Wirth, Mary J. - Purdue University - Department of Chemistry

个人简介

B.S. Northern Illinois University, 1974; Ph.D. Purdue University, 1978.

研究领域

We work at the interface of chemistry and medicine, and our focus is to create technology for earlier detection of diseases. The dream of 21st century medicine is that simple lab tests will reveal diseases well before the onset of symptoms, while the disease is easily curable. We are using nanotechnology to modernize the materials used for lab tests and for the discovery of the biomarkers that are the targets of lab tests. As one example, the image (right) shows a capillary for nanoUPLC that is packed with silica nanoparticles. The packing is an artificial opal, which exhibits a Bragg diffraction due to the crystalline packing of the nanoparticles. The scanning electron micrograph of the capillary cross-section shows the face-centered cubic packing. This highly ordered packing imparts extraordinary separation efficiency and speed. The ability to form these face-centered cubic structures in capillaries facilitates mass spectrometric detection of proteins. We are using these materials for a range of tools used for biomarker discovery and medical tests, including capillary chromatography with nanospray MS detection, high-throughput, lab-on-a-chip devices, and basic research on biomolecule transport in nanoscale media. We are collaborating with medical researchers and industrial scientists to maximize the impact of our research.

近期论文

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Robert E. Birdsall and Mary J. Wirth Modeling of protein electrophoresis in silica colloidal crystals bearing brush layers of polyacrylamide Electrophoresis 2013 DOI: 10.1002 /elps.201200413 Benjamin A. Rogers and Mary J. Wirth Slip flow through hydrophobic silica colloidal crystals of varying particle diameter ACS Nano 2013 DOI: 10.1021 /nn305028f Birdsall, R. E.;Koshel, B. M.;Hua, Y. M.;Ratnayaka, S. N.;Wirth, M. J. Modeling of protein electrophoresis in silica colloidal crystals having brush layers of polyacrylamide Electrophoresis 2013 28 - 52-54 Mondjinou, Y. A.;McCauiff, L. A.;Kulkarni, A.;Paul, L.;Hyun, S. H.;Zhang, Z. R.;Wu, Z.;Wirth, M.;Storch, J.;Thompson, D. H. Synthesis of 2-Hydroxypropyl-beta-cyclodextrin/Pluronic-Based Polyrotaxanes via Heterogeneous Reaction as Potential Niemann-Pick Type C Therapeutics Biomacromolecules 2013 98 1 1203-1213 Njoya, N. K.;Birdsall, R. E.;Wirth, M. J. Silica Colloidal Crystals as Emerging Materials for High-Throughput Protein Electrophoresis Aaps Journal 2013 105 - 235-246 Rogers, B. J.;Birdsall, R. E.;Wu, Z.;Wirth, M. J. RPLC of Intact Proteins Using Sub-0.5 mu m Particles and Commercial Instrumentation Analytical Chemistry 2013 117 47 12350-12362 Rogers, B. J.;Wirth, M. J. Obstructed Diffusion in Silica Colloidal Crystals Journal of Physical Chemistry A 2013 19 39 12938-12942 Rogers, B. J.;Wirth, M. J. Slip Flow through Colloidal Crystals of Varying Particle Diameter Acs Nano 2013 66 349-386 Wu, Z.;Rogers, B. J.;Wei, B. C.;Wirth, M. J. Insights from theory and experiments on slip flow in chromatography Journal of Separation Science 2013 85 14 6545-6552 Zhang, Z. R.;Wu, Z.;Wirth, M. J. Polyacrylamide brush layer for hydrophilic interaction liquid chromatography of intact glycoproteins Journal of Chromatography A 2013 32 3 218-243 Koshel, B. M.;Wirth, M. J. Trajectory of isoelectric focusing from gels to capillaries to immobilized gradients in capillaries Proteomics 2012 12 2918-2926 Bingchuan Wei, Benjamin A. Rogers, and Mary J. Wirth Slip flow in silica colloidal crystals for ultra-efficient chromatography Journal of the American Chemical Society 2012 134 10780-10782 Newby, J. J.;Legg, M. A.;Rogers, B.;Wirth, M. J. Annealing of silica to reduce the concentration of isolated silanols and peak tailing in reverse phase liquid chromatography Journal of Chromatography A 2011 1218 31 5131-5135 Zhang, Z. R.;Ratnayaka, S. N.;Wirth, M. J. Protein UTLC-MALDI-MS using thin films of submicrometer silica particles Journal of Chromatography A 2011 1218 40 7196-7202 Bingchaun Wei, Douglas S. Malkin and Mary J Wirth Plate Heights Below 50 nm for Protein Electrochromatography Using Silica Colloidal Crystals Analytical Chemistry 2010 82 10216-10221 Yimin Hua, Brooke Koshel and Mary J. Wirth Field-Free Remobilization after Isoelectric Focusing of Proteins in Packed Capillaries Analytical Chemistry 2010 82 8910–8915 Velarde, T.R.C.; Wirth, M.J. Silica colloidal crystals as porous substrates for total internal reflection fluorescence microscopy of live cells Applied Spectroscopy 2008 62 611-616 Egas, D.A.; Wirth, M.J. Fundamentals of protein separations: 50 years of nanotechnology and growing Annual Review of Analytical Chemistry 2008 1 833-855 Zheng, S.; Ross,E.E.; Legg, M.A.; Wirth, M.J. High Speed Electroseparations inside of Silica Colloidal Crystals Journal of the American Chemical Society 2006 128 9016-9017