个人简介

2013/06-至今温州医科大学副研究员 2009/06-2013/06NationalInstitutesofHealth(NIH),USA博士后 2002/04-2008/03日本名古屋大学硕士、医学博士 1996/09-2000/07上海交通大学学士

研究领域

核受体与代谢调控

获得项目 国家自然科学基金，孕烷X受体（PXR）对FGF15/19的调控机制及其在抵抗高脂饮食引起肥胖中的作用(2018) 国家自然科学基金，Med25作为共激活因子对糖皮质激素受体GRα介导的CYP2C9的调控机制研究（2015）

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

HanYang,ZheShi,Xiao-XiaoWang,RongCheng,MinLu,JiayinZhu,WenhaiDeng,YuyaoZeng,Li-YangZhao,Shu-YunZhang*. Phenanthrene,butnotitsisomeranthracene,effectivelyactivatesbothhumanandmousenuclearreceptorconstitutiveandrostanereceptor(CAR)andinduceshepatotoxicityinmice. ToxicologyandAppliedPharmacology,2019 JiayinZhu,FengtingZhu,SiyiHuang,HuilingChen,XuehuaZhao,Shu-YunZhang*.ANewEvolutionaryMachineLearningApproachtoIdentifythePyreneInducedRatHepatotoxicityandRenalDysfunction.IEEEAccess, 7:15320-15329,2019  JiayinZhu,Li-YangZhao,Xiao-XiaoWang,ZheShi,YangZhang,GangWu, Shu-YunZhang*. IdentificationofHepatotoxicityandRenalDysfunctionofPyreneinAdultMaleRats. EnvironmentalToxicology,33:1304-1311,2018 Li-YangZhao,Jia-YiXu, ZheShi, NealA.Englert,andShu-YunZhang*.PregnaneXreceptor(PXR) deficiencyimproveshighfatdiet-inducedobesityviainductionoffibroblastgrowthfactor15(FGF15)expression.BiochemicalPharmacology,142:194-203,2017  Jia-YiXu,LiangWu,ZheShi,Xiao-JieZhang,NealA.Englert,Shu-YunZhang*.UpregulationofhumanCYP2C9 expressionbyBisphenolAvia estrogenreceptoralpha(ERα)andMed25.EnvironmentalToxicology,32(3):970-978,2017   Xiao-JieZhang,ZheShi,Jing-XiLyv,XuyanHe,NealA.Englert,Shu-YunZhang*. Pyreneisanovelconstitutiveandrostanereceptor (CAR)activator andcauseshepatotoxicitybyCAR.ToxicologicalSciences,147(2):436-445,2015  ZheShi,WenjunYang,JoyceA.Goldstein, Shu-YunZhang*. Med25isrequiredforestrogenreceptoralpha(ERα)-mediatedregulationofhumanCYP2C9expression. BiochemicalPharmacology,90(4):425-431,2014

学术兼职

中国环境诱变剂学会理事 中国环境诱变剂学会致突变专业委员会委员 中国环境诱变剂学会毒性测试与替代方法专业委员会委员