个人简介
个人简介:
王文晟,博士,河南师范大学特聘教授,博士生导师,2000年毕业于日本东京大学药学院,获药学博士学位。毕业后作为特别研究员在日本国立食品药品卫生研究所(NIHS)工作,从事与DNA的复制,修复和同源重组相关的罕见遗传病(Bloomsyndrome,Wernersyndrome等)的研究。后转到美国加州大学,罗切斯特大学从事DNA的复制,修复和同源重组,及自免疫疾病方面的研究工作。2016年回国,被新乡医学院聘为特聘教授。现作为特聘教授到河南师范大学生命科学学院工作。近年来在国家自然科学基金和美国健康卫生研究所的资助下从事与神经精神性疾病(抑郁症)和骨相关疾病(如溶骨病和骨关节炎)方面的研究。在国际权威期刊发表SCI论文28篇。
1.国家自然科学基金面上项目,淋巴内皮细胞来源的Sema3A在戈勒姆综合症发病中的作用和机制(81974321),2020/01-2023/12,60万元,在研,主持
2.河南省自然科学基金,162300410217,可用于抑郁症诊断的标示microRNA的筛选和其作用机制的探讨,2017/01-2018/12,10万元,结题,主持
3.国家自然科学基金面上项目,31170733,布鲁姆蛋白质和DNA连接酶I在抑制同源重组产生过程中的相互关系的解析,2012/01-2015/12,60万元,结题,主持
研究领域
骨生物学,神经生物学,主要从事神经精神性疾病,骨关节炎和溶骨病的研究。
近期论文
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WangWensheng,LinX,XuH,SunW,BoutaEM,ZuscikMJ,ChenD,SchwarzEM,XingL.AttenuatedJointTissueDamageAssociatedWithImprovedSynovialLymphaticFunctionFollowingTreatmentWithBortezomibinaMouseModelofExperimentalPosttraumaticOsteoarthritis.ArthritisRheumatol.2019Feb;71(2):244-257.(一区,IF=9.002)
WangWensheng,WangH,ZhouX,LiX,SunW,DellingerM,BoyceBF,XingL.LymphaticendothelialcellsproduceM-CSFcausingmassivebonelossinmice.Journalofboneandmineralresearch.2017May;32(5):939-950.(一区,IF=6.314)
Chao-ZhiTang,Dong-FangZhang,Jun-TangYang,Qing-HuiLiu,Ya-RuWang,andWen-ShengWang*.OverexpressionofmicroRNA-301baccelerateshippocampalmicrogliaactivationandcognitiveimpairmentinmicewithdepressive-likebehaviorthroughtheNF-κBsignalingpathway.CellDeathDis.2019Apr;10(4):316.(二区,IF=5.959)*通讯作者
Chao-ZhiTang,Jun-TangYang,Qing-HuiLiu,Ya-RuWang,Wen-ShengWang*.Up-regulatedmiR-192-5pexpressionrescuescognitiveimpairmentandrestoresneuralfunctioninmicewithdepressionviatheFbln2-mediatedTGF-β1signalingpathway.FASEBJ.2019Jan;33(1):606-618.(二区,IF=5.391)*通讯作者
TangChaozhi,ZhangYuling,WangWensheng*,LiWeiguo,ShiJipeng.Serumlevelsofhigh-sensitivityC-reactiveproteinatadmissionaremorestronglyassociatedwithpoststrokedepressioninacuteischemicstrokethanhomocysteinelevels[J].MolecularNeurobiology.2016;53(4):2152-60.(二区,IF=6.19)*通讯作者
TangChaozhi,ZhangYuling,WangWensheng*,LiWeiguo,ShiJipeng.Elevatedserumlevelsofneopterinatadmissionpredictsdepressionafteracuteischemicstroke:A6-monthfollow-upstudy[J].MolecularNeurobiology.2016July;53(5):3194-204.(二区,IF=6.19)*通讯作者
TangChaozhi,ZhangYuling,ShiJipeng.WangWensheng*,LiangLe,.ThecompletemitochondrialgenomeofBosgaurusgon-shan(Bovidae;Bovinae).MitochondrialDNA.2016;27(2):1050-1.(四区,IF=3.35)*通讯作者
WenshengWang,JavierRangel-Moreno,TeresaOwena,JenniferBarnarda,TravisIchikawaa,andJenniferH.Anolik.Long-termBcelldepletioninmurinelupuseliminatesautoantibody-secretingcellsbyalteringtheplasmacellniche.JImmunol.2014;192(7):3011-20.(二区,IF=5.362)
ChiuYH,SchwarzE,LiD,XuY,SheuTR,LiJ,BentleyKL,FengC,WangB,WangJC,Albertorio-SaezL,WoodR,KimM,WangWensheng,RitchlinCT.DendriticCell-SpecificTransmembraneProtein(DC-STAMP)RegulatesOsteoclastDifferentiationviatheCa2+/NFATc1Axis.JCellPhysiol.2017;232:2538–2549(二区,IF=4.155)
QianqianLiang,YawenJu,YanChen,WenshengWang,JinlongLi,LiZhang,HaoXu,RonaldW.Wood,Edward.M.Schwarz,BrendanF.Boyce,YongjunWangandLianpingXing.LymphaticendothelialcellsefferenttoinflamedjointsproduceiNOSandinhibitlymphaticvesselcontractionanddrainageinTNF-inducedarthritisinmice.ArthritisResTher.2016;18:62.(二区,IF=3.979)
DianaAdlowitz,JenniferHossler,JamieBiear,ChristopherCistrone,TeresaOwen,WenshengWang,ArumugamPalanichamy,EzinmaEzealah,DebbieCampbell,ChungwenWei,R.JohnLooney,InakiSanz,andJenniferH.Anolik.ExpansionofactivatedmemoryBcellsinRAandimpactofBcelldepletiontherapy.PLoSOne.2015;10(6).(二区,IF=3.53)