杨崇林 - 云南大学 - 生命科学学院

个人简介

个人简历 1998年于北京大学获博士学位。 1998-1999年为意大利Internationalschoolforadvancedstudies分子神经生物学实验室访问学者。 1999-2005年先后在UniversityofMarylandSchoolofMedicine和UniversityofColorado从事博士后研究。 2006年入选中国科学院"百人计划"，终期获评优秀。 2010年获国家杰出青年基金资助。 2013年被中国科协授予“全国优秀科技工作者”荣誉称号。 2016年云南大学生命科学学院院长、生命科学研究中心主任、教授（二级） 2017年入选国家“百千万人才工程”。 FEBSJournal,JournalofGeneticsandGenomic等国际国内外学术期刊编委。

研究领域

杨崇林研究组主要以秀丽线虫(Caenorhabditiselegans)为模式，运用正向和反向遗传、生化以及细胞生物学等综合手段，探索程序性细胞死亡的调控机制以及溶酶体和线粒体的调控机制。当前研究主要集中在以下三个方面： 1.细胞程序性死亡的遗传与分子调控机制程序性细胞死亡是多细胞有机体生长和发育过程中最重要的生命现象之一，对组织和器官发育、生物体动态平衡的维持等起着决定性的作用。 2.溶酶体介导的细胞降解机制溶酶体是细胞内物质降解的主要场所，我们利用重要模式生物-秀丽线虫作为强大的遗传工具，筛选和鉴定影响溶酶体功能和动态的必需调控因子。目前，通过多个正向遗传学筛选，我们已经获得多个表现溶酶体功能失调的突变体。 3.线粒体动态平衡的调控机制我们将以线虫为模式，利用正、反向遗传学手段筛选并克隆参与线粒体代谢与细胞凋亡的新调控因子。我们将利用电镜分析、基因和功能表达分析、蛋白质亚细胞定位和动态分析，研究所克隆的新基因调控线粒体发生、形状维持的作用机制。

近期论文

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1.QiwenGan#,XinWang,QianZhang,QiuyuanYin#,YouliJian,YubingLiu,NanXuan,JinglinLi#,JunxiangZhou,KaiLiu,YudongJing,XiaochenWang,andChonglinYang*.TheaminoacidtransporterSLC-36.1cooperateswithPtdIns3P5-kinasetocontrolphagocyticlysosomereformation.TheJournalofCellBiology.2019.doi:10.1083/jcb.201901074. 2.JunxiangZhou,XinWang,MinWang,YuweiChang,FengxiaZhang,ZhaonanBan,RuofengTang,QiwenGan,ShaohuanWu,YeGuo,QianZhang,FengyangWang,LiyuanZhao,YudongJing,WenfengQian,GuodongWang,WeixiangGuo*,andChonglinYang*.Thelysinecatabolitesaccharopineimpairsdevelopmentbydisruptingmitochondrialhomeostasis.TheJournalofCellBiology.2019,218(2):580-597. 3.MinWang#,ChangyongTang#,RuxiaoXing,XuezhaoLiu,YinghaoLiu,LeiWang,ChonglinYang*andWeixiangGuo*.WDR81regulatesadulthippocampalneurogenesisthroughendosomalSARA-TGFβsignaling.MolecularPsychiatry.doi:10.1038/s41380-018-0307-y. 4.YangLi*,YuZhang,QiwenGan,MengXu,XiaoDing,GuihuaTang,JingjingLiang,KaiLiu,XuezhaoLiu,XinWang,LingliGuo,ZhiyangGao,XiaojiangHao*,ChonglinYang*.(2018).C.elegans-basedscreenidentifieslysosome-damagingalkaloidsthatinduceSTAT3-dependentlysosomalcelldeath.Protein&cell.9(12):1013–1026. 5.CaitlinMorris,OliviaK.Foster,SimranHanda,KimberlyPeloza,LauraVoss,HannahSomhegyi,YouliJian,MyVanVo,MarieHarp,FionaM.Rambo,ChonglinYang,GregJ.Hermann*.(2018).FunctionandregulationoftheCaenorhabditiselegansRab32familymemberGLO-1inlysosome-relatedorganellebiogenesis.PLoSGenetics.14(11):e1007772. 6.XinliMa#,KaiLiu#,JianLi,HuanhuanLi,JunLi,YingfangLiu,ChonglinYang*andHuanhuanLiang*.(2018).Anon-canonicalGTPaseinteractionenablesORP1L-Rab7-RILPcomplexformationandlateendosomepositioning.theJournalofBiologicalChemistry.293(36):14155-14164. 7.KaiLiu,RuxiaoXing,YouliJian,ZhiyangGao,XinliMa,XiaojuanSun,YangLi,MengXu,XinWang,YudongJing,WeixiangGuoandChonglinYang.(2017).WDR91isaRab7effectorrequiredforneuronaldevelopment.TheJournalofCellBiology.216(10):3307-3321. 8.JianhuaYin,YalingHuang,PengfeiGuo,SiqiHu,SawakoYoshina,NanXuan,QiwenGan,ShoheiMitani,ChonglinYang,XiaochenWang*.(2017).GOP-1promotesapoptoticcelldegradationbyactivatingthesmallGTPaseRab2inC.elegans.TheJournalofCellBiology.216(6),1775-1794. 9.XuezhaoLiu#,YangLi#,XinWang,RuxiaoXing,KaiLiu,QiwenGan,ChangyongTang,ZhiyangGao,YouliJian,ShouqingLuo,WeixiangGuo,andChonglinYang.(2017).TheBEACH-containingproteinWDR81coordinatesp62andLC3Ctopromoteaggrephagy.TheJournalofCellBiology.216(5):1301-1320. 10.ChonglinYang*,XiaochenWang*.(2017).CellBiologyinChina:FocusingontheLysosome.Traffic.18(6):348-357. 11.ShiyaCheng,KaiLiu,ChonglinYang*,XiaochenWang*.(2017).DissectingPhagocyticRemovalofApoptoticCellsinCaenorhabditiselegans.InMethodsinMolecularBiology:PhagocytosisandPhagosomes(Eds.RobertoBotelho)SpringerNewYork,265-284.PrintISBN:978-1-4939-6579-3. 12.YuanLi,BaohuiChen,WeiZou,XinWang,YanweiWu,DongfengZhao,YananSun,YubingLiu,LianwanChen,LongMiao,ChonglinYang,XiaochenWang*.(2016).ThelysosomalmembraneproteinSCAV-3maintainslysosomeintegrityandadultlongevity.TheJournalofCellBiology215(2),167-185. 13.YangLi#,MengXu#,XiaoDing,ChenYan,ZhiqinSong,LianwanChen,XiaheHuang,XinWang,YouliJian,GuihuaTang,ChangyongTang,YingtongDi,ShuzhenMu,XuezhaoLiu,KaiLiu,TingLi,YingchunWang,LongMiao,WeixiangGuo,XiaojiangHaoandChonglinYang.(2016).ProteinkinaseCcontrolslysosomebiogenesisindependentlyofmTORC1.NatureCellBiology18,1065-1077. (NewsandViews:Turnupthelysosome.PaulSaftig,AlbertHaas.NatureCellBiology18,1025-1027). 14.XiaochenWang*,ChonglinYang*.(2016).ProgrammedcelldeathandclearanceofcellcorpsesinCaenorhabditiselegans.CellularandMolecularLifeSciences73,2221-2236. 15.KaiLiu#,YouliJian#,XiaojuanSun#,ChengkuiYang,ZhiyangGao,ZhiliZhang,XuezhaoLiu,YangLi,JingXu,YudongJing,ShoheiMitani,SudanHe,ChonglinYang.(2016).Negativeregulationofphosphatidylinositol3-phosphatelevelsinearly-to-lateendosomeconversion.TheJournalofCellBiology212(2),181-198.(InFocus:Makingsurelateendosomesareontime.MitchLeslie.JCellBiol212:127). 16.MengXu#,YubingLiu,LiyuanZhao,QiwenGan,XiaochenWang,andChonglinYang.(2014).ThelysosomalcathepsinproteaseCPL-1playsaleadingroleinphagosomaldegradationofapoptoticcellsinCaenorhabditiselegans.MolecularBiologyoftheCell25,2071-2083. 17.DidiChen#,YouliJian#,XuezhaoLiu,YuanyaZhang,JingjingLiang,XiayingQi,HongweiDu,WeiZou,LianwanChen,YongpingChai,GuangshuoOu,LongMiao,YingchunWang,andChonglinYang.(2013).ClathrinandAP2arerequiredforphagocyticreceptor-mediatedapoptoticcellclearanceinCaenorhabditiselegans.PLoSGenetics9(5),e1003517. 18.JingXu,XiaojuanSun,YudongJing,MoWang,KaiLiu,YouliJian,MeiYang,ZhukuanCheng,ChonglinYang.(2012).MRG-1isrequiredforgenomicintegrityinCaenorhabditiselegansgermcells.CellResearch22,886-902. 19.DidiChen#,HuiXiao#,KaiZhang,BinWang,ZhiyangGao,YouliJian,XiayingQi,JianweiSun,LongMiao,ChonglinYang,2010.RetromerIsRequiredforApoptoticCellClearancebyPhagocyticReceptorRecycling.Science,327：1261-1264. 20.XiaoYang*andChonglinYang*.2010.Aneverlastingroleofanimalmodelsinunderstandinghumandisease.JournalofGeneticsandGenomics37:557. 21.YouliJian,ZhiyangGao,JianweiSun,QinfangShen,FengFeng,YudongJingandChonglinYang,2009.RNAaptamersinterferingwithnucleophosminoligomerizationinduceapoptosisincancercells,Oncogene.28:4201-4211. 22.QinfangShen#,FengsongQin#,ZhiyangGao#,JieCui,HuiXiao,ZhihengXu,andChonglinYang,2009.AdenineNucleotideTranslocatorCooperateswithCoreCellDeathMachinerytoPromoteApoptosisinCaenorhabditiselegans.MolecularandCellularBiology,29(14):3881–3893. 23.MeiYang,JianweiSun,XiaojuanSun,QinfangShen,ZhiyangGao,ChonglinYang,2009.CaenorhabditiselegansProteinArginineMethyltransferasePRMT-5NegativelyRegulatesDNADamage-InducedApoptosis.PLoSGenetics,5(6):e1000514.doi:10.1371/journal.pgen.1000514. 24.HuiXiao,DidiChen,ZhouFang,XiaojuanSun,JingXu,SongSong,JiajiaLiuandChonglinYang,2009.Lysosomebiogenesismediatedbyvps-18affectsapoptoticcelldegradationinCaenorhabditiselegans.MolecularBiologyoftheCell,20:21-32. 25.ChonglinYang,MyoungSookKim,DevulapalliChakravarty,FredE.IndigandFranceCarrier,2009.NucleolinBindstotheProliferatingCellNuclearAntigenandInhibitsNucleotideExcisionRepair.MolecularandCellularPharmacology,1(3):130-137. 26.XiaochenWang,JinWang,KeikoGengyo-Ando,LichuanGu,Chun-LingSun,ChonglinYang,YongShi,TetsuoKobayashi,YigongShi,ShoheiMitani,Xiao-SongXie&DingXue,2007.C.elegansmitochondrialfactorWAH-1promotesphosphatidylserineexternalizationinapoptoticcellsthroughphospholipidscramblaseSCRM-1.NatureCellBiology,9:541-549. 27.ChonglinYang,NiengYan,JayParish,XiaochenWang,YigongShiandDingXue，2006.RNAaptamerstargetingthecelldeathinhibitorCED-9inducecellkillinginC.elegans.JournalofBiologicalChemistry,281:9137-44.