个人简介

2010/11-至今温州医科大学校特聘教授、营养与疾病研究所所长、老年神经病学研究所副所长 2008/02-2010/11约翰霍普金斯大学医学院博士后、助理研究员 2006/08-2008/01斯克里普斯研究所博士后 2002/08-2006/08康奈尔大学博士、动物科学（辅修：细胞生物学、化学） 1999/09-2002/07南开大学硕士、生物化学与分子生物学 1995/09-1999/06南开大学学士、生物学

研究领域

神经退行性病变、分子营养学

主要在研主持项目： 1.浙江省自然科学基金重大项目，5-羟甲基胞嘧啶修饰和TET2/3在帕金森病发病中的作用及分子机制研究，2019-2022 2.国家自然科学基金面上项目，81771380，DNA甲基化调控α-突触核蛋白的体内研究及其对帕金森病发病的影响，2018-2021

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.ShaoZQ#,ZhangX#,FanHH,WangXS,WuHM,ZhangL,ChengWH*,ZhuJH*.SelenoproteinTpromotesproliferationandG1-to-StransitioninSK-N-SHcells:ImplicationsinParkinson’sdisease.J.Nutr.,2019,doi:10.1093/jn/nxz199 2.ZhangX,LiuRP,ChengWH*,ZhuJH*.PrioritizedBrainSeleniumRetentionandSelenoproteinExpression:NutritionalInsightsintoParkinson’sDisease.Mech.AgeingDev.,2019,180:89-96 3.WangJY#,FanQY#,HeJH,ZhuSG,HuangCP,ZhangX*,ZhuJH*.SLC6A4repeatandsingle-nucleotidepolymorphismsareassociatedwithdepressionandresttremorinParkinson’sdisease:Anexploratorystudy.Front.Neurol.,2019,10:333. 4.ZouM#,LiR#,WangJY,WangK,WangYN,LiY,JiFX,SunSN,HuangSS,FanHH,HuangCP,ZhangX*,ZhuJH*.AssociationanalysesofvariantsofSIPA1L2,MIR4697,GCH1,VPS13CandDDRGK1withParkinson'sdiseaseinEastAsians.Neurobiol.Aging,2018,68:159.e7-159.e14. 5.WuHM#,LiT#,WangZF,HuangSS,ShaoZQ,WangK,ZhongHQ,ChenSF,ZhangX*,ZhuJH*.MitochondrialDNAvariantsmodulategeneticsusceptibilitytoParkinson’sdiseaseinHanChinese.Neurobiol.Dis.,2018,114:17-23. 6.ZhangX,YangR,HuBL,LuP,ZhouLL,HeZY,WuHM*,ZhuJH*.ReducedcirculatinglevelsofmiR-433andmiR-133barepotentialbiomarkersforParkinson’sdisease.Front.Cell.Neurosci.,2017,11:170. 7.FanHH,ZhuLB,LiT,ZhuH,WangYN,RenXL,HuBL,HuangCP,ZhuJH*,ZhangX*.Hyperosideinhibitslipopolysaccharide-inducedinflammatoryresponsesinmicroglialcellsviap38andNFκBpathways.Int.Immunopharmacol.,2017,50:14-21. 8.WangJY#,ZhuangQQ#,ZhuLB,ZhuH,LiT,LiR,ChenSF,HuangCP*,ZhangX*,ZhuJH*.Meta-analysisofbrainironlevelsofParkinson’sdiseasepatientsdeterminedbypostmortemandMRImeasurements.Sci.Rep.,2016,6:36669. 9.ZhangX#,YeYL#,ZhuH,SunSN,ZhengJ,FanHH,WuHM,ChenSF,ChengWH,ZhuJH*.SelenotranscriptomicanalysesidentifysignatureselenoproteinsinbrainregionsinamousemodelofParkinson’sdisease.PLoSOne,2016,11(9):e0163372. 10.LaiJM#,ZhangX#,LiuFF,YangR,LiSY,ZhuLB,ZouM,ChengWH*,ZhuJH*.Redox-sensitiveMAPKandNotch3regulatefibroblastdifferentiationandactivation:adualroleofERK1/2.Oncotarget,2016,7(28):43731-43745. 11.ZhangX#,WangYN#,ZhuJJ,LiuXX,YouH,GongMY,ZouM,ChengWH,ZhuJH*.N-acetylcysteinenegativelyregulatesNotch3anditsmalignantsignaling.Oncotarget,2016,7(21):30855-30866. 12.LeiXG*,ZhuJH,ChengWH,BaoY,HoYS,ReddiAR,HolmgrenA,ArnerESJ.Paradoxicalrolesofantioxidantenzymes:Basicmechanismsandhealthimplications.Physiol.Rev.,2016,96(1):307-364. 13.ZhangX,YeYL,WangYN,LiuFF,LiuXX,HuBL,ZouM,ZhuJH*.Aldehydedehydrogenase2geneticvariationsmayincreasesusceptibilitytoParkinson'sdiseaseinHanChinesePopulation.Neurobiol.Aging,2015,36(9):2660.e9-2660.e13. 14.WangJY,GongMY,YeYL,YeJM,LinGL,ZhuangQQ,ZhangX*,ZhuJH*.TheRIT2andSTX1BpolymorphismsareassociatedwithParkinson'sdisease.ParkinsonismRelat.Disord.,2015,21(3):300-302. 15.ZhangX,ChengX,HuYB,LaiJM,YouH,HuBL,ZouM,ZhuJH*.Serotonintransporterpolymorphicregion5-HTTLPRmodulatesriskforParkinson’sdisease.Neurobiol.Aging,2014,35(8):1957.e9-1957.e14. 16.LiuRP#,ZouM#,WangJY,ZhuJJ,LaiJM,ZhouLL,ChenSF,ZhangX*,ZhuJH*.Paroxetineameliorateslipopolysaccharide-inducedmicrogliaactivationviadifferentialregulationofMAPKsignaling.J.Neuroinflammation,2014,11:47.(标签为“高访问”论文) 著作章节 1.D.L.哈特菲尔德等主编;雷新根,王福俤主编译;刘琼,闵军霞,张焱,郑文兴,周军,祝建洪(按拼音排序)副主编译.硒:分子生物学与人体健康(原书第4版).科学出版社,2018.@ISBN978-7030577993;3/93

学术兼职

BiologicalTraceElementResearch编委；中国营养学会微量元素营养分会委员；中国粮油学会理事；浙江省遗传学会理事；浙江省转化医学学会公共卫生管理学分会委员；温州市营养学会理事