祁元明 - 郑州大学 - 生命科学学院

个人简介

祁元明，教授，博士生导师。中国生物化学与分子生物学会理事，河南省生物化学与分子生物学会理事长，河南省杰出人才基金获得者，河南省医学创新人才基金获得者，河南省教育厅学术与技术带头人，享受政府特殊津贴专家。主持完成国家自然科学基金、河南省杰出人才基金和河南省重点科技攻关等项目，现主持国家自然科学基金、科技部“十二五”重大新药创制专项和河南省重点科技攻关项目，共发表论文90余篇，其中SCI论文24篇，研究成果获得省部级科技进步二等奖3项、三等奖2项，获国家发明专利10余项。主编普通高等教育“十二五”规划教材1部，副主编教材2部，受邀参编外文专著1部。教育经历 ·1980.9－1985.7河南医科大学，医疗系，本科/学士 ·1986.9－1989.7河南医科大学，基础医学院，硕士 ·1999.9－2002.6兰州大学，生命科学学院，博士工作经历 ·1985.7－1999.9河南医科大学医学实验中心，讲师、副教授，副主任 ·2002.7－2003.3郑州大学医学实验中心，教授，主任 ·2003.3-2015.2郑州大学生命科学学院，教授，院长 ·2009.12－2010.12纽约血液中心，访问学者主持课题： 1.国家自然科学基金（81273228）：结核分枝杆菌耐药相关抗原CTL表位的鉴定及多价疫苗的免疫活性研究，起止年月：2013年～2016年. 2.“十二五”科技部“重大新药创制”重大专项（2012ZX09103301-023）：新型抗肿瘤多肽药物AS16的研制，起止年月：2012年～2015年 3.国家自然科学基金（30872381）：食管癌高表达抗原COX-2和MAGE-4的HLA-A多等位基因广谱CTL表位的筛选和鉴定，起止年月：2009年～2011年. 4.河南省杰出人才计划项目（084200510014）：结核病抗原肽表位的筛选和多价疫苗的研制.起止年月：2008年～2010年授权专利： 1.祁元明，吴亚红，高艳锋，陈飞，孙萌，韩艳林，时冉冉，陈艳平.MTA1来源的抗肿瘤CTL表位肽及其应用.国家发明专利授权号：ZL201110138635.4;ZL201310112954.7;ZL201310112755.6;ZL201310112763.0. 2.祁元明，陈飞，高艳锋，朱宇皇，吴亚红，陈艳平，韩艳林.结核耐药相关外排蛋白来源抗结核CTL表位肽及其应用.国家发明专利授权号：ZL201110138646.2;ZL201310101212.4;ZL201310101237.4;ZL201310101482.5. 3.祁元明，朱宇皇，高艳锋，吕虹，翟明霞，陈飞.结核分枝杆菌抗原限制性表位肽.国家发明专利授权号：ZL201010030225.3. 4.祁元明，吴宗胤，高艳锋，吕虹，刘伟，吴亚红，李璐.MAGE-4抗肿瘤CTL表位肽及其应用.国家发明专利授权号：ZL201010212521.5. 5.祁元明，吕虹，高艳锋，朱宇皇，刘伟，李璐，吴亚红，吴宗胤.抗结核CTL表位肽.国家发明专利授权号：ZL200910065403.3. 6.高艳锋，陈艳平，祁元明，刘蓓媛.具有抗肿瘤活性的PD-L1亲和肽及其应用.国家发明专利授权号：ZL201310283767.5. 7.高艳锋，刘伟，祁元明，吕虹，吴宗胤，李璐，吴亚红.PLAC1抗肿瘤CTL表位肽及其应用.国家发明专利授权号：ZL201010205684.0;ZL201110423341.6. 8.高艳锋，翟明霞，刘伟，祁元明，吕虹，吴亚红，代怊，康巧珍.PIWIL2抗肿瘤CTL表位肽及其应用.国家发明专利授权号：ZL201010276917.6. 9.翟明霞，时冉冉，高艳锋，祁元明，刘伟.PL2L60来源的CTL表位肽及其应用.国家发明专利授权号：ZL201210001557.8. 10.祁元明，孙战强，陈鲤翔，李永欣，祁峰，娄慧萍，李静静，胡红敏.具有人群广谱性的抗肿瘤CTL表位肽.国家发明专利授权号：ZL200710054307.X. 11.康巧珍，李黎，刘鑫，汲振余，翟文杰，李国栋，高艳锋，祁元明.Th1细胞因子免疫调节多肽及其应用.国家发明专利授权号：ZL201210004099.3. 教材： ·祁元明主编，高艳锋，张守涛副主编.生物化学实验原理与技术，化学工业出版社，2011.普通高等教育“十二五”规划教材。 ·FeiChen,YanfengGao,YuanmingQi.(Bookchapter)IdentificationofCD8+TCellEpitopesAgainstMycobacteriumtuberculosis.UnderstandingTuberculosis–AnalyzingtheOriginofMycobacteriumTuberculosisPathogenicity,ISBN978-953-307-942-4.InTechPress.2012.

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1.ShiRR,LiuJ,ZouZ,QiYM,ZhaiMX,ZhaiWJ,GaoYF*.TheimmunogenicityofanovelcytotoxicTlymphocyteepitopefromtumorantigenPL2L60couldbeenhancedby4-chlorophenylalaninesubstitutionatposition1.CancerImmunolImmunother.2013,62(11):1723-32. 2.HailiWang,XiChen,YanpingChen,LeiSun,GuodongLi,MingxiaZhai,WenjieZhai,QiaozhenKang,YanfengGao*,YuanmingQi*.AntitumoractivityofnovelchimericpeptidesderivedfromcyclinD/CDK4andtheproteintransductiondomain4.AminoAcids,2013,44(2):499-510. 3.JiZ,ShiX,LiuX,ShiY,ZhouQ,LiuX,LiL,JiX,GaoY,QiY,KangQ.Themembrane-cytoskeletalprotein4.1Nisinvolvedintheprocessofcelladhesion,migrationandinvasionofbreastcancercells.ExpTherMed.2012,4(4):736-740. 4.YahongWu,YanfengGao*,YujieHe,RanranShi,MingxiaZhai,ZongyinWu,MengSun,WenjieZhai,XiChen,YuanmingQi*.AnovelcytotoxicTlymphocyteepitopeanaloguewithenhancedactivityderivedfromcyclooxygenase-2.ScandJImmunol.2012,76(3):278-85. 5.FeiChen,MingxiaZhai,YuhuangZhu,YuanmingQi,WenjieZhai,YanfengGao*.InvitroandinvivoidentificationofanovelcytotoxicTlymphocyteepitopefromRv3425ofMycobacteriumtuberculosis.MicrobiologyandImmunology.2012,56(8):548-53. 6.WeiLiu,MingxiaZhai,ZongyinWu,YuanmingQi,YahongWu,ChaoDai,MengSun,LuLi,YanfengGao*IdentificationofanovelHLA-A2-restrictedcytotoxicTlymphocyteepitopefromcancer-testisantigenPLAC1inbreastcancer.AminoAcids.2012,42(6):2257-65. 7.ZongyinWu,YanfengGao*,YahongWu,WeiLiu,MengSun,MingxiaZhai,YuanmingQi,YongYe.IdentificationofanovelCD8+Tcellepitopederivedfromcancer-testisantigenMAGE-4inoesophagealcarcinoma.ScandJImmunol.2011,74:561-567. 8.Yu-huangZhu,Yan-fengGao*,FeiChen,WeiLiu,Ming-xiaZhai,Wen-jieZhai,Yuan-mingQi*,YongYe.IdentificationofnovelTcellepitopesfromeffluxpumpsofMycobacteriumtuberculosis.ImmunologyLetters.2011,140(1-2):68-73. 9.Jun-weiZhao,Zhan-qiangSun,Hong-guoYang,Chong-zhenZhangandXiao-liYu,Zi-luWen,Yan-fengGao,Xiao-kuiGuo,Yuan-mingQi,Shu-linZhang.Cloning,expressionandimmunologicalevaluationofashortfragmentfromRv3391ofMycobacteriumtuberculosis.AnnalsofMicrobiology,2011,61(2):345-353. 10.HongLv,Yan-fengGao*,Ya-hongWu,Ming-xiaZhai,LuLi,Yu-huangZhu,WeiLiu,Zong-yinWu,FeiChen,Yuan-mingQi.IdentificationofanovelcytotoxicTlymphocyteepitopefromCFP21,asecretedproteinofMycobacteriumtuberculosis.ImmunologyLetters.2010,133(2):94-8. 11.YanfengGao*,KunChen,BinZhang,XiangLi,LuChen,YuanjunLi,XiangjiaoJia,YongxingLei,ZhongyiYan,LiangliangKong,NanWang,WeiLiu,YuanmingQi.AntioxidantandfreeradicalscavengingactivityoftheextracellulardeathfactorinEscherichiacoli.Peptides,2010,31(10):1821-1825. 12.Dong-dongWu,Yan-fengGao,Li-xiangChen*,Yuan-mingQi*,Qiao-zhenKang,Hai-liWang,Lin-yuZhu,YongYe,Ming-xiaZhai.Anti-tumoreffectsofanovelchimericpeptideonS180andH22xenograftsbearingnudemice.Peptides.2010,31(5):850-864. 13.Yan-fengGao,Zhan-qiangSun,FengQi,Yuan-mingQi*,Ming-xiaZhai,Hui-pingLou,Li-xiangChen,Yong-xinLi,Xian-yuanWang.Identificationofanewbroad-spectrumCD8+Tcellepitopefromover-expressedantigenCOX-2inesophagealcarcinoma.CancerLetters,2009,284(1):55-61. 14.ZhangSL,ZhaoJW,SunZQ,YangEZ,YanJH,ZhaoQ,ZhangGL,ZhangHM,QiYM,WangHH,SunQW.Developmentandevaluationofanovelmultiple-antigenELISAforserodiagnosisoftuberculosis.Tuberculosis(Edinb).2009,89(4):278-284. 15.Hui-pingLou,Yan-fengGao*,Ming-xiaZhai,Yuan-mingQi*,Li-xiangChen,HongLv,Ji-bingYu,Yong-xinLi.Anovelpeptidefromα5helixofAsterinapectiniferacyclinBconjugatedtoHIV-Tat49–57withcytotoxicandapoptoticeffectsagainsthumancancercells.Bioorganic&MedicinalChemistryLetters,2008,18(16):4633-4637. 16.Yan-fengGao,Ming-xiaZhai,Wei-xiaLiu,XinLiu,YeYuan,Yuan-mingQi*,RuiWang*.Structure-activityrelationshipsofthedimericanaloguesofendomorphin-2withdifferentlengthsofspacers.Protein&PeptideLetters,2008,15(3):275-279. 17.LuGF,TangFA,ZhengPY,YangPC,QiYM.Entecavirup-regulatesdendriticcellfunctioninpatientswithchronichepatitisB.WorldJGastroenterol.2008,14(10):1617-1621. 18.ZhengPY,ZhangDY,LuGF,YangPC,QiYM,WangBS.EffectsoflamivudineonthefunctionofdendriticcellsderivedfrompatientswithchronichepatitisBvirusinfection.WorldJGastroenterol.2007,13(34):4641-5. 19.Li-xiangChen,Yuan-mingQi*,RuiWang*,XinDuan,Yan-fengGao,Ding-jianYang.Rolesofnitricoxidesynthaseinhibitoronantinociceptiveeffectsofμ-Opioidagonistinmice.Protein&PeptideLetters,2006,13(10):993-997. 20.Yan-fengGao,XinLiu,Wei-xiaLiu,Yuan-mingQi,Xue-fengLiu,RuiWang*.Opioidreceptorbindingandantinociceptiveactivityoftheanaloguesofendomorphin-2andmorphiceptinwithphenylalaninemimicsintheposition3or4.Bioorganic&MedicinalChemistryLetters,2006,16(14):3688-3692. 21.WangJX,LiuGH,FanYZ,LiuQL,ZhouJ,ZhangDY,QiYM.HepatobiliaryPancreatDisInt.2006,5(3):422-427. 22.ZhengPY,TangFA,QiYM,LiJ.AssociationofpepticulcerwithincreasedexpressionofLewisantigens,butnotvacuolatingcytotoxinactivityorbabA2genestatus,inHelicobacterpyloristrainsfromChina.ChinJDigDis.2006,7(1):61-65. 23.QiYM,YangDJ,DuanX,YangF,LiSR,ShenJM,WangR.EndomorphinsinhibitcontractileresponsesofratthoracicaortaringsinducedbyphenylephrineandangiotensinIIinvitro.ActaPharmacolSin.2002,23(1):40-44.