RajanBabu, T.V. (Babu) - The Ohio State University - Department of Chemistry & Biochemistry

个人简介

T. V. (Babu) RajanBabu received his undergraduate education in India (Kerala University and Indian Institute of Technology, Madras). He obtained a Ph. D. degree from The Ohio State University under the direction of Professor Harold Shechter, and was a postdoctoral fellow at Harvard University with the late Professor R. B. Woodward. He then joined the Research Staff of Dupont Central Research and Development, becoming a Research Fellow in 1993. He returned to OSU as a Professor of Chemistry in 1995. Education 1969 CMS College, Kottayam, Kerala University. B.Sc. (special), Chemistry. 1971 Indian Inst. Tech., Madras. M.Sc., Chemistry. 1977 The Ohio State University, Ph.D., Organic Chemistry. 1978-1979 Harvard University, Postdoctoral Fellow, Organic Chemistry. Professional 1995 – Professor of Chemistry, The Ohio State University. 1980-1994 Member of Research Staff and Research Fellow, DuPont Central Research

研究领域

We are engaged in two major areas of research that deals with new methodology for stereoselective synthesis: (a) Enantioselective catalysis of C-C, C-H and C-O bond formations. (b) Novel multicomponent cyclization methods that lead to vinyl Si, Sn and B derivatives, which are amenable to further stereoselective transformations. We are also pursuing applications of the newly developed methods for the synthesis of biologically relevant molecules. In the asymmetric catalysis area, we recently developed practical methods for C-C bond-formations based on hydrovinylation of vinylarenes, 1,3-dienes and strained olefins. Applications of this chemistry include a new synthesis of (S)-ibuprofen and a new approach to controlling the exocyclic side-chain stereochemistry in molecules such as helioporin D. Examples of multicomponent addition/cyclization of diynes (giving novel axially chiral 1,3-dienes) and of allenynes, and potential targets that can be approached by this chemistry are shown below. In published work we have shown that related cyclization of allene-aldehydes allowed expeditious entry into highly alkylated indolizidines such as IND-223A. Other areas of our research interests are asymmetric hydrocyanation, coordination catalysis (kinetic resolution via epoxide opening, transesterification) by yttrium, new radical cyclization methods and development of organometallic reagents for aqueous organic chemistry.

近期论文

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“Chemoselective Reactions of (E)-1,3-Dienes: Cobalt-Mediated Isomerization to (Z)-1,3-Dienes and Reactions with Ethylene”, Timsina, Y. T.; Biswas, S.; RajanBabu, T. V. J. Am. Chem. Soc. 2014, 136, 6215-6218. “Triarylphosphine Ligands with Hemilabile Alkoxy Groups. Ligands for Nickel(II)-Catalyzed Olefin Dimerization Reactions. Hydrovinylation of Vinylarenes, 1,3-Dienes, and Cycloisomerization of 1,6-Dienes”, Biswas, S.; Zhang, A.; Raya, B.; RajanBabu, T. V. Adv. Synth. Catal. 2014, , (In Press) “Bimetallic Catalysis in the Highly Stereoselective Ring-Opening Reactions of Aziridines”, Wu, B.; Gallucci, J. C.; Parquette, J. R.; RajanBabu, T. V. Chem. Sci. 2014, 5, 1102-1117. “Highly Efficient Catalytic Dimerization of Styrenes via Cationic Palladium(II) Complexes”, Choi, J. H.; Kwon, J. K.; RajanBabu, T. V.; Lim, H. J. Adv. Synth. Catal. 2013, 355, 3633-3638. “Conformation and reactivity in dibenzocyclooctadienes (DBCOD). A general approach to the total synthesis of fully substituted DBCOD lignans via borostannylative cyclization of ?,?-diynes”, Gong, W.; RajanBabu, T. V. Chem. Sci. 2013, 4, 3979-3985. “Asymmetric Hydrovinylation of 1-Vinylcycloalkenes. Reagent Control of Regio- and Stereoselectivity”, Page, J. P.; RajanBabu, T. V. J. Am. Chem. Soc. 2012, 134, 6556-6559. “Asymmetric Hydrovinylation of Vinylindoles. A Facile Route to Cyclopenta[g]indole Natural Products (+)-cis-Trikentrin A and (+)-cis-Trikentrin B”, Liu, W.; Lim, H. J.; RajanBabu, T. V. J. Am. Chem. Soc. 2012, 134, 5496-5499. “On the stereochemistry of acetylide additions to highly functionalized biphenylcarbaldehydes and multi-component cyclization of 1,n-diynes. syntheses of dibenzocyclooctadiene lignans.”, Gong, W.; Singidi, R. R.; Gallucci, J. C.; RajanBabu, T. V. Chem. Sci. 2012, 3, 1221-1230. “Ethylene in Organic Synthesis: A New Route to Anticholenergic Pyrrolidinoindolines, and Other Molecules with All Carbon-Quaternary Centers via Asymmetric Hydrovinylation”, Lim, H. J.; RajanBabu, T. V. Org. Lett. 2011, 13, 6596-6599. “Ethylene in Organic Synthesis. Repetitive Hydrovinylation of Alkenes for Highly Enantioselective Syntheses of Pseudopterosins”, Mans, D. J.; Cox, G. A.; RajanBabu, T. V. J. Am. Chem. Soc. 2011, 133, 5776-5779. “Reactivity and Selectivity in Hydrovinylation of Strained Alkenes”, Liu, W.; RajanBabu, T. V. J. Org. Chem. 2010, 75, 7636-7643. “Stereoselective Cyclization of Functionalized 1,n-Diynes Mediated by [X-Y]- Reagents [X-Y = R3Si-SnR’3 or (R2N)2B-SnR’3]. Synthesis and Properties of Atropisomeric 1,3-Dienes”, Singidi, R. R.; Kutney, A. M.; Gallucci, J. C.; RajanBabu, T. V. J. Am. Chem. Soc. 2010, 132, 13078-13087. “Borostannylation of Alkynes and Enynes. Scope and Limitations of the Reaction and Utility of the Adducts”, Singidi, R. R.; RajanBabu, T. V. Org. Lett. 2010, 12, 2622-2625. “Annulated Diketopiperazines from Dipeptides or Schollkopf Reagents via Tandem Cyclization-N-Arylation”, Lim, H. J.; Gallucci, J. C.; RajanBabu, T. V. Org. Lett. 2010, 12, 2162-2165. “Mechanism and Stereoselection in a Y-Catalyzed Transacylation Reaction. A Computational Modeling Study”, Sanan, T.T; RajanBabu, T. V.; Hadad, C. M. J. Org. Chem. 2010, 75, 2369-2381. “Asymmetric Hydrovinylation of Unactivated Linear 1,3-Dienes”, Sharma, R. S.; RajanBabu, T. V. J. Am. Chem. Soc. 2010, 132, 3295-3297. “A Low Pressure Vinylation of Aryl and Vinyl Halides via Mizoroki-Heck Reactions Using Ethylene”, Smith, C. R.; RajanBabu, T. V. Tetrahedron 2010, 66, 1102-1110. “Regiodivergent Ring Opening of Chiral Aziridines”, Wu, B.; Parquette, J. R.; RajanBabu, T. V. Science 2009, 326, 1662. “Seleniranium Ion-Triggered Reactions:New Aspects of Friedel-Crafts and N-Detosylative Cyclizations”, Lim, H. J.; RajanBabu, T. V. Org. Lett. 2009, 11, 2924-2927.