Lambert group is focused in the area of catalysis. We are especially interested in the development of novel catalytic strategies for selective organic synthesis. Projects that we have been active in include dehydrative reactions, enantioselective Bronsted base catalysis, and carbonyl-olefin metathesis. In approaching these and other problems, we strive to develop highly effective practical solutions while asking interesting questions of reactivity and mechanism. We bring both synthetic and physical organic techniques to bear on answering these questions as we work to develop catalyst systems of practical value for the field of organic synthesis.

近期论文

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Self-Assembly of Aminocyclopropenium Salts: En Route to Deltic Ionic Liquid Crystals.Litterscheidt, J.; Bandar, J. S.; Ebert, M.; Forschner, R.; Bader, K.; Lambert, T. H.; Frey, W.; Bühlmeyer, A.; Brändle, M.; Schulz, F.; Laschat. S. Angew. Chem. Int. Ed. 2020, 59, early view. Ring-Opening Carbonyl-Olefin Metathesis of Norbornenes.Jermaks, J.; Quach, P.; Seibel, Z. M.; Pomerole, J.; Lambert, T. H. Manuscript submitted. Preprint: ChemRxiv, Synthesis of 1,2-Dihydroquinolines via Hydrazine-Catalysed Ring-Closing Carbonyl-Olefin Metathesis.Zhang, Y.; Sim, J. H.; MacMillan, S. N.; Lambert, T. H. Manuscript submitted. Preprint: ChemRxiv, Primary Alcohols via Nickel Pentacarboxycyclopentadienyl Diamide-Catalyzed Hydrosilylation of Terminal Epoxides.Steiniger, K. A.; Lambert, T. H. Manuscript submitted. Preprint: ChemRxiv, Reductive Electrophotocatalysis: Merging Electricity and Light to Achieve Extreme Reduction Potentials.Kim, H.; Kim, H.; Lambert, T. H.; Lin, S. J. Am. Chem. Soc. 2020, 142, ASAP. Electrophotocatalytic C–H Functionalization of Ethers with High Regioselectivity.Huang, H.; Strater, Z. M.; Lambert, T. H. J. Am. Chem. Soc. 2020, 142, ASAP. Room Temperature, Base-Free SNAr Reactions with Unactivated Aryl Fluorides.Huang, H.; Lambert, T. H. Angew. Chem. Int. Ed. 2020, 59, 658-662 Synthesis of 2H-Chromenes via Hydrazine-Catalyzed Ring-Closing Carbonyl-Olefin Metathesis.Zhang, Y.; Jermaks, J.; MacMillan, S. N.; Lambert, T. H. ACS Catal. 2019, 9, 9259-9264. In Situ Coupling of Single Molecules Driven by Au-Catalyzed Electrooxidation.Zang, Y.; Stone, I.; Inkpen, M. S.; Liu, Z.-F.; Ng, F.; Lambert, T. H.; Nuckolls, C.; Steigerwald, M. L.; Roy, X.; Venkataraman, L. Angew. Chem. Int. Ed. 2019, 58, 16008-16012. Electrophotocatalysis with a Trisaminocyclopropenium Radical Dication.Huang, H.; Strater, Z. M.; Rauch, M.; Shee, J.; Sisto, T. J.; Nuckolls, C.; Lambert, T. H. Angew. Chem. Int. Ed. 2019, 58, 13318-13322. Controlled Cationic Polymerization: Single-Component Initiation Under Ambient Conditions.Kottisch, V.; O’Leary, J. M.; Michaudel, Q.; Stache, E.; Lambert, T. H.; Fors, B. J. Am. Chem. Soc. 2019, 141, 10605-10609. Development of a Hydrazine-Catalyzed Carbonyl-Olefin Metathesis Reaction.Lambert, T. H. Synlett 2019, 30, 1954-1965. Oxidizable Ketones: Persistent Radical Cations from the Single Electron Oxidation of 2,3‐Diaminocyclopropenones.Strater, Z. M.; Rauch, M.; Jockusch, S.; Griffith, A. K.; Lambert, T. H. Angew. Chem. Int. Ed. 2019, 58, 8049-8052. A Scalable, One-Pot Synthesis of 1,2,3,4,5-Pentacarbomethoxycyclopentadiene.Radtke, M. A.; Dudley, C. C.; O'Leary, J. M.; Lambert, T. H. Synthesis 2019, 51, 1135-1138. The Hydrazine–O2 Redox Couple as a Platform for Organocatalytic Oxidation: Benzo[c]cinnoline-Catalyzed Oxidation of Alkyl Halides to Aldehydes.Stone, I. B.; Jermaks, J.; MacMillan, S. N.; Lambert, T. H. Angew. Chem. Int. Ed. 2018, 57, 12494-12498. Silylated Cyclopentadienes as Competent Silicon Lewis Acid Catalysts.Radtke, M. A.; Lambert, T. H. Chem. Sci. 2018, 9, 6406–6410. Asymmetric Induction via a Helically Chiral Anion: Enantioselective PCCP Bronsted Acid-Catalyzed Inverse Electron-Demand Diels-Alder Cycloaddition of Oxocarbenium Ions. Gheewala, C.; Hirschi, J. S.; Lee, W.-H.; Paley, D. W.; Vetticatt, M. J.; Lambert, T. H. J. Am Chem. Soc. 2018, 140, 3523-3527. Ion Transport in Cyclopropenium-Based Polymerized Ionic Liquids. Griffin, P. J.; Freyer, J. L.; Han, N.; Yin, X.; Gheewala, C.; Lambert, T. H.; Campos, L. M.; Winey, K. I. Macromolecules 2018, 51, 1681-1687. When Size Matters: Exploring the Potential of Aminocyclopropenium Cations as Head Groups in Triphenylene-Derived Ionic Liquid Crystals in Comparison with Guanidinium and Ammonium Units.Litterscheidt, J.; Judge, P.; Bühlmeyer, A.; Bader, K.; Bandar, J. S.; Lambert, T. H.; Laschat, S. Liquid Crystals 2018, 45, 1250-1258. Cross-coupling of Sulfonic Acid Derivatives via Aryl Radical Transfer (ART) using TTMSS or Photoredox.Nacsa, E. D.; Lambert, T. H. Org. Chem. Front. 2018, 5, 64-69.