Wilker, Jonathan - Purdue University - Department of Chemistry

个人简介

Professor of Materials Engineering, August 2011-Present, Purdue University Professor of Chemistry, August 2011-Present, Purdue University Associate Professor of Materials Engineering, March 2010-August 2011, Purdue University Associate Professor of Chemistry, August 2005-August 2011, Purdue University Assistant Professor of Chemistry, August 1999-August 2005, Purdue University Postdoctoral Scholar in Biochemistry 1996-1999, California Institute of Technology. Laboratory of Professor Harry B. Gray. Ph.D. in Chemistry 1996, Massachusetts Institute of Technology. Laboratory of Professor Stephen J. Lippard. B.S. in Chemistry 1991, University of Massachusetts at Amherst. Laboratory of Professor Michael J. Maroney.

研究领域

Marine Biological Materials: Characterization, Synthetic Mimics, and Applications The oceans abound with a fascinating array of materials produced by nature. Barnacles cement themselves to rocks. Starfish use adhesives for locomotion. Oysters create aggregate reef structures. Mussels generate an impressive adhesive that can bond to nearly any surface, including Teflon (polytetrafluoroethylene, PTFE). Our laboratory is working to understand how such biological materials function, design synthetic mimics, and develop applications for these new materials. Characterization of Marine Biological Materials: Discovering How Nature Makes Materials Ongoing studies include characterizing the composition, bonding, and performance of these biomaterials produced by mussels, barnacles, oysters, and other species. Here the chemistry, biochemistry, and biology of adhesion are all being examined. In order to obtain chemical insights on specific bonding motifs in the materials, we are using synthetic peptide models to obtain atom-by-atom level detail of the cross-links present in mussel adhesive. At a biochemical level we are extracting adhesive proteins, characterizing proteins, and exploring how such macromolecules can bring about bulk adhesion. Several methods including spectroscopy, reactivity, and microscopy are being used to provide direct observation of the bonding. More biological work with live animals includes changes made to the water chemistry and then quantifying the influences upon adhesion. With all of these studies we keep in mind mechanical performance of the materials. For example, we are uncovering links between protein cross-linking and adhesion strengths of the animals. Figure 1. Left to right: An oyster reef, a mussel sticking to glass, barnacles, and a kelp forest.Synthetic Polymer Mimics: New Materials Inspired By Nature As we learn how sea creatures stick we can use this information to create new classes of synthetic materials. Bioinspired synthetic materials can have advantages over the natural versions such as the ability to tailor the material for a given property (e.g., adhesion, modulus, porosity, etc.) as well as provide access to large quantities of material. We have found that complex adhesive proteins can be mimicked with simple polymer backbones into which we incorporate biological cross-linking chemistry. Applications: Developing Biomedical Materials, High Performance Adhesives, and Coatings The underwater adhesion and high bonding strengths of marine biological materials bring to mind many applications ranging from wet-setting biomedical adhesives to new materials with tailored moduli. Current materials engineering efforts rely on our abilities to alter the polymer compositions and carry out the syntheses on large scales. As we incorporate more advanced functionalities into the polymers we are tailoring the materials for specific uses. Perhaps most in demand are new adhesive materials for biomedical procedures and devices. At the moment there are no adhesives available that are simultaneously wet setting, strong bonding, and non-toxic. Marine biology may have already solved this problem, hence our exploration of these materials for bi

近期论文

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“Self-Healing Polymers: Sticky When Wet”, Jon Wilker*, Nature Materials, 2014, Volume 13, Issue 9, pages 849-850 “Sum Frequency Generation Vibrational Spectroscopic Studies on Buried Heterogeneous Biointerfaces”, Chi Zang, Joshua Jasensky, Chaun Leng, Chelsey Del Grosso, Gary Smith, Jonathan Wilker, and Zhan Chen*, Optics Letters, 2014, Volume 39, Issue 9, pages 2715-2718 “Enhancing the Adhesion of a Biomimetic Polymer Yields Performance Rivaling Commercial Glues”, Heather Meredith, Courtney Jenkins, and Jonathan Wilker*, Advanced Functional Materials, 2014, Volume 24, Issue 21, pages 3259-3267 “Molecular Weight Effects upon the Adhesive Bonding of a Mussel Mimetic Polymer”, Courtney Jenkins, Heather Meredith, and Jonathan Wilker*, ACS Appl. Materials Interfaces, 2013, Volume 5, Issue 11, pages 5091-5096 “A Review on Tough and Sticky Hydrogels”, Charles Peak, Jonathan Wilker, and Gudrun Schmidt*, Colloid Polymer Sci., 2013, Issue 291, pages 2031-2047 “Interfacial Structure of a DOPA-Inspired Adhesive Polymer Studied by Sum Frequency Generation Vibrational Spectroscopy”, Chuan Leng, Yuwei Liu, Courtney Jenkins, Heather Meredith, Jonathan Wilker*, and Zhan Chen*, Langmuir, 2013, Volume 29, 6659-6654 “Combining Biomimetic Principles from the Lotus Leaf and Mussel Adhesive: Polystyrene Films with Superhydrophobic and Adhesive Layers”, Ana Isabel Neto, Heather Meredith, Courtney Jenkins, Jonathan Wilker, and Joao F. F. Mano*, RSC Advances, 2013, Volume 3, 9352-9356 “Robust and Adhesive Hydrogels from Cross-linked Polyethylene Glycol and Silicate for Biomedical Use”, Chia-Jung Wu, Jonathan J. Wilker, and Gudrun Schmidt*, Macromolecular Bioscience, 2013, Volume 13, pages 59-66 “Ambivalent Adhesives: Combining Biomimetic Cross-Linking With Antiadhesive Oligo(ethylene glycol)”, Cristina R. Matos-Peréz and Jonathan J. Wilker*, Macromolecules, 2012, Volume 45, pages 6634-6639 “Polymer Composition and Substrate Influences on the Adhesive Bonding of a Biomimetic, Cross-Linking Polymer”, Cristina R. Matos-Peréz, James D. White, and Jonathan J. Wilker*, Journal of the American Chemical Society, 2012, Volume 134, pages 9498-9505 “Underwater Bonding With Charged Polymer Mimics of Marine Mussel Adhesive Proteins”, James D. White and Jonathan J. Wilker*, Macromolecules, 2011, Volume 44, pages 5085-5088 “Biomaterials: Redox and Adhesion on the Rocks”, Jonathan J. Wilker*, Nature Chemical Biology, 2011, Volume 7, Pages 579-580