个人简介

Sherwin Singer received his A.B. 1976 from University of Chicago, and his Ph.D. in 1984, also from the University of Chicago, where he was a National Science Foundation predoctoral fellow working with Karl Freed. He subsequently did postdoctoral studies with David Chandler at University of Pennsylvania, and John Weeks at AT&T Bell Labs. Sherwin Singer has been a faculty member at The Ohio State University since 1987, being promoted to Associate Professor in 1992 and Full Professor in 2003. He was awarded the Camille and Henry Dreyfus Distinguished New Faculty Award in 1986, and the Dozor Fellowship from Ben-Gurion University of the Negev in 1998.

研究领域

Physical/Theoretical/Materials/Chemical Physics

New Methods for Stereoselective Synthesis, Enantioselective Catalysis, Multi-component Cyclization Methods, Free Radical Chemistry, Natural Product Synthesis We are engaged in two major areas of research that deals with new methodology for stereoselective synthesis: (a) enantioselective catalysis of C-C, C-H and C-N bond formations; (b) novel multi-component cyclization methods that lead to uncommon, atropisomeric 1,3-diene derivatives. These intermediates are formed with vinyl Si, Sn or B moieties, which make them useful for further stereoselective transformations. We are also pursuing applications of the newly developed methods for the synthesis of biologically relevant molecules. In the asymmetric catalysis area, we recently developed practical methods for C-C bond-formations based on hydrovinylation of vinylarenes, 1,3-dienes and strained olefins. Applications of this chemistry include a new highly enantioselective synthesis of popular 2-arylpropionic acids such as (S)-ibuprofen, and a new approach to controlling the exocyclic side-chain stereochemistry in molecules such as pseudopterosins, deoxyeseroline (a molecule containing an all-carbon quaternary asymmetric center) and side-chains of steroid D-ring substituents. Examples of multi-component addition/cyclization of diynes (giving novel axially chiral 1,3-dienes), and a prototypical highly functionalized dibenzocyclooctadiene that has been synthesized by this chemistry are shown below. In other published work we have shown that related cyclization of allene-aldehydes allows expeditious entry into highly alkylated indolizidine alkaloids such as IND-223A. Other areas of our research interests are, coordination catalysis (asymmetric ring opening reactions of epoxides and aziridines), asymmetric hydrocyanation, new free radical cyclization methods, development of organometallic reagents for aqueous organic chemistry, and synthesis of feedstock chemicals from renewable sources. External support for our research comes primarily from by the National Science Foundation and the National Institutes of Health. Former members of our group hold faculty positions at Nagoya University (Japan), University of North Carolina (Chapel Hill), Hanyang University (Korea), Indian Institute of Technology (Rajasthan); National Changhua University of Education (Taiwan); research positions at National Institute of Health, Federal Drug Administration as well as industrial positions at Abbott Pharmaceuticals, Albany Molecular, Boehringer-Ingelheim, Firestone, Manville, Novartis, Pharmacore and Sanofi Aventis. I recruit 1-3 graduate students each academic year and welcome inquiries regarding these openings.

近期论文

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Antitsa D. Stoycheva and Sherwin J. Singer, ``Stripe melting in a two-dimensional system with competing interactions'', Phys. Rev. Lett. 84(20):4657 (2000). Sherwin J. Singer, ``Buckling induced by dilative strain in two- and three-dimensional layered materials'', Phys. Rev. E62(3):3736 (2000). Cristian V. Ciobanu, Lars Ojamäe, Isaiah Shavitt and Sherwin J. Singer, ``Structure and vibrational spectra of H+(H2O)8: Is the excess proton in a symmetrical hydrogen bond?'', J. Chem. Phys. 113(13): 5321 (2000). Jer-Lai Kuo, James V. Coe, Sherwin J. Singer, Yehuda B. Band, and Lars Ojamäe, ``On the use of graph invariants for efficiently generating hydrogen bond topologies and predicting physical properties of water clusters and ice'', J. Chem. Phys. 114(6):2527 (2001). Antitsa D. Stoycheva and Sherwin J. Singer, ``Scaling theory for two-dimensional systems with competing interactions'', Phys. Rev. E64(1):016118 (2001). Christopher Callam, Sherwin J. Singer, Todd L. Lowary, and Christopher M. Hadad, ``Computational analysis of the potential energy surfaces of glycerol in the gas and aqueous phases. Effects of level of theory, basis set, and solvation on strongly intramolecularly hydrogen-bonded systems'', J. Amer. Chem. Soc. 123(47):11743 (2001). Antitsa D. Stoycheva and Sherwin J. Singer, ``Computer simulations of a two-dimensional system with competing interactions'', Phys. Rev. E65(3):036706 (2002). Jer-Lai Kuo and Sherwin J. Singer, ``Graph invariants for periodic systems: towards predicting physical properties from the hydrogen bond topology of ice'', Phys. Rev.E67(1):016114 (2003). Jer-Lai Kuo, Cristian V. Ciobanu, Lars Ojamäe, Isaiah Shavitt and Sherwin J. Singer, ``Short H-Bonds and Spontaneous Self-Dissociation in (H2O)20: Effects of H-Bond Topology'', J. Chem. Phys. 118(8):3583 (2003). Xinchuan Huang, Hyung Min Cho, Stuart Carter, Lars Ojamäe, Joel M. Bowman, and Sherwin J. Singer, ``Full Dimensional Quantum Calculations of Vibrational Energies of H5O2+'', J. Phys. Chem. 107(37):7142 (2003). Hyung Min Cho and Sherwin J. Singer, ``Correlation function quantum Monte Carlo study of the excited vibrational states of H5O2+'', J. Phys. Chem. A108(41):8691 (2004). Stephen D. Belair, Joseph S. Francisco and Sherwin J. Singer ``Hydrogen bonding in cubic (H2O)8 and OH·(H2O)7 clusters'', Phys. Rev. A 71(1): 013204 (2005). Wei Zhu, Sherwin J. Singer, Zhi Zheng and A. T. Conlisk, ``Electroosmotic flow of a model electrolyte'', Phys. Rev. E71(4): 041501 (2005). Wei Zhu and Sherwin J. Singer, ``Monte Carlo simulation of methyl chloride monolayer on the surface of graphite'', Surf. Sci. 579(2-3):141 (2005). Sherwin J. Singer, Jer-Lai Kuo, Tomas K. Hirsch, Chris Knight, Lars Ojamäe and Michael L. Klein, ``Hydrogen bond topology and the ice VII/VIII and Ih/XI proton ordering phase transitions'', Phys.Rev.Lett. 94(13):135701 (2005). Chris Knight and Sherwin J. Singer, ``Prediction of a phase transition to a hydrogen bond ordered form of ice VI'', J.Phys.Chem. B109(44):21040 (2005). Chris Knight, Sherwin J. Singer, Jer-Lai Kuo, Tomas K. Hirsch, Lars Ojamäe and Michael L. Klein, ``Hydrogen bond topology and the ice VII/VIII and Ih/XI proton ordering phase transitions'', Phys.Rev. E73(5):056113 (2006). Ali Hassanali, Tanping Li, Dongping Zhong and Sherwin J. Singer,``Lys-trp-lys: Structure and dynamics in solution following photoexcitation'', J. Phys. Chem. B110(21):10497 (2006). Chris Knight and Sherwin J. Singer, ``A re-examination of the ice III/IX hydrogen bond ordering phase transition '', J.Chem.Phys. 125(6):064506 (2006). A. T. Conlisk and Sherwin Singer, ``Modeling electroosmotic flow in nanochannels.'' BioMEMS and Biomedical Nanotechnology 4:301-330 (2006).