个人简介
2018年评为东陆学者
2017年晋升为三级教授
2016年荣获伍达观优秀教师奖先进奖
2010年云南省引进高层次人才
2010/08–至今,云南大学,生命科学学院,教授
2019/01-2019/12,美国德州大学,圣安东尼奥健康科学中心,生物化学与结构生物学系,访问学者
2013/03-2013/06,法国马赛大学,法国国家免疫研究中心,高级访问学者
2006/10-2009/07,美国克莱蒙森大学,昆虫系,细胞生物学实验室,博士后
2001/09-2006/06,中山大学,生命科学学院,硕博连读
2003/07-2006/07,云南省农业科学院,农业资源与环境研究所,副研究员
1998/07-2003/06,云南省农业科学院,植物保护研究所,助理研究员
1992/07-1998/06,云南省农业科学院,植物保护研究所,实习研究员
1988/09-1992/06,云南师范大学,生物系,理学学士
教授课程:
本科生课程:《PrinciplesofVirology》(校级双语课),
《LehningerPrinciplesofBiochemistry》,
《食品安全纵横谈》;
研究生课程:《MolecularGenetics》。
研究领域
Hemichannel在先天免疫反应中的细胞通讯调控机制
1.Innexin-hemichannel在无脊椎动物先天免疫反应中的细胞通讯调控机制
以无脊椎动物寄生蜂病毒-寄生蜂-寄主作为研究模式,研究在茧蜂病毒免疫抑制下hemichannel在细胞通讯调控作用,研究主要集中在:1)茧蜂病毒介导的hemichannel关闭与凋亡细胞形成凋亡小体的关系;2)Hemichnanel在凋亡小体传递免疫抑制信号的作用;3)调控hemichannel在细胞通讯调控的害虫生物防治。
2.Connexin-hemichannel在哺乳动物癌细胞免疫反应中的细胞通讯调控机制
以云南宣威肺癌细胞的脑转移模式,研究Connexin-hemichannel在脑神经中枢的肿瘤免疫反应中的通讯调控机制,研究主要集中在:(1)Hemichannel在宣威肺癌脑转移中的调控机制;(2)Hemichannel在星形胶质细胞与肺癌细胞间的调控机制;(3)调控hemichannel在脑转移瘤细胞间的通讯机制,为肺癌脑转移的治疗提供实验基础。
近期论文
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1.Ji-HuiCui#,Shu-MeiDong#,Chang-XuChen#,WeiXiao#,Qiu-ChengCai,Li-DanZhang,Hao-JuanHe,WeiZhang,Xue-WenZhang,TianLiu,LeiDing,YangYang,Jian-HuaLai,Qi-ShunZhu,andKai-JunLuo*.(2019)MicroplitisbicoloratusbracovirusmodulatesinnateimmunesuppressionthroughtheeIF4E-eIF4AaxisintheinsectSpodopteralitura.Developmental&ComparativeImmunology95,101-107.
2.Hang-YuTian#,YanHu#,PanZhang#,Wen-XiXing,Cui-XianXu,DanYu,YangYang,Kai-JunLuo*,andMingLi*.(2019)SpodopteralituracyclophilinAisrequiredforMicroplitisbicoloratusbracovirus-inducedapoptosisduringinsectcellularimmuneresponse.ArchInsectBiochemPhysiol100,21534.
3.Li-DanZhang#,Qiu-ChengCai#,Ji-HuiCui#,WeiZhang#,Shu-MeiDong#,WeiXiao#,JiangLi,Tian-ChaoKou,Xue-WenZhang,Hao-JuanHe,LeiDing,YangYang,Jian-HuaLai,MingLi,Qi-ShunZhu,Kai-JunLuo*.(2019)Asecreted-Cu/ZnsuperoxidedismutasefromMicroplitisbicoloratusreducesreactiveoxygenspeciestriggeredbysymbioticbracovirus.Developmental&ComparativeImmunology92,129-139.
4.Ji-HuiCui#,Yan-BinChen#,MingLi#,Qiu-ChengCai,Li-DanZhang,Zi-YunLu,Jian-ChengLi,Qi-ShunZhu,GangJi*,Kai-JunLuo*.(2018)Cryo-EMstructurerevealscylindricalnucleocapsidsfromtwopolydnaviruses.ArchivesofVirology163,3357-3363.
5.WeiZhang#,Meng-WeiLiu#,MingLi#,WeiXiao#,Xue-WenZhangHao-JuanHe,Yan-BinChen,LeiDing,Kai-JunLuo*.(2018)UnexpectedlinkbetweeninsectinnexinsandapoptosisofHeLacells.ArchInsectBiochemPhysiol99,e21473.
6.Shu-MeiDong,Ji-HuiCui,WeiZhang,Xue-WenZhang,Tian-ChaoKou,Qiu-ChenCai,ShaXu,Dong-ShuaiYu,LeiDing,Jian-HuaLai,MingLi,Kai-JunLuo*.(2017).InhibitionoftranslationinitiationfactoreIF4AisrequiredforapoptosismediatedbyMicroplitisbicoloratusbracovirus.ArchInsectBiochemPhysiol96,e21423.
7.Tian-ChaoKou#,Yue-TongLiu#,MingLi#,YangYang#,WeiZhang,Ji-HuiCui,Xue-WenZhang,Shu-MeiDong,ShaXu,ShanYou,Dong-ShuaiYu,Zun-YuPang,Kai-JunLuo*.(2017).Identificationofβ-chainofFoF1-ATPaseinapoptoticcellpopulationinducedbyMicroplitisbicoloratusbracoviruaanditsroleinthedevelopmentofSpodopteralitura.ArchInsectBiochemPhysiol95,e21389
8.Dong-ShuaiYu#,Ya-BinChen#,MingLi#,Ming-JunYang,YangYang,Jian-ShengHu,Kai-JunLuo*.(2016).ApolydnaviralgenomeofMicroplitisbicoloratusbracovirusandmolecularinteractionsbetweenthehostandvirusinvolvedinNF-κBsignaling.ArchVirol161,3095-3125.
9.Ya-BinChen#,WeiXiao#,MingLi#,YanZhang,YangYang,Jian-ShengHu,Kai-JunLuo*.(2016).N-terminallyelongatedSpliInx2andSpliInx3reducebaculovirus-triggeredapoptosisviahemichannelclosure.ArchInsectBiochemPhysiol92,24-37.
10.Lin-EGuo#,Jun-FengZhang#,Xin-YiLiu,Li-MeiZhang,Hong-LiZhang,Jian-HuaChen,Xiao-GuangXie,YingZhou*,Kai-JunLuo*,Ju-YongYoon*.(2015)Phosphateiontargetedcolorimetricandfluorescentprobeanditsusetomonitorendogeneousphosphateioninahemichannel-closedcell.AnalChem87,1196-1201.
11.ZunyuPang#,MingLi#,DongshuaiYu#,YanZhang,XinyiLiu,XinglaiJi,YangYang,JianshengHu,KaijunLuo*.(2015).TwoinnexinsofSpodopteraliturainfluenceshemichannelandgapjunctionfunctionsincellularimmuneresponses,Arch.InsectBiochem.Physiol90,43-57.
12.MingLi#,ZunyuPang#,WeiXiao#,XinyiLiu,YanZhang,MinjunYang,YangYang,JianshengHu,KaijunLuo*.(2014).ATranscriptomeanalysisSuggestsapoptosis-relatedsignalingpathwaysinhemocytesofSpodopteralituraafterparasitizationbyMicroplitisbicoloratus,PLoSONE9(10),1-18,e110967.
13.TianLiu#,MingLi#,YanZhang,ZunyuPang,WeiXiao,YangYang,KaijunLuo*.(2013).AroleforInnexin2andInnexin3proteinsfromSpodopteraliturainapoptosis,PLoSONE,8(7),e70456.