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个人简介

1990.9-1995.7哈尔滨医科大学预防医学专业医学学士 1995.9-1998.7白求恩医科大学卫生毒理学专业医学硕士 1998.7-2000.9白求恩医科大学预防医学院助教 1999.9-2002.7吉林大学白求恩医学部放射医学专业医学博士 2000.9-2004.9吉林大学公共卫生学院讲师 2002.10-2004.10东北师范大学细胞与遗传研究所生物学专业博士后 2003.2-2004.3加拿大曼尼托巴大学医学院免疫学专业博士后 2004.12-2007.12吉林大学公共卫生学院副教授/副院长 2005.11-2006.11美国哈佛大学公共卫生学院遗传和复杂疾病系放射生物学专业博士后 2007.12-2017.06吉林大学公共卫生学院教授/博士生导师/副院长 2015.3-2015.9美国哥伦比亚大学医学院辐射研究中心访问学者 2018年6月-至今温州医科大学公共卫生与管理学院教授/博士生导师/院长

研究领域

放射医学/辐射肿瘤学与肿瘤转化医学/放射卫生学

获得项目 1.国家重点研发计划“数字诊疗装备研发”重点专项(2017YFC0108602,458万元):光子放疗生物学效应评估技术研究,2017-2019,课题负责人(TheNationalKeyResearchandDevelopmentProgramofChina) 2.教育部新世纪优秀人才支持计划(NCET-09-0424,50万):辐射诱导肿瘤细胞自噬性死亡的非编码调控及表观遗传学调控,2009-2012,负责人 3.国家自然科学基金项目(81972969,55万):电离辐射诱导PRMT5发生选择性剪接的调控机制与辐射敏感性,2020-2023,负责人 4.国家自然科学基金项目(81773363,72万):蛋白质精氨酸甲基转移酶5的选择性剪切子PRMT5S在辐射损伤及细胞死亡中的作用及调控机制,2018-2021,负责人 5.国家自然科学基金项目(81573082,84万):电离辐射作用后溶酶体介导的细胞死亡机制研究,2016-2019,负责人 6.国家自然科学基金项目(31370837,80万):dCK与Cdk1相互作用对辐射诱导的细胞周期G2/M期检查点激活的调控机制,2014-2017,第二负责人 7.国家自然科学基金项目(30970682,30万):MicroRNA在电离辐射诱导的肿瘤细胞自噬性死亡中的作用及其表观遗传学调控;2010-2012,负责人 8.国家自然科学基金项目(30770649,31万):电离辐射诱导肿瘤细胞自噬性死亡机制的研究;2008-2010,负责人 9.国家自然科学基金项目(30500142,23万):RNA干预(RNAi)联合放射治疗p53第八外显子肿瘤相关性杂合突变研究;2006-2008,负责人 10.国家重点基础研究发展规划项目(973项目,2011CB503706,100万):电磁辐射危害健康的机理及医学防护的基础研究,2010-2014,分课题负责人 11.国家重点基础研究发展规划项目(973项目,2009CB930102,60万):纳米生物材料合成、组装及在生物领域的应用,2009-2013,分课题参加人 12.国家高校博士点基金项目(20100061110070,6万):分割剂量放疗联合p53突变子基因治疗逆转肿瘤多药耐药实验研究,2010-2012,负责人(ResearchFundfortheDoctoralProgramofHigherEducationofChina) 13.国家人口与健康科学数据共享服务平台肿瘤专题服务数据购置与共享(NCMI-ABS03-201709-02,20万元),2018年-2020

近期论文

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1.WuB,WangH,ZhangL,SunC,LiH,JiangC,LiuX.HighexpressionofRAD18ingliomainducesradiotherapyresistanceviadown-regulatingP53expression.BiomedPharmacother.2019Apr;112:108555.doi:10.1016/j.biopha.2019.01.016. 2.LiangN,HeQ,LiuX,SunH.MultifacetedrolesofATMinautophagy:Fromnonselectiveautophagytoselectiveautophagy.CellBiochemFunct.2019Apr;37(3):177-184.doi:10.1002/cbf.3385 3.DanShi,ZhenzhenLiang,ChengZhang,HuaiyuZhangandXiaodongLiu.Theeffectofsurgeryonthesurvivalstatusofpatientswithlocallyadvancedcervicalcancerafterradiotherapy/chemoradiotherapy:ameta-analysis.BMCCancer(2018)18:308-317doi.org/10.1186/s12885-018-4232-x 4.DanShi,ChengZhang,XiaodongLiu.LongnoncodingRNAsincervicalcancer.JCanResTher.2018,14:745-753 5.ZhongR,LiangB,XinR,ZhuX,LiuZ,ChenQ,HouY,JinZ,QiM,MaS,LiuX.Deoxycytidinekinaseparticipatesintheregulationofradiation-inducedautophagyandapoptosisinbreastcancercells.IntJOncol.2018Mar;52(3):1000-1010.doi:10.3892/ijo.2018.4250 6.DandanZhou,XiufenLiu,ChengweiLiu,OmPrakashPant,xiaodongLiu.Longnon-codingRNAPVT1:emergingbiomarkerindigestivesystemcancer.CellProlif.,2017Dec;50(6).doi:10.1111/cpr.12398. 7.RuiZhong,RuiXin,ZongyanChen,NanLiang,YangLiu,ShumeiMa,*andXiaodongLiu.*TheRoleofDeoxycytidineKinase(dCK)inRadiation-InducedCellDeath。Int.J.Mol.Sci.2016,17,1939;doi:10.3390/ijms17111939 8.LiCui,ZhihengSong,BingLiang,LiliJia,ShumeiMa,XiaodongLiu.Radiationinducesautophagiccelldeathviathep53/DRAMsignalingpathwayinbreastcancercells.OncologyReports.Apr2016,35:3639-3647 ,. 9.ZongyanChen,XiaodongLiu,ShumeiMa.TheRolesofMitochondriainAutophagicCellDeath.CancerBiother.Radiophaem.,2016,OCT31(8):269-276 10.BingLiang,XiaodongLiu,YangLiu,DejuanKong,XiaomeiLiu,RuiZhong,ShumeiMa.InhibitionofautophagysensitizesMDR-phenotypeovariancancerSKVCRcellstochemotherapy.Biomedicine&Pharmacotherapy.2016,82:98-105 11.XinLiu,ShuangLi,XuejunLin,KangkangYan,LongyuZhao,QiongYu,XiaodongLiu.AXIN2isAssociatedWithPapillaryThyroidCarcinoma,IranRedCrescentMedJ.2016Jan1;18(2):e20960 12.WangB,ChenZ,YuF,ChenQ,TianY,MaS,WangT,LiuX.Hsp90regulatesautophagyandplaysaroleincancertherapy.TumourBiol.2016Jan;37(1):1-6 13.ZongyanChen,BenliWang,FeifeiYu,QiaoChen,YuxiTian,ShumeiMa,XiaodongLiu.Therolesofmitochondriainradiation-inducedautophagiccelldeathincervicalcancercells.TumorBiol.2016Mar;37(3):4083-91 14.YuF,ChenZ,WangB,JinZ,HouY,MaS,LiuX.Theroleoflysosomeincelldeathregulation.TumourBiol.2016Feb;37(2):1427-36 15.NanLiang,RuiZhong,XueHou,GangZhao,ShumeiMa,GuanghuiCheng,XiaodongLiu.ATMparticipatesintheregulationofionizingradiation-inducedcelldeathviaMAPK14inlungcancerH1299cells.CellProlif.,2015,48,561–572 16.ZhongR,XuH,ChenG,ZhaoG,GaoY,LiuX,MaS,DongL.Theroleofhypoxia-induciblefactor-1αinradiation-inducedautophagiccelldeathinbreastcancercells.TumorBiol.2015Sep;36(9):7077-83. 17.HeM,ZhaoY,YiH,SunH,LiuX,MaS.ThecombinationofTP53INP1,TP53INP2andAXIN2:potentialbiomarkersinpapillarythyroidcarcinoma.Endocrine.2015Mar;48(2):712-7 18.ZhaoY,ZhongR,SunL,JiaJ,MaS,LiuX.IonizingRadiation-InducedAdaptiveResponseinFibroblastsunderBothMonolayerand3-DimensionalConditions.PLoSOne.2015Mar25;10(3):e0121289.3.53 19.LiuM,LiuB,WangH,DingL,ShiY,GeC,SuX,LiuX,DongL.Dosimetriccomparativestudyof3differentpostoperativeradiotherapytechniques(3D-CRT,IMRT,andRapidArc)forII-IIIstagerectalcancer.Medicine.2015Jan;94(1):e372.4.87 20.ZhaoYL,ZhongLL,HeMZ,ChenSL,WangTJ,MaSM,LiuXD.ThecombineduseofmiRNAsandmRNAsasbiomarkersforthediagnosisofpapillarythyroidcarcinoma.IntJMolMed.2015Oct;36(4):1097-103 21.ChenS,LiuX,MaS.CombinationofmiRNAandRNAFunctionsasPotentialBiomarkersforGastricCancer.TumourBiol.,2015Dec;36(12):9909-18. 22.CongDan,HeMengzi,chenSilin,Liuxiaoli,LiuXiaodong,SunHui.ExpressionprofilesofpivotalmicroRNAsandtargetsinthyroidpapillarycarcinoma:ananalysisofTheCancerGenomeAtlas.OncoTargetsandTherapy2015:82271–2277 23.YanKK,XuXJ,LiuXD,WangCP,LiuX.Theassociationsbetweenmaternalfactorsduringpregnancyandtheriskofchildhoodacutelymphoblasticleukemia:Ameta-analysis.PediatricBlood&Cancer,2015Mar1,DOI:10.1002/pbc.25443 24.LiS,WangC,LiuX,HuaS,LiuX.TherolesofAXIN2intumorigenesisandepigeneticregulation.FamCancer.2015Jun;14(2):325-31 25.X.Liu,X.J.Lin,C.P.Wangy,K.K.Yan,L.Y.Zhao,W.X.An,X.D.Liu.AssociationbetweenSmokingandp53MutationinLungCancer:AMeta-analysis.ClinOncol(RCollRadiol).2014Jan;26(1):18-24 26.LiuX,YanK,LinX,ZhaoL,AnW,WangC,LiuX.TheassociationbetweenBRAFV600EmutationandpathologicalfeaturesinPTC.EurArchOtorhinolaryngol.2014Nov;271(11):3041-52. 27.YangC,HaoJ,KongD,CuiX,ZhangW,WangH,GuoX,MaS,LiuX,PuP,XuB.ATM-mediatedMad1Serine214phosphorylationregulatesMad1dimerizationandthespindleassemblycheckpoint.Carcinogenesis.2014Sep;35(9):2007-13. 28.WangHY,LiuZS,QiuL,GuoJ,LiYF,ZhangJ,WangTJ,LiuXD.KnockdownofWip1EnhancesSensitivitytoRadiationinHeLaCellsThroughActivationofp38MAPK.OncolRes.2014;22(4):225-33. 29.MinLiu,ShumeiMa,MingboLiu,YufeiHou,BingLiang,XuSu,XiaodongLiu.Synergistickillingoflungcancercellsbycisplatinandradiationviaautophagyandapoptosis.OncolLett.2014june;7(6):1903-1910 30.YiH,LongB,YeX,ZhangL,LiuX,ZhangC.Autophagy:Apotentialtargetforthyroidcancertherapy(Review).MolClinOncol.2014Sep;2(5):661-665. 31.ZhaoL,LiuX,WangC,YanK,LinX,LiS,BaoH,LiuX*.Magneticfieldsexposureandchildhoodleukemiarisk:Ameta-analysisbasedon11,699casesand13,194controls[J].Leukemiaresearch.2014,38(3):269-274. 32.LinXJ,WangCP,LiuXD,YanKK,LiS,BaoHH,ZhaoLY,LiuX*.Bodymassindexandriskofgastriccancer:ameta-analysis.JpnJClinOncol2014;44(9)783–791 33.MengX,MengC,YangB,ZhaoL,SunX,SuY,LiuH,FanF,LiuX,JiaL*.AP-2αdownregulationbycigarettesmokecondensateiscounteractedbyp53inhumanlungcancercells.IntJMolMed.2014Jul17.doi:10.3892/ijmm.2014.1857. 34.LiS,WangC,LiuX,HuaS,LiuX.TherolesofAXIN2intumorigenesisandepigeneticregulation.FamCancer.2014Dec13. 35.LiangN,JiaL,LiuY,LiangB,KongD,YanM,MaS,LiuX.ATMpathwayisessentialforionizingradiation-inducedautophagy.CellularSignaling.25(2013)2530–2539. 36.YiH,LiangB,JiaJ,LiangN,XuH,JuG,MaS,LiuX*.DifferentialrolesofmiR-199a-5pinradiation-inducedautophagyinbreastcancercells.FEBSLett.2013Mar1;587:436-443.被引57次 37.QasedAB,YiH,LiangN,MaS,QiaoS,LiuX*.MicroRNA-18aupregulatesautophagyandataxiatelangiectasiamutatedgeneexpressioninHCT116coloncancercells.MolMedRep.2013Feb;7(2):559-64.被引30次 38.LiuX,HeM,HouY,LiangB,ZhaoL,MaS,YuY,LiuX*.ExpressionprofilesofmicroRNAsandtheirtargetgenesinpapillarythyroidcarcinoma.OncolRep.2013Apr;29(4):1415-20. 39.MaS,KongB,LiuB,LiuX*.Biologicaleffectsoflow-doseradiationfromcomputedtomographyscanning.IntJRadiatBiol.2013May;89(5):326-33. 40.JianhuaLiu,RuiXin,ZhimanLi,RezaGolamaully,YanZhang,JishenZhang,QinghaiYuan,XiaodongLiu.Large-ScaleandFacileSynthesisofBiocompatibleYb-BasedNanoparticlesasaContrastAgentforInVivoX-RayComputedTomographyImaging.CurrTopMedChem.2013;13(4):513-8 41.LiuX,ZhaoLY,YuD,MaS,LiuX.Effectsofextremelylowfrequencyelectromagneticfieldonthehealthofworkersinautomotiveindustry.href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Effects+of+extremely+low+frequency+electromagnetic+field+on+the+health+of+workers+in+automotive+industry."title="Electromagneticbiologyandmedicine."ElectromagnBiolMed.2013;32(4):551-559. 42.JiaL,MaS,HouX,WangX,QasedAB,SunX,LiangN,LiH,YiH,KongD,LiuX,FanF.ThesynergisticeffectsoftraditionalChineseherbsandradiotherapyforcancertreatment.ONCOLOGYLETTERS2013,5:1439-1447. 43.ChengG,KongD,HouX,LiangB,HeM,LiangN,MaS,LiuX*.TheTumorSuppressor,p53,ContributestoRadiosensitivityofLungCancerCellsbyRegulatingAutophagyandApoptosis.CancerBiotherRadiopharm.2013,28(2):153-159. 44.YangC,LeeM,HaoJ,CuiX,GuoX,SmalC,BontempsF,MaS,LiuX,EnglerD,ParkerWB,XuB.DeoxycytidinekinaseregulatestheG2/Mcheckpointthroughinteractionwithcyclin-dependentkinase1inresponsetoDNAdamage.NucleicAcidsRes.2012Oct;40(19):9621-32. 45.WangT,MaS,KongD,YiH,WangX,LiangB,XuH,HeM,JiaL,QasedAB,YangY,LiuX*.Effectofionizingradiationonacinarmorphogenesisofhumanprostaticepithelialcellsunderthree-dimensionalcultureconditions.Neoplasma.2012;59(3):269-81. 46.KongD,MaS,LiangB,YiH,ZhaoY,XinR,CuiL,JiaL,LiuX,LiuX*.Thedifferentregulatoryeffectsofp53statusonmultidrugresistancearedeterminedbyautophagyinovariancancercells.BiomedPharmacother.2012Jun;66(4):271-8. 47.SongXL,LiB,XuK,LiuJ,JuW,WangJ,LiuXD,LiJ,QiYF.Cytotoxicityofwater-solublemPEG-SH-coatedsilvernanoparticlesinHL-7702cells.CellBiolToxicol.2012Aug;28(4):225-37. 48.LiangB,KongD,LiuY,LiangN,HeM,MaS,LiuX*.Autophagyinhibitionplaysthesynergetickillingroleswithradiationinthemulti-drugresistantSKVCRovariancancercells.RadiatOncol.2012Dec17;7:213-224. 49.MaS,JiaoB,LiuX,YiH,KongD,GaoL,ZhaoG,YangY,LiuX*.Approachtoradiationtherapyinhepatocellularcarcinoma.CancerTreatRev.2010Apr;36(2):157-63. 50.MaS,LiuX,JiaoB,YangY,LiuX*.Low-doseradiation-inducedresponses:focusingonepigeneticregulation.IntJRadiatBiol.2010Jul;86(7):517-28.

学术兼职

教育部公共卫生与预防医学类专业教学指导委员会,委员,2018 卫生部放射生物学重点实验室,主任; 中华放射医学与防护杂志,副总编辑;(20181015) 中华医学会放射医学与防护专业委员会,副主任委员;(20181213) 中国生物物理学会辐射与环境生物物理专业委员会,副主任委员; 白求恩医学专家委员会放射肿瘤专委会,副主任委员;(2017-2021) 中国研究型医院学会肿瘤放射生物与多模态诊疗专委会,副主任委员;(2017-2022) 中国卫生监督协会放射卫生专业委员会,常务委员; 中国毒理学会放射毒理专业委员会,常务委员;(2016-2020) 中国生物医学工程学会精确放疗专委会,常务委员; 中国辐射防护学会,理事; 吉林省核学会,荣誉理事长; 吉林省医学会放射医学与防护学分会,主任委员; 吉林省抗癌协会放疗并发放射损伤专业委员会,副主任委员

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