Xia, Yu - Purdue University - Department of Chemistry

个人简介

B.S., 1999, Lanzhou University; M.S., 2002, Shanghai Institute of Materia Medica; Ph.D., 2006, Purdue University.

研究领域

Our research program is centered on the development of new gas-phase ion chemistry and mass spectrometric methods for bio-analysis. We utilize radical reactions as a unique approach to explore radical ion chemistry and develop tools for biomolecule structural elucidation. The current research effort includes: Instrumentation development. We are developing mass spectrometry (MS) systems to perform radical reactions of biomolecules in a linear ion trap and in the plume region of the nanoelectrospray ionization source. These new tools enable research from fundamental studies on radical attack to biomolecules to a variety of analytical applications. Bio-radical chemistry. Diverse types of bio-radical ions can be formed in the gas phase based on radical reactions. We use MS to investigate the intrinsic chemical properties (structures, energetics, and reactivity) of bio-radicals, which provide insight into radical related enzyme catalysis and the fate of biomolecules upon radical attack. MS method development. We have explored the reactions of proteins and lipids with various radicals (•OH, •OCH3, •CH2OH, excited state of carbonyl). These radical reactions when coupled with MS facilitate new analytical capabilities including enhanced disulfide protein sequencing and highly specific C-C double bond location determination in lipids.

近期论文

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C. A. Stinson, Y. Xia Reactions of Hydroxyalkyl Radicals with Cysteinyl Peptides in a NanoESI Plume J. Am. Soc. Mass Spectrom. 2014 25 1192-1201 K. L. Durand, X. Ma, Y. Xia Intra-molecular Reactions as a New Approach to Investigate Bio-Radical Reactivity: A Case Study of Cysteine Sulfinyl Radical Analyst 2014 139 1327-1330 C. Konda, F. Londry, B. Bendiak, Y. Xia Obtaining Stereo-Structural Information with Single-Sugar Resolution from Linear Oligosaccharides by Mass Spectrometry J. Am. Soc. Mass Spectrom. 2014 25 1441-1450 C. Konda, B. Bendiak, Y. Xia Linkage Determination of Linear Oligosaccharides by MSn (n >2) Collision-Induced Dissociation of Z1 Ions in Negative Ion Mode J. Am. Soc. Mass Spectrom. 2014 25 248-257 X. Ma, Y. Xia Pinpointing Double Bonds in Lipids by Paternò–Büchi Reactions and Mass Spectrometry Angew. Chem., Int. Ed 2014 53 2592-2596 L. Tan, H. Hu, J. S. Francisco, Y. Xia A Mass Spectrometric Approach for Probing the Stability of Bioorganic Radicals Angew. Chem., Int. Ed 2014 53 1887-1890 C. B. Love, L. Tan, J. S. Francisco, Y. Xia Competition of Charge- vs. Radical-Directed Fragmentation of Gas-Phase Protonated Cysteine Sulfinyl Radicals J. Am. Chem. Soc. 2013 135 6226–6233